Shiga Toxin Glycosphingolipid Receptors in Human Caco-2 and HCT-8 Colon Epithelial Cell Lines

Colocalization of receptors for Shiga toxins with lipid rafts in primary human renal glomerular endothelial cells and influence of D-PDMP on synthesis and distribution of glycosphingolipid receptors

(2017) Nadine Legros et al.   GLYCOBIOLOGY

Infrared MALDI mass spectrometry imaging of TLC-separated glycosphingolipids with emphasis on Shiga toxin receptors isolated from human colon epithelial cells

(2017) Ivan U. Kouzel et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Extracellular vesicles in renal disease

(2017) Diana Karpman et al.   Nature Reviews Nephrology

Protection against Shiga Toxins

(2017) Simona Kavaliauskiene et al.   Toxins

Protection of Human Colon Cells from Shiga Toxin by Plant-based Recombinant Secretory IgA

(2017) Katsuhiro Nakanishi et al.   Scientific Reports

Shiga toxin of enterohaemorrhagicEscherichia colidirectly injures developing human erythrocytes

(2016) Josefine Betz et al.   CELLULAR MICROBIOLOGY

Shiga toxin glycosphingolipid receptors and their lipid membrane ensemble in primary human blood–brain barrier endothelial cells

(2016) Nadine Legros et al.   GLYCOBIOLOGY

Haemolytic uraemic syndrome

(2016) Diana Karpman et al.   JOURNAL OF INTERNAL MEDICINE

Gastric Adenocarcinomas Express the Glycosphingolipid Gb3/CD77: Targeting of Gastric Cancer Cells with Shiga Toxin B-Subunit

(2016) P. E. Geyer et al.   MOLECULAR CANCER THERAPEUTICS

Shiga Toxins as Multi-Functional Proteins: Induction of Host Cellular Stress Responses, Role in Pathogenesis and Therapeutic Applications

(2016) Moo-Seung Lee et al.   Toxins

Whole Genome Sequencing for Genomics-Guided Investigations of Escherichia coli O157:H7 Outbreaks

(2016) Brigida Rusconi et al.   Frontiers in Microbiology

Shiga toxins: from structure and mechanism to applications

(2015) Yau Sang Chan et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

2-Hydroxy Fatty Acid Enantiomers of Gb 3 Impact Shiga Toxin Binding and Membrane Organization

(2015) Ole M. Schütte et al.   BIOPHYSICAL JOURNAL

Shiga Toxin Producing Escherichia coli

(2015) Allen Bryan et al.   CLINICS IN LABORATORY MEDICINE

Shiga toxin glycosphingolipid receptors of Vero-B4 kidney epithelial cells and their membrane microdomain lipid environment

(2015) Daniel Steil et al.   JOURNAL OF LIPID RESEARCH

Shiga toxin induces membrane reorganization and formation of long range lipid order

(2015) Vita Solovyeva et al.   Soft Matter

The effects of globotriaosylceramide tail saturation level on bilayer phases

(2015) Weria Pezeshkian et al.   Soft Matter

A Novel Mechanism of Bacterial Toxin Transfer within Host Blood Cell-Derived Microvesicles

(2015) Anne-lie Ståhl et al.   PLoS Pathogens

A Rapid and Sensitive Method to Measure the Functional Activity of Shiga Toxins in Human Serum

(2015) Valentina Arfilli et al.   Toxins

Carbohydrate Conformation and Lipid Condensation in Monolayers Containing Glycosphingolipid Gb3: Influence of Acyl Chain Structure

(2014) Erik B. Watkins et al.   BIOPHYSICAL JOURNAL

Human breast cancer and lymph node metastases express Gb3 and can be targeted by STxB-vectorized chemotherapeutic compounds

(2014) Lev Stimmer et al.   BMC CANCER

Glycolipid Binding Preferences of Shiga Toxin Variants

(2014) Sayali S. Karve et al.   PLoS One

Progress in Detection and Structural Characterization of Glycosphingolipids in Crude Lipid Extracts by Enzymatic Phospholipid Disintegration Combined with Thin-Layer Chromatography Immunodetection and IR-MALDI Mass Spectrometry

(2013) Ivan U. Kouzel et al.   ANALYTICAL CHEMISTRY

The Trojan Horse of the microbiological arms race: phage-encoded toxins as a defence against eukaryotic predators

(2013) Jason W. Arnold et al.   ENVIRONMENTAL MICROBIOLOGY

Glycosphingolipids: synthesis and functions

(2013) Giovanni D'Angelo et al.   FEBS Journal

Expression of Shiga toxin 2e glycosphingolipid receptors of primary porcine brain endothelial cells and toxin-mediated breakdown of the blood–brain barrier

(2013) Iris Meisen et al.   GLYCOBIOLOGY

Individual profiles of free ceramide species and the constituent ceramide species of sphingomyelin and neutral glycosphingolipid and their alteration according to the sequential changes of environmental oxygen content in human colorectal cancer Caco-2 cells

(2013) Kouji Tanaka et al.   GLYCOCONJUGATE JOURNAL

Identification of TLR4 as the Receptor That Recognizes Shiga Toxins in Human Neutrophils

(2013) M. Brigotti et al.   JOURNAL OF IMMUNOLOGY

Dietary choice affects Shiga toxin-producingEscherichia coli(STEC) O157:H7 colonization and disease

(2013) Steven D. Zumbrun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shiga Toxin 1, as DNA Repair Inhibitor, Synergistically Potentiates the Activity of the Anticancer Drug, Mafosfamide, on Raji Cells

(2013) Maurizio Brigotti et al.   Toxins

Shiga toxin glycosphingolipid receptor expression and toxin susceptibility of human pancreatic ductal adenocarcinomas of differing origin and differentiation

(2012) Wiebke Storck et al.   BIOLOGICAL CHEMISTRY

Uncommon membrane distribution of Shiga toxin glycosphingolipid receptors in toxin-sensitive human glomerular microvascular endothelial cells

(2012) Josefine Betz et al.   BIOLOGICAL CHEMISTRY

Facing glycosphingolipid–Shiga toxin interaction: dire straits for endothelial cells of the human vasculature

(2012) Andreas Bauwens et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Lipid Sorting by Ceramide Structure from Plasma Membrane to ER for the Cholera Toxin Receptor Ganglioside GM1

(2012) Daniel J.-F. Chinnapen et al.   DEVELOPMENTAL CELL

The enemy within us: lessons from the 2011 EuropeanEscherichia coliO104:H4 outbreak

(2012) Helge Karch et al.   EMBO Molecular Medicine

Promiscuous Shiga toxin 2e and its intimate relationship to Forssman

(2012) Johannes Müthing et al.   GLYCOBIOLOGY

Role of Lipid Rafts and Flagellin in Invasion of Colonic Epithelial Cells by Shiga-Toxigenic Escherichia coli O113:H21

(2012) Trisha J. Rogers et al.   INFECTION AND IMMUNITY

Multicenter Evaluation of a Sequence-Based Protocol for Subtyping Shiga Toxins and Standardizing Stx Nomenclature

(2012) F. Scheutz et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Association of Shiga toxin glycosphingolipid receptors with membrane microdomains of toxin-sensitive lymphoid and myeloid cells

(2012) Ivan U. Kouzel et al.   JOURNAL OF LIPID RESEARCH

Shiga toxins

(2012) Jonas Bergan et al.   TOXICON

Insights on the trafficking and retro-translocation of glycosphingolipid-binding bacterial toxins

(2012) Jin A. Cho et al.   Frontiers in Cellular and Infection Microbiology

Activation of cell stress response pathways by Shiga toxins

(2011) Vernon L. Tesh   CELLULAR MICROBIOLOGY

Shiga toxin glycosphingolipid receptors in microvascular and macrovascular endothelial cells: differential association with membrane lipid raft microdomains

(2011) Josefine Betz et al.   JOURNAL OF LIPID RESEARCH

Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study

(2011) Martina Bielaszewska et al.   LANCET INFECTIOUS DISEASES

Tumor-Specific Targeting of Pancreatic Cancer with Shiga Toxin B-Subunit

(2011) M. Maak et al.   MOLECULAR CANCER THERAPEUTICS

Lipid-Mediated Endocytosis

(2011) H. Ewers et al.   Cold Spring Harbor Perspectives in Biology

Shiga Toxin Interaction with Human Intestinal Epithelium

(2011) Stephanie Schüller   Toxins

Shiga Toxin: Expression, Distribution, and Its Role in the Environment

(2011) Steven A. Mauro et al.   Toxins

Shiga toxin 1 and ricin A chain bind to human polymorphonuclear leucocytes through a common receptor

(2010) Valentina Arfilli et al.   BIOCHEMICAL JOURNAL

Actin Dynamics Drive Membrane Reorganization and Scission in Clathrin-Independent Endocytosis

(2010) Winfried Römer et al.   CELL

Structural characterization and dynamics of globotetraosylceramide in vascular endothelial cells under TNF-α stimulation

(2010) Tetsuya Okuda et al.   GLYCOCONJUGATE JOURNAL

Human Intestinal Tissue and Cultured Colonic Cells Contain Globotriaosylceramide Synthase mRNA and the Alternate Shiga Toxin Receptor Globotetraosylceramide

(2010) S. D. Zumbrun et al.   INFECTION AND IMMUNITY

Endothelial damage induced by Shiga toxins delivered by neutrophils during transmigration

(2010) Maurizio Brigotti et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutral glycosphingolipids in human blood: a precise mass spectrometry analysis with special reference to lipoprotein-associated Shiga toxin receptors

(2010) Christian H. Schweppe et al.   JOURNAL OF LIPID RESEARCH

Shiga toxin-associated hemolytic uremic syndrome: pathophysiology of endothelial dysfunction

(2010) Carla Zoja et al.   PEDIATRIC NEPHROLOGY

On the structural diversity of Shiga toxin glycosphingolipid receptors in lymphoid and myeloid cells determined by nanoelectrospray ionization tandem mass spectrometry

(2010) Petra Hoffmann et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Differential cytotoxic actions of Shiga toxin 1 and Shiga toxin 2 on microvascular and macrovascular endothelial cells

(2010) Andreas Bauwens et al.   THROMBOSIS AND HAEMOSTASIS

Verotoxin-1 Treatment or Manipulation of its Receptor Globotriaosylceramide (Gb3) for Reversal of Multidrug Resistance to Cancer Chemotherapy

(2010) Parviz Behnam-Motlagh et al.   Toxins

Escherichia coli Shiga Toxin Mechanisms of Action in Renal Disease

(2010) Tom G. Obrig   Toxins

Cholera Toxin: An Intracellular Journey into the Cytosol by Way of the Endoplasmic Reticulum

(2010) Naomi L. B. Wernick et al.   Toxins

Shiga toxin and its use in targeted cancer therapy and imaging

(2010) Nikolai Engedal et al.   Microbial Biotechnology

Structural Profiling of Individual Glycosphingolipids in a Single Thin-Layer Chromatogram by Multiple Sequential Immunodetection Matched with Direct IR-MALDI-o-TOF Mass Spectrometry

(2009) Jamal Souady et al.   ANALYTICAL CHEMISTRY

Globotriaosyl ceramide receptor function - Where membrane structure and pathology intersect

(2009) C.A. Lingwood et al.   FEBS LETTERS

Shiga Toxin as a Bacterial Defense against a Eukaryotic Predator, Tetrahymena thermophila

(2009) W. Lainhart et al.   JOURNAL OF BACTERIOLOGY

Advances on the compositional analysis of glycosphingolipids combining thin-layer chromatography with mass spectrometry

(2009) Johannes Müthing et al.   MASS SPECTROMETRY REVIEWS

Shiga toxins — from cell biology to biomedical applications

(2009) Ludger Johannes et al.   NATURE REVIEWS MICROBIOLOGY

Lipid Reorganization Induced by Shiga Toxin Clustering on Planar Membranes

(2009) Barbara Windschiegl et al.   PLoS One

Shiga Toxin Receptor Gb3Cer/CD77: Tumor-Association and Promising Therapeutic Target in Pancreas and Colon Cancer

(2009) Ute Distler et al.   PLoS One

A precise reconstruction of the emergence and constrained radiations of Escherichia coli O157 portrayed by backbone concatenomic analysis

(2009) S. R. Leopold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shiga toxins, glycosphingolipid diversity, and endothelial cell injury

(2009) Johannes Müthing et al.   THROMBOSIS AND HAEMOSTASIS

Endocytosis and retrograde transport of Shiga toxin

(2009) Kirsten Sandvig et al.   TOXICON

Matching IR-MALDI-o-TOF Mass Spectrometry with the TLC Overlay Binding Assay and Its Clinical Application for Tracing Tumor-Associated Glycosphingolipids in Hepatocellular and Pancreatic Cancer

(2008) Ute Distler et al.   ANALYTICAL CHEMISTRY

Shiga toxin 1 induces apoptosis through the endoplasmic reticulum stress response in human monocytic cells

(2008) Sang-Yun Lee et al.   CELLULAR MICROBIOLOGY

Helicobacter pylori binding to new glycans based on N-acetyllactosamine

(2008) H. Miller-Podraza et al.   GLYCOBIOLOGY

Glycosphingolipids in vascular endothelial cells: relationship of heterogeneity in Gb3Cer/CD77 receptor expression with differential Shiga toxin 1 cytotoxicity

(2008) Christian H. Schweppe et al.   GLYCOCONJUGATE JOURNAL

Interactions between Shiga toxins and human polymorphonuclear leukocytes

(2008) Maurizio Brigotti et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Fatty acid-dependent globotriaosyl ceramide receptor function in detergent resistant model membranes

(2008) Radhia Mahfoud et al.   JOURNAL OF LIPID RESEARCH

Human colorectal tumors and metastases express Gb3 and can be targeted by an intestinal pathogen-based delivery tool

(2008) T. Falguieres et al.   MOLECULAR CANCER THERAPEUTICS