P/Q-type calcium channel modulators

Development and Validation of a Fluorescence-Based HTS Assay for the Identification of P/Q-Type Calcium Channel Blockers

(2012) Mario Mezler et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Recent Updates of N-Type Calcium Channel Blockers with Therapeutic Potential for Neuropathic Pain and Stroke

(2012) Takashi Yamamoto et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Neuronal P/Q-type calcium channel dysfunction in inherited disorders of the CNS

(2012) Sanjeev Rajakulendran et al.   Nature Reviews Neurology

A-1048400 is a novel, orally active, state-dependent neuronal calcium channel blocker that produces dose-dependent antinociception without altering hemodynamic function in rats

(2011) Victoria E. Scott et al.   BIOCHEMICAL PHARMACOLOGY

A β-amyloid oligomer directly modulates P/Q-type calcium currents in Xenopus oocytes

(2011) M Mezler et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of different voltage-gated Ca2+channels in cortical spreading depression: Specific requirement of P/Q-type Ca2+channels

(2011) Angelita Tottene et al.   Channels

Targeting voltage-gated calcium channels for the treatment of neuropathic pain: a review of drug development

(2011) Terry Pexton et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Presynaptic Glutamatergic Dysfunction in Bipolar Disorder

(2010) Guang Chen et al.   BIOLOGICAL PSYCHIATRY

Markers of Glutamate Synaptic Transmission and Plasticity Are Increased in the Anterior Cingulate Cortex in Bipolar Disorder

(2010) Sharon L. Eastwood et al.   BIOLOGICAL PSYCHIATRY

Levetiracetam, lamotrigine, and phenobarbital in patients with epileptic seizures and Alzheimer’s disease

(2010) Eduardo Cumbo et al.   EPILEPSY & BEHAVIOR

Gabapentin Suppresses Cortical Spreading Depression Susceptibility

(2010) Ulrike Hoffmann et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Analgesic Effects of a Substituted N-Triazole Oxindole (TROX-1), a State-Dependent, Voltage-Gated Calcium Channel 2 Blocker

(2010) C. Abbadie et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Ziconotide for treatment of severe chronic pain

(2010) Achim Schmidtko et al.   LANCET

Memantine depresses glutamate release through inhibition of voltage-dependent Ca2+ entry and protein kinase C in rat cerebral cortex nerve terminals: An NMDA receptor-independent mechanism

(2010) Cheng-Wei Lu et al.   NEUROCHEMISTRY INTERNATIONAL

Flunarizine blocks voltage-gated Na+ and Ca2+ currents in cultured rat cortical neurons: A possible locus of action in the prevention of migraine

(2010) Qing Ye et al.   NEUROSCIENCE LETTERS

CaV2.1 channelopathies

(2010) Daniela Pietrobon   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Recurrent Stroke Due to a Novel Voltage Sensor Mutation in Ca v 2.1 Responds to Verapamil

(2010) Ellen Knierim et al.   STROKE

Levetiracetam inhibits glutamate transmission through presynaptic P/Q-type calcium channels on the granule cells of the dentate gyrus

(2009) Chun-Yao Lee et al.   BRITISH JOURNAL OF PHARMACOLOGY

Calcium channel diversity: multiple roles of calcium channel subunits

(2009) Annette C Dolphin   CURRENT OPINION IN NEUROBIOLOGY

Seliciclib in malignancies

(2009) Ibrahim T Aldoss et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Isolation and Characterization of Patient-derived, Toxic, High Mass Amyloid β-Protein (Aβ) Assembly from Alzheimer Disease Brains

(2009) Akihiko Noguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Use-Dependent Block of Voltage-Gated Cav2.1 Ca2+ Channels by Petasins and Eudesmol Isomers

(2009) S. Horak et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Nicardipine use in cerebrovascular disease: A review of controlled clinical studies

(2009) Francesco Amenta et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses

(2009) Efrat Abramov et al.   NATURE NEUROSCIENCE

Enhanced Excitatory Transmission at Cortical Synapses as the Basis for Facilitated Spreading Depression in CaV2.1 Knockin Migraine Mice

(2009) Angelita Tottene et al.   NEURON

Role of voltage-gated calcium channels in epilepsy

(2009) Gerald W. Zamponi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Nimodipine and Its Use in Cerebrovascular Disease: Evidence from Recent Preclinical and Controlled Clinical Studies

(2008) Daniele Tomassoni et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Conus Venoms - A Rich Source of Peptide-Based Therapeutics

(2008) Tiffany Han et al.   CURRENT PHARMACEUTICAL DESIGN

Modern management of epilepsy: A practical approach

(2008) Christian E. Elger et al.   EPILEPSY & BEHAVIOR

The separation of antagonist from agonist effects of trisubstituted purines on CaV2.2 (N-type) channels

(2008) Zafir Buraei et al.   JOURNAL OF NEUROCHEMISTRY

Long-Term Intrathecal Ziconotide for Chronic Pain: An Open-Label Study

(2008) Lynn R. Webster et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT