Replication Study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

Pan-mutant-IDH1 inhibitor BAY1436032 is highly effective against human IDH1 mutant acute myeloid leukemia in vivo

(2017) A Chaturvedi et al.   LEUKEMIA

Selective Detection of the D-enantiomer of 2-Hydroxyglutarate in the CSF of Glioma Patients with Mutated Isocitrate Dehydrogenase

(2016) J. Kalinina et al.   CLINICAL CANCER RESEARCH

Non-invasive detection of 2-hydroxyglutarate in IDH-mutated gliomas using two-dimensional localized correlation spectroscopy (2D L-COSY) at 7 Tesla

(2016) Gaurav Verma et al.   Journal of Translational Medicine

In vivo detection of 2-hydroxyglutarate in brain tumors by optimized point-resolved spectroscopy (PRESS) at 7T

(2016) Sandeep K. Ganji et al.   MAGNETIC RESONANCE IN MEDICINE

Detection of 2-hydroxyglutarate in brain tumors by triple-refocusing MR spectroscopy at 3T in vivo

(2016) Zhongxu An et al.   MAGNETIC RESONANCE IN MEDICINE

Urine 2-Hydroxyglutarate in Glioma

(2016) G. Lombardi et al.   ONCOLOGIST

Elevation of Urinary 2-Hydroxyglutarate in IDH-Mutant Glioma

(2016) A. T. Fathi et al.   ONCOLOGIST

The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development

(2016) François Lemonnier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adapting Cancer Immunotherapy Models for the Real World

(2016) Lauryn E. Klevorn et al.   TRENDS IN IMMUNOLOGY

The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway

(2016) Mélissa Carbonneau et al.   Nature Communications

Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function

(2016) Andre Kleensang et al.   Scientific Reports

Reproducibility of High-Throughput Plate-Reader Experiments in Synthetic Biology

(2016) Michael Chavez et al.   ACS Synthetic Biology

Registered report: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

(2016) Oliver Fiehn et al.   eLife

The importance of plasma D-2HG measurement in screening forIDHmutations in acute myeloid leukaemia

(2015) Elizabeth McGehee et al.   BRITISH JOURNAL OF HAEMATOLOGY

Hypoxia Induces Production of L-2-Hydroxyglutarate

(2015) Andrew M. Intlekofer et al.   Cell Metabolism

Integration of 2-hydroxyglutarate-proton magnetic resonance spectroscopy into clinical practice for disease monitoring in isocitrate dehydrogenase-mutant glioma

(2015) Macarena I. de la Fuente et al.   NEURO-ONCOLOGY

Diagnostic Value of Plasma and Urinary 2-Hydroxyglutarate to Identify Patients With Isocitrate Dehydrogenase-Mutated Glioma

(2015) G. Lombardi et al.   ONCOLOGIST

Metabolic consequences of oncogenic IDH mutations

(2015) Seth J. Parker et al.   PHARMACOLOGY & THERAPEUTICS

Conducting Meta-Analyses inRwith themetaforPackage

(2015) Wolfgang Viechtbauer   Journal of Statistical Software

Circulating Oncometabolite 2-Hydroxyglutarate Is a Potential Surrogate Biomarker in Patients with Isocitrate Dehydrogenase-Mutant Intrahepatic Cholangiocarcinoma

(2014) D. R. Borger et al.   CLINICAL CANCER RESEARCH

An open investigation of the reproducibility of cancer biology research

(2014) Timothy M Errington et al.   eLife

Accumulation of 2-hydroxyglutarate in gliomas correlates with survival: a study by 3.0-tesla magnetic resonance spectroscopy

(2014) Manabu Natsumeda et al.   Acta Neuropathologica Communications

Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia

(2013) C. D. DiNardo et al.   BLOOD

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

(2013) J.-A. Losman et al.   GENES & DEVELOPMENT

Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate

(2013) Ovidiu C. Andronesi et al.   JOURNAL OF CLINICAL INVESTIGATION

Serum 2-Hydroxyglutarate Production in IDH1- and IDH2-Mutated De Novo Acute Myeloid Leukemia: A Study by the Acute Leukemia French Association Group

(2013) Maxime Janin et al.   JOURNAL OF CLINICAL ONCOLOGY

Prospective serial evaluation of 2-hydroxyglutarate, during treatment of newly diagnosed acute myeloid leukemia, to assess disease activity and therapeutic response

(2012) A. T. Fathi et al.   BLOOD

The Potential for Isocitrate Dehydrogenase Mutations to Produce 2-Hydroxyglutarate Depends on Allele Specificity and Subcellular Compartmentalization

(2012) Patrick S. Ward et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Strategies to increase the reproducibility of protein fibrillization in plate reader assays

(2010) Lise Giehm et al.   ANALYTICAL BIOCHEMISTRY

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

(2010) Patrick S. Ward et al.   CANCER CELL

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

(2010) Stefan Gross et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inter-laboratory reproducibility of fast gas chromatography–electron impact–time of flight mass spectrometry (GC–EI–TOF/MS) based plant metabolomics

(2009) J. William Allwood et al.   Metabolomics

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE