The enemy within: Targeting host–parasite interaction for antileishmanial drug discovery

From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity

(2016) Emilie Durieu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Host-directed therapies for infectious diseases: current status, recent progress, and future prospects

(2016) Alimuddin Zumla et al.   LANCET INFECTIOUS DISEASES

Possibilities and challenges for developing a successful vaccine for leishmaniasis

(2016) Saumya Srivastava et al.   Parasites & Vectors

A review of visceral leishmaniasis during the conflict in South Sudan and the consequences for East African countries

(2016) Waleed Al-Salem et al.   Parasites & Vectors

Opportunities for the development of novel therapies based on host-microbial interactions

(2016) Patrícia Campi Santos et al.   PHARMACOLOGICAL RESEARCH

Leishmaniasis, conflict, and political terror: A spatio-temporal analysis

(2016) Isha Berry et al.   SOCIAL SCIENCE & MEDICINE

Naloxonazine, an Amastigote-Specific Compound, Affects Leishmania Parasites through Modulation of Host-Encoded Functions

(2016) Géraldine De Muylder et al.   PLoS Neglected Tropical Diseases

Old World Cutaneous Leishmaniasis and Refugee Crises in the Middle East and North Africa

(2016) Rebecca Du et al.   PLoS Neglected Tropical Diseases

Role of Small RNAs in Trypanosomatid Infections

(2016) Leandra Linhares-Lacerda et al.   Frontiers in Microbiology

Escaping Deleterious Immune Response in Their Hosts: Lessons from Trypanosomatids

(2016) Anne Geiger et al.   Frontiers in Immunology

Mapping epigenetic changes to the host cell genome induced by Burkholderia pseudomallei reveals pathogen-specific and pathogen-generic signatures of infection

(2016) Deniz Cizmeci et al.   Scientific Reports

Simultaneous transcriptional profiling of Leishmania major and its murine macrophage host cell reveals insights into host-pathogen interactions

(2015) Laura A. L. Dillon et al.   BMC GENOMICS

Leishmaniahijacking of the macrophage intracellular compartments

(2015) Vanessa Liévin-Le Moal et al.   FEBS Journal

Leishmania and the macrophage: a multifaceted interaction

(2015) Maria Podinovskaia et al.   Future Microbiology

Bacterial infection remodels the DNA methylation landscape of human dendritic cells

(2015) Alain Pacis et al.   GENOME RESEARCH

Proteomic-Based Approach To Gain Insight into Reprogramming of THP-1 Cells Exposed to Leishmania donovani over an Early Temporal Window

(2015) Alok Kumar Singh et al.   INFECTION AND IMMUNITY

Host-directed therapies for improving poor treatment outcomes associated with the middle east respiratory syndrome coronavirus infections

(2015) Alimuddin Zumla et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Leishmania donovaniExploits Myeloid Cell Leukemia 1 (MCL-1) Protein to Prevent Mitochondria-dependent Host Cell Apoptosis

(2015) Jayeeta Giri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cross-resistance of Leishmania infantum isolates to nitric oxide from patients refractory to antimony treatment, and greater tolerance to antileishmanial responses by macrophages

(2015) Tatiana R. de Moura et al.   PARASITOLOGY RESEARCH

New Compound Sets Identified from High Throughput Phenotypic Screening Against Three Kinetoplastid Parasites: An Open Resource

(2015) Imanol Peña et al.   Scientific Reports

Intrachromosomal Amplification, Locus Deletion and Point Mutation in the Aquaglyceroporin AQP1 Gene in Antimony Resistant Leishmania (Viannia) guyanensis

(2015) Rubens Monte-Neto et al.   PLoS Neglected Tropical Diseases

Impact of Leishmania Infection on Host Macrophage Nuclear Physiology and Nucleopore Complex Integrity

(2015) Amandine Isnard et al.   PLoS Pathogens

Leishmania infantum Modulates Host Macrophage Mitochondrial Metabolism by Hijacking the SIRT1-AMPK Axis

(2015) Diana Moreira et al.   PLoS Pathogens

Drug resistance analysis by next generation sequencing in Leishmania

(2015) Philippe Leprohon et al.   International Journal for Parasitology-Drugs and Drug Resistance

Recent Developments in Drug Discovery for Leishmaniasis and Human African Trypanosomiasis

(2014) Advait S. Nagle et al.   CHEMICAL REVIEWS

Toxoplasma gondii Prevents Chromatin Remodeling Initiated by TLR-Triggered Macrophage Activation

(2014) J. Leng et al.   JOURNAL OF IMMUNOLOGY

Imipramine Exploits Histone Deacetylase 11 To Increase the IL-12/IL-10 Ratio in Macrophages Infected with Antimony-ResistantLeishmania donovaniand Clears Organ Parasites in Experimental Infection

(2014) Sandip Mukherjee et al.   JOURNAL OF IMMUNOLOGY

Unmethylated CpG motifs in the L. donovani DNA regulate TLR9-dependent delay of programmed cell death in macrophages

(2014) Sushmita Das et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Toxoplasma gondii infection reduces predator aversion in rats through epigenetic modulation in the host medial amygdala

(2014) Shantala Arundhati Hari Dass et al.   MOLECULAR ECOLOGY

Post Kala-Azar Dermal Leishmaniasis following Treatment with 20 mg/kg Liposomal Amphotericin B (Ambisome) for Primary Visceral Leishmaniasis in Bihar, India

(2014) Sakib Burza et al.   PLoS Neglected Tropical Diseases

Impact of Leishmania mexicana Infection on Dendritic Cell Signaling and Functions

(2014) Irazú Contreras et al.   PLoS Neglected Tropical Diseases

Leishmania donovani Infection Causes Distinct Epigenetic DNA Methylation Changes in Host Macrophages

(2014) Alexandra K. Marr et al.   PLoS Pathogens

Immunotherapy and Targeted Therapies in Treatment of Visceral Leishmaniasis: Current Status and Future Prospects

(2014) Om Prakash Singh et al.   Frontiers in Immunology

Immunotherapy and Immunochemotherapy in Visceral Leishmaniasis: Promising Treatments for this Neglected Disease

(2014) Bruno Mendes Roatt et al.   Frontiers in Immunology

Pharmacological Assessment Defines Leishmania donovani Casein Kinase 1 as a Drug Target and Reveals Important Functions in Parasite Viability and Intracellular Infection

(2013) Najma Rachidi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Legionella pneumophila Effector RomA Uniquely Modifies Host Chromatin to Repress Gene Expression and Promote Intracellular Bacterial Replication

(2013) Monica Rolando et al.   Cell Host & Microbe

Leishmania Evades Host Immunity by Inhibiting Antigen Cross-Presentation through Direct Cleavage of the SNARE VAMP8

(2013) Diana Matheoud et al.   Cell Host & Microbe

Therapy of chronic hepatitis C virus infection in the era of direct-acting and host-targeting antiviral agents

(2013) Vincenza Conteduca et al.   JOURNAL OF INFECTION

Proteomic analysis reveals differentially expressed proteins in macrophages infected with Leishmania amazonensis or Leishmania major

(2013) J.P.B. Menezes et al.   MICROBES AND INFECTION

Telomeric gene deletion and intrachromosomal amplification in antimony-resistantLeishmania

(2013) Angana Mukherjee et al.   MOLECULAR MICROBIOLOGY

(Post-) Genomic approaches to tackle drug resistance in Leishmania

(2013) MAYA BERG et al.   PARASITOLOGY

A Role for SIRT2-Dependent Histone H3K18 Deacetylation in Bacterial Infection

(2013) H. A. Eskandarian et al.   SCIENCE

Suppression of the antiviral response by an influenza histone mimic

(2012) Ivan Marazzi et al.   NATURE

Leishmaniasis Worldwide and Global Estimates of Its Incidence

(2012) Jorge Alvar et al.   PLoS One

Adaptive mechanisms in pathogens: universal aneuploidy in Leishmania

(2012) An Mannaert et al.   TRENDS IN PARASITOLOGY

Adherence to miltefosine treatment for visceral leishmaniasis under routine conditions in Nepal

(2012) Surendra Uranw et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

Transcriptomic Signature of Leishmania Infected Mice Macrophages: A Metabolic Point of View

(2012) Imen Rabhi et al.   PLoS Neglected Tropical Diseases

Multiple Mutations in Heterogeneous Miltefosine-Resistant Leishmania major Population as Determined by Whole Genome Sequencing

(2012) Adriano C. Coelho et al.   PLoS Neglected Tropical Diseases

Molecular Mechanisms of Drug Resistance in Natural Leishmania Populations Vary with Genetic Background

(2012) Saskia Decuypere et al.   PLoS Neglected Tropical Diseases

Impaired Chromatin Remodelling at STAT1-Regulated Promoters Leads to Global Unresponsiveness of Toxoplasma gondii-Infected Macrophages to IFN-γ

(2012) Christine Lang et al.   PLoS Pathogens

SMYD3 Promotes Cancer Invasion by Epigenetic Upregulation of the Metalloproteinase MMP-9

(2011) A. M. Cock-Rada et al.   CANCER RESEARCH

Leishmania Promotes Its Own Virulence by Inducing Expression of the Host Immune Inhibitory Ligand CD200

(2011) Mauro Cortez et al.   Cell Host & Microbe

Uncoupling Protein 2 Negatively Regulates Mitochondrial Reactive Oxygen Species Generation and Induces Phosphatase-Mediated Anti-Inflammatory Response in Experimental Visceral Leishmaniasis

(2011) W. Basu Ball et al.   JOURNAL OF IMMUNOLOGY

Combination therapy for visceral leishmaniasis

(2011) Johan van Griensven et al.   LANCET

Leishmaniasis: complexity at the host–pathogen interface

(2011) Paul Kaye et al.   NATURE REVIEWS MICROBIOLOGY

Metabolic Pathways Required for the Intracellular Survival of Leishmania

(2010) Malcolm J. McConville et al.   Annual Review of Microbiology

ToxoplasmaRhoptry Protein 16 (ROP16) Subverts Host Function by Direct Tyrosine Phosphorylation of STAT6

(2010) Yi-Ching Ong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An exosome-based secretion pathway is responsible for protein export from Leishmania and communication with macrophages

(2010) Judith Maxwell Silverman et al.   JOURNAL OF CELL SCIENCE

Plasmodium falciparum FIKK Kinase Members Target Distinct Components of the Erythrocyte Membrane

(2010) Marta C. Nunes et al.   PLoS One

Antimony Toxicity

(2010) Shyam Sundar et al.   International Journal of Environmental Research and Public Health

Geographical Variation in the Response of Visceral Leishmaniasis to Paromomycin in East Africa: A Multicentre, Open-Label, Randomized Trial

(2010) Asrat Hailu et al.   PLoS Neglected Tropical Diseases

Histone Methylation by NUE, a Novel Nuclear Effector of the Intracellular Pathogen Chlamydia trachomatis

(2010) Meghan E. Pennini et al.   PLoS Pathogens

Transcriptional signatures of BALB/c mouse macrophages housing multiplying Leishmania amazonensis amastigotes

(2009) Jose Osorio y Fortea et al.   BMC GENOMICS

A single polymorphic amino acid onToxoplasma gondiikinase ROP16 determines the direct and strain-specific activation of Stat3

(2009) Masahiro Yamamoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mammalian Casein Kinase 1  and Its Leishmanial Ortholog Regulate Stability of IFNAR1 and Type I Interferon Signaling

(2009) J. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Gene expression modulation is associated with gene amplification, supernumerary chromosomes and chromosome loss in antimony-resistant Leishmania infantum

(2009) P. Leprohon et al.   NUCLEIC ACIDS RESEARCH

Induction of apoptosis in host cells: a survival mechanism for Leishmania parasites?

(2008) G. T. GETTI et al.   PARASITOLOGY

Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy

(2008) Jean-Michel Ubeda et al.   GENOME BIOLOGY

Proteomic analysis of the secretome of Leishmania donovani

(2008) J Maxwell Silverman et al.   GENOME BIOLOGY