Fragile X syndrome: a preclinical review on metabotropic glutamate receptor 5 (mGluR5) antagonists and drug development
Published 2013 View Full Article
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Title
Fragile X syndrome: a preclinical review on metabotropic glutamate receptor 5 (mGluR5) antagonists and drug development
Authors
Keywords
Fragile X syndrome, mGluR5, FMR1, FMRP, DNA methylation, Epigenetic regulation, AFQ056, Mavoglurant, Dendritic spines, mGluR5 antagonist
Journal
PSYCHOPHARMACOLOGY
Volume 231, Issue 6, Pages 1217-1226
Publisher
Springer Nature
Online
2013-11-14
DOI
10.1007/s00213-013-3330-3
References
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Note: Only part of the references are listed.- Chronic administration of AFQ056/Mavoglurant restores social behaviour in Fmr1 knockout mice
- (2012) Ilse Gantois et al. BEHAVIOURAL BRAIN RESEARCH
- The mGluR5 antagonist AFQ056 does not affect methylation and transcription of the mutant FMR1 gene in vitro
- (2012) Elisabetta Tabolacci et al. BMC Medical Genetics
- Species-Dependent Posttranscriptional Regulation of NOS1 by FMRP in the Developing Cerebral Cortex
- (2012) Kenneth Y. Kwan et al. CELL
- mGluR5 Negative Allosteric Modulators Overview: A Medicinal Chemistry Approach Towards a Series of Novel Therapeutic Agents
- (2012) Jean-Philippe Rocher et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- The effect of an mGluR5 inhibitor on procedural memory and avoidance discrimination impairments inFmr1KO mice
- (2012) M. F. Vinueza Veloz et al. GENES BRAIN AND BEHAVIOR
- Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome
- (2012) C. A. Hoeffer et al. GENES BRAIN AND BEHAVIOR
- Altered maturation of the primary somatosensory cortex in a mouse model of fragile X syndrome
- (2012) Sally M. Till et al. HUMAN MOLECULAR GENETICS
- Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome
- (2012) Xinglong Wang et al. JOURNAL OF NEUROCHEMISTRY
- Learning and Memory Deficits Consequent to Reduction of the Fragile X Mental Retardation Protein Result from Metabotropic Glutamate Receptor-Mediated Inhibition of cAMP Signaling in Drosophila
- (2012) A. K. Kanellopoulos et al. JOURNAL OF NEUROSCIENCE
- Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice
- (2012) Aubin Michalon et al. NEURON
- Cytoplasmic RNA-Binding Proteins and the Control of Complex Brain Function
- (2012) J. C. Darnell et al. Cold Spring Harbor Perspectives in Biology
- Modifying behavioral phenotypes in Fmr1KO mice: genetic background differences reveal autistic-like responses
- (2011) Corinne M. Spencer et al. Autism Research
- Complex effects of mGluR5 antagonism on sociability and stereotypic behaviors in mice: Possible implications for the pharmacotherapy of autism spectrum disorders
- (2011) Jessica A. Burket et al. BRAIN RESEARCH BULLETIN
- FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism
- (2011) Jennifer C. Darnell et al. CELL
- The Psychiatric Presentation of Fragile X: Evolution of the Diagnosis and Treatment of the Psychiatric Comorbidities of Fragile X Syndrome
- (2011) Michael R. Tranfaglia DEVELOPMENTAL NEUROSCIENCE
- Ablation of Fmrp in adult neural stem cells disrupts hippocampus-dependent learning
- (2011) Weixiang Guo et al. NATURE MEDICINE
- Which Comes First in Fragile X Syndrome, Dendritic Spine Dysgenesis or Defects in Circuit Plasticity?
- (2011) Carlos Portera-Cailliau NEUROSCIENTIST
- Genetic-Background Modulation of Core and Variable Autistic-Like Symptoms in Fmr1 Knock-Out Mice
- (2011) Susanna Pietropaolo et al. PLoS One
- Testing the FMR1 Promoter for Mosaicism in DNA Methylation among CpG Sites, Strands, and Cells in FMR1-Expressing Males with Fragile X Syndrome
- (2011) Reinhard Stöger et al. PLoS One
- Epigenetic Characterization of the FMR1 Gene and Aberrant Neurodevelopment in Human Induced Pluripotent Stem Cell Models of Fragile X Syndrome
- (2011) Steven D. Sheridan et al. PLoS One
- Cognitive dysfunction and prefrontal synaptic abnormalities in a mouse model of fragile X syndrome
- (2011) D. D. Krueger et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Group I metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndrome
- (2011) Alexia M. Thomas et al. PSYCHOPHARMACOLOGY
- Epigenetic Modification of the FMR1 Gene in Fragile X Syndrome Is Associated with Differential Response to the mGluR5 Antagonist AFQ056
- (2011) S. Jacquemont et al. Science Translational Medicine
- Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P
- (2010) R. L. Coffee et al. Disease Models & Mechanisms
- Excess Phosphoinositide 3-Kinase Subunit Synthesis and Activity as a Novel Therapeutic Target in Fragile X Syndrome
- (2010) C. Gross et al. JOURNAL OF NEUROSCIENCE
- Altered mRNA transport, docking, and protein translation in neurons lacking fragile X mental retardation protein
- (2010) D.-I. Kao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Early continuous inhibition of group 1 mGlu signaling partially rescues dendritic spine abnormalities in the Fmr1 knockout mouse model for fragile X syndrome
- (2010) Tao Su et al. PSYCHOPHARMACOLOGY
- Potential therapeutic interventions for fragile X syndrome
- (2010) Josien Levenga et al. TRENDS IN MOLECULAR MEDICINE
- A Distinct DNA-Methylation Boundary in the 5′- Upstream Sequence of the FMR1 Promoter Binds Nuclear Proteins and Is Lost in Fragile X Syndrome
- (2009) Anja Naumann et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Fragile X Mental Retardation Protein Regulates the Levels of Scaffold Proteins and Glutamate Receptors in Postsynaptic Densities
- (2009) Janin Schütt et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A pilot open label, single dose trial of fenobam in adults with fragile X syndrome
- (2009) E Berry-Kravis et al. JOURNAL OF MEDICAL GENETICS
- Modest reactivation of the mutant FMR1 gene by valproic acid is accompanied by histone modifications but not DNA demethylation
- (2009) Elisabetta Tabolacci et al. Pharmacogenetics and Genomics
- Generation and Characterization of Fmr1 Knockout Zebrafish
- (2009) Marjo J. den Broeder et al. PLoS One
- A Mouse Model of the Human Fragile X Syndrome I304N Mutation
- (2009) Julie B. Zang et al. PLoS Genetics
- TheFMR1gene and fragile X-associated tremor/ataxia syndrome
- (2008) J.R. Brouwer et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
- Evidence for social anxiety and impaired social cognition in a mouse model of fragile X syndrome.
- (2008) Caitlyn H. McNaughton et al. BEHAVIORAL NEUROSCIENCE
- Temporal requirements of the fragile X mental retardation protein in the regulation of synaptic structure
- (2008) C. L. Gatto et al. DEVELOPMENT
- Epigenetic analysis reveals a euchromatic configuration in the FMR1 unmethylated full mutations
- (2008) Elisabetta Tabolacci et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Fragile X syndrome
- (2008) Kathryn B Garber et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Social approach in genetically engineered mouse lines relevant to autism
- (2008) S. S. Moy et al. GENES BRAIN AND BEHAVIOR
- Open-Label Treatment Trial of Lithium to Target the Underlying Defect in Fragile X Syndrome
- (2008) Elizabeth Berry-Kravis et al. JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
- Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice
- (2008) Femke M.S. de Vrij et al. NEUROBIOLOGY OF DISEASE
- Elevated glycogen synthase kinase-3 activity in Fragile X mice: Key metabolic regulator with evidence for treatment potential
- (2008) Wenzhong William Min et al. NEUROPHARMACOLOGY
- Metabotropic Glutamate Receptors and Fragile X Mental Retardation Protein: Partners in Translational Regulation at the Synapse
- (2008) J. A. Ronesi et al. Science Signaling
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