Part I: Diastereoselective Reactions Involving β-Mono- and β,β′-Disubstituted Alkylidene Oxindoles: Pondering Alkene Geometry

Design, synthesis and biological evaluation of 3-substituted-2-oxindole hybrid derivatives as novel anticancer agents

(2017) Romeo Romagnoli et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Visible-Light-Promoted Tandem Difluoroalkylation–Amidation: Access to Difluorooxindoles from Free Anilines

(2017) Ling-Chao Yu et al.   JOURNAL OF ORGANIC CHEMISTRY

Lanthanide amide-catalyzed one-pot functionalization of isatins: synthesis of spiro[cyclopropan-1,3′-oxindoles] and 2-oxoindolin-3-yl phosphates

(2017) Cheng Peng et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Diastereoselective [3 + 2] cycloaddition of 3-ylideneoxindoles with in situ generated CF2HCHN2: syntheses of CF2H-containing spirooxindoles

(2017) Wen-Yong Han et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Spirooxindole synthesis via palladium-catalyzed dearomative reductive-Heck reaction

(2017) Ren-Rong Liu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Spiroannulation of Oxindoles via Aryne and Alkyne Incorporation: Substituent-Diverted, Transition-Metal-Free, One-Pot Access to Spirooxindoles

(2017) Ramesh Samineni et al.   ORGANIC LETTERS

Structural engineering of poly-(methacrylate) bearing push-pull type pendants oxindole-phenothiazine with tetrazole anchoring acceptor for efficient organic photovoltaic cells

(2017) Selvam Ramasamy et al.   POLYMER

Furochromone-isatin conjugates via an uncatalyzed diastereoselective [4 + 1] cycloaddition/tautomerization/Friedel-Crafts hydroxyalkylation domino reaction

(2017) Mohammad Bagher Teimouri et al.   TETRAHEDRON

N -heterocyclic carbene-mediated formal [3+3] annulation of isatin-derived α, β-unsaturated acids: Access to functionalized 3,4′-spirooxindole δ -lactones

(2017) Weiguo Zhang et al.   TETRAHEDRON

Metal-free visible-light-promoted intermolecular [2+2]-cycloaddition of 3-ylideneoxindoles

(2017) Ling-Ling Wu et al.   TETRAHEDRON

A novel three-component method for the synthesis of spiro[chromeno [4′,3′:4,5] pyrimido[1,2- b ] indazole-7,3′-indoline]-2′,6(9 H )-dione

(2017) Amol Maruti Jadhav et al.   TETRAHEDRON

Convenient one-pot synthesis of thiobarbituro-quinoline derivatives via catalyst-free multicomponent reactions in water

(2017) Dulin Kong et al.   TETRAHEDRON LETTERS

Cascade synthesis of selective dihydro pyridazino fused acridinone derivatives via MCM-41 catalyzed ring-opening/ring-closure reaction

(2017) Rajiv Karmakar et al.   TETRAHEDRON LETTERS

A facile synthesis of novel endo -selective polycyclic spiropyrrolidine oxindoles via 1,3-dipolar cycloaddition of α,γ-dialkylallenoate esters

(2017) Yingwei Wang et al.   TETRAHEDRON LETTERS

An efficient synthesis of dihydrofuranyl spirooxindoles from isatin-derived propargylic alcohols and 1,3-dicarbonyls

(2017) Hwa Jung Roh et al.   TETRAHEDRON LETTERS

Diethyl oxalacetate sodium salt as a reagent to obtain functionalized spiro[indoline-3,4′-pyrano[2,3- c ]pyrazoles]

(2017) Vladimir L. Gein et al.   TETRAHEDRON LETTERS

An efficient method based on indoles for the synthesis of isatins by taking advantage of I 2 O 5 as oxidant

(2017) Ci-Ping Wang et al.   TETRAHEDRON LETTERS

Straightforward synthesis of novel substituted 1,3,4-thiadiazole derivatives in choline chloride-based deep eutectic solvent

(2017) Seyyed Mohammad Shahcheragh et al.   TETRAHEDRON LETTERS

Part II: Diastereoselective Reactions Involving β-Mono- and β,β′-Disubstituted Alkylidene Oxindoles: Pondering Alkene Geometry

(2017) Madhu Ganesh et al.   Asian Journal of Organic Chemistry

N-Unsubstituted thienoisoindigos: preparation, molecular packing and ambipolar organic field-effect transistors

(2017) Dongho Yoo et al.   Journal of Materials Chemistry C

Synthesis of spiropyrazoline oxindoles by a formal [4 + 1] annulation reaction between 3-bromooxindoles and in situ-derived 1,2-diaza-1,3-dienes

