PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis

Metabolic crosstalk between host and pathogen: sensing, adapting and competing

(2016) Andrew J. Olive et al.   NATURE REVIEWS MICROBIOLOGY

Glutamate Dehydrogenase Is Required by Mycobacterium bovis BCG for Resistance to Cellular Stress

(2016) James L. Gallant et al.   PLoS One

Ser/Thr phosphorylation as a regulatory mechanism in bacteria

(2015) Jonathan Dworkin   CURRENT OPINION IN MICROBIOLOGY

Dynamic exometabolome analysis reveals active metabolic pathways in non-replicating mycobacteria

(2015) Michael Zimmermann et al.   ENVIRONMENTAL MICROBIOLOGY

Mycobacterial genes essential for the pathogen's survival in the host

(2015) Sabine Ehrt et al.   IMMUNOLOGICAL REVIEWS

E1 of α-ketoglutarate dehydrogenase defendsMycobacterium tuberculosisagainst glutamate anaplerosis and nitroxidative stress

(2015) Christina Maksymiuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Basis of the Activity and the Regulation of the Eukaryotic-like S/T Protein Kinase PknG from Mycobacterium tuberculosis

(2015) María-Natalia Lisa et al.   STRUCTURE

A Redox Regulatory System Critical for Mycobacterial Survival in Macrophages and Biofilm Development

(2015) Kerstin A. Wolff et al.   PLoS Pathogens

Agents of change - concepts inMycobacterium tuberculosis Ser/Thr/Tyr phosphosignalling

(2014) David R. Sherman et al.   MOLECULAR MICROBIOLOGY

Nitrogen metabolism in Mycobacterium tuberculosis physiology and virulence

(2014) Alexandre Gouzy et al.   NATURE REVIEWS MICROBIOLOGY

Mycobacterium Tuberculosis Proteome Microarray for Global Studies of Protein Function and Immunogenicity

(2014) Jiaoyu Deng et al.   Cell Reports

Nontargeted Profiling of Coenzyme A thioesters in biological samples by tandem mass spectrometry

(2013) Michael Zimmermann et al.   ANALYTICAL CHEMISTRY

Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing

(2013) Yanjia J. Zhang et al.   CELL

Feast or famine: the host-pathogen battle over amino acids

(2013) Yanjia J. Zhang et al.   CELLULAR MICROBIOLOGY

Analysis of SecA2-dependent substrates inMycobacterium marinumidentifies protein kinase G (PknG) as a virulence effector

(2013) Aniek D. van der Woude et al.   CELLULAR MICROBIOLOGY

13C-Flux Spectral Analysis of Host-Pathogen Metabolism Reveals a Mixed Diet for Intracellular Mycobacterium tuberculosis

(2013) Dany J.V. Beste et al.   CHEMISTRY & BIOLOGY

Inhibition of Mycobacterium tuberculosis PknG by non-catalytic rubredoxin domain specific modification: reaction of an electrophilic nitro-fatty acid with the Fe–S center

(2013) Magdalena Gil et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mycobacterium tuberculosisMaltosyltransferase GlgE, a Genetically Validated Antituberculosis Target, Is Negatively Regulated by Ser/Thr Phosphorylation

(2013) Jade Leiba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systems-Based Approaches to Probing Metabolic Variation within the Mycobacterium tuberculosis Complex

(2013) Emma K. Lofthouse et al.   PLoS One

The Role of Glutamine Oxoglutarate Aminotransferase and Glutamate Dehydrogenase in Nitrogen Metabolism in Mycobacterium bovis BCG

(2013) Albertus J. Viljoen et al.   PLoS One

High-Throughput, Accurate Mass Metabolome Profiling of Cellular Extracts by Flow Injection–Time-of-Flight Mass Spectrometry

(2011) Tobias Fuhrer et al.   ANALYTICAL CHEMISTRY

Functional Plasticity and Allosteric Regulation of α-Ketoglutarate Decarboxylase in Central Mycobacterial Metabolism

(2011) Tristan Wagner et al.   CHEMISTRY & BIOLOGY

ESAT-6 Secretion-Independent Impact of ESX-1 Genes espF and espG1 on Virulence of Mycobacterium tuberculosis

(2011) Daria Bottai et al.   JOURNAL OF INFECTIOUS DISEASES

Ultrahigh Performance Liquid Chromatography−Tandem Mass Spectrometry Method for Fast and Robust Quantification of Anionic and Aromatic Metabolites

(2010) Joerg Martin Buescher et al.   ANALYTICAL CHEMISTRY

Metabolomics of Mycobacterium tuberculosis Reveals Compartmentalized Co-Catabolism of Carbon Substrates

(2010) Luiz Pedro S. de Carvalho et al.   CHEMISTRY & BIOLOGY

Improved Phos-tag SDS-PAGE under neutral pH conditions for advanced protein phosphorylation profiling

(2010) Eiji Kinoshita et al.   PROTEOMICS

Protein Kinase G Is Required for Intrinsic Antibiotic Resistance in Mycobacteria

(2009) K. A. Wolff et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Requirement of de novo synthesis of the OdhI protein in penicillin-induced glutamate production by Corynebacterium glutamicum

(2009) Jongpill Kim et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Protein kinase and phosphatase signaling in Mycobacterium tuberculosis physiology and pathogenesis

(2009) Joseph Chao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Key Residues inMycobacterium tuberculosisProtein Kinase G Play a Role in Regulating Kinase Activity and Survival in the Host

(2009) Divya Tiwari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential expression of a virulence factor in pathogenic and non-pathogenic mycobacteria

(2009) Edith N. G. Houben et al.   MOLECULAR MICROBIOLOGY

Genetic and biochemical analysis of the serine/threonine protein kinases PknA, PknB, PknG and PknL ofCorynebacterium glutamicum: evidence for non-essentiality and for phosphorylation of OdhI and FtsZ by multiple kinases

(2009) Christian Schultz et al.   MOLECULAR MICROBIOLOGY

An Anaerobic-Type α-Ketoglutarate Ferredoxin Oxidoreductase Completes the Oxidative Tricarboxylic Acid Cycle of Mycobacterium tuberculosis

(2009) Anthony D. Baughn et al.   PLoS Pathogens

The FHA-containing protein GarA acts as a phosphorylation-dependent molecular switch in mycobacterial signaling

(2008) Patrick England et al.   FEBS LETTERS

Regulation of glutamate metabolism by protein kinases in mycobacteria

(2008) Helen M. O'Hare et al.   MOLECULAR MICROBIOLOGY