Signaling of the Complement Cleavage Product Anaphylatoxin C5a Through C5aR (CD88) Contributes to Pharmacological Hematopoietic Stem Cell Mobilization

Eculizumab treatment: stochastic occurrence of C3 binding to individual PNH erythrocytes

(2017) Michela Sica et al.   Journal of Hematology & Oncology

Olaptesed pegol, an anti-CXCL12/SDF-1 Spiegelmer, alone and with bortezomib–dexamethasone in relapsed/refractory multiple myeloma: a Phase IIa Study

(2017) H Ludwig et al.   LEUKEMIA

MP393LONG-TERM SAFETY AND EFFECTIVENESS OF ECULIZUMAB FOR PATIENTS WITH ATYPICAL HAEMOLYTIC URAEMIC SYNDROME: OUTCOMES FROM A PROSPECTIVE OBSERVATIONAL CLINICAL TRIAL

(2017) Jan Menne et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

A Combined PD-1/C5a Blockade Synergistically Protects against Lung Cancer Growth and Metastasis

(2017) Daniel Ajona et al.   Cancer Discovery

Compstatin Cp40 blocks hematin-mediated deposition of C3b fragments on erythrocytes: Implications for treatment of malarial anemia

(2016) Margaret A. Lindorfer et al.   CLINICAL IMMUNOLOGY

Novel evidence that the mannan-binding lectin pathway of complement activation plays a pivotal role in triggering mobilization of hematopoietic stem/progenitor cells by activation of both the complement and coagulation cascades

(2016) M Adamiak et al.   LEUKEMIA

Inducible Nitric Oxide Synthase (iNOS) Is a Novel Negative Regulator of Hematopoietic Stem/Progenitor Cell Trafficking

(2016) Mateusz Adamiak et al.   Stem Cell Reviews and Reports

The Involvment of Hematopoietic-Specific PLC -β2 in Homing and Engraftment of Hematopoietic Stem/Progenitor Cells

(2016) Mateusz Adamiak et al.   Stem Cell Reviews and Reports

Inducible Nitric Oxide Synthase (iNOS) Is a Novel Negative Regulator of Hematopoietic Stem/Progenitor Cell Trafficking

(2016) Mateusz Adamiak et al.   Stem Cell Reviews and Reports

The Involvment of Hematopoietic-Specific PLC -β2 in Homing and Engraftment of Hematopoietic Stem/Progenitor Cells

(2016) Mateusz Adamiak et al.   Stem Cell Reviews and Reports

Turning mirror-image oligonucleotides into drugs: the evolution of Spiegelmer® therapeutics

(2015) Axel Vater et al.   DRUG DISCOVERY TODAY

Evidence that a lipolytic enzyme—hematopoietic-specific phospholipase C-β2—promotes mobilization of hematopoietic stem cells by decreasing their lipid raft-mediated bone marrow retention and increasing the promobilizing effects of granulocytes

(2015) M Adamiak et al.   LEUKEMIA

Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer

(2015) Laure Yatime et al.   Nature Communications

Novel evidence that crosstalk between the complement, coagulation and fibrinolysis proteolytic cascades is involved in mobilization of hematopoietic stem/progenitor cells (HSPCs)

(2014) S Borkowska et al.   LEUKEMIA

A novel view of the adult bone marrow stem cell hierarchy and stem cell trafficking

(2014) M Z Ratajczak   LEUKEMIA

Restoration of MBL-deficiency: Redefining the safety, efficacy and viability of MBL-substitution therapy

(2014) M.P. Keizer et al.   MOLECULAR IMMUNOLOGY

Optimizing Autologous Stem Cell Mobilization Strategies to Improve Patient Outcomes: Consensus Guidelines and Recommendations

(2013) Sergio Giralt et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Novel compstatin family peptides inhibit complement activation by drusen-like deposits in human retinal pigmented epithelial cell cultures

(2013) Ronald D. Gorham et al.   EXPERIMENTAL EYE RESEARCH

A Novel C5a-neutralizing Mirror-image (l-)Aptamer Prevents Organ Failure and Improves Survival in Experimental Sepsis

(2013) Kai Hoehlig et al.   MOLECULAR THERAPY

Terminal Complement Inhibitor Eculizumab in Atypical Hemolytic–Uremic Syndrome

(2013) C.M. Legendre et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of Complement in Multiorgan Failure

(2012) Daniel Rittirsch et al.   Clinical & Developmental Immunology

Inhibiting the C5–C5a receptor axis

(2011) Trent M. Woodruff et al.   MOLECULAR IMMUNOLOGY

Fifth complement cascade protein (C5) cleavage fragments disrupt the SDF-1/CXCR4 axis: Further evidence that innate immunity orchestrates the mobilization of hematopoietic stem/progenitor cells

(2010) Ali Jalili et al.   EXPERIMENTAL HEMATOLOGY

Innate immunity as orchestrator of stem cell mobilization

(2010) M Z Ratajczak et al.   LEUKEMIA

Novel insight into stem cell mobilization-Plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascade/membrane attack complex

(2010) M Z Ratajczak et al.   LEUKEMIA

The endosteal ‘osteoblastic’ niche and its role in hematopoietic stem cell homing and mobilization

(2010) J-P Lévesque et al.   LEUKEMIA

Circadian rhythms influence hematopoietic stem cells

(2009) Simón Méndez-Ferrer et al.   CURRENT OPINION IN HEMATOLOGY

Time-dependent mobilization of circulating progenitor cells during strenuous exercise in healthy individuals

(2009) Sven Möbius-Winkler et al.   JOURNAL OF APPLIED PHYSIOLOGY

Mobilization studies in complement-deficient mice reveal that optimal AMD3100 mobilization of hematopoietic stem cells depends on complement cascade activation by AMD3100-stimulated granulocytes

(2009) H M Lee et al.   LEUKEMIA

Impaired mobilization of hematopoietic stem/progenitor cells in C5-deficient mice supports the pivotal involvement of innate immunity in this process and reveals novel promobilization effects of granulocytes

(2009) H M Lee et al.   LEUKEMIA