Epigenetics and Signaling Pathways in Glaucoma

Role of the Rho GTPase/Rho kinase signaling pathway in pathogenesis and treatment of glaucoma: Bench to bedside research

(2017) Ponugoti Vasantha Rao et al.   EXPERIMENTAL EYE RESEARCH

Smad-independent TGF-β2 signaling pathways in human trabecular meshwork cells

(2017) Cynthia L. Pervan   EXPERIMENTAL EYE RESEARCH

Reaching the brain: Advances in optic nerve regeneration

(2017) Larry I. Benowitz et al.   EXPERIMENTAL NEUROLOGY

Discovery of the ROCK inhibitor netarsudil for the treatment of open-angle glaucoma

(2016) Jill M. Sturdivant et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Restoration of Visual Function by Enhancing Conduction in Regenerated Axons

(2016) Fengfeng Bei et al.   CELL

Pharmacology of novel intraocular pressure-lowering targets that enhance conventional outflow facility: Pitfalls, promises and what lies ahead?

(2016) Ganesh Prasanna et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Epigenetics in liver disease: from biology to therapeutics

(2016) Timothy Hardy et al.   GUT

Increased Global DNA Methylation and Decreased TGFβ1 Promoter Methylation in Glaucomatous Lamina Cribrosa Cells

(2016) Fiona S. McDonnell et al.   JOURNAL OF GLAUCOMA

MicroRNAs in glaucoma and neurodegenerative diseases

(2016) Milena Molasy et al.   JOURNAL OF HUMAN GENETICS

Calcium channel inhibition-mediated axonal stabilization improves axonal regeneration after optic nerve crush

(2016) ViniciusT Ribas et al.   Neural Regeneration Research

Epistatic Gene-Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium

(2016) Shefali Setia Verma et al.   PLoS Genetics

Caloric restriction promotes cell survival in a mouse model of normal tension glaucoma

(2016) Xiaoli Guo et al.   Scientific Reports

Viral vector-based improvement of optic nerve regeneration: characterization of individual axons’ growth patterns and synaptogenesis in a visual target

(2015) B J Yungher et al.   GENE THERAPY

Caspase-7: a critical mediator of optic nerve injury-induced retinal ganglion cell death

(2015) Shreyasi Choudhury et al.   Molecular Neurodegeneration

Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons

(2015) Songshan Li et al.   NEUROBIOLOGY OF DISEASE

Diabetes, Fasting Glucose, and the Risk of Glaucoma

(2015) Di Zhao et al.   OPHTHALMOLOGY

Neuroprotective therapies in glaucoma: I. Neurotrophic factor delivery

(2015) Nafiseh Nafissi et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Cellular commitment in the developing cerebellum

(2015) Hassan Marzban et al.   Frontiers in Cellular Neuroscience

The Association of Blood Pressure and Primary Open-Angle Glaucoma: A Meta-analysis

(2014) Di Zhao et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Downregulation of microRNA-100 protects apoptosis and promotes neuronal growth in retinal ganglion cells

(2014) Ning Kong et al.   BMC MOLECULAR BIOLOGY

Ripasudil: First Global Approval

(2014) Karly P. Garnock-Jones   DRUGS

Minocycline mechanism of neuroprotection involves the Bcl-2 gene family in optic nerve transection

(2014) Hani Levkovitch-Verbin et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Protective effects of protocatechuic acid on retinal ganglion cells from oxidative damage induced by H2O2

(2014) Zhuo Wang et al.   NEUROLOGICAL RESEARCH

Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040

(2014) Yih-Chung Tham et al.   OPHTHALMOLOGY

Nocturnal Systemic Hypotension Increases the Risk of Glaucoma Progression

(2014) Mary E. Charlson et al.   OPHTHALMOLOGY

Neuroprotection of a Novel Cyclopeptide C*HSDGIC* from the Cyclization of PACAP (1–5) in Cellular and Rodent Models of Retinal Ganglion Cell Apoptosis

(2014) Huanhuan Cheng et al.   PLoS One

Profiles of Extracellular miRNAs in the Aqueous Humor of Glaucoma Patients Assessed with a Microarray System

(2014) Yuji Tanaka et al.   Scientific Reports

The Role of Epigenetics in the Fibrotic Processes Associated with Glaucoma

(2014) Fiona McDonnell et al.   Journal of Ophthalmology

Long non-coding RNA-dependent transcriptional regulation in neuronal development and disease

(2014) Brian S. Clark et al.   Frontiers in Genetics

VEGF-A Is Necessary and Sufficient for Retinal Neuroprotection in Models of Experimental Glaucoma

(2013) Richard H. Foxton et al.   AMERICAN JOURNAL OF PATHOLOGY

Bimatoprost protects retinal neuronal damage via Akt pathway

(2013) Norihito Takano et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Smad3 is necessary for transforming growth factor-beta2 induced ocular hypertension in mice

