Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor

Knock-in human FGFR3 achondroplasia mutation as a mouse model for human skeletal dysplasia

(2017) Yi-Ching Lee et al.   Scientific Reports

Confocal imaging of mouse mandibular condyle cartilage

(2017) Y. He et al.   Scientific Reports

Safety, Tolerability, and Preliminary Activity of LB-100, an Inhibitor of Protein Phosphatase 2A, in Patients with Relapsed Solid Tumors: An Open-Label, Dose Escalation, First-in-Human, Phase I Trial

(2016) Vincent Chung et al.   CLINICAL CANCER RESEARCH

FGF signaling in the osteoprogenitor lineage non-autonomously regulates postnatal chondrocyte proliferation and skeletal growth

(2016) Kannan Karuppaiah et al.   DEVELOPMENT

Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase is required for rapid resumption of oocyte meiosis in response to luteinizing hormone

(2016) Leia C. Shuhaibar et al.   DEVELOPMENTAL BIOLOGY

A combined series of Fgf9 and Fgf18 mutant alleles identifies unique and redundant roles in skeletal development

(2016) Irene H. Hung et al.   DEVELOPMENTAL BIOLOGY

Parathyroid Hormone-Related Protein Analogs as Osteoporosis Therapies

(2015) Pedro Esbrit et al.   CALCIFIED TISSUE INTERNATIONAL

A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation

(2015) E. Kozhemyakina et al.   DEVELOPMENT

Fibroblast growth factor signaling in skeletal development and disease

(2015) David M. Ornitz et al.   GENES & DEVELOPMENT

Advances in treatment of achondroplasia and osteoarthritis

(2015) Kendra A. Klag et al.   HUMAN MOLECULAR GENETICS

C-Type Natriuretic Peptide Plasma Levels Are Elevated in Subjects With Achondroplasia, Hypochondroplasia, and Thanatophoric Dysplasia

(2015) Robert C. Olney et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles

(2015) Leia C. Shuhaibar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic imaging of the growth plate cartilage reveals multiple contributors to skeletal morphogenesis

(2015) Yuwei Li et al.   Nature Communications

The Local CNP/GC-B system in growth plate is responsible for physiological endochondral bone growth

(2015) Kazumasa Nakao et al.   Scientific Reports

Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the LH-induced decrease in cGMP that causes resumption of meiosis in rat oocytes

(2014) J. R. Egbert et al.   DEVELOPMENT

A Novel Homozygous Mutation in FGFR3 Causes Tall Stature, Severe Lateral Tibial Deviation, Scoliosis, Hearing Impairment, Camptodactyly, and Arachnodactyly

(2014) Periklis Makrythanasis et al.   HUMAN MUTATION

Bifurcation of Axons from Cranial Sensory Neurons Is Disabled in the Absence of Npr2-Induced cGMP Signaling

(2014) Gohar Ter-Avetisyan et al.   JOURNAL OF NEUROSCIENCE

G-protein stimulatory subunit alpha and Gq/11α G-proteins are both required to maintain quiescent stem-like chondrocytes

(2014) Andrei S. Chagin et al.   Nature Communications

Overgrowth syndrome associated with a gain-of-function mutation of the natriuretic peptide receptor 2 (NPR2) gene

(2013) Kohji Miura et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Transgenic Mice for cGMP Imaging

(2013) Martin Thunemann et al.   CIRCULATION RESEARCH

An Activating Mutation in the Kinase Homology Domain of the Natriuretic Peptide Receptor-2 Causes Extremely Tall Stature Without Skeletal Deformities

(2013) Sabine E. Hannema et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The B55  Regulatory Subunit of Protein Phosphatase 2A Mediates Fibroblast Growth Factor-Induced p107 Dephosphorylation and Growth Arrest in Chondrocytes

(2013) V. Kolupaeva et al.   MOLECULAR AND CELLULAR BIOLOGY

Evaluation of the Therapeutic Potential of a CNP Analog in a Fgfr3 Mouse Model Recapitulating Achondroplasia

(2012) Florence Lorget et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Novel mutations in natriuretic peptide receptor-2 gene underlie acromesomelic dysplasia, type maroteaux

(2012) Saadullah Khan et al.   BMC Medical Genetics

A novel loss-of-function mutation in Npr2 clarifies primary role in female reproduction and reveals a potential therapy for acromesomelic dysplasia, Maroteaux type

(2012) K. A. Geister et al.   HUMAN MOLECULAR GENETICS

A Functional Screen Provides Evidence for a Conserved, Regulatory, Juxtamembrane Phosphorylation Site in Guanylyl Cyclase A and B

(2012) Andrea R. Yoder et al.   PLoS One

An Overgrowth Disorder Associated with Excessive Production of cGMP Due to a Gain-of-Function Mutation of the Natriuretic Peptide Receptor 2 Gene

(2012) Kohji Miura et al.   PLoS One

The phosphoprotein phosphatase family of Ser/Thr phosphatases as principal targets of naturally occurring toxins

(2011) Susana R. Pereira et al.   CRITICAL REVIEWS IN TOXICOLOGY

Gastrointestinal Tract Disorder in Natriuretic Peptide Receptor B Gene Mutant Mice

(2010) Chizuru Sogawa et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation and therapeutic targeting of peptide-activated receptor guanylyl cyclases

(2010) Lincoln R. Potter   PHARMACOLOGY & THERAPEUTICS

Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte

(2009) R. P. Norris et al.   DEVELOPMENT

Systemic Administration of C-Type Natriuretic Peptide as a Novel Therapeutic Strategy for Skeletal Dysplasias

(2009) Akihiro Yasoda et al.   ENDOCRINOLOGY

Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms

(2009) Jie Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Persistent cAMP-Signals Triggered by Internalized G-Protein–Coupled Receptors

(2009) Davide Calebiro et al.   PLOS BIOLOGY

Phosphorylation of GSK-3β by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes

(2008) Yosuke Kawasaki et al.   JOURNAL OF CLINICAL INVESTIGATION