Shiga Toxins as Multi-Functional Proteins: Induction of Host Cellular Stress Responses, Role in Pathogenesis and Therapeutic Applications

In Vivo Tumor Targeting by the B-Subunit of Shiga Toxin

(2018) Thomas Viel et al.   Molecular Imaging

Tumor Delivery of Ultrasound Contrast Agents Using Shiga Toxin B Subunit

(2018) Olivier Couture et al.   Molecular Imaging

Shiga toxins induce autophagic cell death in intestinal epithelial cells via the endoplasmic reticulum stress pathway

(2015) Bin Tang et al.   Autophagy

A new delivery system for auristatin in STxB-drug conjugate therapy

(2015) Cornélie Batisse et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Shiga Toxins Activate the NLRP3 Inflammasome Pathway To Promote Both Production of the Proinflammatory Cytokine Interleukin-1β and Apoptotic Cell Death

(2015) Moo-Seung Lee et al.   INFECTION AND IMMUNITY

Microbe- and danger-induced inflammation

(2015) Achille Broggi et al.   MOLECULAR IMMUNOLOGY

A Novel Mechanism of Bacterial Toxin Transfer within Host Blood Cell-Derived Microvesicles

(2015) Anne-lie Ståhl et al.   PLoS Pathogens

Shiga Toxin 2-Induced Endoplasmic Reticulum Stress Is Minimized by Activated Protein C but Does Not Correlate with Lethal Kidney Injury

(2015) Caitlin Parello et al.   Toxins

Human breast cancer and lymph node metastases express Gb3 and can be targeted by STxB-vectorized chemotherapeutic compounds

(2014) Lev Stimmer et al.   BMC CANCER

Upregulation of Shiga Toxin Receptor CD77/Gb3 and Interleukin-1β Expression in the Brain of EHEC Patients with Hemolytic Uremic Syndrome and Neurologic Symptoms

(2014) Christian Hagel et al.   BRAIN PATHOLOGY

Effects of Shiga Toxin Type 2 on a Bioengineered Three-Dimensional Model of Human Renal Tissue

(2014) Teresa M. DesRochers et al.   INFECTION AND IMMUNITY

Caspases: A Molecular Switch Node in the Crosstalk between Autophagy and Apoptosis

(2014) Haijian Wu et al.   International Journal of Biological Sciences

Shiga toxins expressed by human pathogenic bacteria induce immune responses in host cells

(2014) Moo-Seung Lee et al.   JOURNAL OF MICROBIOLOGY

Bacteria, the endoplasmic reticulum and the unfolded protein response: friends or foes?

(2014) Jean Celli et al.   NATURE REVIEWS MICROBIOLOGY

Glycolipid Binding Preferences of Shiga Toxin Variants

(2014) Sayali S. Karve et al.   PLoS One

Lipid requirements for entry of protein toxins into cells

(2014) Kirsten Sandvig et al.   PROGRESS IN LIPID RESEARCH

Hemolytic uremic syndrome

(2014) Caterina Mele et al.   Seminars in Immunopathology

Unfolded protein response in hepatitis C virus infection

(2014) Shiu-Wan Chan   Frontiers in Microbiology

Distinct Renal Pathology and a Chemotactic Phenotype after Enterohemorrhagic Escherichia coli Shiga Toxins in Non-Human Primate Models of Hemolytic Uremic Syndrome

(2013) Deborah J. Stearns-Kurosawa et al.   AMERICAN JOURNAL OF PATHOLOGY

The role of cell signalling in the crosstalk between autophagy and apoptosis

(2013) Laurence A. Booth et al.   CELLULAR SIGNALLING

The Crystal Structure of Shiga Toxin Type 2 with Bound Disaccharide Guides the Design of a Heterobifunctional Toxin Inhibitor

(2013) Jared M. Jacobson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of TLR4 as the Receptor That Recognizes Shiga Toxins in Human Neutrophils

(2013) M. Brigotti et al.   JOURNAL OF IMMUNOLOGY

Host innate immune responses to sepsis

(2013) Willem Joost Wiersinga et al.   Virulence

Autophagy, Apoptosis, Mitoptosis and Necrosis: Interdependence Between Those Pathways and Effects on Cancer

(2012) Wiem Chaabane et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Regulation of Cytokine and Chemokine Expression by the Ribotoxic Stress Response Elicited by Shiga Toxin Type 1 in Human Macrophage-Like THP-1 Cells

(2012) Dinorah Leyva-Illades et al.   INFECTION AND IMMUNITY

Multicenter Evaluation of a Sequence-Based Protocol for Subtyping Shiga Toxins and Standardizing Stx Nomenclature

(2012) F. Scheutz et al.   JOURNAL OF CLINICAL MICROBIOLOGY

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microparticle generation and leucocyte death in Shiga toxin-mediated HUS

(2012) Shuwang Ge et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Estimates of Illnesses, Hospitalizations, and Deaths Caused By Major Bacterial Enteric Pathogens in Young Children in the United States

(2012) Elaine Scallan et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Shiga Toxin Binding to Glycolipids and Glycans

(2012) Karen M. Gallegos et al.   PLoS One

Shiga toxins

(2012) Jonas Bergan et al.   TOXICON

Shiga Toxin 1 Induces on Lipopolysaccharide-Treated Astrocytes the Release of Tumor Necrosis Factor-alpha that Alter Brain-Like Endothelium Integrity

(2012) Verónica I. Landoni et al.   PLoS Pathogens

Shiga Toxins and the Pathophysiology of Hemolytic Uremic Syndrome in Humans and Animals

(2012) Chad L. Mayer et al.   Toxins

Complement activation on platelet-leukocyte complexes and microparticles in enterohemorrhagic Escherichia coli-induced hemolytic uremic syndrome

(2011) A.-l. Stahl et al.   BLOOD

Shiga toxins induce autophagy leading to differential signalling pathways in toxin-sensitive and toxin-resistant human cells

(2011) Moo-Seung Lee et al.   CELLULAR MICROBIOLOGY

Multiple organ failure in sepsis: prognosis and role of systemic inflammatory response

(2011) Thierry Gustot   Current Opinion in Critical Care

Differential Response of the Human Renal Proximal Tubular Epithelial Cell Line HK-2 to Shiga Toxin Types 1 and 2

(2011) Erin K. Lentz et al.   INFECTION AND IMMUNITY

Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study

(2011) Martina Bielaszewska et al.   LANCET INFECTIOUS DISEASES

Tumor-Specific Targeting of Pancreatic Cancer with Shiga Toxin B-Subunit

(2011) M. Maak et al.   MOLECULAR CANCER THERAPEUTICS

German Outbreak ofEscherichia coliO104:H4 Associated with Sprouts

(2011) Udo Buchholz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Shiga Toxin Interaction with Human Intestinal Epithelium

(2011) Stephanie Schüller   Toxins

Regulation of innate immunity through RNA structure and the protein kinase PKR

(2010) Subba Rao Nallagatla et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Role of Tumor Necrosis Factor Alpha in Disease Using a Mouse Model of Shiga Toxin-Mediated Renal Damage

(2010) E. K. Lentz et al.   INFECTION AND IMMUNITY

Signaling through C/EBP Homologous Protein and Death Receptor 5 and Calpain Activation Differentially Regulate THP-1 Cell Maturation-Dependent Apoptosis Induced by Shiga Toxin Type 1

(2010) M.-S. Lee et al.   INFECTION AND IMMUNITY

Distinct Physiologic and Inflammatory Responses Elicited in Baboons after Challenge with Shiga Toxin Type 1 or 2 from Enterohemorrhagic Escherichia coli

(2010) D. J. Stearns-Kurosawa et al.   INFECTION AND IMMUNITY

Shiga Toxin 2 and Flagellin from Shiga-Toxigenic Escherichia coli Superinduce Interleukin-8 through Synergistic Effects on Host Stress-Activated Protein Kinase Activation

(2010) D. M. Jandhyala et al.   INFECTION AND IMMUNITY

Endothelial damage induced by Shiga toxins delivered by neutrophils during transmigration

(2010) Maurizio Brigotti et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Molecular Basis of Differential B-Pentamer Stability of Shiga Toxins 1 and 2

(2010) Deborah G. Conrady et al.   PLoS One

Hematopoietic Cell Kinase Associates with the 40S Ribosomal Subunit and Mediates the Ribotoxic Stress Response to Deoxynivalenol in Mononuclear Phagocytes

(2010) Heekyong Bae et al.   TOXICOLOGICAL SCIENCES

Structure, biological functions and applications of the AB5 toxins

(2010) Travis Beddoe et al.   TRENDS IN BIOCHEMICAL SCIENCES

Shiga toxin and its use in targeted cancer therapy and imaging

(2010) Nikolai Engedal et al.   Microbial Biotechnology

Enterohemorrhagic Escherichia coli suppresses inflammatory response to cytokines and its own toxin

(2009) Amy Bellmeyer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Expression of verotoxin-1 receptor Gb3 in breast cancer tissue and verotoxin-1 signal transduction to apoptosis

(2009) David Johansson et al.   BMC CANCER

Caspase-8-mediated cleavage of Bid and protein phosphatase 2A-mediated activation of Bax are necessary for Verotoxin-1-induced apoptosis in Burkitt's lymphoma cells

(2009) Julie Garibal et al.   CELLULAR SIGNALLING

Hemolytic Uremic Syndrome and Death in Persons withEscherichia coliO157:H7 Infection, Foodborne Diseases Active Surveillance Network Sites, 2000–2006

(2009) L. Hannah Gould et al.   CLINICAL INFECTIOUS DISEASES

Bcl-2 Regulates the Onset of Shiga Toxin 1-Induced Apoptosis in THP-1 Cells

(2009) M.-S. Lee et al.   INFECTION AND IMMUNITY

Shiga Toxin 1-Induced Proinflammatory Cytokine Production Is Regulated by the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin Signaling Pathway

(2009) R. P. Cherla et al.   INFECTION AND IMMUNITY

Shiga Toxin 2 Targets the Murine Renal Collecting Duct Epithelium

(2009) M. A. Psotka et al.   INFECTION AND IMMUNITY

Protein Kinase PKR-Dependent Activation of Mitogen-Activated Protein Kinases Occurs through Mitochondrial Adapter IPS-1 and Is Antagonized by Vaccinia Virus E3L

(2009) P. Zhang et al.   JOURNAL OF VIROLOGY

Shiga toxin-associated hemolytic uremic syndrome and thrombotic thrombocytopenic purpura: distinct mechanisms of pathogenesis

(2009) Phillip I Tarr   KIDNEY INTERNATIONAL

Shiga toxins — from cell biology to biomedical applications

(2009) Ludger Johannes et al.   NATURE REVIEWS MICROBIOLOGY

Ultrasound contrast microbubbles in imaging and therapy: physical principles and engineering

(2009) Shengping Qin et al.   PHYSICS IN MEDICINE AND BIOLOGY

Shiga Toxin Receptor Gb3Cer/CD77: Tumor-Association and Promising Therapeutic Target in Pancreas and Colon Cancer

(2009) Ute Distler et al.   PLoS One

HCV Induces Oxidative and ER Stress, and Sensitizes Infected Cells to Apoptosis in SCID/Alb-uPA Mice

(2009) Michael A. Joyce et al.   PLoS Pathogens

Macropinocytosis in Shiga toxin 1 uptake by human intestinal epithelial cells and transcellular transcytosis

(2008) Irina Malyukova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Retrograde Delivery of Photosensitizer (TPPp-O-β-GluOH)3Selectively Potentiates Its Photodynamic Activity

(2008) Mohamed Amessou et al.   BIOCONJUGATE CHEMISTRY

ZAK: a MAP3Kinase that transduces Shiga toxin- and ricin-induced proinflammatory cytokine expression

(2008) Dakshina M. Jandhyala et al.   CELLULAR MICROBIOLOGY

Shiga toxin 1 induces apoptosis through the endoplasmic reticulum stress response in human monocytic cells

(2008) Sang-Yun Lee et al.   CELLULAR MICROBIOLOGY

Interactions between Shiga toxins and human polymorphonuclear leukocytes

(2008) Maurizio Brigotti et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Effects of the VEGFR inhibitor ZD6474 in combination with radiotherapy and temozolomide in an orthotopic glioma model

(2008) Maria Sandström et al.   JOURNAL OF NEURO-ONCOLOGY

Neuronal apoptosis and inflammatory responses in the central nervous system of a rabbit treated with Shiga toxin-2

(2008) Kiyomi Takahashi et al.   Journal of Neuroinflammation

Human colorectal tumors and metastases express Gb3 and can be targeted by an intestinal pathogen-based delivery tool

(2008) T. Falguieres et al.   MOLECULAR CANCER THERAPEUTICS