Therapy Development for Diffuse Axonal Injury

Serum levels of ubiquitin C-terminal hydrolase distinguish mild traumatic brain injury from trauma controls and are elevated in mild and moderate traumatic brain injury patients with intracranial lesions and neurosurgical intervention

(2015) Linda Papa et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Neuropathology of mild traumatic brain injury: relationship to neuroimaging findings

(2012) Erin D. Bigler et al.   Brain Imaging and Behavior

Effect of PACAP in Central and Peripheral Nerve Injuries

(2012) Andrea Tamas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Unmyelinated Axons Show Selective Rostrocaudal Pathology in the Corpus Callosum After Traumatic Brain Injury

(2012) Thomas M. Reeves et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Electrophysiological Abnormalities in Both Axotomized and Nonaxotomized Pyramidal Neurons following Mild Traumatic Brain Injury

(2012) J. E. Greer et al.   JOURNAL OF NEUROSCIENCE

Early induction of hypothermia for evacuated intracranial hematomas: a post hoc analysis of two clinical trials

(2012) Guy L. Clifton et al.   JOURNAL OF NEUROSURGERY

Effects of Hypothermia on Cerebral Autoregulatory Vascular Responses in Two Rodent Models of Traumatic Brain Injury

(2012) Motoki Fujita et al.   JOURNAL OF NEUROTRAUMA

Calpastatin Overexpression Protects Axonal Transport in an In Vivo Model of Traumatic Axonal Injury

(2012) Marek Ma et al.   JOURNAL OF NEUROTRAUMA

Brain Injury Biomarkers May Improve the Predictive Power of the IMPACT Outcome Calculator

(2012) Endre Czeiter et al.   JOURNAL OF NEUROTRAUMA

Therapeutic Hypothermia for Severe Traumatic Brain Injury

(2012) Christopher Kramer et al.   NEUROLOGIST

Traumatic brain injury alters the functional brain network mediating working memory

(2011) Maki Kasahara et al.   BRAIN INJURY

Widespread Tau and Amyloid-Beta Pathology Many Years After a Single Traumatic Brain Injury in Humans

(2011) Victoria E. Johnson et al.   BRAIN PATHOLOGY

Partial interruption of axonal transport due to microtubule breakage accounts for the formation of periodic varicosities after traumatic axonal injury

(2011) Min D. Tang-Schomer et al.   EXPERIMENTAL NEUROLOGY

Kollidon VA64, a Membrane-Resealing Agent, Reduces Histopathology and Improves Functional Outcome after Controlled Cortical Impact in Mice

(2011) Lamin H Mbye et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pharmacological inhibition of lipid peroxidation attenuates calpain-mediated cytoskeletal degradation after traumatic brain injury

(2011) Ayman G. Mustafa et al.   JOURNAL OF NEUROCHEMISTRY

Diffuse Traumatic Axonal Injury in the Mouse Induces Atrophy, c-Jun Activation, and Axonal Outgrowth in the Axotomized Neuronal Population

(2011) J. E. Greer et al.   JOURNAL OF NEUROSCIENCE

Traumatic Axonal Injury in the Optic Nerve: Evidence for Axonal Swelling, Disconnection, Dieback, and Reorganization

(2011) Jiaqiong Wang et al.   JOURNAL OF NEUROTRAUMA

The Combination of Either Tempol or FK506 with Delayed Hypothermia: Implications for Traumatically Induced Microvascular and Axonal Protection

(2011) Motoki Fujita et al.   JOURNAL OF NEUROTRAUMA

Mild Traumatic Brain Injury and Diffuse Axonal Injury in Swine

(2011) Kevin D. Browne et al.   JOURNAL OF NEUROTRAUMA

Biokinetic Analysis of Ubiquitin C-Terminal Hydrolase-L1 (UCH-L1) in Severe Traumatic Brain Injury Patient Biofluids

(2011) Gretchen M. Brophy et al.   JOURNAL OF NEUROTRAUMA

Selective Vulnerability of Non-Myelinated Axons to Stretch Injury in an In Vitro Co-Culture System

(2011) Jerome A. Staal et al.   JOURNAL OF NEUROTRAUMA

Engineering a High Throughput Axon Injury System

(2011) George C. Magou et al.   JOURNAL OF NEUROTRAUMA

Common Data Elements for Pediatric Traumatic Brain Injury: Recommendations from the Biospecimens and Biomarkers Workgroup

(2011) Rachel P. Berger et al.   JOURNAL OF NEUROTRAUMA

Short-Duration Treatment with the Calpain Inhibitor MDL-28170 Does Not Protect Axonal Transport in an in Vivo Model of Traumatic Axonal Injury

(2011) Marek Ma et al.   JOURNAL OF NEUROTRAUMA

Glial Neuronal Ratio: A Novel Index for Differentiating Injury Type in Patients with Severe Traumatic Brain Injury

(2011) Stefania Mondello et al.   JOURNAL OF NEUROTRAUMA

Serum Concentrations of Ubiquitin C-Terminal Hydrolase-L1 and αII-Spectrin Breakdown Product 145 kDa Correlate with Outcome after Pediatric TBI

(2011) Rachel P. Berger et al.   JOURNAL OF NEUROTRAUMA

Recommendations for the Use of Common Outcome Measures in Pediatric Traumatic Brain Injury Research

(2011) Stephen R. McCauley et al.   JOURNAL OF NEUROTRAUMA

Thalamic and Subthalamic Deep Brain Stimulation for Essential Tremor

(2011) Ulrika Sandvik et al.   NEUROSURGERY

Detection of Blast-Related Traumatic Brain Injury in U.S. Military Personnel

(2011) Christine L. Mac Donald et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evidence that a Panel of Neurodegeneration Biomarkers Predicts Vasospasm, Infarction, and Outcome in Aneurysmal Subarachnoid Hemorrhage

(2011) Robert Siman et al.   PLoS One

Common Data Elements in Radiologic Imaging of Traumatic Brain Injury

(2010) Ann-Christine Duhaime et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Recommendations for the Use of Common Outcome Measures in Traumatic Brain Injury Research

(2010) Elisabeth A. Wilde et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Advancing Integrated Research in Psychological Health and Traumatic Brain Injury: Common Data Elements

(2010) Veronica A. Thurmond et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Proteolysis of Submembrane Cytoskeletal Proteins Ankyrin-G and αII-Spectrin Following Diffuse Brain Injury: A Role in White Matter Vulnerability at Nodes of Ranvier

(2010) Thomas M. Reeves et al.   BRAIN PATHOLOGY

Ubiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and traumatic brain injury in rats

(2010) Ming C. Liu et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The effects of cyclosporin-A on axonal conduction deficits following traumatic brain injury in adult rats

(2010) Beverly S. Colley et al.   EXPERIMENTAL NEUROLOGY

Combinational Therapy Using Hypothermia and the Immunophilin Ligand FK506 to Target Altered Pial Arteriolar Reactivity, Axonal Damage, and Blood–Brain Barrier Dysfunction after Traumatic Brain Injury in Rat

(2010) Yasutaka Oda et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Common data elements in radiologic imaging of traumatic brain injury

(2010) E. Mark Haacke et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Omega-3 fatty acid supplementation and reduction of traumatic axonal injury in a rodent head injury model

(2010) James D. Mills et al.   JOURNAL OF NEUROSURGERY

αII-Spectrin Breakdown Products (SBDPs): Diagnosis and Outcome in Severe Traumatic Brain Injury Patients

(2010) Stefania Mondello et al.   JOURNAL OF NEUROTRAUMA

Stereology and Ultrastructure of Chronic Phase Axonal and Cell Soma Pathology in Stretch-Injured Central Nerve Fibers

(2010) Ahmed Mohammed Sulaiman et al.   JOURNAL OF NEUROTRAUMA

Very early hypothermia induction in patients with severe brain injury (the National Acute Brain Injury Study: Hypothermia II): a randomised trial

(2010) Guy L Clifton et al.   LANCET NEUROLOGY

Altered functional connectivity in the motor network after traumatic brain injury

(2010) M. Kasahara et al.   NEUROLOGY

Multiple alphaII-spectrin breakdown products distinguish calpain and caspase dominated necrotic and apoptotic cell death pathways

(2009) Zhiqun Zhang et al.   APOPTOSIS

Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury*

(2009) Linda Papa et al.   CRITICAL CARE MEDICINE

Mechanical membrane injury induces axonal beading through localized activation of calpain

(2009) Devrim Kilinc et al.   EXPERIMENTAL NEUROLOGY

Mechanical breaking of microtubules in axons during dynamic stretch injury underlies delayed elasticity, microtubule disassembly, and axon degeneration

(2009) Min D. Tang-Schomer et al.   FASEB JOURNAL

Initial calcium release from intracellular stores followed by calcium dysregulation is linked to secondary axotomy following transient axonal stretch injury

(2009) Jerome A. Staal et al.   JOURNAL OF NEUROCHEMISTRY

Biochemical, Structural, and Biomarker Evidence for Calpain-Mediated Cytoskeletal Change After Diffuse Brain Injury Uncomplicated by Contusion

(2009) Melissa J. McGinn et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Calpain Mediates Proteolysis of the Voltage-Gated Sodium Channel  -Subunit

(2009) C. R. von Reyn et al.   JOURNAL OF NEUROSCIENCE

Sodium channelopathy induced by mild axonal trauma worsens outcome after a repeat injury

(2009) Tracy J. Yuen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

αII-Spectrin Breakdown Product Cerebrospinal Fluid Exposure Metrics Suggest Differences in Cellular Injury Mechanisms after Severe Traumatic Brain Injury

(2009) Gretchen M. Brophy et al.   JOURNAL OF NEUROTRAUMA

Combination Therapies for Traumatic Brain Injury: Prospective Considerations

(2009) Susan Margulies et al.   JOURNAL OF NEUROTRAUMA

A Panel of Neuron-Enriched Proteins as Markers for Traumatic Brain Injury in Humans

(2009) Robert Siman et al.   JOURNAL OF NEUROTRAUMA

A Lack of Amyloid β Plaques Despite Persistent Accumulation of Amyloid β in Axons of Long-Term Survivors of Traumatic Brain Injury

(2008) Xiao-Han Chen et al.   BRAIN PATHOLOGY

Biomarker evidence for mild central nervous system injury after surgically-induced circulation arrest

(2008) Robert Siman et al.   BRAIN RESEARCH

Hemostatic and neuroprotective effects of human recombinant activated factor VII therapy after traumatic brain injury in pigs

(2008) Jun Zhang et al.   EXPERIMENTAL NEUROLOGY

Mechanically-induced membrane poration causes axonal beading and localized cytoskeletal damage

(2008) Devrim Kilinc et al.   EXPERIMENTAL NEUROLOGY

Immediate short-duration hypothermia provides long-term protection in an in vivo model of traumatic axonal injury

(2008) Marek Ma et al.   EXPERIMENTAL NEUROLOGY

Neuroprotective Effects of Tempol, a Catalytic Scavenger of Peroxynitrite-Derived Free Radicals, in a Mouse Traumatic Brain Injury Model

(2008) Ying Deng-Bryant et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Diffusion tensor imaging of acute mild traumatic brain injury in adolescents

(2008) E. A. Wilde et al.   NEUROLOGY

Proteolysis of multiple myelin basic protein isoforms after neurotrauma: characterization by mass spectrometry

(2007) Andrew K. Ottens et al.   JOURNAL OF NEUROCHEMISTRY