Harnessing Neutrophil Survival Mechanisms during Chronic Infection by Pseudomonas aeruginosa: Novel Therapeutic Targets to Dampen Inflammation in Cystic Fibrosis

High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators

(2017) Jung-Ho Son et al.   JOURNAL OF MEDICINAL CHEMISTRY

The infectious hypoxia: occurrence and causes during Shigella infection

(2017) Ellen T. Arena et al.   MICROBES AND INFECTION

Neutrophil-Expressed p21/waf1 Favors Inflammation Resolution inPseudomonas aeruginosaInfection

(2016) Clémence Martin et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Neutrophils in cystic fibrosis

(2016) Julie Laval et al.   BIOLOGICAL CHEMISTRY

Anoxia and glucose supplementation preserve neutrophil viability and function

(2016) Valérie Monceaux et al.   BLOOD

Pondering neutrophil extracellular traps with healthy skepticism

(2016) William M. Nauseef et al.   CELLULAR MICROBIOLOGY

Proliferating cell nuclear antigen in neutrophil fate

(2016) Véronique Witko-Sarsat et al.   IMMUNOLOGICAL REVIEWS

Causes of death in French cystic fibrosis patients: The need for improvement in transplantation referral strategies!

(2016) Clémence Martin et al.   Journal of Cystic Fibrosis

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

(2016) Laurent Meijer et al.   Journal of Innate Immunity

Cystic Fibrosis Lung Immunity: The Role of the Macrophage

(2016) Emanuela M. Bruscia et al.   Journal of Innate Immunity

The role of neutrophils in inflammation resolution

(2016) Hefin R. Jones et al.   SEMINARS IN IMMUNOLOGY

Human neutrophils in auto-immunity

(2016) Nathalie Thieblemont et al.   SEMINARS IN IMMUNOLOGY

NET Confusion

(2016) Natalia Malachowa et al.   Frontiers in Immunology

Macrophage Dysfunction in Cystic Fibrosis: A Therapeutic Target to Enhance Self-Immunity

(2015) Tracey L. Bonfield   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

DCTN4 as a modifier of chronicPseudomonas aeruginosainfection in cystic fibrosis

(2015) Marion Viel et al.   Clinical Respiratory Journal

Future trends in cystic fibrosis demography in 34 European countries

(2015) Pierre-Régis Burgel et al.   EUROPEAN RESPIRATORY JOURNAL

TRPC6 channel translocation into phagosomal membrane augments phagosomal function

(2015) Vladimir Riazanski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolution Pharmacology: Opportunities for Therapeutic Innovation in Inflammation

(2015) Mauro Perretti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Early Respiratory Infection Is Associated with Reduced Spirometry in Children with Cystic Fibrosis

(2014) Kathryn A. Ramsey et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Longevity of Patients With Cystic Fibrosis in 2000 to 2010 and Beyond: Survival Analysis of the Cystic Fibrosis Foundation Patient Registry

(2014) Todd MacKenzie et al.   ANNALS OF INTERNAL MEDICINE

A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy

(2014) K. Pohl et al.   BLOOD

Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del-CFTR by a CDK-independent mechanism

(2014) C Norez et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeting Mucus Hypersecretion: New Therapeutic Opportunities for COPD?

(2014) Clémence Martin et al.   DRUGS

Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation

(2014) Eric L. Campbell et al.   IMMUNITY

Marker genes for the metabolic adaptation of Pseudomonas aeruginosa to the hypoxic cystic fibrosis lung environment

(2014) Anja Eichner et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

A randomized double blind, placebo controlled phase 2 trial of BIIL 284 BS (an LTB4 receptor antagonist) for the treatment of lung disease in children and adults with cystic fibrosis

(2014) M.W. Konstan et al.   Journal of Cystic Fibrosis

Cystic Fibrosis Sputum DNA Has NETosis Characteristics and Neutrophil Extracellular Trap Release Is Regulated by Macrophage Migration-Inhibitory Factor

(2014) Markryan Dwyer et al.   Journal of Innate Immunity

Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity

(2014) Erwan Pernet et al.   Nature Communications

Extracellular DNA traps in allergic, infectious, and autoimmune diseases

(2013) D. Simon et al.   ALLERGY

Metabolic Adaptation of Neutrophils in Cystic Fibrosis Airways Involves Distinct Shifts in Nutrient Transporter Expression

(2013) J. Laval et al.   JOURNAL OF IMMUNOLOGY

CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells

(2013) C Delehouzé et al.   ONCOGENE

Hypoxia Modulates Infection of Epithelial Cells by Pseudomonas aeruginosa

(2013) Bettina Schaible et al.   PLoS One

Hypoxia Increases Antibiotic Resistance in Pseudomonas aeruginosa through Altering the Composition of Multidrug Efflux Pumps

(2012) Bettina Schaible et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation

(2012) A E Leitch et al.   CELL DEATH AND DIFFERENTIATION

Safety and early treatment effects of the CXCR2 antagonist SB-656933 in patients with cystic fibrosis

(2012) Richard B. Moss et al.   Journal of Cystic Fibrosis

The Impact of Various Reactive Oxygen Species on the Formation of Neutrophil Extracellular Traps

(2012) Tina Kirchner et al.   MEDIATORS OF INFLAMMATION

Oxygen Transport in the Microcirculation and Its Regulation

(2012) Roland N. Pittman   MICROCIRCULATION

Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis

(2012) Mary J Emond et al.   NATURE GENETICS

Cystic fibrosis: a mucosal immunodeficiency syndrome

(2012) Taylor Sitarik Cohen et al.   NATURE MEDICINE

Targeting cytosolic proliferating cell nuclear antigen in neutrophil-dominated inflammation

(2012) Alessia De Chiara et al.   Frontiers in Immunology

The Cystic Fibrosis Neutrophil: A Specialized Yet Potentially Defective Cell

(2011) Elaine Hayes et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Singlet oxygen is essential for neutrophil extracellular trap formation

(2011) Yoko Nishinaka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Peculiarities of cell death mechanisms in neutrophils

(2011) B Geering et al.   CELL DEATH AND DIFFERENTIATION

Hypochlorous acid regulates neutrophil extracellular trap release in humans

(2011) L. J. Palmer et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Ultrastructural characterization of cystic fibrosis sputum using atomic force and scanning electron microscopy

(2011) Reinhard Manzenreiter et al.   Journal of Cystic Fibrosis

Neutrophil Extracellular Trap (NET)-Mediated Killing of Pseudomonas aeruginosa: Evidence of Acquired Resistance within the CF Airway, Independent of CFTR

(2011) Robert L. Young et al.   PLoS One

Regulation of Neutrophil Survival/Apoptosis by Mcl-1

(2011) Eric Milot et al.   TheScientificWorldJOURNAL

Regulating neutrophil apoptosis: new players enter the game

(2011) Véronique Witko-Sarsat et al.   TRENDS IN IMMUNOLOGY

Neutrophil clearance: when the party is over, clean-up begins

(2011) Donna L. Bratton et al.   TRENDS IN IMMUNOLOGY

Contribution of oxygen-limiting conditions to persistent infection ofPseudomonas aeruginosa

(2010) Max Schobert et al.   Future Microbiology

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

Proliferating cell nuclear antigen acts as a cytoplasmic platform controlling human neutrophil survival

(2010) Véronique Witko-Sarsat et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In Cystic Fibrosis Homozygotes and Heterozygotes, Neutrophil Apoptosis Is Delayed and Modulated by Diamide or Roscovitine: Evidence for an Innate Neutrophil Disturbance

(2010) Sandra Moriceau et al.   Journal of Innate Immunity

Cyclin-dependent kinase inhibitor drugs as potential novel anti-inflammatory and pro-resolution agents

(2009) AE Leitch et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hypoxia: a window intoMycobacterium tuberculosislatency

(2009) Tige R. Rustad et al.   CELLULAR MICROBIOLOGY

Non-classic cystic fibrosis associated with D1152HCFTRmutation

(2009) P-R Burgel et al.   CLINICAL GENETICS

Apoptosis Is Essential for Neutrophil Functional Shutdown and Determines Tissue Damage in Experimental Pneumococcal Meningitis

(2009) Uwe Koedel et al.   PLoS Pathogens

Macrophages Directly Contribute to the Exaggerated Inflammatory Response in Cystic Fibrosis Transmembrane Conductance Regulator−/−Mice

(2008) Emanuela M. Bruscia et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Targeting neutrophil elastase in cystic fibrosis

(2008) Emer Kelly et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Neutrophil apoptosis and the resolution of infection

(2008) Adam D. Kennedy et al.   IMMUNOLOGIC RESEARCH

The role of chloride anion and CFTR in killing of Pseudomonas aeruginosa by normal and CF neutrophils

(2008) R. G. Painter et al.   JOURNAL OF LEUKOCYTE BIOLOGY

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(2008) Minou Adib-Conquy et al.   MOLECULAR MEDICINE

Profound functional and signaling changes in viable inflammatory neutrophils homing to cystic fibrosis airways

(2008) R. Tirouvanziam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prolonged survival of neutrophils from patients with  F508 CFTR mutations

(2008) D J McKeon et al.   THORAX

Neutrophils in cystic fibrosis

(2008) D G Downey et al.   THORAX