Abnormal subchondral bone remodeling and its association with articular cartilage degradation in knees of type 2 diabetes patients

Epidemiology of fractures in type 2 diabetes

(2016) Ann V. Schwartz   BONE

Deterioration of trabecular plate-rod and cortical microarchitecture and reduced bone stiffness at distal radius and tibia in postmenopausal women with vertebral fractures

(2016) Ji Wang et al.   BONE

Insulin decreases autophagy and leads to cartilage degradation

(2016) M. Ribeiro et al.   OSTEOARTHRITIS AND CARTILAGE

Trabecular plates and rods determine elastic modulus and yield strength of human trabecular bone

(2015) Ji Wang et al.   BONE

Treatment with recombinant lubricin attenuates osteoarthritis by positive feedback loop between articular cartilage and subchondral bone in ovariectomized rats

(2015) Zhuang Cui et al.   BONE

Characterization of diabetic osteoarthritic cartilage and role of high glucose environment on chondrocyte activation: toward pathophysiological delineation of diabetes mellitus-related osteoarthritis

(2015) M.-C. Laiguillon et al.   OSTEOARTHRITIS AND CARTILAGE

Bone turnover and articular cartilage differences localized to subchondral cysts in knees with advanced osteoarthritis

(2015) Y. Chen et al.   OSTEOARTHRITIS AND CARTILAGE

Severe radiographic knee osteoarthritis – does Kellgren and Lawrence grade 4 represent end stage disease? – the MOST study

(2015) A. Guermazi et al.   OSTEOARTHRITIS AND CARTILAGE

The adverse effects of diabetes on osteoarthritis: update on clinical evidence and molecular mechanisms

(2015) K.B. King et al.   OSTEOARTHRITIS AND CARTILAGE

Subchondral bone turnover, but not bone volume, is increased in early stage osteoarthritic lesions in the human hip joint

(2015) R. Klose-Jensen et al.   OSTEOARTHRITIS AND CARTILAGE

FFA-ROS-P53-mediated mitochondrial apoptosis contributes to reduction of osteoblastogenesis and bone mass in type 2 diabetes mellitus

(2015) Jun Li et al.   Scientific Reports

Bone Cells and Bone Turnover in Diabetes Mellitus

(2015) Mishaela R. Rubin   Current Osteoporosis Reports

Fracture risk in diabetic elderly men: the MrOS study

(2014) Nicola Napoli et al.   DIABETOLOGIA

The relationship between subchondral sclerosis detected with MRI and cartilage loss in a cohort of subjects with knee pain: the knee osteoarthritis progression (KOAP) study

(2014) M.D. Crema et al.   OSTEOARTHRITIS AND CARTILAGE

Suppressed bone turnover was associated with increased osteoporotic fracture risks in non-obese postmenopausal Chinese women with type 2 diabetes mellitus

(2014) R. Jiajue et al.   OSTEOPOROSIS INTERNATIONAL

Targeting subchondral bone in osteoporotic osteoarthritis

(2014) Jorge A Roman-Blas et al.   ARTHRITIS RESEARCH & THERAPY

The association of body mass index with the risk of type 2 diabetes: a case–control study nested in an electronic health records system in the United States

(2014) Michael L Ganz et al.   Diabetology & Metabolic Syndrome

Characterisation of osteoarthritis in a small animal model of type 2 diabetes mellitus

(2014) T. Onur et al.   Bone & Joint Research

The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?

(2013) M A Karsdal et al.   ANNALS OF THE RHEUMATIC DISEASES

Alendronate protects against articular cartilage erosion by inhibiting subchondral bone loss in ovariectomized rats

(2013) Songsong Zhu et al.   BONE

Executive Summary: Standards of Medical Care in Diabetes--2014

(2013)   DIABETES CARE

Fast Trabecular Bone Strength Predictions of HR-pQCT and Individual Trabeculae Segmentation-Based Plate and Rod Finite Element Model Discriminate Postmenopausal Vertebral Fractures

(2013) X Sherry Liu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Premenopausal and postmenopausal differences in bone microstructure and mechanical competence in Chinese-American and white women

(2013) Marcella D Walker et al.   JOURNAL OF BONE AND MINERAL RESEARCH

In Vivo Assessment of Bone Quality in Postmenopausal Women With Type 2 Diabetes

(2013) Joshua N Farr et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

(2013) Gehua Zhen et al.   NATURE MEDICINE

Osteoporotic OA: a reasonable target for bone-acting agents

(2013) Gabriel Herrero-Beaumont et al.   Nature Reviews Rheumatology

Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis

(2013) D. Bobinac et al.   OSTEOARTHRITIS AND CARTILAGE

Bone loss at subchondral plate in knee osteoarthritis patients with hypertension and type 2 diabetes mellitus

(2013) C.Y. Wen et al.   OSTEOARTHRITIS AND CARTILAGE

The role of varus and valgus alignment in the initial development of knee cartilage damage by MRI: the MOST study

(2012) Leena Sharma et al.   ANNALS OF THE RHEUMATIC DISEASES

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Diabetes Is an Independent Predictor for Severe Osteoarthritis: Results from a longitudinal cohort study

(2012) G. Schett et al.   DIABETES CARE

Prevalence of Obesity and Trends in Body Mass Index Among US Children and Adolescents, 1999-2010

(2012) Cynthia L. Ogden et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fractures

(2012) Janina M Patsch et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Metabolic syndrome meets osteoarthritis

(2012) Qi Zhuo et al.   Nature Reviews Rheumatology

Bone and cartilage demonstrate changes localized to bone marrow edema-like lesions within osteoarthritic knees

(2012) G.J. Kazakia et al.   OSTEOARTHRITIS AND CARTILAGE

Role of glucose as a modulator of anabolic and catabolic gene expression in normal and osteoarthritic human chondrocytes

(2011) Susana C. Rosa et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Bone structure and turnover in type 2 diabetes mellitus

(2011) A. Shu et al.   OSTEOPOROSIS INTERNATIONAL

The bone–cartilage unit in osteoarthritis

(2010) Rik J. Lories et al.   Nature Reviews Rheumatology

Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis

(2010) Miriam Bellido et al.   ARTHRITIS RESEARCH & THERAPY

Ethnic comparisons of the cross-sectional relationships between measures of body size with diabetes and hypertension

(2008) R. Huxley et al.   Obesity Reviews

Bone formation in spontaneously diabetic Torii-newly established model of non-obese type 2 diabetes rats

(2007) Hideki Fujii et al.   BONE