(2017) Dong-Zhen Chen et al.   Organic Chemistry Frontiers

Recent Developments in the Stereoselective Synthesis of Nitrogen-Containing Heterocycles usingN-Acylimines as Reactive Substrates

(2016) Enrico Marcantoni et al.   ADVANCED SYNTHESIS & CATALYSIS

Discovery of SOAT2 inhibitors from synthetic small molecules

(2016) Keisuke Kobayashi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Efficient synthesis of new 2,3-dihydrooxazole-spirooxindoles hybrids as antimicrobial agents

(2016) Shailendra Tiwari et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of new arylisoxazole-oxindole conjugates as potent antiproliferative agents

(2016) Gajjela Bharath Kumar et al.   Chemical Biology & Drug Design

Synthesis,in vitroevaluation and molecular docking studies of novel coumarin-isatin derivatives as α-glucosidase inhibitors

(2016) Guangcheng Wang et al.   Chemical Biology & Drug Design

A Divergent Approach to the Diastereoselective Synthesis of 3,3-Disubstituted Oxindoles from AtropisomericN-Aryl Oxindole Derivatives

(2016) Atsuo Nakazaki et al.   Chemistry-An Asian Journal

Discovery of pyrrolospirooxindole derivatives as novel cyclin dependent kinase 4 (CDK4) inhibitors by catalyst-free, green approach

(2016) Ahmed Kamal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Oxindole: A chemical prism carrying plethora of therapeutic benefits

(2016) Maninder Kaur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of isatin/triazole conjugates that induce apoptosis and inhibit migration of MGC-803 cells

(2016) Bin Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Diastereoselective Three-Component Cascade Reaction to Construct Oxindole-Fused Spirotetrahydro­furochroman Scaffolds for Drug Discovery

(2016) Lin Qiu et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Diastereoselective synthesis of dispiro[indoline-3,1′-cyclobutane-2′,3″-indolines] via visible light catalyzed cyclodimerization of 3-phenacylideneoxindoles

(2016) Yan-Hong Jiang et al.   HETEROCYCLIC COMMUNICATIONS

A facile and consecutive approach to trifluoromethylated spirochromeno[2,3- c ]-6 H -Pyrazol-2′,5-dione derivatives

(2016) Zhangping Kang et al.   JOURNAL OF FLUORINE CHEMISTRY

Stereoselective Synthesis of Methylene Oxindoles via Palladium(II)-Catalyzed Intramolecular Cross-Coupling of Carbamoyl Chlorides

(2016) Christine M. Le et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

(Z)-(Thienylmethylene)oxindole-Based Polymers for High-Performance Solar Cells

(2016) Jian Wu et al.   MACROMOLECULES

Synthesis and biological evaluation of new spirooxindoles with embedded pharmacophores

(2016) Sadasivam Mathusalini et al.   NEW JOURNAL OF CHEMISTRY

Isatin-based three-component synthesis of new spirooxindoles using magnetic nano-sized copper ferrite

(2016) Mojtaba Baghernejad et al.   NEW JOURNAL OF CHEMISTRY

Tin powder-promoted one-pot synthesis of 3-spiro-fused or 3,3′-disubstituted 2-oxindoles

(2016) Juanjuan Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Annulation Reaction of 3-Acylmethylidene Oxindoles with Huisgen Zwitterions and Its Applications in the Syntheses of Pyrrolo[4,3,2-de]quinolinones and Marine Alkaloids Ammosamides

(2016) Changjiang Yang et al.   ORGANIC LETTERS

Synthesis of Functionalized 6-Hydroxy-2-oxindole Derivatives by Phenoxide Cyclization

(2016) B. Narendraprasad Reddy et al.   ORGANIC LETTERS

Synthesis of Quaternary 3,3-Disubstituted 2-Oxindoles from 2-Substituted Indole Using Selectfluor

(2016) Xiaojian Jiang et al.   ORGANIC LETTERS

Palladium-Catalyzed Nitration of Arenes by 1,2,3-Triazole-Directed C–H Activation

(2016) Yubo Jiang et al.   SYNTHESIS-STUTTGART

Review of synthesis and various biological activities of spiro heterocyclic compounds comprising oxindole and pyrrolidine moities

(2016) Pankaj Saraswat et al.   SYNTHETIC COMMUNICATIONS

Highly regio- and stereoselective 1,3-dipolar cycloaddition of stabilised azomethine ylides to 3,3,3-trihalogeno-1-nitropropenes: synthesis of trihalomethylated spiro[indoline-3,2′-pyrrolidin]-2-ones and spiro[indoline-3,3′-pyrrolizin]-2-ones

(2016) Alexey Yu. Barkov et al.   TETRAHEDRON

A highly stereoselective, catalytic four-component synthesis of dispiroindolo-pyrrolidines/-imidazolidines via azomethine ylides

(2016) Sengodagounder Muthusamy et al.   TETRAHEDRON

Ru(III)-mediated intramolecular ortho-C(sp2)–H activation/oxidative acylation: one-pot synthesis of isatins from α-hydroxy amides

(2016) Yaoling Wang et al.   TETRAHEDRON

Copper-catalyzed synthesis of 1-amino-5-arylindazolo[3,2- b ]quinazolin-7(5 H )-ones via a ring-opening reaction of 4-halogenated isatin

(2016) Yong-Gang Ma et al.   TETRAHEDRON

An efficient green approach for the synthesis of novel triazolyl spirocyclic oxindole derivatives via one-pot five component protocol using DBU as catalyst in PEG-400

(2016) Sudesh Kumari et al.   TETRAHEDRON LETTERS

Ferric(III) chloride catalyzed intramolecular cyclization of N -alkyl-2-oxo-acetanilides: a facile access to isatins

(2016) Yang Zheng et al.   TETRAHEDRON LETTERS

Ambient temperature synthesis of spiro[indoline-3,2′-thiazolidinones] by a DBSA-catalyzed sequential reaction in water

(2016) Amreeta Preetam et al.   TETRAHEDRON LETTERS

Highly efficient and regioselective synthesis of spirooxindolo pyrrolizidines by reaction of isatin, proline and acrylonitrile/methyl acrylate in water

(2016) Keshri Nath Tiwari et al.   TETRAHEDRON LETTERS

Diethylene glycol-bis(3-methylimidazolium) dihydroxide as a dicationic ionic liquid catalyst for the synthesis of 4H-pyrane derivatives in aqueous medium

(2016) Khodabakhsh Niknam et al.   TETRAHEDRON LETTERS

Diastereoselective synthesis of isoxazolidines and spiroisoxazolidines via catalytic 1,3-dipolar cycloaddition reactions in the presence of Fe 3 O 4 - l -proline nanoparticles as a magnetic organocatalyst

(2016) Javad Safaei-Ghomi et al.   TETRAHEDRON LETTERS

One-pot synthesis of spirofluorenyl- and spiroindeno[1,2- b ]indolyl oxindoles via sequential inter- and intramolecular Friedel–Crafts reactions

(2016) Jin Woo Lim et al.   TETRAHEDRON LETTERS

A new entry to synthesis of neocryptolepine related skeletons. An unexpected behavior of 3-acety-2-ethoxyindole and isatins

(2016) Wentao Gao et al.   TETRAHEDRON LETTERS

A simple one-pot synthesis of quinoline-4-carboxylic acids by the Pfitzinger reaction of isatin with enaminones in water

(2016) Ibrahim Elghamry et al.   TETRAHEDRON LETTERS

Enzyme-catalyzed domino reaction: efficient construction of spirocyclic oxindole skeleton using porcine pepsin

(2016) Yan-Hong He et al.   Catalysis Science & Technology

A highly efficient one-pot synthesis of indenopyridine-fused spirocyclic systems

(2016) Ghazaleh Imani Shakibaei et al.   RSC Advances

One-pot four component domino strategy for the synthesis of novel spirooxindole pyrrolizine linked 1,2,3-triazoles via stereo- and regioselective [3 + 2] cycloaddition reaction in acidic medium

(2016) Rajeswari M. et al.   RSC Advances

Asymmetric Total Synthesis and Structural Elucidation of Unusual Oxindole Alkaloid Leucolusine

(2016) Ganesh Pandey et al.   Asian Journal of Organic Chemistry

Recent Advances in Green Synthesis of 3,3′-Spirooxindoles via Isatin-based One-pot Multicomponent Cascade Reactions in Aqueous Medium

(2016) Li-Jun Yan et al.   ChemistrySelect

Regio- and Enantioselective Aza-Diels-Alder Reactions of 3-Vinylindoles: A Concise Synthesis of the Antimalarial Spiroindolone NITD609

(2015) Haifeng Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An unprecedented base-promoted domino reaction of methyleneindolinones and N-tosyloxycarbamates for the construction of bispirooxindoles and spiroaziridine oxindoles

(2015) Qi-Lin Wang et al.   CHEMICAL COMMUNICATIONS

Copper-catalyzed 1,3-dipolar cycloaddition of methyleneindolinones and N,N′-cyclic azomethine imines

(2015) Di Zhang et al.   CHINESE CHEMICAL LETTERS

Spirooxindoles: Promising scaffolds for anticancer agents

(2015) Bin Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Atom economical synthesis of oxindoles by metal-catalyzed intramolecular C–C bond formation under solvent-free and aerobic conditions

(2015) Se In Son et al.   GREEN CHEMISTRY

An Efficient Synthesis for Some New Heterocyclic Compound-fused Oxindole Derivatives

(2015) R. Ahdenov et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Cascade Arylalkylation of Activated Alkenes: Synthesis of Chloro- and Cyano-Containing Oxindoles

(2015) Xueqin Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Facile synthesis of spirooxindole-pyrazolines and spirobenzofuranone-pyrazolines and their fungicidal activity

(2015) Changjiang Yang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Substrate-controlled product-selectivity in the reaction of the Bestmann–Ohira reagent with N-unprotected isatin-derived olefins

(2015) Ashis Kumar Gupta et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

An efficient one pot regioselective synthesis of a 3,3′-spiro-phosphonylpyrazole-oxindole framework via base mediated [1,3]-dipolar cycloaddition reaction of the Bestmann–Ohira reagent with methyleneindolinones

(2015) Anil M. Shelke et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Rh-Catalyzed Domino Addition–Enolate Arylation: Generation of 3-Substituted Oxindoles via a Rh(lll) Intermediate

(2015) Young Jin Jang et al.   ORGANIC LETTERS

Indium(III) Chloride-Catalyzed Isocyanide Insertion Reaction to Construct Complex Spirooxindole

(2015) Yaming Tian et al.   ORGANIC LETTERS

Synthesis of Nitromethyl-Substituted Oxindole Derivatives via a Desulfonylation Cascade

(2015) Aihua Zhou et al.   SYNLETT

Catalyst-Free and Oxidant-Free Synthesis of 1,3,5-Trisubstituted Pyrazoles by Michael-Type Addition of Hydrazone sp2 Nitrogen Atoms to Enones

(2015) Chunyin Zhu et al.   SYNTHESIS-STUTTGART

Recent Advances in Organocatalytic Cascade Reactions toward the Formation of Quaternary Stereocenters

(2015) Tecla Gasperi et al.   SYNTHESIS-STUTTGART

A cascade synthetic route to new bioactive spiroindolinepyrido[1,2-a]indolediones from indirubin

(2015) Alexander M. Sele et al.   TETRAHEDRON

DMAP-catalyzed Diels–Alder reaction of 3-hydroxy-2-pyrone and methyleneindolinones for the synthesis of spirocyclic oxindoles

(2015) Ming-Qiang Zhou et al.   TETRAHEDRON

Stereochemical implications in the synthesis of 3,3′-spirocyclopropyl oxindoles from β-aryl/alkyl-substituted alkylidene oxindoles

(2015) Erin E. Wilson et al.   TETRAHEDRON

Asymmetric synthesis of chiral 3,3-disubstituted oxindoles using isatin as starting material

(2015) Ghodsi Mohammadi Ziarani et al.   TETRAHEDRON-ASYMMETRY

Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor

(2015) Lorna H. Mitchell et al.   ACS Medicinal Chemistry Letters

3-Alkyl-3-(alkylamino)indolin-2-ones via Base-Mediated C-Arylation of 2-Nitrobenzenesulfonamides

(2015) Vanesa Giménez-Navarro et al.   ACS Combinatorial Science

Synthesis of novel benzoxaborinin-4-ones and its application in indolin-2-ones synthesis using a Suzuki–Miyaura reaction protocol

(2015) Kannan Murugan et al.   RSC Advances

Stereoselective synthesis of 3-amino-2-oxindoles from isatin imines: new scaffolds for bioactivity evaluation

(2015) Jasneet Kaur et al.   RSC Advances

A Catalyst-Free Approach to Construct 3-(Cyclopentenone)oxindoles Through a Phosphine-Ylide-Initiated Triple Domino Sequence

(2015) Yanlong Du et al.   Asian Journal of Organic Chemistry

Catalytic asymmetric synthesis of polysubstituted spirocyclopropyl oxindoles: organocatalysis versus transition metal catalysis

(2015) Zhong-Yan Cao et al.   Organic Chemistry Frontiers

Syntheses and Evaluation of Carbon-11- and Fluorine-18-Radiolabeled pan-Tropomyosin Receptor Kinase (Trk) Inhibitors: Exploration of the 4-Aza-2-oxindole Scaffold as Trk PET Imaging Agents

(2014) Vadim Bernard-Gauthier et al.   ACS Chemical Neuroscience

Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids

(2014) Kunal Nepali et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthetic Routes towards Benzofuro[2,3-b]pyrroles and Benzofuro[2,3-b]indoles

(2014) Okiko Miyata et al.   HETEROCYCLES

KAl(SO4)2.12H2O(Alum): An Efficient Catalyst for the Synthesis of Novel bis[spiro(quinazoline-oxindole)] Derivatives Via One-Pot Pseudo Five-Component Reactions

(2014) Ali A. Mohammadi et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

AlCl3-Promoted Selective Michael Addition with Allenoate and Methyleneindolinone: Synthesis of Spirocyclic Oxindole by Using Allenoate as a Four-Carbon Component Building Block

(2014) Shibo Xu et al.   JOURNAL OF ORGANIC CHEMISTRY

Selective Synthesis of Polyfunctionalized Pyrido[2,3-b]indoles by Multicomponent Domino Reactions

(2014) Jun-Die Hu et al.   JOURNAL OF ORGANIC CHEMISTRY

Diastereoselective Synthesis of Functionalized Spirocyclopropyl Oxindoles via P(NMe2)3-Mediated Reductive Cyclopropanation

(2014) Rong Zhou et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of CF3-Containing 3,3′-Cyclopropyl Spirooxindoles by Sequential [3 + 2] Cycloaddition/Ring Contraction of Ylideneoxindoles with 2,2,2-Trifluorodiazoethane

(2014) Tian-Ren Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly regioselective synthesis of 3-alkenyl-oxindole ring-fused 3,3′-disubstituted oxindoles via direct gamma-substitution of Morita–Baylis–Hillman carbonates of isatins with 3-substituted oxindoles

(2014) Ting-Ting Feng et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Studies on the stereochemical assignment of 3-acylidene 2-oxindoles

(2014) Steven J. Edeson et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Lewis Acid Catalyzed Unprecedented [3 + 2] Cycloaddition Yields 3,3′-Pyrrolidinyldispirooxindoles Containing Four Contiguous Chiral Stereocenters with Two Contiguous Quaternary Spirostereocenters

(2014) Koorathota Suman et al.   ORGANIC LETTERS

A Convergent Synthesis of the Fully Elaborated Macrocyclic Core of TMC-95A

(2014) Alexis Coste et al.   ORGANIC LETTERS

Titanium(IV)-Catalyzed Stereoselective Synthesis of Spirooxindole-1-pyrrolines

(2014) Joseph J. Badillo et al.   ORGANIC LETTERS

Relay Catalytic Cascade Hydrosiloxylation and Asymmetric Hetero-Diels–Alder Reaction

(2014) Liu-Zhu Gong et al.   SYNTHESIS-STUTTGART

Recent advances in the synthesis of biologically active spirooxindoles

(2014) Maria M.M. Santos   TETRAHEDRON

Reactions of vinyl sulfone with α-diazo-β-ketosulfone and Bestmann–Ohira reagent for the regioselective synthesis of highly functionalized pyrazoles

(2014) Rahul Kumar et al.   TETRAHEDRON

Synthesis of 3-carbonyl pyrazole-5-phosphonates via 1,3-dipolar cycloaddition of Bestmann–Ohira reagent with ynones

(2014) Mukund M.D. Pramanik et al.   TETRAHEDRON

Synthesis of complex dispirocyclopentanebisoxindoles via cycloaddition reactions of 4-dimethylamino-1-alkoxycarbonylmethylpyridinium bromides with 2-oxoindolin-3-ylidene derivatives

(2014) Li-Juan Lu et al.   TETRAHEDRON

Catalytic asymmetric synthesis of 3,3-disubstituted oxindoles: diazooxindole joins the field

(2014) Zhong-Yan Cao et al.   TETRAHEDRON LETTERS

Stoichiometry-controlled cycloaddition of azomethine ylide with dipolarophiles: chemoselective and regioselective synthesis of bis- and tris-spirooxindole derivatives

(2014) Srinu Lanka et al.   TETRAHEDRON LETTERS

Three-component synthesis of disubstituted 2H-pyrrol-2-ones: preparation of the violacein scaffold

(2014) Emily C. McLaughlin et al.   TETRAHEDRON LETTERS

Catalyst and solvent-free cyclopropanation of electron-deficient olefins with cyclic diazoamides for the synthesis of spiro[cyclopropane-1,3′-indolin]-2′-one derivatives

(2014) Govindaraju Karthik et al.   TETRAHEDRON LETTERS

Indium trichloride catalyzed sp3 C–H bond functionalization of 2-alkyl azaarenes under microwave irradiation

(2014) Sourav Chatterjee et al.   TETRAHEDRON LETTERS

Organocatalytic Asymmetric Assembly Reactions: Synthesis of Spirooxindoles via Organocascade Strategies

(2014) Daojuan Cheng et al.   ACS Catalysis

A highly efficient DBU-catalyzed green synthesis of spiro-oxindoles

(2014) Liqun Wang et al.   RSC Advances

Diastereoselective synthesis of spiro[cyclopropane-1,3′-indolin]-2′-ones through metal-free cyclopropanation using tosylhydrazone salts

(2014) Jeevak Sopanrao Kapure et al.   RSC Advances

One-pot synthesis of 6,11-dihydro-5H-indolizino[8,7-b]indoles via sequential formation of β-enamino ester, Michael addition and Pictet–Spengler reactions

(2014) Dan Zhu et al.   RSC Advances

Tandem Diels-Alder/Coupling Reaction Involving Two Arynes: Highly Stereoselective Synthesis of Dihydronaphtho-Fused Oxindole

(2014) Shikuan Su et al.   Asian Journal of Organic Chemistry

Counterion effects in the catalytic stereoselective synthesis of 2,3′-pyrrolidinyl spirooxindoles

(2013) Jacob P. MacDonald et al.   CHEMICAL COMMUNICATIONS

Cascade Oxidative Dearomatization/Semipinacol Rearrangement: An Approach to 2-Spirocyclo-3-oxindole Derivatives

(2013) Jin-Bao Peng et al.   Chemistry-An Asian Journal

Recent Progress on Routes to Spirooxindole Systems Derived from Isatin

(2013) Min Xia et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Synthesis of Pyrrolo(spiro-[2.3′]-oxindole)-spiro-[4.3″]-oxindole via 1,3-Dipolar Cycloaddition of Azomethine Ylides with 3-Acetonylideneoxindole

(2013) Jun-An Xiao et al.   JOURNAL OF ORGANIC CHEMISTRY

Construction of Dispirocyclopentanebisoxindoles via Self-Domino Michael-Aldol Reactions of 3-Phenacylideneoxindoles

(2013) Jing Sun et al.   JOURNAL OF ORGANIC CHEMISTRY

Diastereomeric Spirooxindoles as Highly Potent and Efficacious MDM2 Inhibitors

(2013) Yujun Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regio- and stereoselective synthesis of spirooxindole 1′-nitro pyrrolizidines with five concurrent stereocenters under aqueous medium and their bioprospection using the zebrafish (Danio rerio) embryo model

(2013) Carlos E. Puerto Galvis et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Novel Oxindole Based Sensitizers: Synthesis and Application in Dye-Sensitized Solar Cells

(2013) Yogesh S. Tingare et al.   ORGANIC LETTERS

A Csp3–Csp3 Bond Forming Reductive Condensation of α-Keto Esters and Enolizable Carbon Pronucleophiles

(2013) Wei Zhao et al.   ORGANIC LETTERS

Synthesis of 3,3′-Spirocyclic Oxindoles via Phosphine Catalyzed [4 + 2] Cyclizations

(2013) Maxime Gicquel et al.   ORGANIC LETTERS

NHC-Catalyzed Ester Activation: Access to Sterically Congested Spirocyclic Oxindoles via Reaction of α-Aryl Esters and Unsaturated Imines

(2013) Yonggui Chi et al.   SYNLETT

Review of Synthesis of Spiro Heterocyclic Compounds from Isatin

(2013) Mayuri A. Borad et al.   SYNTHETIC COMMUNICATIONS

Review of Synthesis of Multispiro Heterocyclic Compounds from Isatin

(2013) Mayuri A. Borad et al.   SYNTHETIC COMMUNICATIONS

Chemoselective synthesis of 3H-pyrrolo[2,3-c]quinolin-4(5H)-one derivatives from 3-phenacylideneoxindoles and substituted tosylmethyl isocyanide (TosMIC)

(2013) Rong Wang et al.   TETRAHEDRON

Diastereoselective synthesis of dispirooxindoline fused [1,3]oxazines via Diels–Alder reaction of functionalized 1,2-dihydropyridines with (E)-1,3-dihydro-3-phenacylidene-2H-indol-2-ones

(2013) Jing Sun et al.   TETRAHEDRON

Highly efficient and diastereoselective construction of bispirooxindoles through a cascade Michael-cyclization reaction

(2013) Song Wu et al.   TETRAHEDRON

Regioselective synthesis of spiropyrrolidine/spiropyrrolizidine/spirothiazolidine-grafted macrocycles through 1,3-dipolar cycloaddition methodology

(2013) S. Purushothaman et al.   TETRAHEDRON

Construction of spiro[indoline]oxindoles through one-pot thermal-induced [3+2] cycloaddition/silica gel-promoted fragmentation sequence between isatin ketonitrones and electron-deficient alkynes

(2013) Hai-Bin Yang et al.   TETRAHEDRON

New formal (3+3) cycloaddition of enaminones for forming tetracyclic indolo[2,3-b]quinolines under microwave irradiation

(2013) Meng-Yuan Li et al.   TETRAHEDRON

Quinine as an organocatalytic dual activator for the diastereoselective synthesis of spiro-epoxyoxindoles

(2013) Mangilal Chouhan et al.   TETRAHEDRON LETTERS

Regio- and stereoselective synthesis of spiro-pyrrolidine/pyrrolizidine/thiazolidine-grafted macrocycles through intramolecular 1,3-dipolar cycloaddition reaction

(2013) S. Purushothaman et al.   TETRAHEDRON LETTERS

Development of Novel Alkene Oxindole Derivatives As Orally Efficacious AMP-Activated Protein Kinase Activators

(2013) Li-Fang Yu et al.   ACS Medicinal Chemistry Letters

Recent Advances in Diversity Oriented Synthesis through Isatin-based Multicomponent Reactions

(2013) Yunyun Liu et al.   Asian Journal of Organic Chemistry

Catalytic “triangles”: binding of iron in task-specific ionic liquids

(2012) Denis Prodius et al.   CHEMICAL COMMUNICATIONS

Recent advances in organocatalytic methods for the synthesis of disubstituted 2- and 3-indolinones

(2012) Renato Dalpozzo et al.   CHEMICAL SOCIETY REVIEWS

Catalytic Asymmetric Michael Addition/Cyclization of Isothiocyanato Oxindoles: Highly Efficient and Versatile Approach for the Synthesis of 3,2′-Pyrrolidinyl Mono- and Bi-spirooxindole Frameworks

(2012) Yi-Ming Cao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Strategies for the enantioselective synthesis of spirooxindoles

(2012) Nicolas R. Ball-Jones et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Construction of Naphtho-Fused Oxindoles via the Aryne Diels–Alder Reaction with Methyleneindolinones

(2012) Jian Li et al.   ORGANIC LETTERS

Facile Synthesis of Dispirooxindole-Fused Heterocycles via Domino 1,4-Dipolar Addition and Diels–Alder Reaction of in Situ Generated Huisgen 1,4-Dipoles

(2012) Jing Sun et al.   ORGANIC LETTERS

Synthesis of Oxindolyl Pyrazolines and 3-Amino Oxindole Building Blocks via a Nitrile Imine [3 + 2] Cycloaddition Strategy

(2012) Anand Singh et al.   ORGANIC LETTERS

Access to Spirocyclic Oxindoles via N-Heterocyclic Carbene-Catalyzed Reactions of Enals and Oxindole-Derived α,β-Unsaturated Imines

(2012) Kun Jiang et al.   ORGANIC LETTERS

FeCl3-Catalyzed Stereoselective Construction of Spirooxindole Tetrahydroquinolines via Tandem 1,5-Hydride Transfer/Ring Closure

(2012) Yan-Yan Han et al.   ORGANIC LETTERS

Efficient synthesis of pentasubstituted pyrroles via one-pot reactions of arylamines, acetylenedicarboxylates, and 3-phenacylideneoxindoles

(2012) Ying Han et al.   TETRAHEDRON

Visible light induced intermolecular [2+2]-cycloaddition reactions of 3-ylideneoxindoles through energy transfer pathway

(2012) You-Quan Zou et al.   TETRAHEDRON

Direct construction of novel exo′-selective spiropyrrolidine bisoxindoles via a three-component 1,3-dipolar cycloaddition reaction

(2012) Jie Liu et al.   TETRAHEDRON LETTERS

Ionic liquid mediated 1,3-dipolar cycloaddition of azomethine ylides: a facile and green synthesis of novel dispiro heterocycles

(2012) Renuka Jain et al.   TETRAHEDRON LETTERS

Palladium-catalyzed oxidative arylation of trisubstituted olefin: an efficient synthesis of 3-(disubstituted)alkylidene-oxindoles

(2012) Hyun Ju Lee et al.   TETRAHEDRON LETTERS

Recent developments in solvent-free multicomponent reactions: a perfect synergy for eco-compatible organic synthesis

(2012) Maya Shankar Singh et al.   RSC Advances

Enantioselective Michael/Cyclization Reaction Sequence: Scaffold-Inspired Synthesis of Spirooxindoles with Multiple Stereocenters

(2011) Yiming Cao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iodine-catalyzed conjugate addition of indoles onto en-1,4-dione: A novel synthesis of 3-(1-(1H-indol-3-yl)-2-oxo-2-phenylethyl)indolin-2-ones as antibacterial and antifungal agents

(2011) B.V. Subba Reddy et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Regioselective Synthesis of 3-Carbo-5-phosphonylpyrazoles through a One-Pot Claisen-Schmidt/1,3-Dipolar Cycloaddition/Oxidation Sequence

(2011) Anthony R. Martin et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Unusual Formal [4 + 2] Cycloaddition of Ethyl Allenoate with Arylidenoxindoles: Synthesis of Dihydropyran-Fused Indoles

(2011) Xiang-Yu Chen et al.   ORGANIC LETTERS

Synthesis of 3-pyrrol-3′-yloxindoles with a carbamate function

(2011) A. V. Velikorodov et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

L-proline-catalyzed 1,3-dipolar cycloaddition of some Schiff bases to methyl 4-[1-oxo-2-(2-oxo-2,3-dihydro-1H-indol-3-ylidene)ethyl]phenylcarbamate

(2011) A. V. Velikorodov et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

Three-component synthesis of spiro compounds with a carbamate functionality

(2011) A. V. Velikorodov et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

Direct construction of novel dispiro heterocycles through 1,3-dipolar cycloaddition of azomethine ylides

(2011) Anshu Dandia et al.   TETRAHEDRON LETTERS

Facile stereoslective synthesis of spiro[indole-oxiranes] by combination of phase transfer catalyst and ultrasound irradiation and their bioassay

(2011) Anshu Dandia et al.   ULTRASONICS SONOCHEMISTRY

Three-Component Reaction Using the Bestmann-Ohira Reagent: A Regioselective Synthesis of Phosphonyl Pyrazole Rings

(2010) Kishor Mohanan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phosphine-catalyzed highly diastereoselective [3+2] cyclization of isatin derived electron-deficient alkenes with α-allenic esters

(2010) Xiu-Chun Zhang et al.   CHEMICAL COMMUNICATIONS

Recent Contributions from the Baylis−Hillman Reaction to Organic Chemistry

(2010) Deevi Basavaiah et al.   CHEMICAL REVIEWS

Synthesis, antibacterial activity evaluation and QSAR studies of novel dispiropyrrolidines

(2010) K. Karthikeyan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Regio- and Stereoselective Synthesis of Novel Dispiropyrrolidine Bisoxindole Derivatives via Multicomponent Reactions

(2010) Hai Liu et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

One-pot approach for the stereoselective synthesis of spirocyclopropyl oxindoles from isatins and arsonium salts

(2010) Haigang Yu et al.   TETRAHEDRON

Chemistry of andrographolide: formation of novel di-spiropyrrolidino and di-spiropyrrolizidino-oxindole adducts via one-pot three-component [3+2] azomethine ylide cycloaddition

(2010) Abhijit Hazra et al.   TETRAHEDRON LETTERS

A facile synthesis and antimycobacterial evaluation of novel spiro-pyrido-pyrrolizines and pyrrolidines

(2009) Raju Ranjith Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and in vivo antidiabetic activity of novel dispiropyrrolidines through [3+2] cycloaddition reactions with thiazolidinedione and rhodanine derivatives

(2009) Ramalingam Murugan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New 14-membered octaazamacrocyclic complexes: Synthesis, spectral, antibacterial and antifungal studies

(2009) D.P. Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Asymmetric Syntheses of Oxindole and Indole Spirocyclic Alkaloid Natural Products

(2009) Barry Trost et al.   SYNTHESIS-STUTTGART

A facile one-pot three-component synthesis of ferrocene-grafted dispiro pyrrolidine/pyrrolizidine scaffolds through intermolecular [3+2] cycloaddition reaction of ferrocenyl Baylis–Hillman adduct

(2009) Subban Kathiravan et al.   TETRAHEDRON LETTERS

InCl3-catalyzed efficient one-pot synthesis of 2-pyrrolo-3′-yloxindoles

(2009) Gnanamani Shanthi et al.   TETRAHEDRON LETTERS

An expedient approach for the synthesis of dispiropyrrolidine bisoxindoles, spiropyrrolidine oxindoles and spiroindane-1,3-diones through 1,3-dipolar cycloaddition reactions

(2009) Neelakandan Vidhya Lakshmi et al.   TETRAHEDRON LETTERS

Synthesis of Maremycins A and D1via Cycloaddition of a Nitrone with (E)-3-Ethylidene-1-methylindolin-2-one

(2008) Tohru Ueda et al.   ORGANIC LETTERS

A facile and efficient synthesis of highly functionalised 3,3′-dispiropyrrolidine- and 3,3′-dispiropyrrolizidine bisoxindoles via [3+2] cycloaddition

(2008) Ponnusamy Shanmugam et al.   TETRAHEDRON LETTERS