In vivo detection of 2-hydroxyglutarate in brain tumors by optimized point-resolved spectroscopy (PRESS) at 7T

Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations

(2015) U. E. Emir et al.   CANCER RESEARCH

Metabolic consequences of oncogenic IDH mutations

(2015) Seth J. Parker et al.   PHARMACOLOGY & THERAPEUTICS

Proton T2measurement and quantification of lactate in brain tumors by MRS at 3 Tesla in vivo

(2014) Akshay Madan et al.   MAGNETIC RESONANCE IN MEDICINE

Detection of glutamate, glutamine, and glutathione by radiofrequency suppression and echo time optimization at 7 tesla

(2014) Li An et al.   MAGNETIC RESONANCE IN MEDICINE

Measurement of regional variation of GABA in the human brain by optimized point-resolved spectroscopy at 7 Tin vivo

(2014) Sandeep K. Ganji et al.   NMR IN BIOMEDICINE

Quantification of Tumor Vessels in Glioblastoma Patients Using Time-of-Flight Angiography at 7 Tesla: A Feasibility Study

(2014) Alexander Radbruch et al.   PLoS One

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

(2013) J.-A. Losman et al.   GENES & DEVELOPMENT

Methodology for improved detection of low concentration metabolites in MRS: Optimised combination of signals from multi-element coil arrays

(2013) Emma L. Hall et al.   NEUROIMAGE

A comparative study of short- and long-TE1H MRS at 3 T forin vivodetection of 2-hydroxyglutarate in brain tumors

(2013) Changho Choi et al.   NMR IN BIOMEDICINE

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

(2013) D. Rohle et al.   SCIENCE

Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation

(2013) F. Wang et al.   SCIENCE

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas

(2012) Changho Choi et al.   NATURE MEDICINE

Detection of 2-Hydroxyglutarate in IDH-Mutated Glioma Patients by In Vivo Spectral-Editing and 2D Correlation Magnetic Resonance Spectroscopy

(2012) O. C. Andronesi et al.   Science Translational Medicine

Advances in ultra-high field MRI for the clinical management of patients with brain tumors

(2011) Janine M. Lupo et al.   CURRENT OPINION IN NEUROLOGY

Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy

(2011) Whitney B. Pope et al.   JOURNAL OF NEURO-ONCOLOGY

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

(2010) Patrick S. Ward et al.   CANCER CELL

Improvement of resolution for brain coupled metabolites by optimized 1H MRS at 7 T

(2010) Changho Choi et al.   NMR IN BIOMEDICINE

In vivo1H NMR spectroscopy of the human brain at high magnetic fields: Metabolite quantification at 4T vs. 7T

(2009) Ivan Tkáč et al.   MAGNETIC RESONANCE IN MEDICINE

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE