The Molecular Basis of Toxins’ Interactions with Intracellular Signaling via Discrete Portals

On the translocation of botulinum and tetanus neurotoxins across the membrane of acidic intracellular compartments

(2016) Marco Pirazzini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Invited review: Small GTPases and their GAPs

(2016) Ashwini K. Mishra et al.   BIOPOLYMERS

A Diverse Set of Single-domain Antibodies (VHHs) against the Anthrax Toxin Lethal and Edema Factors Provides a Basis for Construction of a Bispecific Agent That Protects against Anthrax Infection

(2016) Catherine E. Vrentas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ecological venomics: How genomics, transcriptomics and proteomics can shed new light on the ecology and evolution of venom

(2016) Kartik Sunagar et al.   Journal of Proteomics

131I-labeled multifunctional dendrimers modified with BmK CT for targeted SPECT imaging and radiotherapy of gliomas

(2016) Yongjun Cheng et al.   Nanomedicine

Bee Venom Phospholipase A2: Yesterday’s Enemy Becomes Today’s Friend

(2016) Gihyun Lee et al.   Toxins

From Mollusks to Medicine: A Venomics Approach for the Discovery and Characterization of Therapeutics from Terebridae Peptide Toxins

(2016) Aida Verdes et al.   Toxins

Helicobacter pylori virulence factors affecting gastric proton pump expression and acid secretion

(2015) Charles E. Hammond et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Structure and function of mitochondrial membrane protein complexes

(2015) Werner Kühlbrandt   BMC BIOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Other ion channels

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Ligand-gated ion channels

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Transporters

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Voltage-gated ion channels

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Enzymes

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Disintegrins from Snake Venoms and their Applications in Cancer Research and Therapy

(2015) Jessica Arruda Macedo et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Organic Toxins as Tools to Understand Ion Channel Mechanisms and Structure

(2015) Sara Morales-Lazaro et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

A new era of secreted phospholipase A2

(2015) Makoto Murakami et al.   JOURNAL OF LIPID RESEARCH

Calcium-independent phospholipases A2and their roles in biological processes and diseases

(2015) Sasanka Ramanadham et al.   JOURNAL OF LIPID RESEARCH

Cytosolic phospholipase A2: physiological function and role in disease

(2015) Christina C. Leslie   JOURNAL OF LIPID RESEARCH

Molecular assembly of lethal factor enzyme and pre-pore heptameric protective antigen in early stage of translocation

(2015) Laleh Alisaraie et al.   JOURNAL OF MOLECULAR MODELING

Pore-forming toxins: ancient, but never really out of fashion

(2015) Matteo Dal Peraro et al.   NATURE REVIEWS MICROBIOLOGY

Histone exchange, chromatin structure and the regulation of transcription

(2015) Swaminathan Venkatesh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The nicotinic acetylcholine receptor and its prokaryotic homologues: Structure, conformational transitions & allosteric modulation

(2015) Marco Cecchini et al.   NEUROPHARMACOLOGY

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Recombinant expression of Bacillus anthracis lethal toxin components of Indian isolate in Escherichia coli and determination of its acute toxicity level in mouse model

(2015) Suryanarayana Nagendra et al.   TOXICON

The long journey of botulinum neurotoxins into the synapse

(2015) Andreas Rummel   TOXICON

Cardiac contraction-induced GLUT4 translocation requires dual signaling input

(2015) Joost J.F.P. Luiken et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Voltage-Gated Ptassium Channels Kv1.3 - Potentially New Molecular Target in Cancer Diagnostics and Therapy

(2015) Andrzej Teisseyre et al.   Advances in Clinical and Experimental Medicine

A Mutational Analysis of Residues in Cholera Toxin A1 Necessary for Interaction with Its Substrate, the Stimulatory G Protein Gsα

(2015) Michael Jobling et al.   Toxins

Chlorotoxin: A Helpful Natural Scorpion Peptide to Diagnose Glioma and Fight Tumor Invasion

(2015) Lucie Dardevet et al.   Toxins

The Molecular Machinery of Neurotransmitter Release (Nobel Lecture)

(2014) Thomas C. Südhof   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PLA2R1: Expression and function in cancer

(2014) David Bernard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Delivery of Antibody Mimics into Mammalian Cells via Anthrax Toxin Protective Antigen

(2014) Xiaoli Liao et al.   CHEMBIOCHEM

Rapid detection of convallatoxin using five digoxin immunoassays

(2014) S. L. Fink et al.   CLINICAL TOXICOLOGY

Tetanus Neurotoxin Utilizes Two Sequential Membrane Interactions for Channel Formation

(2014) Joshua R. Burns et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Botulinum neurotoxins: genetic, structural and mechanistic insights

(2014) Ornella Rossetto et al.   NATURE REVIEWS MICROBIOLOGY

Binding of Clostridium botulinum C3 exoenzyme to intact cells

(2014) Astrid Rohrbeck et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Nidogens are therapeutic targets for the prevention of tetanus

(2014) K. Bercsenyi et al.   SCIENCE

Membrane pore formation at protein–lipid interfaces

(2014) Robert J.C. Gilbert et al.   TRENDS IN BIOCHEMICAL SCIENCES

Effect of crotamine, a cell-penetrating peptide, on blastocyst production and gene expression of in vitro fertilized bovine embryos

(2014) Iana S. Campelo et al.   ZYGOTE

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

Thioredoxin and Its Reductase Are Present on Synaptic Vesicles, and Their Inhibition Prevents the Paralysis Induced by Botulinum Neurotoxins

(2014) Marco Pirazzini et al.   Cell Reports

Mechanisms of conotoxin inhibition of N-type (Cav2.2) calcium channels

(2013) David J. Adams et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

PKA: Lessons learned after twenty years

(2013) Susan S. Taylor et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Ziconotide: a clinical update and pharmacologic review

(2013) Jason E Pope et al.   EXPERT OPINION ON PHARMACOTHERAPY

Bee Venom Phospholipase A2 Induces a Primary Type 2 Response that Is Dependent on the Receptor ST2 and Confers Protective Immunity

(2013) Noah W. Palm et al.   IMMUNITY

Characterization of Botulinum Neurotoxin A Subtypes 1 Through 5 by Investigation of Activities in Mice, in Neuronal Cell Cultures, andIn Vitro

(2013) Regina C. M. Whitemarsh et al.   INFECTION AND IMMUNITY

Applications of snake venom components to modulate integrin activities in cell–matrix interactions

(2013) Cezary Marcinkiewicz   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle

(2013) Thomas C. Südhof   NEURON

Anthrax Edema Factor Toxicity Is Strongly Mediated by the N-end Rule

(2013) Clinton E. Leysath et al.   PLoS One

Molecular dissection of botulinum neurotoxin reveals interdomain chaperone function

(2013) Audrey Fischer et al.   TOXICON

Scorpion venom components that affect ion-channels function

(2013) V. Quintero-Hernández et al.   TOXICON

Ribosome-inactivating proteins

(2013) Matthew J Walsh et al.   Virulence

Staphylococcus aureus α-Toxin: Nearly a Century of Intrigue

(2013) Bryan Berube et al.   Toxins

Time course and temperature dependence of the membrane translocation of tetanus and botulinum neurotoxins C and D in neurons

(2012) Marco Pirazzini et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structure of the S. aureus PI-Specific Phospholipase C Reveals Modulation of Active Site Access by a Titratable π-Cation Latched Loop

(2012) Rebecca Goldstein et al.   BIOCHEMISTRY

The Inhibitory G Protein Gi Identified as Pertussis Toxin-Catalyzed ADP-Ribosylation

(2012) Toshiaki Katada   BIOLOGICAL & PHARMACEUTICAL BULLETIN

P/Q-type calcium channel modulators

(2012) V Nimmrich et al.   BRITISH JOURNAL OF PHARMACOLOGY

The thioredoxin reductase-thioredoxin system is involved in the entry of tetanus and botulinum neurotoxins in the cytosol of nerve terminals

(2012) Marco Pirazzini et al.   FEBS LETTERS

C-type lectin-like proteins from snake venoms

(2012) Franziska T. Arlinghaus et al.   TOXICON

Crystallographic characterization of functional sites of crotoxin and ammodytoxin, potent β-neurotoxins from Viperidae venom

(2012) Grazyna Faure et al.   TOXICON

Three-finger toxins, a deadly weapon of elapid venom – Milestones of discovery

(2012) Yuri N. Utkin   TOXICON

Atomic structures of the eukaryotic ribosome

(2012) Sebastian Klinge et al.   TRENDS IN BIOCHEMICAL SCIENCES

Selective targeting of G-protein-coupled receptor subtypes with venom peptides

(2011) K. Näreoja et al.   Acta Physiologica

Eukaryotic elongation factor-2 (eEF2): its regulation and peptide chain elongation

(2011) Gautam Kaul et al.   CELL BIOCHEMISTRY AND FUNCTION

Targeting the Platelet Integrin GPIIb/IIIa

(2011) Christoph E. Hagemeyer et al.   CURRENT PHARMACEUTICAL DESIGN

Venoms as a platform for human drugs: translating toxins into therapeutics

(2011) Glenn F King   EXPERT OPINION ON BIOLOGICAL THERAPY

Protective effects of ginsenoside Rd against okadaic acid-induced neurotoxicity in vivo and in vitro

(2011) Ling Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Bacterial protein toxins that modify host regulatory GTPases

(2011) Klaus Aktories   NATURE REVIEWS MICROBIOLOGY

Mapping the receptor site for  -scorpion toxins on a Na+ channel voltage sensor

(2011) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Muscarinic toxins

(2011) Denis Servent et al.   TOXICON

Pharmacological Aspects of Vipera xantina palestinae Venom

(2011) Tatjana Momic et al.   Toxins

Nano Aptasensor for Protective Antigen Toxin of Anthrax

(2010) Lakshmi N. Cella et al.   ANALYTICAL CHEMISTRY

Direct modifications of Rho proteins: deconstructing GTPase regulation

(2010) Orane Visvikis et al.   BIOLOGY OF THE CELL

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Transcutaneous delivery of tetanus toxin Hc fragment induces superior tetanus toxin neutralizing antibody response compared to tetanus toxoid

(2010) Louise Johnston et al.   Human vaccines & immunotherapeutics

Contributions of Edema Factor and Protective Antigen to the Induction of Protective Immunity by Bacillus anthracis Edema Toxin as an Intranasal Adjuvant

(2010) A. Duverger et al.   JOURNAL OF IMMUNOLOGY

Therapeutic effects of Clostridium botulinum C3 exoenzyme

(2010) Ingo Just et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Acute physiopathological effects of honeybee (Apis mellifera) envenoming by subcutaneous route in a mouse model

(2010) Mónica Prado et al.   TOXICON

Snaclecs (snake C-type lectins) that inhibit or activate platelets by binding to receptors

(2010) Kenneth J. Clemetson   TOXICON

Structure, function and evolution of three-finger toxins: Mini proteins with multiple targets

(2010) R. Manjunatha Kini et al.   TOXICON

SV2 Mediates Entry of Tetanus Neurotoxin into Central Neurons

(2010) Felix L. Yeh et al.   PLoS Pathogens

Tetanus Toxin C-Fragment: The Courier and the Cure?

(2010) Janne M. Toivonen et al.   Toxins

Spider-Venom Peptides as Therapeutics

(2010) Natalie J. Saez et al.   Toxins

Toxin-Based Therapeutic Approaches

(2010) Assaf Shapira et al.   Toxins

Botulinum toxin

(2010) PK Nigam et al.   INDIAN JOURNAL OF DERMATOLOGY

Intrathecal Ziconotide for Severe Chronic Pain: Safety and Tolerability Results of an Open-Label, Long-Term Trial

(2009) Mark S. Wallace et al.   ANESTHESIA AND ANALGESIA

Chloride Channels: Often Enigmatic, Rarely Predictable

(2009) Charity Duran et al.   Annual Review of Physiology

Mammalian Mitochondrial Complex I: Biogenesis, Regulation, and Reactive Oxygen Species Generation

(2009) Werner J.H. Koopman et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of accelerated segment switch in exons to alter targeting (ASSET) in the molecular evolution of snake venom proteins

(2009) Robin Doley et al.   BMC EVOLUTIONARY BIOLOGY

Drugs from slugs—Past, present and future perspectives of ω-conotoxin research

(2009) Jon-Paul Bingham et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Transbilayer (flip-flop ) lipid motion and lipid scrambling in membranes

(2009) F.-Xabier Contreras et al.   FEBS LETTERS

Cell entry strategy of clostridial neurotoxins

(2009) Thomas Binz et al.   JOURNAL OF NEUROCHEMISTRY

The adenylyl cyclase activity of anthrax edema factor

(2009) Wei-Jen Tang et al.   MOLECULAR ASPECTS OF MEDICINE

Voltage-gated potassium channels as therapeutic targets

(2009) Heike Wulff et al.   NATURE REVIEWS DRUG DISCOVERY

Ion channels versus ion pumps: the principal difference, in principle

(2009) David C. Gadsby   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Central effects of tetanus and botulinum neurotoxins

(2009) Matteo Caleo et al.   TOXICON

Molecular Mechanisms of the Cytotoxicity of ADP-Ribosylating Toxins

(2008) Qing Deng et al.   Annual Review of Microbiology

Marine toxins and the cytoskeleton: okadaic acid and dinophysistoxins

(2008) Carmen Vale et al.   FEBS Journal

Domoic Acid Toxicologic Pathology: A Review

(2008) Olga Pulido   Marine Drugs

Cardiac Glycosides as Novel Cancer Therapeutic Agents

(2008) R. A. Newman et al.   MOLECULAR INTERVENTIONS

A nomenclature for ligand-gated ion channels

(2008) Graham L. Collingridge et al.   NEUROPHARMACOLOGY