Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality

Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G

(2016) Guillaume B.E. Stewart-Jones et al.   CELL

Dissecting How CD4 T Cells Are Lost During HIV Infection

(2016) Gilad Doitsh et al.   Cell Host & Microbe

Macrophages and HIV-1: An Unhealthy Constellation

(2016) Quentin J. Sattentau et al.   Cell Host & Microbe

CCR5 interaction with HIV-1 Env contributes to Env-induced depletion of CD4 T cells in vitro and in vivo

(2016) Li-Chung Tsao et al.   Retrovirology

Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins

(2016) Alon Herschhorn et al.   mBio

Compartmentalized intrathecal immunoglobulin synthesis during HIV infection — A model of chronic CNS inflammation?

(2015) Mickael Bonnan et al.   JOURNAL OF NEUROIMMUNOLOGY

Phenotypic Correlates of HIV-1 Macrophage Tropism

(2015) Kathryn T. Arrildt et al.   JOURNAL OF VIROLOGY

HIV-1 Fitness Cost Associated with Escape from the VRC01 Class of CD4 Binding Site Neutralizing Antibodies

(2015) Rebecca M. Lynch et al.   JOURNAL OF VIROLOGY

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

(2015) Matthew R. Gardner et al.   NATURE

Bottlenecks in HIV-1 transmission: insights from the study of founder viruses

(2015) Sarah B. Joseph et al.   NATURE REVIEWS MICROBIOLOGY

CD4 mimetics sensitize HIV-1-infected cells to ADCC

(2015) Jonathan Richard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 non-macrophage-tropic R5 envelope glycoproteins are not more tropic for entry into primary CD4+ T-cells than envelopes highly adapted for macrophages

(2015) Thomas Musich et al.   Retrovirology

The HIV-1 Entry Process: A Stoichiometric View

(2015) Oliver F. Brandenberg et al.   TRENDS IN MICROBIOLOGY

Bioinformatic analysis of neurotropic HIV envelope sequences identifies polymorphisms in the gp120 bridging sheet that increase macrophage-tropism through enhanced interactions with CCR5

(2015) Megan E. Mefford et al.   VIROLOGY

Compartmentalized Replication of R5 T Cell-Tropic HIV-1 in the Central Nervous System Early in the Course of Infection

(2015) Christa Buckheit Sturdevant et al.   PLoS Pathogens

Different Infectivity of HIV-1 Strains Is Linked to Number of Envelope Trimers Required for Entry

(2015) Oliver F. Brandenberg et al.   PLoS Pathogens

Capacity of Broadly Neutralizing Antibodies to Inhibit HIV-1 Cell-Cell Transmission Is Strain- and Epitope-Dependent

(2015) Lucia Reh et al.   PLoS Pathogens

Human macrophage polarization in vitro: Maturation and activation methods compared

(2014) Daphne Y.S. Vogel et al.   IMMUNOBIOLOGY

HIV-1 target cells in the CNS

(2014) Sarah B. Joseph et al.   JOURNAL OF NEUROVIROLOGY

HIV-1 Entry and Trans-Infection of Astrocytes Involves CD81 Vesicles

(2014) Lachlan R. Gray et al.   PLoS One

Distinct HIV-1 entry phenotypes are associated with transmission, subtype specificity, and resistance to broadly neutralizing antibodies

(2014) Kelechi Chikere et al.   Retrovirology

Differences in coreceptor specificity contribute to alternative tropism of HIV-1 subtype C for CD4+T-cell subsets, including stem cell memory T-cells

(2014) Kieran Cashin et al.   Retrovirology

Selection bias at the heterosexual HIV-1 transmission bottleneck

(2014) J. M. Carlson et al.   SCIENCE

Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor

(2014) A. Pegu et al.   Science Translational Medicine

CD4+T-cell depletion in HIV infection: mechanisms of immunological failure

(2013) Afam A. Okoye et al.   IMMUNOLOGICAL REVIEWS

HIV-1 envelope-receptor interactions required for macrophage infection and implications for current HIV-1 cure strategies

(2013) P. R. Gorry et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Retrovirus Glycoprotein Functionality Requires Proper Alignment of the Ectodomain and the Membrane-Proximal Cytoplasmic Tail

(2013) Sanath Kumar Janaka et al.   JOURNAL OF VIROLOGY

Conformation-Dependent Recognition of HIV gp120 by Designed Ankyrin Repeat Proteins Provides Access to Novel HIV Entry Inhibitors

(2013) A. Mann et al.   JOURNAL OF VIROLOGY

Quantification of Entry Phenotypes of Macrophage-Tropic HIV-1 across a Wide Range of CD4 Densities

(2013) S. B. Joseph et al.   JOURNAL OF VIROLOGY

Comparison of Viral Env Proteins from Acute and Chronic Infections with Subtype C Human Immunodeficiency Virus Type 1 Identifies Differences in Glycosylation and CCR5 Utilization and Suggests a New Strategy for Immunogen Design

