E1 of α-ketoglutarate dehydrogenase defendsMycobacterium tuberculosisagainst glutamate anaplerosis and nitroxidative stress

Methylcitrate cycle defines the bactericidal essentiality of isocitrate lyase for survival ofMycobacterium tuberculosison fatty acids

(2014) Hyungjin Eoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Triosephosphate Isomerase Is Dispensable In Vitro yet Essential for Mycobacterium tuberculosis To Establish Infection

(2014) C. Trujillo et al.   mBio

Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis

(2014) Madhumitha Nandakumar et al.   Nature Communications

Inactivation of Fructose-1,6-Bisphosphate Aldolase Prevents Optimal Co-catabolism of Glycolytic and Gluconeogenic Carbon Substrates in Mycobacterium tuberculosis

(2014) Susan Puckett et al.   PLoS Pathogens

Influence of Allosteric Regulators on Individual Steps in the Reaction Catalyzed byMycobacterium tuberculosis2-Hydroxy-3-oxoadipate Synthase

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Coordination of bacterial proteome with metabolism by cyclic AMP signalling

(2013) Conghui You et al.   NATURE

Multifunctional essentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis

(2013) H. Eoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Lysine Modification by an Intrinsically Reactive Primary Glycolytic Metabolite

(2013) R. E. Moellering et al.   SCIENCE

Glucose Phosphorylation Is Required for Mycobacterium tuberculosis Persistence in Mice

(2013) Joeli Marrero et al.   PLoS Pathogens

Cholesterol Catabolism by Mycobacterium tuberculosis Requires Transcriptional and Metabolic Adaptations

(2012) Jennifer E. Griffin et al.   CHEMISTRY & BIOLOGY

Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials

(2012) B. Gold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On the chemical mechanism of succinic semialdehyde dehydrogenase (GabD1) from Mycobacterium tuberculosis

(2011) Luiz Pedro S. de Carvalho et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Virulence of Mycobacterium tuberculosis Depends on Lipoamide Dehydrogenase, a Member of Three Multienzyme Complexes

(2011) Aditya Venugopal et al.   Cell Host & Microbe

Multiple Targets of Nitric Oxide in the Tricarboxylic Acid Cycle of Salmonella enterica Serovar Typhimurium

(2011) Anthony R. Richardson et al.   Cell Host & Microbe

Functional Plasticity and Allosteric Regulation of α-Ketoglutarate Decarboxylase in Central Mycobacterial Metabolism

(2011) Tristan Wagner et al.   CHEMISTRY & BIOLOGY

α-ketoglutarate coordinates carbon and nitrogen utilization via enzyme I inhibition

(2011) Christopher D Doucette et al.   Nature Chemical Biology

Repurposing lipoic acid changes electron flow in two important metabolic pathways of Escherichia coli

(2011) M. A. Feeney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activity-Based Metabolomic Profiling of Enzymatic Function: Identification of Rv1248c as a Mycobacterial 2-Hydroxy-3-oxoadipate Synthase

(2010) Luiz Pedro S. de Carvalho et al.   CHEMISTRY & BIOLOGY

Metabolomics of Mycobacterium tuberculosis Reveals Compartmentalized Co-Catabolism of Carbon Substrates

(2010) Luiz Pedro S. de Carvalho et al.   CHEMISTRY & BIOLOGY

The E2 Domain of OdhA of Corynebacterium glutamicum Has Succinyltransferase Activity Dependent on Lipoyl Residues of the Acetyltransferase AceF

(2010) M. Hoffelder et al.   JOURNAL OF BACTERIOLOGY

Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an α-glucan pathway

(2010) Rainer Kalscheuer et al.   Nature Chemical Biology

Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection

(2010) J. Marrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tuberculosis: What We Don't Know Can, and Does, Hurt Us

(2010) D. G. Russell et al.   SCIENCE

A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

(2010) Kevin Pethe et al.   Nature Communications

Metabolic control exerted by the 2-oxoglutarate dehydrogenase reaction: a cross-kingdom comparison of the crossroad between energy production and nitrogen assimilation

(2009) Victoria I. Bunik et al.   BIOCHEMICAL JOURNAL

Metabolite Profiling Reveals YihU as a Novel Hydroxybutyrate Dehydrogenase for Alternative Succinic Semialdehyde Metabolism inEscherichia coli

(2009) Natsumi Saito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Granuloma in Tuberculosis — Friend or Foe?

(2009) Eric J. Rubin   NEW ENGLAND JOURNAL OF MEDICINE

Tuberculosis in Dr Granville's mummy: a molecular re-examination of the earliest known Egyptian mummy to be scientifically examined and given a medical diagnosis

(2009) H. D. Donoghue et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Selective Killing of Nonreplicating Mycobacteria

(2008) Ruslana Bryk et al.   Cell Host & Microbe

Functional Characterization of a Vitamin B12-Dependent Methylmalonyl Pathway in Mycobacterium tuberculosis: Implications for Propionate Metabolism during Growth on Fatty Acids

(2008) S. Savvi et al.   JOURNAL OF BACTERIOLOGY

A Genomic View on Nitrogen Metabolism and Nitrogen Control in Mycobacteria

(2008) Johannes Amon et al.   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

Regulation of glutamate metabolism by protein kinases in mycobacteria

(2008) Helen M. O'Hare et al.   MOLECULAR MICROBIOLOGY