Leishmaniasis: complexity at the host–pathogen interface

Functional Dichotomy of Dendritic Cells following Interaction with Leishmania braziliensis: Infected Cells Produce High Levels of TNF- , whereas Bystander Dendritic Cells Are Activated to Promote T Cell Responses

(2014) L. P. Carvalho et al.   JOURNAL OF IMMUNOLOGY

Priming of CD8+ and CD4+ T Cells in Experimental Leishmaniasis Is Initiated by Different Dendritic Cell Subtypes

(2014) N. Brewig et al.   JOURNAL OF IMMUNOLOGY

CD40-Modulated Dual-Specificity Phosphatases MAPK Phosphatase (MKP)-1 and MKP-3 Reciprocally Regulate Leishmania major Infection

(2011) N. Srivastava et al.   JOURNAL OF IMMUNOLOGY

Leishmania RNA Virus Controls the Severity of Mucocutaneous Leishmaniasis

(2011) A. Ives et al.   SCIENCE

Vaccines for the Leishmaniases: Proposals for a Research Agenda

(2011) et al.   PLoS Neglected Tropical Diseases

Temperature increase prevails over acidification in gene expression modulation of amastigote differentiation in Leishmania infantum

(2010) Pedro J Alcolea et al.   BMC GENOMICS

Exosomes and other microvesicles in infection biology: organelles with unanticipated phenotypes

(2010) Judith Maxwell Silverman et al.   CELLULAR MICROBIOLOGY

Leishmania parasitophorous vacuoles interact continuously with the host cell's endoplasmic reticulum; parasitophorous vacuoles are hybrid compartments

(2010) Blaise Ndjamen et al.   CELLULAR MICROBIOLOGY

The stage-regulated HASPB and SHERP proteins are essential for differentiation of the protozoan parasite Leishmania major in its sand fly vector, Phlebotomus papatasi

(2010) Jovana Sádlová et al.   CELLULAR MICROBIOLOGY

Role of chemokines in regulation of immunity against leishmaniasis

(2010) Steve Oghumu et al.   EXPERIMENTAL PARASITOLOGY

Leukocytes Infiltrate the Skin and Draining Lymph Nodes in Response to the ProtozoanLeishmania infantum chagasi

(2010) Colin J. Thalhofer et al.   INFECTION AND IMMUNITY

Selective Fusion of Azurophilic Granules withLeishmania-containing Phagosomes in Human Neutrophils

(2010) Faustino Mollinedo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An exosome-based secretion pathway is responsible for protein export from Leishmania and communication with macrophages

(2010) Judith Maxwell Silverman et al.   JOURNAL OF CELL SCIENCE

Inhibition of receptor tyrosine kinases restores immunocompetence and improves immune-dependent chemotherapy against experimental leishmaniasis in mice

(2010) Jane E. Dalton et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-10 production differentially influences the magnitude, quality, and protective capacity of Th1 responses depending on the vaccine platform

(2010) Patricia A. Darrah et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type I IFN Receptor Regulates Neutrophil Functions and Innate Immunity to Leishmania Parasites

(2010) L. Xin et al.   JOURNAL OF IMMUNOLOGY

Leishmania donovani Promastigotes Evade the Antimicrobial Activity of Neutrophil Extracellular Traps

(2010) C. Gabriel et al.   JOURNAL OF IMMUNOLOGY

CD40 Signaling in CD8+CD40+ T Cells Turns On Contra-T Regulatory Cell Functions

(2010) S. Martin et al.   JOURNAL OF IMMUNOLOGY

Leishmania Exosomes Modulate Innate and Adaptive Immune Responses through Effects on Monocytes and Dendritic Cells

(2010) J. M. Silverman et al.   JOURNAL OF IMMUNOLOGY

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

Leishmania major Survival in Selective Phlebotomus papatasi Sand Fly Vector Requires a Specific SCG-Encoded Lipophosphoglycan Galactosylation Pattern

(2010) Deborah E. Dobson et al.   PLoS Pathogens

Innate Killing of Leishmania donovani by Macrophages of the Splenic Marginal Zone Requires IRF-7

(2010) Rebecca Phillips et al.   PLoS Pathogens

Dynamic Imaging of Experimental Leishmania donovani-Induced Hepatic Granulomas Detects Kupffer Cell-Restricted Antigen Presentation to Antigen-Specific CD8+ T Cells

(2010) Lynette Beattie et al.   PLoS Pathogens

Neutrophil-Derived CCL3 Is Essential for the Rapid Recruitment of Dendritic Cells to the Site of Leishmania major Inoculation in Resistant Mice

(2010) Mélanie Charmoy et al.   PLoS Pathogens

CEACAM1+ myeloid cells control angiogenesis in inflammation

(2009) A. K. Horst et al.   BLOOD

Transcriptional signatures of BALB/c mouse macrophages housing multiplying Leishmania amazonensis amastigotes

(2009) Jose Osorio y Fortea et al.   BMC GENOMICS

A Dynamic Map of Antigen Recognition by CD4 T Cells at the Site of Leishmania major Infection

(2009) Orchidée Filipe-Santos et al.   Cell Host & Microbe

Leishmania donovani-induced expression of signal regulatory protein α on Kupffer cells enhances hepatic invariant NKT-cell activation

(2009) Lynette Beattie et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Novel role for the double-stranded RNA-activated protein kinase PKR: modulation of macrophage infection by the protozoan parasite Leishmania

(2009) Renata M. S. Pereira et al.   FASEB JOURNAL

NF-κB-mediated repression of iNOS expression in Leishmania amazonensis macrophage infection

(2009) Teresa C. Calegari-Silva et al.   IMMUNOLOGY LETTERS

Dendritic Cells Matured by Inflammation Induce CD86-Dependent Priming of Naive CD8+ T Cells in the Absence of Their Cognate Peptide Antigen

(2009) A. Maroof et al.   JOURNAL OF IMMUNOLOGY

IL-7 Receptor Expression Provides the Potential for Long-Term Survival of Both CD62Lhigh Central Memory T Cells and Th1 Effector Cells during Leishmania major Infection

(2009) S. L. Colpitts et al.   JOURNAL OF IMMUNOLOGY

Neutrophils and Macrophages Cooperate in Host Resistance against Leishmania braziliensis Infection

(2009) F. O. Novais et al.   JOURNAL OF IMMUNOLOGY

IL-17 Promotes Progression of Cutaneous Leishmaniasis in Susceptible Mice

(2009) S. Lopez Kostka et al.   JOURNAL OF IMMUNOLOGY

Regulatory B Cells Shape the Development of Th2 Immune Responses in BALB/c Mice Infected with Leishmania major Through IL-10 Production

(2009) C. Ronet et al.   JOURNAL OF IMMUNOLOGY

Functional characterization of LIT1, the Leishmania amazonensis ferrous iron transporter

(2009) Ismaele Jacques et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Leishmania major parasites induced macrophage tolerance: Implication of MAPK and NF-κB pathways

(2009) Rym Ben-Othman et al.   MOLECULAR IMMUNOLOGY

Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function

(2009) Abdur Rub et al.   NATURE IMMUNOLOGY

Recruitment of CD8+T cells expressing granzyme A is associated with lesion progression in human cutaneous leishmaniasis

(2009) D. R. FARIA et al.   PARASITE IMMUNOLOGY

Infectivity of Leishmania mexicana Is Associated with Differential Expression of Protein Kinase C-Like Triggered during a Cell-Cell Contact

(2009) Nidia Alvarez-Rueda et al.   PLoS One

A human IL10 BAC transgene reveals tissue-specific control of IL-10 expression and alters disease outcome

(2009) D. Ranatunga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular traps

(2009) A. B. Guimaraes-Costa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Demonstration of Genetic Exchange During Cyclical Development of Leishmania in the Sand Fly Vector

(2009) N. S. Akopyants et al.   SCIENCE

Leishmania GP63 Alters Host Signaling Through Cleavage-Activated Protein Tyrosine Phosphatases

(2009) M. A. Gomez et al.   Science Signaling

Interleukin-33 – cytokine of dual function or novel alarmin?

(2009) Guttorm Haraldsen et al.   TRENDS IN IMMUNOLOGY

B7-H1 Blockade Increases Survival of Dysfunctional CD8+ T Cells and Confers Protection against Leishmania donovani Infections

(2009) Trupti Joshi et al.   PLoS Pathogens

A Novel Role for Stat1 in Phagosome Acidification and Natural Host Resistance to Intracellular Infection by Leishmania major

(2009) Gerald F. Späth et al.   PLoS Pathogens

The Leishmania donovani Lipophosphoglycan Excludes the Vesicular Proton-ATPase from Phagosomes by Impairing the Recruitment of Synaptotagmin V

(2009) Adrien F. Vinet et al.   PLoS Pathogens

iNOS-Producing Inflammatory Dendritic Cells Constitute the Major Infected Cell Type during the Chronic Leishmania major Infection Phase of C57BL/6 Resistant Mice

(2009) Carl De Trez et al.   PLoS Pathogens

Heme as a source of iron to Leishmania infantum amastigotes

(2008) Sandra Carvalho et al.   ACTA TROPICA

Leishmania donovanidepletes labile iron pool to exploit iron uptake capacity of macrophage for its intracellular growth

(2008) Nupur Kanti Das et al.   CELLULAR MICROBIOLOGY

Leishmania major intracellular survival is not altered in SHP-1 deficient mev or CD45−/− mice

(2008) Gerald F. Späth et al.   EXPERIMENTAL PARASITOLOGY

Real-time imaging of Leishmania mexicana-infected early phagosomes: a study using primary macrophages generated from green fluorescent protein-Rab5 transgenic mice

(2008) Christoph Lippuner et al.   FASEB JOURNAL

Posttranscriptional Regulation of Il10 Gene Expression Allows Natural Killer Cells to Express Immunoregulatory Function

(2008) Asher Maroof et al.   IMMUNITY

TheLeishmaniaSurface Protease GP63 Cleaves Multiple Intracellular Proteins and Actively Participates in p38 Mitogen-activated Protein Kinase Inactivation

(2008) Maxime Hallé et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leishmania infantumPromastigotes Reduce Entry of HIV‐1 into Macrophages through a Lipophosphoglycan‐Mediated Disruption of Lipid Rafts

(2008) Ravendra Garg et al.   JOURNAL OF INFECTIOUS DISEASES

Leishmania donovani lipophosphoglycan inhibits phagosomal maturation via action on membrane rafts

(2008) Martin E. Winberg et al.   MICROBES AND INFECTION

Leishmania initially activates but subsequently down-regulates intracellular mitogen-activated protein kinases and nuclear factor-κB signaling in macrophages

(2008) Rym Ben-Othman et al.   MOLECULAR IMMUNOLOGY

Hierarchical Effector Protein Transport by the Salmonella Typhimurium SPI-1 Type III Secretion System

(2008) Brit Winnen et al.   PLoS One

In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies

(2008) N. C. Peters et al.   SCIENCE

Postgenomic research on leishmaniasis: a critical self-appraisal

(2008) Paul M. Kaye et al.   TRENDS IN PARASITOLOGY

Migratory Dermal Dendritic Cells Act as Rapid Sensors of Protozoan Parasites

(2008) Lai Guan Ng et al.   PLoS Pathogens

Control of Parasitophorous Vacuole Expansion by LYST/Beige Restricts the Intracellular Growth of Leishmania amazonensis

(2008) Jude Wilson et al.   PLoS Pathogens

The major surface protease (MSP or GP63) in the intracellular amastigote stage of Leishmania chagasi

(2007) Chia-Hung Christine Hsiao et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY