Effects of Female Sex Steroids Administration on Pathophysiologic Mechanisms in Traumatic Brain Injury

Does progesterone improve outcome in diffuse axonal injury?

(2016) Zahra Soltani et al.   BRAIN INJURY

The immune system in traumatic brain injury

(2016) Nikolaus Plesnila   CURRENT OPINION IN PHARMACOLOGY

Astrocyte roles in traumatic brain injury

(2016) Joshua E. Burda et al.   EXPERIMENTAL NEUROLOGY

Treatment of traumatic brain injury with anti-inflammatory drugs

(2016) Peter J. Bergold   EXPERIMENTAL NEUROLOGY

What are the progesterone-induced changes of the outcome and the serum markers of injury, oxidant activity and inflammation in diffuse axonal injury patients?

(2016) Behshad Mofid et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Progesterone Exacerbates Short-Term Effects of Traumatic Brain Injury on Supragranular Responses in Sensory Cortex and Over-Excites Infragranular Responses in the Long Term

(2016) Benjamin J. Allitt et al.   JOURNAL OF NEUROTRAUMA

Progesterone Provides the Pleiotropic Neuroprotective Effect on Traumatic Brain Injury Through the Nrf2/ARE Signaling Pathway

(2016) Mei Zhang et al.   Neurocritical Care

Evaluating the neurotherapeutic potential of a water-soluble progesterone analog after traumatic brain injury in rats

(2016) Bushra Wali et al.   NEUROPHARMACOLOGY

Phase III Preclinical Trials in Translational Stroke Research: Community Response on Framework and Guidelines

(2016) Johannes Boltze et al.   Translational Stroke Research

Progesterone and vitamin D combination therapy modulates inflammatory response after traumatic brain injury

(2015) Huiling Tang et al.   BRAIN INJURY

The role of the nitric oxide pathway in brain injury and its treatment — From bench to bedside

(2015) P.S. Garry et al.   EXPERIMENTAL NEUROLOGY

The brain cytokine levels are modulated by estrogen following traumatic brain injury: Which estrogen receptor serves as modulator?

(2015) Mohammad Khaksari et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Progesterone treatment reduces neuroinflammation, oxidative stress and brain damage and improves long-term outcomes in a rat model of repeated mild traumatic brain injury

(2015) Kyria M. Webster et al.   Journal of Neuroinflammation

Effect of estrogen and/or progesterone administration on traumatic brain injury-caused brain edema: the changes of aquaporin-4 and interleukin-6

(2015) Zahra Soltani et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Incidence, Prevalence, Costs, and Impact on Disability of Common Conditions Requiring Rehabilitation in the United States: Stroke, Spinal Cord Injury, Traumatic Brain Injury, Multiple Sclerosis, Osteoarthritis, Rheumatoid Arthritis, Limb Loss, and Back Pain

(2014) Vincent Y. Ma et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Oxidative Stress in Traumatic Brain Injury

(2014) Ana Rodriguez-Rodriguez et al.   CURRENT MEDICINAL CHEMISTRY

Neuroglobin expression and oxidant/antioxidant balance after graded traumatic brain injury in the rat

(2014) Valentina Di Pietro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Traumatic white matter injury and glial activation: From basic science to clinics

(2014) Zhifeng Kou et al.   GLIA

Progesterone protects mitochondrial function in a rat model of pediatric traumatic brain injury

(2014) Courtney L. Robertson et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Activation and Regulation of Cellular Inflammasomes: Gaps in Our Knowledge for Central Nervous System Injury

(2014) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pyroptotic Neuronal Cell Death Mediated by the AIM2 Inflammasome

(2014) Stephanie E Adamczak et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Comparative Analysis of Gonadal Steroid-Mediated Neuroprotection after Transient Focal Ischemia in Rats: Route of Application and Substrate Composition

(2014) Stefanie Hoffmann et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

2-Methoxyestradiol confers neuroprotection and inhibits a maladaptive HIF-1α response after traumatic brain injury in mice

(2014) Eva-Verena Schaible et al.   JOURNAL OF NEUROCHEMISTRY

Extracellular signal–regulated kinase 1/2 is involved in a tamoxifen neuroprotective effect in a lateral fluid percussion injury rat model

(2014) Yin-Tzu Tsai et al.   JOURNAL OF SURGICAL RESEARCH

Brain sex matters: Estrogen in cognition and Alzheimer’s disease

(2014) Rena Li et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Estrogen biology: New insights into GPER function and clinical opportunities

(2014) Eric R. Prossnitz et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Progesterone alters Nogo-A, GFAP and GAP-43 expression in a rat model of traumatic brain injury

(2014) FENG LIU et al.   Molecular Medicine Reports

The neuroprotective actions of oestradiol and oestrogen receptors

(2014) Maria-Angeles Arevalo et al.   NATURE REVIEWS NEUROSCIENCE

Models of Mild Traumatic Brain Injury

(2014) Anthony L. Petraglia et al.   NEUROSURGERY

Very Early Administration of Progesterone for Acute Traumatic Brain Injury

(2014) David W. Wright et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Clinical Trial of Progesterone for Severe Traumatic Brain Injury

(2014) Brett E. Skolnick et al.   NEW ENGLAND JOURNAL OF MEDICINE

Progesterone Treatment Shows Benefit in a Pediatric Model of Moderate to Severe Bilateral Brain Injury

(2014) Rastafa I. Geddes et al.   PLoS One

Progesterone protects blood-brain barrier function and improves neurological outcome following traumatic brain injury in rats

(2014) DAOWEN SI et al.   Experimental and Therapeutic Medicine

Translational Research in Acute Central Nervous System Injury

(2014) David S. Warner et al.   JAMA Neurology

Reactive Oxygen Species in Inflammation and Tissue Injury

(2013) Manish Mittal et al.   ANTIOXIDANTS & REDOX SIGNALING

Traumatic Brain Injury as a Chronic Health Condition

(2013) John D. Corrigan et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

An update on the cognitive impact of clinically-used hormone therapies in the female rat: Models, mazes, and mechanisms

(2013) J.I. Acosta et al.   BRAIN RESEARCH

The effect of female sexual hormones on the intestinal and serum cytokine response after traumatic brain injury: different roles for estrogen receptor subtypes

(2013) Mohammad Khaksari et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Effect of progesterone administration on prognosis of patients with diffuse axonal injury due to severe head trauma

(2013) Moslem Shakeri et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Progesterone and vitamin D: Improvement after traumatic brain injury in middle-aged rats

(2013) Huiling Tang et al.   HORMONES AND BEHAVIOR

Menstrual Phase as Predictor of Outcome After Mild Traumatic Brain Injury in Women

(2013) Kathryn Wunderle et al.   JOURNAL OF HEAD TRAUMA REHABILITATION

Contribution of estrogen receptors alpha and beta in the brain response to traumatic brain injury

(2013) Saleh Zahedi Asl et al.   JOURNAL OF NEUROSURGERY

17β-Estradiol Confers Protection after Traumatic Brain Injury in the Rat and Involves Activation of G Protein-Coupled Estrogen Receptor 1

(2013) Nicole L. Day et al.   JOURNAL OF NEUROTRAUMA

Pharmacotherapy of Traumatic Brain Injury: State of the Science and the Road Forward: Report of the Department of Defense Neurotrauma Pharmacology Workgroup

(2013) Ramon Diaz-Arrastia et al.   JOURNAL OF NEUROTRAUMA

Estrogen receptor beta: Tissue distribution and the still largely enigmatic physiological function

(2013) M. Böttner et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

G protein-coupled estrogen receptor is required for the neuritogenic mechanism of 17β-estradiol in developing hippocampal neurons

(2013) Isabel Ruiz-Palmero et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Chronic neuropathologies of single and repetitive TBI: substrates of dementia?

(2013) Douglas H. Smith et al.   Nature Reviews Neurology

Animal models of traumatic brain injury

(2013) Ye Xiong et al.   NATURE REVIEWS NEUROSCIENCE

Age-related changes in brain support cells: Implications for stroke severity

(2013) Farida Sohrabji et al.   NEUROCHEMISTRY INTERNATIONAL

Progesterone treatment improves cognitive outcome following experimental traumatic brain injury in rats

(2013) Daowen Si et al.   NEUROSCIENCE LETTERS

Long-Term Upregulation of Inflammation and Suppression of Cell Proliferation in the Brain of Adult Rats Exposed to Traumatic Brain Injury Using the Controlled Cortical Impact Model

(2013) Sandra A. Acosta et al.   PLoS One

Neuroinflammation: beneficial and detrimental effects after traumatic brain injury

(2013) J. W. Finnie   INFLAMMOPHARMACOLOGY

Differences in brain edema and intracranial pressure following traumatic brain injury across the estrous cycle: Involvement of female sex steroid hormones

(2012) Fatemeh Maghool et al.   BRAIN RESEARCH

Serum levels of protein S100B predict intracranial lesions in mild head injury

(2012) Gianfranco Cervellin et al.   CLINICAL BIOCHEMISTRY

Minireview: Effects of Different HT Formulations on Cognition

(2012) Pauline M. Maki   ENDOCRINOLOGY

Excitotoxicity: Bridge to various triggers in neurodegenerative disorders

(2012) Ankita Mehta et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Progesterone and low-dose vitamin D hormone treatment enhances sparing of memory following traumatic brain injury

(2012) Fang Hua et al.   HORMONES AND BEHAVIOR

The effect of admission spontaneous hypothermia on patients with severe traumatic brain injury

(2012) Andrés M. Rubiano et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

A Comparison of the Effects of Nicotinamide and Progesterone on Functional Recovery of Cognitive Behavior following Cortical Contusion Injury in the Rat

(2012) Todd C. Peterson et al.   JOURNAL OF NEUROTRAUMA

Estrone Is Neuroprotective in Rats after Traumatic Brain Injury

(2012) Joshua W. Gatson et al.   JOURNAL OF NEUROTRAUMA

Therapy Development for Diffuse Axonal Injury

(2012) Douglas H. Smith et al.   JOURNAL OF NEUROTRAUMA

Distribution of membrane progesterone receptor alpha in the male mouse and rat brain and its regulation after traumatic brain injury

(2012) D. Meffre et al.   NEUROSCIENCE

The cytokine temporal profile in rat cortex after controlled cortical impact

(2012) Clifton L. Dalgard et al.   Frontiers in Molecular Neuroscience

Endocrine substrates of cognitive and affective changes during pregnancy and postpartum.

(2011) Joanna L. Workman et al.   BEHAVIORAL NEUROSCIENCE

Antioxidant therapies in traumatic brain and spinal cord injury

(2011) Mona Bains et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Estradiol Promotes Purkinje Dendritic Growth, Spinogenesis, and Synaptogenesis During Neonatal Life by Inducing the Expression of BDNF

(2011) Shogo Haraguchi et al.   CEREBELLUM

Progesterone treatment normalizes the levels of cell proliferation and cell death in the dentate gyrus of the hippocampus after traumatic brain injury

(2011) Cindy K. Barha et al.   EXPERIMENTAL NEUROLOGY

Role of estrogen receptor alpha and beta expression and signaling on cognitive function during aging

(2011) Thomas C. Foster   HIPPOCAMPUS

Effect of estrogens on blood glutamate levels in relation to neurological outcome after TBI in male rats

(2011) Alexander Zlotnik et al.   INTENSIVE CARE MEDICINE

Effects of Chronic and Acute Oestrogen Replacement Therapy in Aged Animals after Experimental Stroke

(2011) F. Liu et al.   JOURNAL OF NEUROENDOCRINOLOGY

Modulation of traumatic brain injury using progesterone and the role of glial cells on its neuroprotective actions

(2011) V. Ramana Feeser et al.   JOURNAL OF NEUROIMMUNOLOGY

The Effect of Progesterone Dose on Gene Expression after Traumatic Brain Injury

(2011) Gail D. Anderson et al.   JOURNAL OF NEUROTRAUMA

Progesterone Increases Circulating Endothelial Progenitor Cells and Induces Neural Regeneration after Traumatic Brain Injury in Aged Rats

(2011) Zhanying Li et al.   JOURNAL OF NEUROTRAUMA

Time- and Dose-Dependent Neuroprotective Effects of Sex Steroid Hormones on Inflammatory Cytokines after a Traumatic Brain Injury

(2011) Ali Reza Sarkaki et al.   JOURNAL OF NEUROTRAUMA

Progesterone inhibition of neuronal calcium signaling underlies aspects of progesterone-mediated neuroprotection

(2011) Jessie I. Luoma et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Mechanisms of cerebrovascular protection: oestrogen, inflammation and mitochondria

(2010) S. P. Duckles et al.   Acta Physiologica

Estrogen attenuates vascular remodeling in Lp(a) transgenic mice

(2010) Futoshi Nakagami et al.   ATHEROSCLEROSIS

Proteolysis of Submembrane Cytoskeletal Proteins Ankyrin-G and αII-Spectrin Following Diffuse Brain Injury: A Role in White Matter Vulnerability at Nodes of Ranvier

(2010) Thomas M. Reeves et al.   BRAIN PATHOLOGY

Estrogen and aging affect the synaptic distribution of estrogen receptor beta-immunoreactivity in the CA1 region of female rat hippocampus

(2010) Elizabeth M. Waters et al.   BRAIN RESEARCH

Effect of sex steroid hormones on brain edema, intracranial pressure, and neurologic outcomes after traumatic brain injury

(2010) Nader Shahrokhi et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

The role of estrogen and progesterone, administered alone and in combination, in modulating cytokine concentration following traumatic brain injury

(2010) Mohammad Khaksari et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Estrogen Therapy and Cognition: A Review of the Cholinergic Hypothesis

(2010) Robert B. Gibbs   ENDOCRINE REVIEWS

Production of Proinflammatory Cytokines and Chemokines During Neuroinflammation: Novel Roles for Estrogen Receptors α and β

(2010) Candice M. Brown et al.   ENDOCRINOLOGY

Progesterone in the clinical treatment of acute traumatic brain injury

(2010) Donald G Stein et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Estrogen receptor agonists and estrogen attenuate TNF- -induced apoptosis in VSC4.1 motoneurons

(2010) A. Das et al.   JOURNAL OF ENDOCRINOLOGY

Calpain as a therapeutic target in traumatic brain injury

(2010) Kathryn E. Saatman et al.   Neurotherapeutics

Role of Inflammation and Oxidative Stress Mediators in Gliomas

(2010) Alfredo Conti et al.   Cancers

Estrogen attenuates glutamate-induced cell death by inhibiting Ca2+ influx through L-type voltage-gated Ca2+ channels

(2009) Eric A. Sribnick et al.   BRAIN RESEARCH

Premarin stimulates estrogen receptor-α to protect against traumatic brain injury in male rats*

(2009) Sheng-Hsien Chen et al.   CRITICAL CARE MEDICINE

Progesterone neuroprotection in traumatic CNS injury and motoneuron degeneration

(2009) Alejandro F. De Nicola et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Neurosteroid biosynthesis: Enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides

(2009) Jean Luc Do Rego et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Sex Differences in Outcome after Mild Traumatic Brain Injury

(2009) Jeffrey J. Bazarian et al.   JOURNAL OF NEUROTRAUMA

Neurobehavioral sequelae of traumatic brain injury

(2009) Silvana Riggio et al.   MOUNT SINAI JOURNAL OF MEDICINE

Pathophysiology of traumatic brain injury

(2009) Mark W. Greve et al.   MOUNT SINAI JOURNAL OF MEDICINE

Vitamin D deficiency reduces the benefits of progesterone treatment after brain injury in aged rats

(2009) Milos Cekic et al.   NEUROBIOLOGY OF AGING

Plasma membrane estrogen receptors

(2009) Ellis R. Levin   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Traumatic brain injury: Can the consequences be stopped?

(2008) E. Park et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Systemic inflammation exacerbates behavioral and histopathological consequences of isolated traumatic brain injury in rats

(2008) Akira Utagawa et al.   EXPERIMENTAL NEUROLOGY

Estrogen anti-inflammatory activity in brain: A therapeutic opportunity for menopause and neurodegenerative diseases

(2008) Elisabetta Vegeto et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Estrogen is a modulator of vascular inflammation

(2008) Subhadeep Chakrabarti et al.   IUBMB LIFE

Progesterone and its Metabolite Allopregnanolone Differentially Regulate Hemostatic Proteins after Traumatic Brain Injury

(2008) Jacob W VanLandingham et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Different Forms of Oestrogen Rapidly Upregulate Cell Proliferation in the Dentate Gyrus of Adult Female Rats

(2008) C. K. Barha et al.   JOURNAL OF NEUROENDOCRINOLOGY

Trauma-Induced Cell Swelling in Cultured Astrocytes

(2008) Arumugam R. Jayakumar et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Distinct Cellular Patterns of Upregulated Chemokine Expression Supporting a Prominent Inflammatory Role in Traumatic Brain Injury

(2008) Charlotte Israelsson et al.   JOURNAL OF NEUROTRAUMA

Efficacy of Progesterone following a Moderate Unilateral Cortical Contusion Injury

(2008) Lesley K. Gilmer et al.   JOURNAL OF NEUROTRAUMA

Classification of Traumatic Brain Injury for Targeted Therapies

(2008) Kathryn E. Saatman et al.   JOURNAL OF NEUROTRAUMA

Impact of Gender on Outcomes after Blunt Injury: A Definitive Analysis of More Than 36,000 Trauma Patients

(2008) Louis J. Magnotti et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Moderate and severe traumatic brain injury in adults

(2008) Andrew IR Maas et al.   LANCET NEUROLOGY

Regulation of Estrogen Rapid Signaling through Arginine Methylation by PRMT1

(2008) Muriel Le Romancer et al.   MOLECULAR CELL

Higher levels of estradiol replacement correlate with better spatial memory in surgically menopausal young and middle-aged rats

(2008) Joshua S. Talboom et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Posttraumatic Epilepsy: Hemorrhage, Free Radicals and the Molecular Regulation of Glutamate

(2008) L. J. Willmore et al.   NEUROCHEMICAL RESEARCH

Capturing the Spectrum: Suggested Standards for Conducting Population-Based Traumatic Brain Injury Incidence Studies

(2008) Suzanne L. Barker-Collo et al.   NEUROEPIDEMIOLOGY

The healthy cell bias of estrogen action: mitochondrial bioenergetics and neurological implications

(2008) Roberta Diaz Brinton   TRENDS IN NEUROSCIENCES

Does Progesterone Have Neuroprotective Properties?

(2007) Donald G. Stein et al.   ANNALS OF EMERGENCY MEDICINE

The membrane-associated progesterone-binding protein 25-Dx: Expression, cellular localization and up-regulation after brain and spinal cord injuries

(2007) R. Guennoun et al.   BRAIN RESEARCH REVIEWS

Brain aging modulates the neuroprotective effects of estrogen on selective aspects of cognition in women: A critical review

(2007) Barbara B. Sherwin et al.   FRONTIERS IN NEUROENDOCRINOLOGY