Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens

Increasing intracellular magnesium levels with the 31-amino acid MgtS protein

(2017) Hanbo Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes

(2016) Saima M. Sidik et al.   CELL

Whole-Genome Sequencing to Evaluate the Resistance Landscape Following Antimalarial Treatment Failure With Fosmidomycin-Clindamycin

(2016) Ann M. Guggisberg et al.   JOURNAL OF INFECTIOUS DISEASES

Synthetic RNA–protein modules integrated with native translation mechanisms to control gene expression in malaria parasites

(2016) Suresh M. Ganesan et al.   Nature Communications

Stage-Specific Changes in Plasmodium Metabolism Required for Differentiation and Adaptation to Different Host and Vector Environments

(2016) Anubhav Srivastava et al.   PLoS Pathogens

Fatty acid metabolism in the Plasmodium apicoplast: Drugs, doubts and knockouts

(2015) Melanie J. Shears et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Structural basis for the inhibition of M1 family aminopeptidases by the natural product actinonin: Crystal structure in complex withE. coliaminopeptidase N

(2015) Roopa Jones Ganji et al.   PROTEIN SCIENCE

Autophagy-Related Protein ATG8 Has a Noncanonical Function for Apicoplast Inheritance in Toxoplasma gondii

(2015) Maude F. Lévêque et al.   mBio

AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control

(2015) Malte Gersch et al.   Nature Communications

A Chemical Rescue Screen Identifies a Plasmodium falciparum Apicoplast Inhibitor Targeting MEP Isoprenoid Precursor Biosynthesis

(2014) Wesley Wu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Peptide Deformylase: A New Target in Antibacterial, Antimalarial and Anticancer Drug Discovery

(2014) Jaiprakash Sangshetti et al.   CURRENT MEDICINAL CHEMISTRY

Kinase-associated Endopeptidase 1 (Kae1) Participates in an Atypical Ribosome-associated Complex in the Apicoplast ofPlasmodium falciparum

(2014) Jeremy P. Mallari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Heme Biosynthesis Pathway Is Essential forPlasmodium falciparumDevelopment in Mosquito Stage but Not in Blood Stages

(2014) Hangjun Ke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Is there new hope for therapeutic matrix metalloproteinase inhibition?

(2014) Roosmarijn E. Vandenbroucke et al.   NATURE REVIEWS DRUG DISCOVERY

Ycf93 (Orf105), a Small Apicoplast-Encoded Membrane Protein in the Relict Plastid of the Malaria Parasite Plasmodium falciparum That Is Conserved in Apicomplexa

(2014) Christopher D. Goodman et al.   PLoS One

Efficient Gene Disruption in Diverse Strains of Toxoplasma gondii Using CRISPR/CAS9

(2014) B. Shen et al.   mBio

A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites

(2014) Ann M. Guggisberg et al.   Nature Communications

A Mitochondrial Ribosomal and RNA Decay Pathway Blocks Cell Proliferation

(2013) Uwe Richter et al.   CURRENT BIOLOGY

Toxoplasma gondii myosin F, an essential motor for centrosomes positioning and apicoplast inheritance

(2013) Damien Jacot et al.   EMBO JOURNAL

The Open Access Malaria Box: A Drug Discovery Catalyst for Neglected Diseases

(2013) Thomas Spangenberg et al.   PLoS One

An FtsH Protease Is Recruited to the Mitochondrion of Plasmodium falciparum

(2013) Aiman Tanveer et al.   PLoS One

Inadequate Efficacy of a New Formulation of Fosmidomycin-Clindamycin Combination in Mozambican Children Less than Three Years Old with Uncomplicated Plasmodium falciparum Malaria

(2012) Miguel Lanaspa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Protein quality control in organelles — AAA/FtsH story

(2012) Hanna Janska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Organelle segregation into Plasmodium liver stage merozoites

(2011) Rebecca R. Stanway et al.   CELLULAR MICROBIOLOGY

Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance inToxoplasma gondii

(2011) Sethu C. Nair et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparum

(2011) Ellen Yeh et al.   PLOS BIOLOGY

A Systematic Screen to Discover and Analyze Apicoplast Proteins Identifies a Conserved and Essential Protein Import Factor

(2011) Lilach Sheiner et al.   PLoS Pathogens

A Novel Dynamin-Related Protein Has Been Recruited for Apicoplast Fission in Toxoplasma gondii

(2009) Giel G. van Dooren et al.   CURRENT BIOLOGY

An Unusual ERAD-Like Complex Is Targeted to the Apicoplast ofPlasmodium falciparum

(2009) Simone Spork et al.   EUKARYOTIC CELL

Sequential processing of the Toxoplasma apicoplast membrane protein FtsH1 in topologically distinct domains during intracellular trafficking

(2009) Anuradha Karnataki et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum

(2009) Neekesh V Dharia et al.   GENOME BIOLOGY

The Fatty Acid Biosynthesis Enzyme FabI Plays a Key Role in the Development of Liver-Stage Malarial Parasites

(2008) Min Yu et al.   Cell Host & Microbe

Type II fatty acid synthesis is essential only for malaria parasite late liver stage development

(2008) Ashley M. Vaughan et al.   CELLULAR MICROBIOLOGY

A photosynthetic alveolate closely related to apicomplexan parasites

(2008) Robert B. Moore et al.   NATURE