(2013) Colleen M. McDowell et al.   EXPERIMENTAL EYE RESEARCH

FOXC1 in human trabecular meshwork cells is involved in regulatory pathway that includes miR-204, MEIS2, and ITGβ1

(2013) Seyed Hassan Paylakhi et al.   EXPERIMENTAL EYE RESEARCH

ANRIL: Molecular Mechanisms and Implications in Human Health

(2013) Ada Congrains et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Obstructive Sleep Apnea and Increased Risk of Glaucoma

(2013) Ching-Chun Lin et al.   OPHTHALMOLOGY

Rho-associated kinase inhibitors: A novel glaucoma therapy

(2013) Toshihiro Inoue et al.   PROGRESS IN RETINAL AND EYE RESEARCH

CDKN2B-AS1 Genotype–Glaucoma Feature Correlations in Primary Open-Angle Glaucoma Patients From the United States

(2012) Louis R. Pasquale et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Axonal degeneration as a therapeutic target in the CNS

(2012) Paul Lingor et al.   CELL AND TISSUE RESEARCH

Regulation of Cell Death and Survival Pathways in Secondary Degeneration of the Optic Nerve – A Long-Term Study

(2012) Shelly Vander et al.   CURRENT EYE RESEARCH

Pharmacological Inhibition of Caspase-2 Protects Axotomised Retinal Ganglion Cells from Apoptosis in Adult Rats

(2012) Vasanthy Vigneswara et al.   PLoS One

Non-Smad signaling pathways

(2011) Yabing Mu et al.   CELL AND TISSUE RESEARCH

TGFβ-induced Early Activation of the Small GTPase RhoA is Smad2/3-independent and Involves Src and the Guanine Nucleotide Exchange Factor Vav2

(2011) Elsa Papadimitriou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Common genetic variants associated with open-angle glaucoma

(2011) Wishal D. Ramdas et al.   HUMAN MOLECULAR GENETICS

Sustained axon regeneration induced by co-deletion of PTEN and SOCS3

(2011) Fang Sun et al.   NATURE

Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1

(2011) Kathryn P Burdon et al.   NATURE GENETICS

The molecular basis of retinal ganglion cell death in glaucoma

(2011) Mohammadali Almasieh et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Histone H4 deacetylation plays a critical role in early gene silencing during neuronal apoptosis

(2010) Heather R. Pelzel et al.   BMC NEUROSCIENCE

Rasagiline-induced Delay of Retinal Ganglion Cell Death in Experimental Glaucoma in Rats

(2010) Hani Levkovitch-Verbin et al.   JOURNAL OF GLAUCOMA

Methylation determines fibroblast activation and fibrogenesis in the kidney

(2010) Wibke Bechtel et al.   NATURE MEDICINE

Mechanisms of acute axonal degeneration in the optic nerve in vivo

(2010) J. Knoferle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using the Utah Population Database to assess familial risk of primary open angle glaucoma

(2010) Xiaolei Wang et al.   VISION RESEARCH

Genomic (epigenetic) DNA methylation in patients with open-angle glaucoma

(2009) A JÜNEMANN et al.   ACTA OPHTHALMOLOGICA

Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells

(2009) Padmanabhan P. Pattabiraman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Neurotrophin roles in retinal ganglion cell survival: Lessons from rat glaucoma models

(2009) Elaine C. Johnson et al.   EXPERIMENTAL EYE RESEARCH

Mechanism of retinal ganglion cells death in secondary degeneration of the optic nerve

(2009) Hani Levkovitch-Verbin et al.   EXPERIMENTAL EYE RESEARCH

The role of local protein synthesis and degradation in axon regeneration

(2009) Laura F. Gumy et al.   EXPERIMENTAL NEUROLOGY

Generation of an epigenetic signature by chronic hypoxia in prostate cells

(2009) J. A. Watson et al.   HUMAN MOLECULAR GENETICS

Lifestyle, Nutrition, and Glaucoma

(2009) Louis R. Pasquale et al.   JOURNAL OF GLAUCOMA

Defective Histone Acetylation Is Responsible for the Diminished Expression of Cyclooxygenase 2 in Idiopathic Pulmonary Fibrosis

(2009) W. R. Coward et al.   MOLECULAR AND CELLULAR BIOLOGY

Non-Smad pathways in TGF-β signaling

(2008) Ying E Zhang   CELL RESEARCH

Calcium ions in neuronal degeneration

(2008) Urszula Wojda et al.   IUBMB LIFE

TRAF6 Mediates Smad-Independent Activation of JNK and p38 by TGF-β

(2008) Motozo Yamashita et al.   MOLECULAR CELL

The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

(2008) Alessandro Sorrentino et al.   NATURE CELL BIOLOGY

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

(2008) K. K. Park et al.   SCIENCE