Targeting Mucus Hypersecretion: New Therapeutic Opportunities for COPD?

Glucocorticoids Inhibit MUC5AC Production Induced by Transforming Growth Factor-α in Human Respiratory Cells

(2015) Satoru Takami et al.   ALLERGOLOGY INTERNATIONAL

Predictors of Objective Cough Frequency in Chronic Obstructive Pulmonary Disease

(2013) Helen Sumner et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Phosphodiesterase-4 Inhibitor Therapy for Lung Diseases

(2013) Bianca Beghè et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Chronic Cough in Chronic Obstructive Pulmonary Disease: Time for Listening?

(2013) Pierre-Régis Burgel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Macrolides Inhibit Fusobacterium nucleatum-Induced MUC5AC Production in Human Airway Epithelial Cells

(2013) Kentaro Nagaoka et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

High-Dose N-Acetylcysteine in Stable COPD

(2013) Hoi Nam Tse et al.   CHEST

First-Line Management of EGFR-Mutated Advanced Lung Adenocarcinoma: Recent Developments

(2013) Bin-Chi Liao et al.   DRUGS

Blocking of thromboxane A2 receptor attenuates airway mucus hyperproduction induced by cigarette smoke

(2013) Jing An et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sildenafil: a definitive NO in COPD

(2013) Anton Vonk-Noordegraaf et al.   EUROPEAN RESPIRATORY JOURNAL

Chronic bronchitis in COPD patients is associated with increased risk of exacerbations: a cross-sectional multicentre study

(2013) J. L. Corhay et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease

(2013) Peter J. Barnes   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

ATP-Mediated Transactivation of the Epidermal Growth Factor Receptor in Airway Epithelial Cells Involves DUOX1-Dependent Oxidation of Src and ADAM17

(2013) Derek Sham et al.   PLoS One

Roflumilast Inhibits Respiratory Syncytial Virus Infection in Human Differentiated Bronchial Epithelial Cells

(2013) Manuel Mata et al.   PLoS One

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease

(2012) Jørgen Vestbo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Influenza A Induces the Major Secreted Airway Mucin MUC5AC in a Protease–EGFR–Extracellular Regulated Kinase–Sp1–Dependent Pathway

(2012) Diane Barbier et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Fine PM induce airway MUC5AC expression through the autocrine effect of amphiregulin

(2012) Stéphanie Val et al.   ARCHIVES OF TOXICOLOGY

SLPI and trappin-2 as therapeutic agents to target airway serine proteases in inflammatory lung diseases: current and future directions

(2012) Marie-Louise Zani et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Chronic cough and sputum production: a clinical COPD phenotype?: Table 1–

(2012) Pierre-Régis Burgel   EUROPEAN RESPIRATORY JOURNAL

The chronic bronchitis phenotype in subjects with and without COPD: the PLATINO study

(2012) Maria Montes de Oca et al.   EUROPEAN RESPIRATORY JOURNAL

Long-term macrolide treatment for chronic respiratory disease

(2012) Paolo Spagnolo et al.   EUROPEAN RESPIRATORY JOURNAL

Role of nicotinic receptors and acetylcholine in mucous cell metaplasia, hyperplasia, and airway mucus formation in vitro and in vivo

(2012) Sravanthi Gundavarapu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways

(2012) M Kesimer et al.   Mucosal Immunology

Respiratory Syncytial Virus Inhibits Ciliagenesis in Differentiated Normal Human Bronchial Epithelial Cells: Effectiveness of N-Acetylcysteine

(2012) Manuel Mata et al.   PLoS One

Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs

(2012) C. Ehre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calpain and MARCKS protein regulation of airway mucin secretion

(2012) W. Randall Lampe et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Long-term safety study of infliximab in moderate-to-severe chronic obstructive pulmonary disease

(2012) Stephen I. Rennard et al.   RESPIRATORY MEDICINE

Walking on Solid Ground

(2012) B. F. Dickey   SCIENCE

A Periciliary Brush Promotes the Lung Health by Separating the Mucus Layer from Airway Epithelia

(2012) B. Button et al.   SCIENCE

N-acetyl-l-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with respiratory syncytial virus (RSV)

(2011) Manuel Mata et al.   BIOCHEMICAL PHARMACOLOGY

IL-13-induced MUC5AC production and goblet cell differentiation is steroid resistant in human airway cells

(2011) S. Kanoh et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Tiotropium inhibits pulmonary inflammation and remodelling in a guinea pig model of COPD

(2011) T. Pera et al.   EUROPEAN RESPIRATORY JOURNAL

Regulation of cigarette smoke-mediated mucin expression by hypoxia-inducible factor-1α via epidermal growth factor receptor-mediated signaling pathways

(2011) Hongmei Yu et al.   JOURNAL OF APPLIED TOXICOLOGY

CCL20/CCR6 Feedback Exaggerates Epidermal Growth Factor Receptor-Dependent MUC5AC Mucin Production in Human Airway Epithelial (NCI-H292) Cells

(2011) S. Kim et al.   JOURNAL OF IMMUNOLOGY

Induction of Mucin and MUC5AC Expression by the Protease Activity of Aspergillus fumigatus in Airway Epithelial Cells

(2011) T. Oguma et al.   JOURNAL OF IMMUNOLOGY

Azithromycin for Prevention of Exacerbations of COPD

(2011) Richard K. Albert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of a Novel Nonantibiotic Macrolide, EM900, on Cytokine and Mucin Gene Expression in a Human Airway Epithelial Cell Line

(2011) Kazuya Otsu et al.   PHARMACOLOGY

Ectopic respiratory epithelial cell differentiation in bronchiolised distal airspaces in idiopathic pulmonary fibrosis

(2011) L. Plantier et al.   THORAX

MARCKS-related peptide modulates in vivo the secretion of airway Muc5ac

(2010) W. Michael Foster et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

MCP-1/CCR2B-dependent loop upregulates MUC5AC and MUC5B in human airway epithelium

(2010) Maria E. Monzon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Lung protease/anti-protease network and modulation of mucus production and surfactant activity

(2010) Ignacio Garcia-Verdugo et al.   BIOCHIMIE

Induced Sputum Concentrations of Mucin in Patients With Asthma and Chronic Cough

(2010) Makiko Jinnai et al.   CHEST

Azithromycin inhibits nontypeable Haemophilus influenzae-induced MUC5AC expression and secretion via inhibition of activator protein-1 in human airway epithelial cells

(2010) Nobuko Araki et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Aclidinium inhibits cholinergic and tobacco smoke-induced MUC5AC in human airways

(2010) J. Cortijo et al.   EUROPEAN RESPIRATORY JOURNAL

Simvastatin attenuates acrolein-induced mucin production in rats: Involvement of the Ras/extracellular signal-regulated kinase pathway

(2010) Ya-Juan Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Macrolide Antibiotics Inhibit Mucus Secretion and Calcium Entry in Swine Airway Submucosal Mucous Gland Cells

(2010) S. Lu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Airway Mucus Function and Dysfunction

(2010) John V. Fahy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dexamethasone and N-acetyl-cysteine attenuate Pseudomonas aeruginosa-induced mucus expression in human airways

(2010) Lisa Sprenger et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Macrolides attenuate mucus hypersecretion in rat airways through inactivation of NF-κB

(2010) Xue-Mei OU et al.   RESPIROLOGY

Ex VivoSputum Analysis Reveals Impairment of Protease-dependent Mucus Degradation by Plasma Proteins in Acute Asthma

(2009) Anh L. Innes et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Safety and Efficacy of an Inhaled Epidermal Growth Factor Receptor Inhibitor (BIBW 2948 BS) in Chronic Obstructive Pulmonary Disease

(2009) Prescott G. Woodruff et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Advances in Mucous Cell Metaplasia

(2009) David R. Curran et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Mucins, Mucus, and Sputum

(2009) Judith A. Voynow et al.   CHEST

Small Airway Mucous Metaplasia and Inflammation in Chronic Obstructive Pulmonary Disease

(2009) Victor Kim et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Effect of sildenafil on acrolein-induced airway inflammation and mucus production in rats

(2009) T. Wang et al.   EUROPEAN RESPIRATORY JOURNAL

Inhibition of neutrophil elastase-induced goblet cell metaplasia by tiotropium in mice

(2009) N. Arai et al.   EUROPEAN RESPIRATORY JOURNAL

Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents

(2009) Songcang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-8 Regulates Mucin Gene Expression at the Posttranscriptional Level in Lung Epithelial Cells

(2009) M. V. Bautista et al.   JOURNAL OF IMMUNOLOGY

IL-6 Is Required for Airway Mucus Production Induced by Inhaled Fungal Allergens

(2009) W. A. Neveu et al.   JOURNAL OF IMMUNOLOGY

Pharmacological Blockade of the DP2 Receptor Inhibits Cigarette Smoke-Induced Inflammation, Mucus Cell Metaplasia, and Epithelial Hyperplasia in the Mouse Lung

(2009) K. J. Stebbins et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Azithromycin, clarithromycin and telithromycin inhibit MUC5AC induction by Chlamydophila pneumoniae in airway epithelial cells

(2009) Yoshitomo Morinaga et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

l-Carbocisteine reduces neutrophil elastase-induced mucin production

(2009) Masanori Yasuo et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Rosiglitazone, a peroxisome proliferator-activated receptor-γ agonist, attenuates acrolein-induced airway mucus hypersecretion in rats

(2009) Dai-Shun Liu et al.   TOXICOLOGY

Corticosteroid therapy increases membrane-tethered while decreases secreted mucin expression in nasal polyps

(2008) A. Martínez-Antón et al.   ALLERGY

Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium

(2008) Jonathan L. Koff et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Long-term Erythromycin Therapy Is Associated with Decreased Chronic Obstructive Pulmonary Disease Exacerbations

(2008) Terence A. R. Seemungal et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

MUC5B Is the Major Mucin in the Gel Phase of Sputum in Chronic Obstructive Pulmonary Disease

(2008) Sara Kirkham et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Rhinovirus-Induced Major Airway Mucin Production Involves a Novel TLR3-EGFR–Dependent Pathway

(2008) Lingxiang Zhu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Glucocorticoids inhibit nontypeable Haemophilus influenzae-induced MUC5AC mucin expression via MAPK phosphatase-1-dependent inhibition of p38 MAPK

(2008) Kensei Komatsu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cough and Sputum Production Are Associated With Frequent Exacerbations and Hospitalizations in COPD Subjects

(2008) Pierre-Régis Burgel et al.   CHEST

Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases

(2008) P-R. Burgel et al.   EUROPEAN RESPIRATORY JOURNAL

Cigarette smoke increases Toll-like receptor 4 and modifies lipopolysaccharide-mediated responses in airway epithelial cells

(2008) Elisabetta Pace et al.   IMMUNOLOGY

Different effects of telithromycin on MUC5AC production induced by human neutrophil peptide-1 or lipopolysaccharide in NCI-H292 cells compared with azithromycin and clarithromycin

(2008) H. Ishimoto et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): a randomised placebo-controlled study

(2008) Jin-Ping Zheng et al.   LANCET

A 4-Year Trial of Tiotropium in Chronic Obstructive Pulmonary Disease

(2008) Donald P. Tashkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Erythromycin attenuates MUC5AC synthesis and secretion in cultured human tracheal cells infected with RV14

(2008) Daisuke INOUE et al.   RESPIROLOGY

Acrolein-Activated Matrix Metalloproteinase 9 Contributes to Persistent Mucin Production

(2007) Hitesh S. Deshmukh et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Structure and Function of the Polymeric Mucins in Airways Mucus

(2007) David J. Thornton et al.   Annual Review of Physiology

Regulation of Airway Mucin Gene Expression

(2007) Philip Thai et al.   Annual Review of Physiology

Regulated Airway Goblet Cell Mucin Secretion

(2007) C. William Davis et al.   Annual Review of Physiology