Mycobacterial genes essential for the pathogen's survival in the host

Survival of mycobacteria depends on proteasome-mediated amino acid recycling under nutrient limitation

(2014) Y. Elharar et al.   EMBO JOURNAL

Methylcitrate cycle defines the bactericidal essentiality of isocitrate lyase for survival ofMycobacterium tuberculosison fatty acids

(2014) Hyungjin Eoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Triosephosphate Isomerase Is Dispensable In Vitro yet Essential for Mycobacterium tuberculosis To Establish Infection

(2014) C. Trujillo et al.   mBio

Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis

(2014) Madhumitha Nandakumar et al.   Nature Communications

Inactivation of Fructose-1,6-Bisphosphate Aldolase Prevents Optimal Co-catabolism of Glycolytic and Gluconeogenic Carbon Substrates in Mycobacterium tuberculosis

(2014) Susan Puckett et al.   PLoS Pathogens

Mycobacterium tuberculosis Exploits Asparagine to Assimilate Nitrogen and Resist Acid Stress during Infection

(2014) Alexandre Gouzy et al.   PLoS Pathogens

Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing

(2013) Yanjia J. Zhang et al.   CELL

13C-Flux Spectral Analysis of Host-Pathogen Metabolism Reveals a Mixed Diet for Intracellular Mycobacterium tuberculosis

(2013) Dany J.V. Beste et al.   CHEMISTRY & BIOLOGY

Substrate Specificity of MarP, a Periplasmic Protease Required for Resistance to Acid and Oxidative Stress inMycobacterium tuberculosis

(2013) Jennifer L. Small et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate

(2013) Alexandre Gouzy et al.   Nature Chemical Biology

A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence

(2013) J.-H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multifunctional essentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis

(2013) H. Eoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial lifestyle shapes stringent response activation

(2013) Cara C. Boutte et al.   TRENDS IN MICROBIOLOGY

Glucose Phosphorylation Is Required for Mycobacterium tuberculosis Persistence in Mice

(2013) Joeli Marrero et al.   PLoS Pathogens

Cholesterol Catabolism by Mycobacterium tuberculosis Requires Transcriptional and Metabolic Adaptations

(2012) Jennifer E. Griffin et al.   CHEMISTRY & BIOLOGY

Global Assessment of Genomic Regions Required for Growth in Mycobacterium tuberculosis

(2012) Yanjia J. Zhang et al.   PLoS Pathogens

Functional Plasticity and Allosteric Regulation of α-Ketoglutarate Decarboxylase in Central Mycobacterial Metabolism

(2011) Tristan Wagner et al.   CHEMISTRY & BIOLOGY

Host Proteasomal Degradation Generates Amino Acids Essential for Intracellular Bacterial Growth

(2011) C. T. D. Price et al.   SCIENCE

Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier

(2011) Kyu Y. Rhee et al.   TRENDS IN MICROBIOLOGY

Evaluating the Sensitivity of Mycobacterium tuberculosis to Biotin Deprivation Using Regulated Gene Expression

(2011) Sae Woong Park et al.   PLoS Pathogens

Fumarate Reductase Activity Maintains an Energized Membrane in Anaerobic Mycobacterium tuberculosis

(2011) Shinya Watanabe et al.   PLoS Pathogens

High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism

(2011) Jennifer E. Griffin et al.   PLoS Pathogens

13C Metabolic Flux Analysis Identifies an Unusual Route for Pyruvate Dissimilation in Mycobacteria which Requires Isocitrate Lyase and Carbon Dioxide Fixation

(2011) Dany J. V. Beste et al.   PLoS Pathogens

Mycobacterium tuberculosis Wears What It Eats

(2010) David G. Russell et al.   Cell Host & Microbe

Activity-Based Metabolomic Profiling of Enzymatic Function: Identification of Rv1248c as a Mycobacterial 2-Hydroxy-3-oxoadipate Synthase

(2010) Luiz Pedro S. de Carvalho et al.   CHEMISTRY & BIOLOGY

Metabolomics of Mycobacterium tuberculosis Reveals Compartmentalized Co-Catabolism of Carbon Substrates

(2010) Luiz Pedro S. de Carvalho et al.   CHEMISTRY & BIOLOGY

Glucose 6-Phosphate Accumulation in Mycobacteria

(2010) Mohammad Rubayet Hasan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Stringent Response Is Required for Full Virulence ofMycobacterium tuberculosisin Guinea Pigs

(2010) Lee G. Klinkenberg et al.   JOURNAL OF INFECTIOUS DISEASES

Is Mycobacterium tuberculosis stressed out? A critical assessment of the genetic evidence

(2010) Christina L. Stallings et al.   MICROBES AND INFECTION

A novel copper-responsive regulon in Mycobacterium tuberculosis

(2010) Richard A. Festa et al.   MOLECULAR MICROBIOLOGY

Molecular analysis of the prokaryotic ubiquitin-like protein (Pup) conjugation pathway in Mycobacterium tuberculosis

(2010) Francisca A. Cerda-Maira et al.   MOLECULAR MICROBIOLOGY

Simultaneous Analysis of Multiple Mycobacterium tuberculosis Knockdown Mutants In Vitro and In Vivo

(2010) Antje Blumenthal et al.   PLoS One

An Incomplete TCA Cycle Increases Survival of Salmonella Typhimurium during Infection of Resting and Activated Murine Macrophages

(2010) Steven D. Bowden et al.   PLoS One

Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection

(2010) J. Marrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Insight into Serine Protease Rv3671c that Protects M. tuberculosis from Oxidative and Acidic Stress

(2010) Tapan Biswas et al.   STRUCTURE

The Mycobacterium tuberculosis Proteasome Active Site Threonine Is Essential for Persistence Yet Dispensable for Replication and Resistance to Nitric Oxide

(2010) Sheetal Gandotra et al.   PLoS Pathogens

Mycobacterial survival strategies in the phagosome: defence against host stresses

(2009) Sabine Ehrt et al.   CELLULAR MICROBIOLOGY

A Thiolase of Mycobacterium tuberculosis Is Required for Virulence and Production of Androstenedione and Androstadienedione from Cholesterol

(2009) N. M. Nesbitt et al.   INFECTION AND IMMUNITY

3-Ketosteroid 9α-hydroxylase is an essential factor in the pathogenesis ofMycobacterium tuberculosis

(2009) Yanmin Hu et al.   MOLECULAR MICROBIOLOGY

Foamy macrophages and the progression of the human tuberculosis granuloma

(2009) David G Russell et al.   NATURE IMMUNOLOGY

Studies of a Ring-Cleaving Dioxygenase Illuminate the Role of Cholesterol Metabolism in the Pathogenesis of Mycobacterium tuberculosis

(2009) Katherine C. Yam et al.   PLoS Pathogens

Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates

(2008) L. E. Via et al.   INFECTION AND IMMUNITY

Functional Characterization of a Vitamin B12-Dependent Methylmalonyl Pathway in Mycobacterium tuberculosis: Implications for Propionate Metabolism during Growth on Fatty Acids

(2008) S. Savvi et al.   JOURNAL OF BACTERIOLOGY

Biosynthesis and Recycling of Nicotinamide Cofactors inMycobacterium tuberculosis

(2008) Helena I. M. Boshoff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis

(2008) Omar H Vandal et al.   NATURE MEDICINE

Mycobacterial persistence requires the utilization of host cholesterol

(2008) A. K. Pandey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA