Neuroprotective therapies in glaucoma: I. Neurotrophic factor delivery

Gene therapy into photoreceptors and Müller glial cells restores retinal structure and function in CRB1 retinitis pigmentosa mouse models

(2015) Lucie P. Pellissier et al.   HUMAN MOLECULAR GENETICS

Localized Delivery of Brain-Derived Neurotrophic Factor-Expressing Mesenchymal Stem Cells Enhances Functional Recovery following Cervical Spinal Cord Injury

(2015) Heather M. Gransee et al.   JOURNAL OF NEUROTRAUMA

Ultrasound-targeted microbubble destruction enhances polyethylenimine-mediated gene transfection in vitro in human retinal pigment epithelial cells and in vivo in rat retina

(2015) CAIFENG WAN et al.   Molecular Medicine Reports

Nanosponge-Mediated Drug Delivery Lowers Intraocular Pressure

(2015) Wendi S. Lambert et al.   Translational Vision Science & Technology

Bacteriophage recombination systems and biotechnical applications

(2014) Nafiseh Nafissi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Optimized production of a safe and efficient gene therapeutic vaccine versus HIV via a linear covalently closed DNA minivector

(2014) Roderick Slavcev et al.   BMC INFECTIOUS DISEASES

Noninvasive Ocular Drug Delivery

(2014) Marianna Foldvari   JOURNAL OF GLAUCOMA

Preclinical development and ocular biodistribution of gemini-DNA nanoparticles after intravitreal and topical administration: Towards non-invasive glaucoma gene therapy

(2014) Samih Alqawlaq et al.   Nanomedicine-Nanotechnology Biology and Medicine

Optimization of a One-Step Heat-Inducible In Vivo Mini DNA Vector Production System

(2014) Nafiseh Nafissi et al.   PLoS One

Rescue of Retinal Function by BDNF in a Mouse Model of Glaucoma

(2014) Luciano Domenici et al.   PLoS One

Development of Poly(β-amino ester)-Based Biodegradable Nanoparticles for Nonviral Delivery of Minicircle DNA

(2013) Michael Keeney et al.   ACS Nano

Beyond the Niche: Tissue-Level Coordination of Stem Cell Dynamics

(2013) Lucy Erin O'Brien et al.   Annual Review of Cell and Developmental Biology

Biomaterial-based drug delivery systems for the controlled release of neurotrophic factors

(2013) Nima Khadem Mohtaram et al.   Biomedical Materials

Neurotrophin delivery using nanotechnology

(2013) Angelina Angelova et al.   DRUG DISCOVERY TODAY

Dendrimers for gene delivery - a potential approach for ocular therapy?

(2013) Sahil P. Chaplot et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

From Molecular to Nanotechnology Strategies for Delivery of Neurotrophins: Emphasis on Brain-Derived Neurotrophic Factor (BDNF)

(2013) Claire Géral et al.   Pharmaceutics

Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs

(2012) Tokushige Nakano et al.   Cell Stem Cell

Minicircle DNA electrotransfer for efficient tissue-targeted gene delivery

(2012) S Chabot et al.   GENE THERAPY

Construction and Characterization of an in-vivo Linear Covalently Closed DNA Vector Production System

(2012) Nafiseh Nafissi et al.   Microbial Cell Factories

Performance of High Quality Minicircle DNA for In Vitro and In Vivo Gene Transfer

(2012) Dennis Kobelt et al.   MOLECULAR BIOTECHNOLOGY

Dendrimer-Driven Neurotrophin Expression Differs in Temporal Patterns between Rodent and Human Stem Cells

(2012) Antos Shakhbazau et al.   MOLECULAR PHARMACEUTICS

Challenges in neuroprotective nanomedicine development: progress towards noninvasive gene therapy of glaucoma

(2012) Samih Alqawlaq et al.   Nanomedicine

NTS-Polyplex: a potential nanocarrier for neurotrophic therapy of Parkinson's disease

(2012) Daniel Martinez-Fong et al.   Nanomedicine-Nanotechnology Biology and Medicine

Protecting the retinal neurons from glaucoma: Lowering ocular pressure is not enough

(2012) Alessia Pascale et al.   PHARMACOLOGICAL RESEARCH

Clinical applications of retinal gene therapy

(2012) Daniel M. Lipinski et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Defining the Integration Capacity of Embryonic Stem Cell-Derived Photoreceptor Precursors

(2012) Emma L. West et al.   STEM CELLS

Non-Viral Nucleic Acid Delivery: Key Challenges and Future Directions

(2012) Mahmoud Elsabahy et al.   Current Drug Delivery

Neurons and Stromal Stem Cells as Targets for Polycation-Mediated Transfection

(2011) A. V. Shakhbazau et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Nanostructured lipid carriers for triamcinolone acetonide delivery to the posterior segment of the eye

(2011) Joana Araújo et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Gene therapy for retinal ganglion cell neuroprotection in glaucoma

(2011) A M Wilson et al.   GENE THERAPY

Non-viral gene therapy for GDNF production in RCS rat: the crucial role of the plasmid dose

(2011) E Touchard et al.   GENE THERAPY

Retinal ganglion cells survival in a glaucoma model by GDNF/Vit E PLGA microspheres prepared according to a novel microencapsulation procedure

(2011) Patricia Checa-Casalengua et al.   JOURNAL OF CONTROLLED RELEASE

AAV Mediated GDNF Secretion From Retinal Glia Slows Down Retinal Degeneration in a Rat Model of Retinitis Pigmentosa

(2011) Deniz Dalkara et al.   MOLECULAR THERAPY

Stem Cells for Retinal Replacement Therapy

(2011) Jeffrey H. Stern et al.   Neurotherapeutics

Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice

(2011) Budd A. Tucker et al.   PLoS One

Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration

(2011) K. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem cells as a therapeutic tool for the blind: biology and future prospects

(2011) M. S. Singh et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Solid lipid nanoparticles for ocular drug delivery

(2010) Ali Seyfoddin et al.   DRUG DELIVERY

Neuroprotection in glaucoma – Is there a future role?

(2010) Abeir Baltmr et al.   EXPERIMENTAL EYE RESEARCH

Neurotrophic factor delivery as a protective treatment for glaucoma

(2010) Thomas V. Johnson et al.   EXPERIMENTAL EYE RESEARCH

Minicircle DNA-based Gene Therapy Coupled With Immune Modulation Permits Long-term Expression of α-L-Iduronidase in Mice With Mucopolysaccharidosis Type I

(2010) Mark J Osborn et al.   MOLECULAR THERAPY

Generation of adult human induced pluripotent stem cells using nonviral minicircle DNA vectors

(2010) Kazim H Narsinh et al.   Nature Protocols

Non-Invasive Stem Cell Therapy in a Rat Model for Retinal Degeneration and Vascular Pathology

(2010) Shaomei Wang et al.   PLoS One

Generation, Purification and Transplantation of Photoreceptors Derived from Human Induced Pluripotent Stem Cells

(2010) Deepak A. Lamba et al.   PLoS One

Cyclosporine A-Loaded Solid Lipid Nanoparticles: Ocular Tolerance andIn VivoDrug Release in Rabbit Eyes

(2009) Evren H. Gökçe et al.   CURRENT EYE RESEARCH

Retinal pigment epithelial phenotype induced in human adipose tissue-derived mesenchymal stromal cells

(2009) Urs Vossmerbaeumer et al.   CYTOTHERAPY

Does elevated intraocular pressure reduce retinal TRKB-mediated survival signaling in experimental glaucoma?

(2009) Ying Guo et al.   EXPERIMENTAL EYE RESEARCH

Brain-derived neurotrophic factor released from engineered mesenchymal stem cells attenuates glutamate- and hydrogen peroxide-mediated death of staurosporine-differentiated RGC-5 cells

(2009) Matthew M. Harper et al.   EXPERIMENTAL EYE RESEARCH

Polymeric nanoparticulate system: A potential approach for ocular drug delivery

(2009) Ramesh C. Nagarwal et al.   JOURNAL OF CONTROLLED RELEASE

BDNF-Hypersecreting Human Mesenchymal Stem Cells Promote Functional Recovery, Axonal Sprouting, and Protection of Corticospinal Neurons after Spinal Cord Injury

(2009) M. Sasaki et al.   JOURNAL OF NEUROSCIENCE

Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

(2009) Lajos Mátés et al.   NATURE GENETICS

Brain-derived neurotrophic factor in neurodegenerative diseases

(2009) Chiara Zuccato et al.   Nature Reviews Neurology

Combined effect of brain-derived neurotrophic factor and LINGO-1 fusion protein on long-term survival of retinal ganglion cells in chronic glaucoma

(2009) Q.-L. Fu et al.   NEUROSCIENCE

Modeling early retinal development with human embryonic and induced pluripotent stem cells

(2009) J. S. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Derivation of Functional Retinal Pigmented Epithelium from Induced Pluripotent Stem Cells

(2009) David E. Buchholz et al.   STEM CELLS

Gene Therapy Targeting Glaucoma: Where Are We?

(2009) Xuyang Liu et al.   SURVEY OF OPHTHALMOLOGY

Molecular Engineering of Viral Gene Delivery Vehicles

(2008) David V. Schaffer et al.   Annual Review of Biomedical Engineering

The Biology of Neurotrophins, Signalling Pathways, and Functional Peptide Mimetics of Neurotrophins and their Receptors

(2008) Stephen Skaper   CNS & Neurological Disorders-Drug Targets

Clinical gene therapy using recombinant adeno-associated virus vectors

(2008) C Mueller et al.   GENE THERAPY

Retinal p75 and bax overexpression is associated with retinal ganglion cells apoptosis in a rat model of glaucoma

(2008) Marco Coassin et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Inhibition of p75NTR in glia potentiates TrkA-mediated survival of injured retinal ganglion cells

(2008) Frédéric Lebrun-Julien et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression

(2008) Stephen C Hyde et al.   NATURE BIOTECHNOLOGY

Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells

(2008) Fumitaka Osakada et al.   NATURE BIOTECHNOLOGY

Cell-penetrating Peptide for Enhanced Delivery of Nucleic Acids and Drugs to Ocular Tissues Including Retina and Cornea

(2007) Leslie N Johnson et al.   MOLECULAR THERAPY