Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model

Identifying the functional contribution of the defatty-acylase activity of SIRT6

(2016) Xiaoyu Zhang et al.   Nature Chemical Biology

Insulin secretion impairment in Sirt6 knockout pancreatic β cells is mediated by suppression of the FoxO1-Pdx1-Glut2 pathway

(2016) Mi-Young Song et al.   Scientific Reports

Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics

(2015) Giovanna Sociali et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model

(2015) Giovanna Sociali et al.   Oncotarget

Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models

(2015) Giovanna Bianchi et al.   Oncotarget

Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6

(2015) Jason G. Anderson et al.   Molecular Metabolism

Discovery of Novel and Selective SIRT6 Inhibitors

(2014) Marco Daniele Parenti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chromatin and beyond: the multitasking roles for SIRT6

(2014) Sita Kugel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Tricarboxylic acid cycle-sustained oxidative phosphorylation in isolated myelin vesicles

(2013) Silvia Ravera et al.   BIOCHIMIE

Moderate GLUT4 Overexpression Improves Insulin Sensitivity and Fasting Triglyceridemia in High-Fat Diet-Fed Transgenic Mice

(2013) B. J. Atkinson et al.   DIABETES

Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

(2013) Jessica L. Feldman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6

(2013) Rongya Tao et al.   JOURNAL OF LIPID RESEARCH

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

(2013) Hong Jiang et al.   NATURE

The Deacetylase Sirt6 Activates the Acetyltransferase GCN5 and Suppresses Hepatic Gluconeogenesis

(2012) John E. Dominy et al.   MOLECULAR CELL

Type 2 diabetes across generations: from pathophysiology to prevention and management

(2011) Christopher J Nolan et al.   LANCET

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis

(2010) Hyun-Seok Kim et al.   Cell Metabolism

SIRT6 Deficiency Results in Severe Hypoglycemia by Enhancing Both Basal and Insulin-stimulated Glucose Uptake in Mice

(2010) Cuiying Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Decrease of Serum Levels of Human Neutrophil Alpha-Defensins Parallels with the Surgery-Induced Amelioration of NASH in Obesity

(2010) Melania Manco et al.   OBESITY SURGERY

SIRT6 protects against pathological damage caused by diet-induced obesity

(2009) Yariv Kanfi et al.   AGING CELL

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

Serum levels of hyaluronic acid and tissue metalloproteinase inhibitor-1 combined with age predict the presence of nonalcoholic steatohepatitis in a pilot cohort of subjects with nonalcoholic fatty liver disease

(2009) Luca Miele et al.   Translational Research