An update on stem cell biology and engineering for brain development

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size

(2016) Tomoki Otani et al.   Cell Stem Cell

Epigenetic Variation between Human Induced Pluripotent Stem Cell Lines Is an Indicator of Differentiation Capacity

(2016) Masatoshi Nishizawa et al.   Cell Stem Cell

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

(2016) Junghyun Jo et al.   Cell Stem Cell

Directed differentiation of basal forebrain cholinergic neurons from human pluripotent stem cells

(2016) Yao Hu et al.   JOURNAL OF NEUROSCIENCE METHODS

Advancing the understanding of autism disease mechanisms through genetics

(2016) Luis de la Torre-Ubieta et al.   NATURE MEDICINE

Highly multiplexed simultaneous detection of RNAs and proteins in single cells

(2016) Andreas P Frei et al.   NATURE METHODS

Pluripotent stem cells in disease modelling and drug discovery

(2016) Yishai Avior et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A decade of transcription factor-mediated reprogramming to pluripotency

(2016) Kazutoshi Takahashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience

(2016) Jerome Mertens et al.   NATURE REVIEWS NEUROSCIENCE

Zika virus impairs growth in human neurospheres and brain organoids

(2016) P. P. Garcez et al.   SCIENCE

MicroRNA-302 switch to identify and eliminate undifferentiated human pluripotent stem cells

(2016) Callum J. C. Parr et al.   Scientific Reports

Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson’s Disease Patients

(2016) Lin Lin et al.   Cell Reports

High-resolution Identification and Separation of Living Cell Types by Multiple microRNA-responsive Synthetic mRNAs

(2016) Kei Endo et al.   Scientific Reports

Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency

(2015) Davide Cacchiarelli et al.   CELL

FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

(2015) Jessica Mariani et al.   CELL

Efficient Detection and Purification of Cell Populations Using Synthetic MicroRNA Switches

(2015) Kenji Miki et al.   Cell Stem Cell

Ground State Conditions Induce Rapid Reorganization of Core Pluripotency Factor Binding before Global Epigenetic Reprogramming

(2015) Christina Galonska et al.   Cell Stem Cell

m6A RNA Methylation Is Regulated by MicroRNAs and Promotes Reprogramming to Pluripotency

(2015) Tong Chen et al.   Cell Stem Cell

Direct Conversion of Normal and Alzheimer’s Disease Human Fibroblasts into Neuronal Cells by Small Molecules

(2015) Wenxiang Hu et al.   Cell Stem Cell

Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects

(2015) Jerome Mertens et al.   Cell Stem Cell

Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons

(2015) Xiang Li et al.   Cell Stem Cell

In vitro myelin formation using embryonic stem cells

(2015) B. E. Kerman et al.   DEVELOPMENT

Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities

(2015) J M Madison et al.   MOLECULAR PSYCHIATRY

Generation of functional human serotonergic neurons from fibroblasts

(2015) K C Vadodaria et al.   MOLECULAR PSYCHIATRY

Direct conversion of human fibroblasts to induced serotonergic neurons

(2015) Z Xu et al.   MOLECULAR PSYCHIATRY

Mammalian synthetic circuits with RNA binding proteins for RNA-only delivery

(2015) Liliana Wroblewska et al.   NATURE BIOTECHNOLOGY

Generation of serotonin neurons from human pluripotent stem cells

(2015) Jianfeng Lu et al.   NATURE BIOTECHNOLOGY

Modeling psychiatric disorders for developing effective treatments

(2015) Tobias Kaiser et al.   NATURE MEDICINE

Do glia drive synaptic and cognitive impairment in disease?

(2015) Won-Suk Chung et al.   NATURE NEUROSCIENCE

Generation and isolation of oligodendrocyte progenitor cells from human pluripotent stem cells

(2015) Panagiotis Douvaras et al.   Nature Protocols

The Outer Subventricular Zone and Primate-Specific Cortical Complexification

(2015) Colette Dehay et al.   NEURON

Swimming muscles power suction feeding in largemouth bass

(2015) Ariel L. Camp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Principles of connectivity among morphologically defined cell types in adult neocortex

(2015) X. Jiang et al.   SCIENCE

Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons

(2015) Houbo Jiang et al.   Nature Communications

Rapid and Efficient Direct Conversion of Human Adult Somatic Cells into Neural Stem Cells by HMGA2/let-7b

(2015) Kyung-Rok Yu et al.   Cell Reports

The miR-302/367 cluster: a comprehensive update on its evolution and functions

(2015) Zeqian Gao et al.   Open Biology

MicroRNA-302/367 Cluster Governs hESC Self-Renewal by Dually Regulating Cell Cycle and Apoptosis Pathways

(2015) Zhonghui Zhang et al.   Stem Cell Reports

Precise Correction of the Dystrophin Gene in Duchenne Muscular Dystrophy Patient Induced Pluripotent Stem Cells by TALEN and CRISPR-Cas9

(2015) Hongmei Lisa Li et al.   Stem Cell Reports

Two miRNA Clusters Reveal Alternative Paths in Late-Stage Reprogramming

(2014) Ronald J. Parchem et al.   Cell Stem Cell

Neural progenitors, neurogenesis and the evolution of the neocortex

(2014) M. Florio et al.   DEVELOPMENT

Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia

(2014) K Brennand et al.   MOLECULAR PSYCHIATRY

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

(2014) Mike A Nalls et al.   NATURE GENETICS

Regulation of microRNA function in somatic stem cell proliferation and differentiation

(2014) Archana Shenoy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Whole-Brain Atlas of Inputs to Serotonergic Neurons of the Dorsal and Median Raphe Nuclei

(2014) Iskra Pollak Dorocic et al.   NEURON

Generation of Human Striatal Neurons by MicroRNA-Dependent Direct Conversion of Fibroblasts

(2014) Matheus B. Victor et al.   NEURON

Dynamic regulation of human endogenous retroviruses mediates factor-induced reprogramming and differentiation potential

(2014) M. Ohnuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Enhancing the efficiency of direct reprogramming of human primary fibroblasts into dopaminergic neuron-like cells through p53 suppression

(2014) XinJian Liu et al.   Science China-Life Sciences

Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits

(2013) Yuanchao Xue et al.   CELL

Trnp1 Regulates Expansion and Folding of the Mammalian Cerebral Cortex by Control of Radial Glial Fate

(2013) Ronny Stahl et al.   CELL

Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

(2013) Justine D. Miller et al.   Cell Stem Cell

Steps Toward Safe Cell Therapy Using Induced Pluripotent Stem Cells

(2013) Hideyuki Okano et al.   CIRCULATION RESEARCH

Deterministic direct reprogramming of somatic cells to pluripotency

(2013) Yoach Rais et al.   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Genome-wide association analysis identifies 13 new risk loci for schizophrenia

(2013) Stephan Ripke et al.   NATURE GENETICS

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells

(2013) Yan Liu et al.   Nature Protocols

Mechanisms and models of somatic cell reprogramming

(2013) Yosef Buganim et al.   NATURE REVIEWS GENETICS

Differentiation-defective phenotypes revealed by large-scale analyses of human pluripotent stem cells

(2013) M. Koyanagi-Aoi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid Generation of Functional Dopaminergic Neurons From Human Induced Pluripotent Stem Cells Through a Single-Step Procedure Using Cell Lineage Transcription Factors

(2013) Ilda Theka et al.   Stem Cells Translational Medicine

Direct Comparison of Autologous and Allogeneic Transplantation of iPSC-Derived Neural Cells in the Brain of a Nonhuman Primate

(2013) Asuka Morizane et al.   Stem Cell Reports

A novel nonsenseCDK5RAP2mutation in a Somali child with primary microcephaly and sensorineural hearing loss

(2012) Alistair T. Pagnamenta et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

The expanding role of miR-302–367 in pluripotency and reprogramming

(2012) Inna Lipchina et al.   CELL CYCLE

Direct Reprogramming of Fibroblasts into Neural Stem Cells by Defined Factors

(2012) Dong Wook Han et al.   Cell Stem Cell

Generating an iPSC Bank for HLA-Matched Tissue Transplantation Based on Known Donor and Recipient HLA Types

(2012) Craig J. Taylor et al.   Cell Stem Cell

Direct Conversion of Fibroblasts into Stably Expandable Neural Stem Cells

(2012) Marc Thier et al.   Cell Stem Cell

Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs

(2012) Tokushige Nakano et al.   Cell Stem Cell

Glia: Regulating Synaptogenesis from Multiple Directions

(2012) Allison Rosen Bialas et al.   CURRENT BIOLOGY

A simplified method to generate serotonergic neurons from mouse embryonic stem and induced pluripotent stem cells

(2012) Takeshi Shimada et al.   JOURNAL OF NEUROCHEMISTRY

Rett syndrome induced pluripotent stem cell-derived neurons reveal novel neurophysiological alterations

(2012) N Farra et al.   MOLECULAR PSYCHIATRY

High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries

(2012) Gavriel Mullokandov et al.   NATURE METHODS

Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses

(2012) Yichen Shi et al.   NATURE NEUROSCIENCE

Modeling human cortical development in vitro using induced pluripotent stem cells

(2012) J. Mariani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells

(2012) M. Kajiwara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells

(2012) N. Egawa et al.   Science Translational Medicine

γ-Secretase Inhibitors Prevent Overgrowth of Transplanted Neural Progenitors Derived from Human-Induced Pluripotent Stem Cells

(2012) Aya Ogura et al.   STEM CELLS AND DEVELOPMENT

A novel role of miR-302/367 in reprogramming

(2011) Chih-Hao Kuo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RETRACTED: Directed Conversion of Alzheimer's Disease Patient Skin Fibroblasts into Functional Neurons

(2011) Liang Qiang et al.   CELL

Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells

(2011) Xinjian Liu et al.   CELL RESEARCH

Functional Integration of Dopaminergic Neurons Directly Converted from Mouse Fibroblasts

(2011) Jongpil Kim et al.   Cell Stem Cell

Induced Neuronal Cells: How to Make and Define a Neuron

(2011) Nan Yang et al.   Cell Stem Cell

Direct Reprogramming of Adult Human Fibroblasts to Functional Neurons under Defined Conditions

(2011) Rajesh Ambasudhan et al.   Cell Stem Cell

Direct Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons

(2011) Samuele Marro et al.   Cell Stem Cell

Conversion of Mouse and Human Fibroblasts into Functional Spinal Motor Neurons

(2011) Esther Y. Son et al.   Cell Stem Cell

Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state

(2011) L. Lapasset et al.   GENES & DEVELOPMENT

MicroRNA Cluster 302–367 Enhances Somatic Cell Reprogramming by Accelerating a Mesenchymal-to-Epithelial Transition

(2011) Baojian Liao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modelling schizophrenia using human induced pluripotent stem cells

(2011) Kristen J. Brennand et al.   NATURE

MicroRNA-mediated conversion of human fibroblasts to neurons

(2011) Andrew S. Yoo et al.   NATURE

Direct generation of functional dopaminergic neurons from mouse and human fibroblasts

(2011) Massimiliano Caiazzo et al.   NATURE

Induction of human neuronal cells by defined transcription factors

(2011) Zhiping P. Pang et al.   NATURE

Self-organizing optic-cup morphogenesis in three-dimensional culture

(2011) Mototsugu Eiraku et al.   NATURE

Specification of transplantable astroglial subtypes from human pluripotent stem cells

(2011) Robert Krencik et al.   NATURE BIOTECHNOLOGY

Directed differentiation of functional astroglial subtypes from human pluripotent stem cells

(2011) Robert Krencik et al.   Nature Protocols

Direct reprogramming of mouse fibroblasts to neural progenitors

(2011) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct conversion of human fibroblasts to dopaminergic neurons

(2011) U. Pfisterer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

(2010) Maria C.N. Marchetto et al.   CELL

Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors

(2010) Masaki Ieda et al.   CELL

Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

(2010) Luigi Warren et al.   Cell Stem Cell

Three hypotheses for developmental defects that may underlie some forms of autism spectrum disorder

(2010) John LR Rubenstein   CURRENT OPINION IN NEUROLOGY

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency

(2010) B.-Y. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Naive and Primed Pluripotent States

(2009) Jennifer Nichols et al.   Cell Stem Cell

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Variation in the safety of induced pluripotent stem cell lines

(2009) Kyoko Miura et al.   NATURE BIOTECHNOLOGY

FOXG1 Is Responsible for the Congenital Variant of Rett Syndrome

(2008) Francesca Ariani et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

(2008) Mototsugu Eiraku et al.   Cell Stem Cell

Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

(2008) J. T. Dimos et al.   SCIENCE