(2013) L.-H. Ping et al.   JOURNAL OF VIROLOGY

HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration

(2013) Arik Cooper et al.   NATURE

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

(2013) Gilad Doitsh et al.   NATURE

Cell-to-Cell Transmission Can Overcome Multiple Donor and Target Cell Barriers Imposed on Cell-Free HIV

(2013) Peng Zhong et al.   PLoS One

M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding

(2013) Philippe Selhorst et al.   Retrovirology

A systematic study of the N-glycosylation sites of HIV-1 envelope protein on infectivity and antibody-mediated neutralization

(2013) Wenbo Wang et al.   Retrovirology

Elicitation of HIV-1-neutralizing antibodies against the CD4-binding site

(2013) Ivelin S. Georgiev et al.   Current Opinion in HIV and AIDS

Kruppel-like Factor 2 Modulates CCR5 Expression and Susceptibility to HIV-1 Infection

(2012) M. W. Richardson et al.   JOURNAL OF IMMUNOLOGY

Macrophage-tropic HIV-1 variants from brain demonstrate alterations in the way gp120 engages both CD4 and CCR5

(2012) Hamid Salimi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Development of CD4 Binding Site Antibodies during HIV-1 Infection

(2012) R. M. Lynch et al.   JOURNAL OF VIROLOGY

Efficiency of Bridging-Sheet Recruitment Explains HIV-1 R5 Envelope Glycoprotein Sensitivity to Soluble CD4 and Macrophage Tropism

(2012) O. O'Connell et al.   JOURNAL OF VIROLOGY

Transmitted/Founder and Chronic HIV-1 Envelope Proteins Are Distinguished by Differential Utilization of CCR5

(2012) Z. F. Parker et al.   JOURNAL OF VIROLOGY

Immune surveillance in the central nervous system

(2012) Shalina S Ousman et al.   NATURE NEUROSCIENCE

Persistent Humoral Immune Responses in the CNS Limit Recovery of Reactivated Murine Cytomegalovirus

(2012) Manohar B. Mutnal et al.   PLoS One

Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors

(2012) Paul J Peters et al.   Retrovirology

Identification of interdependent variables that influence coreceptor switch in R5 SHIVSF162P3N-infected macaques

(2012) Ke Zhuang et al.   Retrovirology

Affinofile profiling: How efficiency of CD4/CCR5 usage impacts the biological and pathogenic phenotype of HIV

(2012) Kelechi Chikere et al.   VIROLOGY

HIV-1 Induced Bystander Apoptosis

(2012) Himanshu Garg et al.   Viruses-Basel

Use of (alternative) coreceptors for HIV entry

(2012) Georgios Pollakis et al.   Current Opinion in HIV and AIDS

Correlation of coreceptor usage and disease progression

(2012) Chris Verhofstede et al.   Current Opinion in HIV and AIDS

Transmitted/Founder and Chronic Subtype C HIV-1 Use CD4 and CCR5 Receptors with Equal Efficiency and Are Not Inhibited by Blocking the Integrin α4β7

(2012) Nicholas F. Parrish et al.   PLoS Pathogens

Cell-Cell Transmission Enables HIV-1 to Evade Inhibition by Potent CD4bs Directed Antibodies

(2012) Irene A. Abela et al.   PLoS Pathogens

The efficacy of an anti-CD4 monoclonal antibody for HIV-1 treatment

(2011) W. Jeffrey Fessel et al.   ANTIVIRAL RESEARCH

Reanalysis of Coreceptor Tropism in HIV-1-Infected Adults Using a Phenotypic Assay with Enhanced Sensitivity

(2011) T. J. Wilkin et al.   CLINICAL INFECTIOUS DISEASES

MPER-specific antibodies induce gp120 shedding and irreversibly neutralize HIV-1

(2011) Claudia R. Ruprecht et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Systematic validation of specific phenotypic markers for in vitro polarized human macrophages

(2011) C.A. Ambarus et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Adoption of an “Open” Envelope Conformation Facilitating CD4 Binding and Structural Remodeling Precedes Coreceptor Switch in R5 SHIV-Infected Macaques

(2011) Ke Zhuang et al.   PLoS One

CD4-binding site alterations in CCR5-using HIV-1 envelopes influencing gp120–CD4 interactions and fusogenicity

(2011) Jasminka Sterjovski et al.   VIROLOGY

Highly conserved HIV-1 gp120 glycans proximal to CD4-binding region affect viral infectivity and neutralizing antibody induction

(2011) Xin Huang et al.   VIROLOGY

Viral Determinants of HIV-1 Macrophage Tropism

(2011) Christopher J. A. Duncan et al.   Viruses-Basel

HIV-1 Replication in the Central Nervous System Occurs in Two Distinct Cell Types

(2011) Gretja Schnell et al.   PLoS Pathogens

HIVBrainSeqDB: a database of annotated HIV envelope sequences from brain and other anatomical sites

(2011) Alexander G Holman et al.   AIDS Research and Therapy

HIV-1 transmission after cessation of early antiretroviral therapy among men having sex with men

(2010) Philip Rieder et al.   AIDS

HIV coreceptor tropism in antiretroviral treatment-naive patients newly diagnosed at a late stage of HIV infection

(2010) Benedikt Simon et al.   AIDS

Protection against HIV-envelope-induced neuronal cell destruction by HIV attachment inhibitors

(2010) Sharon Zhang et al.   ARCHIVES OF VIROLOGY

Variation in the biological properties of HIV-1 R5 envelopes: implications of envelope structure, transmission and pathogenesis

(2010) Maria José Duenas-Decamp et al.   Future Virology

Ibalizumab: an anti-CD4 monoclonal antibody for the treatment of HIV-1 infection

(2010) C. J. Bruno et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A V3 Loop-Dependent gp120 Element Disrupted by CD4 Binding Stabilizes the Human Immunodeficiency Virus Envelope Glycoprotein Trimer

(2010) S.-H. Xiang et al.   JOURNAL OF VIROLOGY

A Conserved Determinant in the V1 Loop of HIV-1 Modulates the V3 Loop To Prime Low CD4 Use and Macrophage Infection

(2010) T. Musich et al.   JOURNAL OF VIROLOGY

Modulation of HIV-1 macrophage-tropism among R5 envelopes occurs before detection of neutralizing antibodies

(2010) Kathryn H Richards et al.   Retrovirology

An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes

(2010) Jasminka Sterjovski et al.   VIROLOGY

Estimating the Stoichiometry of HIV Neutralization

(2010) Carsten Magnus et al.   PLoS Computational Biology

Quantitative Comparison of HTLV-1 and HIV-1 Cell-to-Cell Infection with New Replication Dependent Vectors

(2010) Dmitriy Mazurov et al.   PLoS Pathogens

Coreceptors and HIV-1 Pathogenesis

(2010) Paul R. Gorry et al.   Current HIV/AIDS Reports

HIV sensitivity to neutralization is determined by target and virus producer cell properties

(2009) Axel M Mann et al.   AIDS

Divergent effects of cell environment on HIV entry inhibitor activity

(2009) Peter Rusert et al.   AIDS

Cohort Profile: The Swiss HIV Cohort Study

(2009) et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Acquired immunodeficiency syndrome and the blood-brain barrier

(2009) Nathan S Ivey et al.   JOURNAL OF NEUROVIROLOGY

Tissue-Specific Sequence Alterations in the Human Immunodeficiency Virus Type 1 Envelope Favoring CCR5 Usage Contribute to Persistence of Dual-Tropic Virus in the Brain

(2009) L. Gray et al.   JOURNAL OF VIROLOGY

Determinants Flanking the CD4 Binding Loop Modulate Macrophage Tropism of Human Immunodeficiency Virus Type 1 R5 Envelopes

(2009) M. J. Duenas-Decamp et al.   JOURNAL OF VIROLOGY

A Quantitative Affinity-Profiling System That Reveals Distinct CD4/CCR5 Usage Patterns among Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus Strains

(2009) Samantha. H. Johnston et al.   JOURNAL OF VIROLOGY

Enhanced macrophage tropism of HIV in brain and lymphoid tissues is associated with sensitivity to the broadly neutralizing CD4 binding site antibody b12

(2009) Rebecca L Dunfee et al.   Retrovirology

Early Steps of HIV-1 Fusion Define the Sensitivity to Inhibitory Peptides That Block 6-Helix Bundle Formation

(2009) Kosuke Miyauchi et al.   PLoS Pathogens

Soluble CD4 and CD4-Mimetic Compounds Inhibit HIV-1 Infection by Induction of a Short-Lived Activated State

(2009) Hillel Haim et al.   PLoS Pathogens

Bioinformatic Prediction Programs Underestimate the Frequency of CXCR4 Usage by R5X4 HIV Type 1 in Brain and Other Tissues

(2008) Megan E. Mefford et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Emergence and Persistence of CXCR4‐Tropic HIV‐1 in a Population of Men from the Multicenter AIDS Cohort Study

(2008) James C. Shepherd et al.   JOURNAL OF INFECTIOUS DISEASES

Combinatorial Optimization of a CD4-Mimetic Miniprotein and Cocrystal Structures with HIV-1 gp120 Envelope Glycoprotein

(2008) François Stricher et al.   JOURNAL OF MOLECULAR BIOLOGY

Estimating the Stoichiometry of Human Immunodeficiency Virus Entry

(2008) C. Magnus et al.   JOURNAL OF VIROLOGY

Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection

(2008) B. F. Keele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Primary HIV-1 R5 isolates from end-stage disease display enhanced viral fitness in parallel with increased gp120 net charge

(2008) Johanna Repits et al.   VIROLOGY

CD4-Specific Designed Ankyrin Repeat Proteins Are Novel Potent HIV Entry Inhibitors with Unique Characteristics

(2008) Andreas Schweizer et al.   PLoS Pathogens

HIV-1 induced activation of CD4+ T cells creates new targets for HIV-1 infection in human lymphoid tissue ex vivo

(2007) A. Biancotto et al.   BLOOD