Treatments for Pulmonary Ricin Intoxication: Current Aspects and Future Prospects

Benzyl alcohol induces a reversible fragmentation of the Golgi apparatus and inhibits membrane trafficking between endosomes and the trans-Golgi network

(2017) Roger Simm et al.   EXPERIMENTAL CELL RESEARCH

Determination of ricin intoxication in biological samples by monitoring depurinated 28S rRNA in a unique reverse transcription-ligase-polymerase chain reaction assay

(2017) Ofir Israeli et al.   Forensic Toxicology

JNK Inhibitor SP600125 Attenuates Paraquat-Induced Acute Lung Injury: an In Vivo and In Vitro Study

(2017) Haitao Shen et al.   INFLAMMATION

Novel Noncatalytic Substrate-Selective p38α-Specific MAPK Inhibitors with Endothelial-Stabilizing and Anti-Inflammatory Activity

(2017) Nirav G. Shah et al.   JOURNAL OF IMMUNOLOGY

Extended therapeutic window for post-exposure treatment of ricin intoxication conferred by the use of high-affinity antibodies

(2017) Tal Noy-Porat et al.   TOXICON

Concise Review: Mesenchymal Stromal Cell-Based Approaches for the Treatment of Acute Respiratory Distress and Sepsis Syndromes

(2017) Christian L. Johnson et al.   Stem Cells Translational Medicine

An in vitro evaluation of epigallocatechin gallate (eGCG) as a biocompatible inhibitor of ricin toxin

(2016) Paul D.R. Dyer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Baicalin exerts protective effects against lipopolysaccharide-induced acute lung injury by regulating the crosstalk between the CX3CL1-CX3CR1 axis and NF-κB pathway in CX3CL1-knockout mice

(2016) XIN-MIN DING et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Development of a drug delivery system for efficient alveolar delivery of a neutralizing monoclonal antibody to treat pulmonary intoxication to ricin

(2016) Renaud Respaud et al.   JOURNAL OF CONTROLLED RELEASE

Isolation of Anti-Ricin Protective Antibodies Exhibiting High Affinity from Immunized Non-Human Primates

(2016) Tal Noy-Porat et al.   Toxins

A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response

(2016) Dakshina Jandhyala et al.   Toxins

Expression Profiling Elucidates a Molecular Gene Signature for Pulmonary Hypertension in Sarcoidosis

(2016) Sunit Singla et al.   Pulmonary Circulation

Inhibition of Cholera Toxin and Other AB Toxins by Polyphenolic Compounds

(2016) Patrick Cherubin et al.   PLoS One

Bithionol blocks pathogenicity of bacterial toxins, ricin and Zika virus

(2016) William Leonardi et al.   Scientific Reports

Atorvastatin along with imipenem attenuates acute lung injury in sepsis through decrease in inflammatory mediators and bacterial load

(2015) Soumen Choudhury et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The xanthine oxidase inhibitor Febuxostat reduces tissue uric acid content and inhibits injury-induced inflammation in the liver and lung

(2015) Hiroshi Kataoka et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Baicalin Inhibits the Lethality of Ricin in Mice by Inducing Protein Oligomerization

(2015) Jing Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Auranofin-induced oxidative stress causes redistribution of the glutathione pool in Taenia crassiceps cysticerci

(2015) J.J. Martínez-González et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Febuxostat protects rats against lipopolysaccharide-induced lung inflammation in a dose-dependent manner

(2015) Alaa N. A. Fahmi et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

N -acetyl cysteine improves the effects of corticosteroids in a mouse model of chlorine-induced acute lung injury

(2015) Elisabeth Wigenstam et al.   TOXICOLOGY

The Tie2-agonist Vasculotide rescues mice from influenza virus infection

(2015) Michael G. Sugiyama et al.   Scientific Reports

Diverse Profiles of Ricin-Cell Interactions in the Lung Following Intranasal Exposure to Ricin

(2015) Anita Sapoznikov et al.   Toxins

NLRP3 inflammasome and its inhibitors: a review

(2015) Bo-Zong Shao et al.   Frontiers in Pharmacology

Chimeric Plantibody Passively Protects Mice against Aerosolized Ricin Challenge

(2014) Erin K. Sully et al.   Clinical and Vaccine Immunology

Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNF

(2014) Michaela Finsterbusch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Critical Role for the NLRP3 Inflammasome during Acute Lung Injury

(2014) J. J. Grailer et al.   JOURNAL OF IMMUNOLOGY

Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation

(2014) Hiroe Honda et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Epigallocatechin-3-gallate Ameliorates Seawater Aspiration-Induced Acute Lung Injury via Regulating Inflammatory Cytokines and Inhibiting JAK/STAT1 Pathway in Rats

(2014) Wei Liu et al.   MEDIATORS OF INFLAMMATION

JNK inhibitor SP600125 protects against lipopolysaccharide-induced acute lung injury via upregulation of claudin-4

(2014) YUELIANG ZHENG et al.   Experimental and Therapeutic Medicine

Direct Activation of Ribosome-Associated Double-Stranded RNA-Dependent Protein Kinase (PKR) by Deoxynivalenol, Anisomycin and Ricin: A New Model for Ribotoxic Stress Response Induction

(2014) Hui-Ren Zhou et al.   Toxins

Role of Fc in Antibody-Mediated Protection from Ricin Toxin

(2014) Seth. Pincus et al.   Toxins

Narrative Review: The Systemic Capillary Leak Syndrome

(2013) Kirk M. Druey   ANNALS OF INTERNAL MEDICINE

A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility

(2013) Michael C. Bassik et al.   CELL

Targeting the “Cytokine Storm” for Therapeutic Benefit

(2013) Riccardo V. D'Elia et al.   Clinical and Vaccine Immunology

Small-Molecule Inhibitors of PKR Improve Glucose Homeostasis in Obese Diabetic Mice

(2013) T. Nakamura et al.   DIABETES

A Novel Pharmacologic Inhibitor of the NLRP3 Inflammasome Limits Myocardial Injury After Ischemia–Reperfusion in the Mouse

(2013) Carlo Marchetti et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Intratracheal IL-6 Protects against Lung Inflammation in Direct, but Not Indirect, Causes of Acute Lung Injury in Mice

(2013) Rhea Bhargava et al.   PLoS One

Novel genetically-humanized mouse model established to evaluate efficacy of therapeutic agents to human interleukin-6 receptor

(2013) Otoya Ueda et al.   Scientific Reports

Common Pharmacophore of Structurally Distinct Small-Molecule Inhibitors of Intracellular Retrograde Trafficking of Ribosome Inactivating Proteins

(2013) Shichao Yu et al.   Scientific Reports

Novel Class of Potential Therapeutics that Target Ricin Retrograde Translocation

(2013) Veronika Redmann et al.   Toxins

Glycotechnology for Decontamination of Biological Agents: A Model Study Using Ricin and Biotin-Tagged Synthetic Glycopolymers

(2012) Takehiro Nagatsuka et al.   ACS Applied Materials & Interfaces

Iloprost improves endothelial barrier function in lipopolysaccharide-induced lung injury

(2012) A. A. Birukova et al.   EUROPEAN RESPIRATORY JOURNAL

Reductive Activation of Type 2 Ribosome-inactivating Proteins Is Promoted by Transmembrane Thioredoxin-related Protein

(2012) Matteo Pasetto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Humanization and Characterization of an Anti-Ricin Neutralization Monoclonal Antibody

(2012) Wei-Gang Hu et al.   PLoS One

Identification of Small Molecules That Suppress Ricin-Induced Stress-Activated Signaling Pathways

(2012) Paul G. Wahome et al.   PLoS One

Pre-Treatment with Allopurinol or Uricase Attenuates Barrier Dysfunction but Not Inflammation during Murine Ventilator-Induced Lung Injury

(2012) Maria T. Kuipers et al.   PLoS One

Prevention and amelioration of rodent endotoxin-induced lung injury with administration of a novel therapeutic tripeptide feG

(2012) Alison S.F. Elder et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Inhibitors of the Cellular Trafficking of Ricin

(2012) Julien Barbier et al.   Toxins

Conformation-Dependent High-Affinity Potent Ricin-Neutralizing Monoclonal Antibodies

(2012) Wei-Gang Hu et al.   Biomed Research International

Inhibitory kappa B kinases as targets for pharmacological regulation

(2011) Carly Gamble et al.   BRITISH JOURNAL OF PHARMACOLOGY

Suppression of PKR Promotes Network Excitability and Enhanced Cognition by Interferon-γ-Mediated Disinhibition

(2011) Ping Jun Zhu et al.   CELL

Bacitracin inhibits the reductive activity of protein disulfide isomerase by disulfide bond formation with free cysteines in the substrate-binding domain

(2011) Nina Dickerhof et al.   FEBS Journal

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

(2011) Simon A. Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

Small-Molecule Inhibitor Leads of Ribosome-Inactivating Proteins Developed Using the Doorstop Approach

(2011) Yuan-Ping Pang et al.   PLoS One

Neutralising Antibodies against Ricin Toxin

(2011) Julie Prigent et al.   PLoS One

Baicalein inhibits oxidative stress-induced cellular damage via antioxidant effects

(2011) Kyoung Ah Kang et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Protective immunity to ricin toxin conferred by antibodies against the toxin's binding subunit (RTB)

(2011) Anastasiya Yermakova et al.   VACCINE

Plant-based expression of a partially humanized neutralizing monoclonal IgG directed against an immunodominant epitope on the ricin toxin A subunit

(2011) Joanne M. O’Hara et al.   VACCINE

Anti-inflammatory properties of Doxycycline and Minocycline in experimental models: an in vivo and in vitro comparative study

(2011) Liz M. Leite et al.   INFLAMMOPHARMACOLOGY

Use of Lactose against the Deadly Biological Toxin Ricin

(2010) Takehiro Nagatsuka et al.   ACS Applied Materials & Interfaces

Zinc modulates the innate immune response in vivo to polymicrobial sepsis through regulation of NF-κB

(2010) Shengying Bao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Extracellular ATP Is a Danger Signal Activating P2X7Receptor in Lung Inflammation and Fibrosis

(2010) Nicolas Riteau et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Identification of known drugs that act as inhibitors of NF-κB signaling and their mechanism of action

(2010) Susanne C. Miller et al.   BIOCHEMICAL PHARMACOLOGY

Inhibition of Retrograde Transport Protects Mice from Lethal Ricin Challenge

(2010) Bahne Stechmann et al.   CELL

Pretreatment with atorvastatin attenuates lung injury caused by high-stretch mechanical ventilation in an isolated rabbit lung model

(2010) Ilias I. Siempos et al.   CRITICAL CARE MEDICINE

Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome

(2010) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Salivary gland derived peptides as a new class of anti-inflammatory agents: review of preclinical pharmacology of C-terminal peptides of SMR1 protein

(2010) Ronald D Mathison et al.   Journal of Inflammation-London

Nonantibiotic Properties of Tetracyclines: Structural Basis for Inhibition of Secretory Phospholipase A2

(2010) Daniela Dalm et al.   JOURNAL OF MOLECULAR BIOLOGY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

Identification of new classes of ricin toxin inhibitors by virtual screening

(2010) Yan Bai et al.   TOXICON

Identification of small-molecule inhibitors of ricin and shiga toxin using a cell-based high-throughput screen

(2010) Paul G. Wahome et al.   TOXICON

Ricin Toxin Activates the NALP3 Inflammasome

(2010) Meghan Lindauer et al.   Toxins

Secretory group V phospholipase A2 regulates acute lung injury and neutrophilic inflammation caused by LPS in mice

(2009) Nilda M. Muñoz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Uric Acid Is a Danger Signal Activating NALP3 Inflammasome in Lung Injury Inflammation and Fibrosis

(2009) Pamela Gasse et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Two-Step Binding Model Proposed for the Electrostatic Interactions of Ricin A Chain with Ribosomes

(2009) Xiao-Ping Li et al.   BIOCHEMISTRY

A Monoclonal Immunoglobulin G Antibody Directed against an Immunodominant Linear Epitope on the Ricin A Chain Confers Systemic and Mucosal Immunity to Ricin

(2009) L. M. Neal et al.   INFECTION AND IMMUNITY

The Effect of Epigallocatechin Gallate on Lipopolysaccharide-Induced Acute Lung Injury in a Murine Model

(2009) Hong-Beom Bae et al.   INFLAMMATION

Ricin A-chain requires c-Jun N-terminal kinase to induce apoptosis in nontransformed epithelial cells

(2009) Amanda E. Jetzt et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

(2009) Mohamed Lamkanfi et al.   JOURNAL OF CELL BIOLOGY

Pulmonary Inflammation Triggered by Ricin Toxin Requires Macrophages and IL-1 Signaling

(2009) M. L. Lindauer et al.   JOURNAL OF IMMUNOLOGY

Neutrophil-Derived IL-6 Limits Alveolar Barrier Disruption in Experimental Ventilator-Induced Lung Injury

(2009) P. J. Wolters et al.   JOURNAL OF IMMUNOLOGY

New Potential Targets to Modulate Neutrophil Function in Inflammation

(2009) R. Burgos et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

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(2009) Jon Mabley et al.   MOLECULAR MEDICINE

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Therapeutic Effects of Baicalin on Lipopolysaccharide-Induced Acute Lung Injury in Rats

(2008) Kun-Lun Huang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Endothelin-1 Impairs Alveolar Epithelial Function via Endothelial ETBReceptor

(2008) Alejandro P. Comellas et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Zinc Deficiency Mediates Alcohol-Induced Alveolar Epithelial and Macrophage Dysfunction in Rats

(2008) Pratibha C. Joshi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Effect of Endothelin-1 on Alveolar Fluid Clearance and Pulmonary Edema Formation in the Rat

(2008) Marc Moritz Berger et al.   ANESTHESIA AND ANALGESIA

A novel sugar-probe biosensor for the deadly plant proteinous toxin, ricin

(2008) Hirotaka Uzawa et al.   BIOSENSORS & BIOELECTRONICS

ZAK: a MAP3Kinase that transduces Shiga toxin- and ricin-induced proinflammatory cytokine expression

(2008) Dakshina M. Jandhyala et al.   CELLULAR MICROBIOLOGY

Advances in Critical Care for the Nephrologist: Acute Lung Injury/ARDS

(2008) K. D. Liu et al.   Clinical Journal of the American Society of Nephrology

Pharmacotherapy of Acute Lung Injury and Acute Respiratory Distress Syndrome

(2008) Krishnan Raghavendran et al.   CURRENT MEDICINAL CHEMISTRY

Doxycycline induces membrane expression of VE-cadherin on endothelial cells and prevents vascular hyperpermeability

(2008) Ofer Fainaru et al.   FASEB JOURNAL

Mepacrine alleviates airway hyperresponsiveness and airway inflammation in a mouse model of asthma

(2008) Arjun Ram et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The tripeptide feG inhibits leukocyte adhesion

(2008) Ronald D Mathison et al.   Journal of Inflammation-London

Zinc Aspartate Alleviates Lung Injury Induced by Intestinal Ischemia-Reperfusion in Rats

(2008) Hasan Türüt et al.   JOURNAL OF SURGICAL RESEARCH

The Nalp3 inflammasome is essential for the development of silicosis

(2008) Suzanne L. Cassel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Double-Stranded RNA–Activated Protein Kinase Mediates Induction of Interleukin-8 Expression by Deoxynivalenol, Shiga Toxin 1, and Ricin in Monocytes

(2008) Jennifer S. Gray et al.   TOXICOLOGICAL SCIENCES

Multivalent binding of ricin to bovine serum albumin-based neoglycoconjugates

(2008) Matthew C. Blome et al.   TOXICON

Protective effects of anti-ricin A-chain RNA aptamer against ricin toxicity

(2008) Shaoan Fan et al.   WORLD JOURNAL OF GASTROENTEROLOGY