Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del-CFTR by a CDK-independent mechanism

The Concise Guide to PHARMACOLOGY 2013/14: Enzymes

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2013/14: Ion Channels

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Managing the Underlying Cause of Cystic Fibrosis: A Future Role for Potentiators and Correctors

(2013) Luis J. V. Galietta   PEDIATRIC DRUGS

Proteasomal Inhibition Restores Biological Function of Mis-sense Mutated Dysferlin in Patient-derived Muscle Cells

(2012) Bilal A. Azakir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The β1-Subunit of Nav1.5 Cardiac Sodium Channel Is Required for a Dominant Negative Effect through α-α Interaction

(2012) Aurélie Mercier et al.   PLoS One

Transient Receptor Potential Canonical Channels Are Required forin VitroEndothelial Tube Formation

(2011) Fabrice Antigny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome

(2011) Masayuki Yazawa et al.   NATURE

Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809

(2011) F. Van Goor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for theF508del-CFTRmutation

(2011) J P Clancy et al.   THORAX

CFTR: folding, misfolding and correcting the ΔF508 conformational defect

(2011) Gergely L. Lukacs et al.   TRENDS IN MOLECULAR MEDICINE

Cystic Fibrosis Transmembrane Conductance Regulator Modulators for Personalized Drug Treatment of Cystic Fibrosis

(2010) Frédéric Becq   DRUGS

Cyclin-dependent kinase inhibitors: a survey of recent patent literature

(2010) Hervé Galons et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

In Cystic Fibrosis Homozygotes and Heterozygotes, Neutrophil Apoptosis Is Delayed and Modulated by Diamide or Roscovitine: Evidence for an Innate Neutrophil Disturbance

(2010) Sandra Moriceau et al.   Journal of Innate Immunity

4-C-Me-DAB and 4-C-Me-LAB—enantiomeric alkyl-branched pyrrolidine iminosugars—are specific and potent α-glucosidase inhibitors; acetone as the sole protecting group

(2010) Filipa P. da Cruz et al.   TETRAHEDRON LETTERS

State-dependent block of HERG potassium channels by R-roscovitine: implications for cancer therapy

(2009) Sindura B. Ganapathi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Airway Delivery of Low-Dose Miglustat Normalizes Nasal Potential Difference in F508del Cystic Fibrosis Mice

(2009) Bob Lubamba et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Cystic Fibrosis Respiratory Epithelial Cell Chronically Treated by Miglustat Acquires a Non–Cystic Fibrosis–Like Phenotype

(2009) Caroline Norez et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pharmacodynamic Effects of Seliciclib, an Orally Administered Cell Cycle Modulator, in Undifferentiated Nasopharyngeal Cancer

(2009) W.-S. Hsieh et al.   CLINICAL CANCER RESEARCH

Seliciclib in malignancies

(2009) Ibrahim T Aldoss et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Novel potent pharmacological cyclin-dependent kinase inhibitors

(2009) Józefa Węsierska-Gądek et al.   Future Medicinal Chemistry

Roscovitine Binds to Novel L-channel (CaV1.2) Sites That Separately Affect Activation and Inactivation

(2009) Viktor Yarotskyy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coronin-1 Is Associated with Neutrophil Survival and Is Cleaved during Apoptosis: Potential Implication in Neutrophils from Cystic Fibrosis Patients

(2009) S. Moriceau et al.   JOURNAL OF IMMUNOLOGY

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

(2009) Darren M Hutt et al.   Nature Chemical Biology

Roscovitine increases intracellular calcium release and capacitative calcium entry in PC12 cells

(2009) Ho Sook Choi et al.   NEUROSCIENCE LETTERS

Practical Synthesis of Roscovitine and CR8

(2009) Nassima Oumata et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

CFTR Function and Prospects for Therapy

(2008) John R. Riordan   Annual Review of Biochemistry

Molecular and cellular aspects of protein misfolding and disease

(2008) Eszter Herczenik et al.   FASEB JOURNAL

Proteasome-Dependent Pharmacological Rescue of Cystic Fibrosis Transmembrane Conductance Regulator Revealed by Mutation of Glycine 622

(2008) C. Norez et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases

(2008) K Bettayeb et al.   ONCOGENE

Neutrophils in cystic fibrosis

(2008) D G Downey et al.   THORAX