Sirtuin 6 contributes to migration and invasion of osteosarcoma cells via the ERK1/2/MMP9 pathway

Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model

(2017) Giovanna Sociali et al.   FASEB JOURNAL

SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity

(2017) Rafael M. Ioris et al.   Cell Reports

CK2α/CSNK2A1 Phosphorylates SIRT6 and Is Involved in the Progression of Breast Carcinoma and Predicts Shorter Survival of Diagnosed Patients

(2016) Jun Sang Bae et al.   AMERICAN JOURNAL OF PATHOLOGY

SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b

(2016) Sita Kugel et al.   CELL

SIRT6 Overexpression Potentiates Apoptosis Evasion in Hepatocellular Carcinoma via BCL2-Associated X Protein-Dependent Apoptotic Pathway

(2016) L.-K. Ran et al.   CLINICAL CANCER RESEARCH

Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs

(2016) Agata Jabłońska-Trypuć et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Identifying the functional contribution of the defatty-acylase activity of SIRT6

(2016) Xiaoyu Zhang et al.   Nature Chemical Biology

A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity

(2016) J Cai et al.   ONCOGENE

Downregulation of IDH2 exacerbates the malignant progression of osteosarcoma cells via increased NF-κB and MMP-9 activation

(2016) WAN-RONG YI et al.   ONCOLOGY REPORTS

EFEMP1 inhibits migration of hepatocellular carcinoma by regulating MMP2 and MMP9 via ERK1/2 activity

(2016) CHENG-YUN DOU et al.   ONCOLOGY REPORTS

SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCC

(2016) Namgyu Lee et al.   PLoS One

Upregulation of SIRT6 predicts poor prognosis and promotes metastasis of non-small cell lung cancer via the ERK1/2/MMP9 pathway

(2016) Lihong Bai et al.   Oncotarget

Hairy/enhancer-of-split related with YRPW motif protein 1 promotes osteosarcoma metastasis via matrix metallopeptidase 9 expression

(2015) A Tsuru et al.   BRITISH JOURNAL OF CANCER

The complex role of SIRT6 in carcinogenesis

(2015) Batia Lerrer et al.   CARCINOGENESIS

Putative tumor suppression function of SIRT6 in endometrial cancer

(2015) Tomohiko Fukuda et al.   FEBS LETTERS

SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non-small cell lung cancer

(2015) Yoko Azuma et al.   JOURNAL OF SURGICAL ONCOLOGY

Coexpression of CXCR4 and MMP9 predicts lung metastasis and poor prognosis in resected osteosarcoma

(2015) Zhiwu Ren et al.   TUMOR BIOLOGY

The histone acetyltransferase hMOF suppresses hepatocellular carcinoma growth

(2014) Jin Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT6 Promotes COX-2 Expression and Acts as an Oncogene in Skin Cancer

(2014) M. Ming et al.   CANCER RESEARCH

Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion

(2014) P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Osteosarcoma metastasis: prospective role of ezrin

(2014) Yuanjin Zhang et al.   TUMOR BIOLOGY

A systematic review of matrix metalloproteinase 9 as a biomarker of survival in patients with osteosarcoma

(2014) Hui Li et al.   TUMOR BIOLOGY

SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer

(2013) Mattaka Khongkow et al.   CARCINOGENESIS

Sirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients

(2013) Jens U. Marquardt et al.   HEPATOLOGY

USP10 Antagonizes c-Myc Transcriptional Activation through SIRT6 Stabilization to Suppress Tumor Formation

(2013) Zhenghong Lin et al.   Cell Reports

SP-1 regulation of MMP-9 expression requires Ser586in the PEST domain

(2012) Shubha Murthy et al.   BIOCHEMICAL JOURNAL

The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

(2012) Carlos Sebastián et al.   CELL

The NAD+-dependent Histone Deacetylase SIRT6 Promotes Cytokine Production and Migration in Pancreatic Cancer Cells by Regulating Ca2+Responses

(2012) Inga Bauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin

(2012) Lihua Min et al.   NATURE CELL BIOLOGY

CITED2 links hormonal signaling to PGC-1α acetylation in the regulation of gluconeogenesis

(2012) Mashito Sakai et al.   NATURE MEDICINE

Identification of Novel Interacting Partners of Sirtuin6

(2012) Oxana Polyakova et al.   PLoS One

SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells

(2011) Michael Van Meter et al.   CELL CYCLE

Arsenic trioxide inhibits osteosarcoma cell invasiveness via MAPK signaling pathway

(2010) Ren Tingting et al.   CANCER BIOLOGY & THERAPY

Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis

(2010) Hyun-Seok Kim et al.   Cell Metabolism

SIRT6 protects against pathological damage caused by diet-induced obesity

(2009) Yariv Kanfi et al.   AGING CELL

Colon cancer metastasis: MACC1 and Met as metastatic pacemakers

(2009) Franziska Arlt et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways

(2009) Ymera Pignochino et al.   Molecular Cancer

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE