Mesenchymal stem cell therapy for the treatment of amyotrophic lateral sclerosis: signals for hope?

Presence of osteoclast precursor cells during ex vivo expansion of bone marrow-derived mesenchymal stem cells for autologous use in cell therapy

(2013) Carolina Allers et al.   CYTOTHERAPY

Two Potential Biomarkers Identified in Mesenchymal Stem Cells and Leukocytes of Patients with Sporadic Amyotrophic lateral Sclerosis

(2013) Henny Nachmany et al.   DISEASE MARKERS

Serial Transplantation and Long-term Engraftment of Intra-arterially Delivered Clonally Derived Mesenchymal Stem Cells to Injured Bone Marrow

(2013) Paul Lin et al.   MOLECULAR THERAPY

The changing scene of amyotrophic lateral sclerosis

(2013) Wim Robberecht et al.   NATURE REVIEWS NEUROSCIENCE

Systemic treatment with adipose-derived mesenchymal stem cells ameliorates clinical and pathological features in the amyotrophic lateral sclerosis murine model

(2013) S. Marconi et al.   NEUROSCIENCE

Intraspinal Stem Cell Transplantation in Amyotrophic Lateral Sclerosis

(2013) Jonathan Riley et al.   NEUROSURGERY

A Review of Experimental Research on Herbal Compounds in Amyotrophic Lateral Sclerosis

(2013) Xue Zhang et al.   PHYTOTHERAPY RESEARCH

Therapeutic Potential of Mesenchymal Stromal Cells and MSC Conditioned Medium in Amyotrophic Lateral Sclerosis (ALS) - In Vitro Evidence from Primary Motor Neuron Cultures, NSC-34 Cells, Astrocytes and Microglia

(2013) Hui Sun et al.   PLoS One

Notch Signaling Is Involved in Neurogenic Commitment of Human Periodontal Ligament-Derived Mesenchymal Stem Cells

(2013) Thanaphum Osathanon et al.   STEM CELLS AND DEVELOPMENT

Mesenchymal stromal-cell transplants induce oligodendrocyte progenitor migration and remyelination in a chronic demyelination model

(2013) J Jaramillo-Merchán et al.   Cell Death & Disease

Emerging drug targets in amyotrophic lateral sclerosis

(2013) Michael P Bova et al.   Expert Opinion on Orphan Drugs

A randomized trial of mesenchymal stem cells in multiple system atrophy

(2012) Phil Hyu Lee et al.   ANNALS OF NEUROLOGY

A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants

(2012) Takao Fujisawa et al.   ANNALS OF NEUROLOGY

Feasibility, Safety, and Preliminary Proof of Principles of Autologous Neural Stem Cell Treatment Combined with T-Cell Vaccination for ALS Patients

(2012) G. A. Moviglia et al.   CELL TRANSPLANTATION

Human mesenchymal stromal cell proteomics: contribution for identification of new markers and targets for medicine intervention

(2012) Vitor Marcel Faça   Expert Review of Proteomics

Improved proteomic profiling of the cell surface of culture-expanded human bone marrow multipotent stromal cells

(2012) Samuel T. Mindaye et al.   Journal of Proteomics

Linking respiratory chain uncoupling to amyotrophic lateral sclerosis implies potential treatment with herbal extracts containing genipin

(2012) M. Hoffmann   MEDICAL HYPOTHESES

Unknown

(2012) Antonio Uccelli et al.   MOLECULAR MEDICINE

Does a loss of TDP-43 function cause neurodegeneration?

(2012) Zuo-Shang Xu   Molecular Neurodegeneration

Autologous bone marrow-derived stem cells in amyotrophic lateral sclerosis: A pilot study

(2012) Sudesh Prabhakar et al.   NEUROLOGY INDIA

Multiple Intravenous Administrations of Human Umbilical Cord Blood Cells Benefit in a Mouse Model of ALS

(2012) Svitlana Garbuzova-Davis et al.   PLoS One

Intracerebroventricular Injection of Encapsulated Human Mesenchymal Cells Producing Glucagon-Like Peptide 1 Prolongs Survival in a Mouse Model of ALS

(2012) Sarah Knippenberg et al.   PLoS One

Human Mesenchymal Stem Cell Expression Program upon Extended Ex-Vivo Cultivation, as Revealed by 2-DE-Based Quantitative Proteomics

(2012) Andreia Madeira et al.   PLoS One

Human Neural Stem Cell Replacement Therapy for Amyotrophic Lateral Sclerosis by Spinal Transplantation

(2012) Michael P. Hefferan et al.   PLoS One

Neurotrophic Bone Marrow Cellular Nests Prevent Spinal Motoneuron Degeneration in Amyotrophic Lateral Sclerosis Patients: A Pilot Safety Study

(2012) Miguel Blanquer et al.   STEM CELLS

Lumbar Intraspinal Injection of Neural Stem Cells in Patients with Amyotrophic Lateral Sclerosis: Results of a Phase I Trial in 12 Patients

(2012) Jonathan D. Glass et al.   STEM CELLS

Mesenchymal Stem Cells and the Treatment of Conditions and Diseases: The Less Glittering Side of a Conspicuous Stem Cell for Basic Research

(2012) Jose J. Minguell et al.   STEM CELLS AND DEVELOPMENT

Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC

(2011) Ralf Hass et al.   Cell Communication and Signaling

Understanding the role of TDP-43 and FUS/TLS in ALS and beyond

(2011) Sandrine Da Cruz et al.   CURRENT OPINION IN NEUROBIOLOGY

Mesenchymal stromal cells prolong the lifespan in a rat model of amyotrophic lateral sclerosis

(2011) Serhiy Forostyak et al.   CYTOTHERAPY

Mesenchymal stromal cell transplantation in amyotrophic lateral sclerosis: a long-term safety study

(2011) Letizia Mazzini et al.   CYTOTHERAPY

The functional deficiency of bone marrow mesenchymal stromal cells in ALS patients is proportional to disease progression rate

(2011) Seong-Ho Koh et al.   EXPERIMENTAL NEUROLOGY

Prevention of Motor Neuron Degeneration by Novel Iron Chelators in SOD1G93A Transgenic Mice of Amyotrophic Lateral Sclerosis

(2011) Qian Wang et al.   Neurodegenerative Diseases

The Cell Surface Proteome of Human Mesenchymal Stromal Cells

(2011) Christian Niehage et al.   PLoS One

Human Glial-Restricted Progenitor Transplantation into Cervical Spinal Cord of the SOD1G93A Mouse Model of ALS

(2011) Angelo C. Lepore et al.   PLoS One

Comparative Effects between Bone Marrow and Mesenchymal Stem Cell Transplantation in GDNF Expression and Motor Function Recovery in a Motorneuron Degenerative Mouse Model

(2011) Diego Pastor et al.   Stem Cell Reviews and Reports

Stem Cell-Derived Motor Neurons: Applications and Challenges in Amyotrophic Lateral Sclerosis

(2011) Jason Thonhoff et al.   Current Stem Cell Research & Therapy

Safety and Immunological Effects of Mesenchymal Stem Cell Transplantation in Patients With Multiple Sclerosis and Amyotrophic Lateral Sclerosis

(2010) Dimitrios Karussis et al.   ARCHIVES OF NEUROLOGY

Human umbilical cord Wharton's jelly-derived mesenchymal stem cells differentiate into a Schwann-cell phenotype and promote neurite outgrowth in vitro

(2010) Jiang Peng et al.   BRAIN RESEARCH BULLETIN

Age-dependent neuroectodermal differentiation capacity of human mesenchymal stromal cells: limitations for autologous cell replacement strategies

(2010) Andreas Hermann et al.   CYTOTHERAPY

Metalloproteinase alterations in the bone marrow of ALS patients

(2010) Patrizia Bossolasco et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mesenchymal stem cells for the treatment of neurodegenerative disease

(2010) Nanette Joyce et al.   Regenerative Medicine

Persistent High Glucose Concentrations Alter the Regenerative Potential of Mesenchymal Stem Cells

(2010) Christopher Cramer et al.   STEM CELLS AND DEVELOPMENT

Neural differentiation potential of human bone marrow-derived mesenchymal stromal cells: misleading marker gene expression

(2009) Katrin Montzka et al.   BMC NEUROSCIENCE

Bone Marrow Mesenchymal Stem Cells from Healthy Donors and Sporadic Amyotrophic Lateral Sclerosis Patients

(2009) Ivana Ferrero et al.   CELL TRANSPLANTATION

Telomerase activity and expression in adult human mesenchymal stem cells derived from amyotrophic lateral sclerosis individuals

(2009) Ailone Tichon et al.   CYTOTHERAPY

Stem-cell transplantation into the frontal motor cortex in amyotrophic lateral sclerosis patients

(2009) Hector R. Martinez et al.   CYTOTHERAPY

Immature Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis

(2009) Sai V. Seetharaman et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Mesenchymal stem cell transplantation in amyotrophic lateral sclerosis: A Phase I clinical trial

(2009) L. Mazzini et al.   EXPERIMENTAL NEUROLOGY

Specific Lineage-Priming of Bone Marrow Mesenchymal Stem Cells Provides the Molecular Framework for Their Plasticity

(2009) Bruno Delorme et al.   STEM CELLS

Bone Marrow-Derived Stromal Cells from Amyotrophic Lateral Sclerosis Patients Have Diminished Stem Cell Capacity

(2009) Goang-Won Cho et al.   STEM CELLS AND DEVELOPMENT

A systematic review of antioxidant treatment for amyotrophic lateral sclerosis/motor neuron disease

(2008) Richard W. Orrell et al.   Amyotrophic Lateral Sclerosis

Implantation of human umbilical cord-derived mesenchymal stem cells as a neuroprotective therapy for ischemic stroke in rats

(2008) Seong-Ho Koh et al.   BRAIN RESEARCH

Long-term In vitro Expansion Alters the Biology of Adult Mesenchymal Stem Cells

(2008) R. Izadpanah et al.   CANCER RESEARCH

Treatment of amyotrophic lateral sclerosis patients by autologous bone marrow-derived hematopoietic stem cell transplantation: a 1-year follow-up

(2008) H. Deda et al.   CYTOTHERAPY

ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1

(2008) H. Nishitoh et al.   GENES & DEVELOPMENT

Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process

(2008) Wolfgang Wagner et al.   PLoS One

Human bone marrow native mesenchymal stem cells

(2008) Charalampos Pontikoglou et al.   Regenerative Medicine

Derivation of Neural Stem Cells from Mesenchymal Stem Cells: Evidence for a Bipotential Stem Cell Population

(2008) Lijuan Fu et al.   STEM CELLS AND DEVELOPMENT