Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei

TLK1B mediated phosphorylation of Rad9 regulates its nuclear/cytoplasmic localization and cell cycle checkpoint

(2016) Sanket Awate et al.   BMC MOLECULAR BIOLOGY

Functional compartmentalization of Rad9 and Hus1 reveals diverse assembly of the 9-1-1 complex components during the DNA damage response in Leishmania

(2016) Jeziel D. Damasceno et al.   MOLECULAR MICROBIOLOGY

Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

(2016) Shilpi Khare et al.   NATURE

Diverged composition and regulation of theTrypanosoma bruceiorigin recognition complex that mediates DNA replication initiation

(2016) Catarina A. Marques et al.   NUCLEIC ACIDS RESEARCH

Toxoplasma gondii Arginine Methyltransferase 1 (PRMT1) Is Necessary for Centrosome Dynamics during Tachyzoite Cell Division

(2016) Kamal El Bissati et al.   mBio

Mapping replication dynamics in Trypanosoma brucei reveals a link with telomere transcription and antigenic variation

(2016) Rebecca Devlin et al.   eLife

Nuclear transport factors: global regulation of mitosis

(2015) Douglass J Forbes et al.   CURRENT OPINION IN CELL BIOLOGY

Eukaryotic DNA polymerase ζ

(2015) Alena V. Makarova et al.   DNA REPAIR

The Wnt and Notch signalling pathways in the developing cochlea: Formation of hair cells and induction of regenerative potential

(2015) Magdalena Żak et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Metabolic responses induced by DNA damage and poly (ADP-ribose) polymerase (PARP) inhibition in MCF-7 cells

(2015) Vijesh J. Bhute et al.   Metabolomics

Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum

(2015) Marie-Michelle Genois et al.   NUCLEIC ACIDS RESEARCH

Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes

(2015) Nicola Baker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

(2015) M. Raschle et al.   SCIENCE

No DDRama at chromosome ends: TRF2 takes centre stage

(2015) Sascha Feuerhahn et al.   TRENDS IN BIOCHEMICAL SCIENCES

CRISPR-Cas9-Mediated Genome Editing in Leishmania donovani

(2015) Wen-Wei Zhang et al.   mBio

MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex

(2015) Kyung Yong Lee et al.   Nature Communications

Histone variants: key players of chromatin

(2014) Burcu Biterge et al.   CELL AND TISSUE RESEARCH

RNA-processing proteins regulate Mec1/ATR activation by promoting generation of RPA-coated ssDNA

(2014) N. Manfrini et al.   EMBO REPORTS

DNA Repair Pathways in Trypanosomatids: from DNA Repair to Drug Resistance

(2014) M.-M. Genois et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Networks of gene expression regulation in Trypanosoma brucei

(2014) C.E. Clayton   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Nucleotide excision repair inTrypanosoma brucei: specialization of transcription-coupled repair due to multigenic transcription

(2014) Carlos R. Machado et al.   MOLECULAR MICROBIOLOGY

Proteomic Analysis of Trypanosoma cruzi Response to Ionizing Radiation Stress

(2014) Helaine Graziele Santos Vieira et al.   PLoS One

DNA damage: RNA-binding proteins protect from near and far

(2014) Martin Dutertre et al.   TRENDS IN BIOCHEMICAL SCIENCES

Repurposing human Aurora kinase inhibitors as leads for anti-protozoan drug discovery

(2014) Gautam Patel et al.   MedChemComm

Regulators of Trypanosoma brucei Cell Cycle Progression and Differentiation Identified Using a Kinome-Wide RNAi Screen

(2014) Nathaniel G. Jones et al.   PLoS Pathogens

Cathepsin-L Can Resist Lysis by Human Serum in Trypanosoma brucei brucei

(2014) Sam Alsford et al.   PLoS Pathogens

Touching from a distance

(2014) Jennifer M Holden et al.   Nucleus

Cyclic AMP Effectors in African Trypanosomes Revealed by Genome-Scale RNA Interference Library Screening for Resistance to the Phosphodiesterase Inhibitor CpdA

(2013) Matthew K. Gould et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Target of rapamycin (TOR) kinase inTrypanosoma brucei: an extended family

(2013) Manuel Saldivia et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Chromatin modifications in trypanosomes due to stress

(2013) Nilmar Silvio Moretti et al.   CELLULAR MICROBIOLOGY

DNA repair mechanisms in dividing and non-dividing cells

(2013) Teruaki Iyama et al.   DNA REPAIR

Global Quantitative SILAC Phosphoproteomics Reveals Differential Phosphorylation Is Widespread between the Procyclic and Bloodstream Form Lifecycle Stages of Trypanosoma brucei

(2013) Michael D. Urbaniak et al.   JOURNAL OF PROTEOME RESEARCH

PPL2 Translesion Polymerase Is Essential for the Completion of Chromosomal DNA Replication in the African Trypanosome

(2013) Sean G. Rudd et al.   MOLECULAR CELL

The Aurora B kinase inTrypanosoma bruceiundergoes post-translational modifications and is targeted to various subcellular locations through binding to TbCPC1

(2013) Huiqing Hu et al.   MOLECULAR MICROBIOLOGY

Trypanosoma bruceiharbours a divergent XPB helicase paralogue that is specialized in nucleotide excision repair and conserved among kinetoplastid organisms

(2013) Nitika Badjatia et al.   MOLECULAR MICROBIOLOGY

Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei

(2013) Binny M. Mony et al.   NATURE

Genome-wide single-cell-level screen for protein abundance and localization changes in response to DNA damage in S. cerevisiae

(2013) Aprotim Mazumder et al.   NUCLEIC ACIDS RESEARCH

Translesion DNA Polymerases

(2013) M. F. Goodman et al.   Cold Spring Harbor Perspectives in Biology

Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library

(2012) Xian Pan et al.   BMC GENOMICS

In silicoanalysis of trypanosomatids' helicases

(2012) Pablo R. Gargantini et al.   FEMS MICROBIOLOGY LETTERS

Clinical features, diagnosis, and treatment of human African trypanosomiasis (sleeping sickness)

(2012) Peter GE Kennedy   LANCET NEUROLOGY

DNA polymerase beta from Trypanosoma cruzi is involved in kinetoplast DNA replication and repair of oxidative lesions

(2012) Bruno Luiz Fonseca Schamber-Reis et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

TbPIF8, a Trypanosoma brucei protein related to the yeast Pif1 helicase, is essential for cell viability and mitochondrial genome maintenance

(2012) Jianyang Wang et al.   MOLECULAR MICROBIOLOGY

Identification of ORC1/CDC6-Interacting Factors in Trypanosoma brucei Reveals Critical Features of Origin Recognition Complex Architecture

(2012) Calvin Tiengwe et al.   PLoS One

Trypanosoma cruzi Gene Expression in Response to Gamma Radiation

(2012) Priscila Grynberg et al.   PLoS One

Inhibition of poly(ADP-ribose) Polymerase Interferes with Trypanosoma cruzi Infection and Proliferation of the Parasite

(2012) Salomé C. Vilchez Larrea et al.   PLoS One

Functional Characterization of 8-Oxoguanine DNA Glycosylase of Trypanosoma cruzi

(2012) Carolina Furtado et al.   PLoS One

Third target of rapamycin complex negatively regulates development of quiescence in Trypanosoma brucei

(2012) A. Barquilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The trypanothione system and the opportunities it offers to create drugs for the neglected kinetoplast diseases

(2011) Leopold Flohé   BIOTECHNOLOGY ADVANCES

The SMC complexes, DNA and chromosome topology: right or knot?

(2011) Sidney D. Carter et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome

(2011) S. Alsford et al.   GENOME RESEARCH

SMC complexes and topoisomerase II work together so that sister chromatids can work apart

(2010) Claudia Tapia-Alveal et al.   CELL CYCLE

Unwinding the functions of the Pif1 family helicases

(2010) Matthew L. Bochman et al.   DNA REPAIR

TbPRMT6 Is a Type I Protein Arginine Methyltransferase That Contributes to Cytokinesis in Trypanosoma brucei

(2010) John C. Fisk et al.   EUKARYOTIC CELL

Centromere-associated topoisomerase activity in bloodstream form Trypanosoma brucei

(2010) Samson O. Obado et al.   NUCLEIC ACIDS RESEARCH

Microhomology-mediated deletion and gene conversion in African trypanosomes

(2010) Lucy Glover et al.   NUCLEIC ACIDS RESEARCH

TOPO3α Influences Antigenic Variation by Monitoring Expression-Site-Associated VSG Switching in Trypanosoma brucei

(2010) Hee-Sook Kim et al.   PLoS Pathogens

CRK9 contributes to regulation of mitosis and cytokinesis in the procyclic form of Trypanosoma brucei

(2009) Stephane Gourguechon et al.   BMC CELL BIOLOGY

RAP1 Is Essential for Silencing Telomeric Variant Surface Glycoprotein Genes in Trypanosoma brucei

(2009) Xiaofeng Yang et al.   CELL

The cell cycle as a therapeutic target againstTrypanosoma brucei: Hesperadin inhibits Aurora kinase-1 and blocks mitotic progression in bloodstream forms

(2009) Neal Jetton et al.   MOLECULAR MICROBIOLOGY

A Network of Conserved Damage Survival Pathways Revealed by a Genomic RNAi Screen

(2009) Dashnamoorthy Ravi et al.   PLoS Genetics

The Aurora Kinase in Trypanosoma brucei Plays Distinctive Roles in Metaphase-Anaphase Transition and Cytokinetic Initiation

(2009) Ziyin Li et al.   PLoS Pathogens

Systems based mapping demonstrates that recovery from alkylation damage requires DNA repair, RNA processing, and translation associated networks

(2008) John P. Rooney et al.   GENOMICS

Trypanosoma cruzi bromodomain factor 2 (BDF2) binds to acetylated histones and is accumulated after UV irradiation

(2008) Gabriela Vanina Villanova et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY