The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism inMycobacterium tuberculosis

Global analyses of TetR family transcriptional regulators in mycobacteria indicates conservation across species and diversity in regulated functions

(2015) Ricardo J. C. Balhana et al.   BMC GENOMICS

Novel Inhibitors of Cholesterol Degradation in Mycobacterium tuberculosis Reveal How the Bacterium’s Metabolism Is Constrained by the Intracellular Environment

(2015) Brian C. VanderVen et al.   PLoS Pathogens

Unraveling Cholesterol Catabolism in Mycobacterium tuberculosis: ChsE4-ChsE5 α2β2 Acyl-CoA Dehydrogenase Initiates β-Oxidation of 3-Oxo-cholest-4-en-26-oyl CoA

(2015) Meng Yang et al.   ACS Infectious Diseases

Structural and Functional Characterization of a Ketosteroid Transcriptional Regulator ofMycobacterium tuberculosis

(2014) Adam M. Crowe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deciphering the Transcriptional Regulation of Cholesterol Catabolic Pathway in Mycobacteria

(2014) Esther García-Fernández et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autoindexing diffraction images withiMosflm

(2013) Harold R. Powell et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Actinobacterial Acyl Coenzyme A Synthetases Involved in Steroid Side-Chain Catabolism

(2013) I. Casabon et al.   JOURNAL OF BACTERIOLOGY

IntracellularMycobacterium tuberculosisExploits Host-derived Fatty Acids to Limit Metabolic Stress

(2013) Wonsik Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the KstR2 regulon ofMycobacterium tuberculosisby a cholesterol catabolite

(2013) Israël Casabon et al.   MOLECULAR MICROBIOLOGY

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

FadD3 is an acyl-CoA synthetase that initiates catabolism of cholesterol rings C and D in actinobacteria

(2012) Israël Casabon et al.   MOLECULAR MICROBIOLOGY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Activity of 3-Ketosteroid 9α-Hydroxylase (KshAB) Indicates Cholesterol Side Chain and Ring Degradation Occur Simultaneously inMycobacterium tuberculosis

(2011) Jenna K. Capyk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of the TetR-like Simocyclinone Efflux Pump Repressor, SimR, and the Mechanism of Ligand-Mediated Derepression

(2011) Tung B.K. Le et al.   JOURNAL OF MOLECULAR BIOLOGY

High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism

(2011) Jennifer E. Griffin et al.   PLoS Pathogens

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

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(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Crystal Structures of the Multidrug Binding Repressor Corynebacterium glutamicum CgmR in Complex with Inducers and with an Operator

(2010) Hiroshi Itou et al.   JOURNAL OF MOLECULAR BIOLOGY

Cholesterol utilization in mycobacteria is controlled by two TetR-type transcriptional regulators: kstR and kstR2

(2010) S. L. Kendall et al.   MICROBIOLOGY-SGM

electronic Ligand Builder and Optimization Workbench(eLBOW): a tool for ligand coordinate and restraint generation

(2009) Nigel W. Moriarty et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A Thiolase of Mycobacterium tuberculosis Is Required for Virulence and Production of Androstenedione and Androstadienedione from Cholesterol

(2009) N. M. Nesbitt et al.   INFECTION AND IMMUNITY

Mycobacterium tuberculosis Is Able To Accumulate and Utilize Cholesterol

(2009) A. Brzostek et al.   JOURNAL OF BACTERIOLOGY

igr Genes and Mycobacterium tuberculosis Cholesterol Metabolism

(2009) J. C. Chang et al.   JOURNAL OF BACTERIOLOGY

3-Ketosteroid 9α-hydroxylase is an essential factor in the pathogenesis ofMycobacterium tuberculosis

(2009) Yanmin Hu et al.   MOLECULAR MICROBIOLOGY

Studies of a Ring-Cleaving Dioxygenase Illuminate the Role of Cholesterol Metabolism in the Pathogenesis of Mycobacterium tuberculosis

(2009) Katherine C. Yam et al.   PLoS Pathogens

Functional Characterization of a Vitamin B12-Dependent Methylmalonyl Pathway in Mycobacterium tuberculosis: Implications for Propionate Metabolism during Growth on Fatty Acids

(2008) S. Savvi et al.   JOURNAL OF BACTERIOLOGY

Crystal Structures of the Streptomyces coelicolor TetR-Like Protein ActR Alone and in Complex with Actinorhodin or the Actinorhodin Biosynthetic Precursor (S)-DNPA

(2008) A.R. Willems et al.   JOURNAL OF MOLECULAR BIOLOGY

Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7

(2008) Gerrit Langer et al.   Nature Protocols

Mycobacterial persistence requires the utilization of host cholesterol

(2008) A. K. Pandey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA