A central role for the acid sphingomyelinase/ceramide system in neurogenesis and major depression

Neurogenesis in the Striatum of the Adult Human Brain

(2014) Aurélie Ernst et al.   CELL

Acid Sphingomyelinase Amplifies Redox Signaling in Pseudomonas aeruginosa-Induced Macrophage Apoptosis

(2014) Y. Zhang et al.   JOURNAL OF IMMUNOLOGY

A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse

(2014) J. P. Magnusson et al.   SCIENCE

Dynamics of Hippocampal Neurogenesis in Adult Humans

(2013) Kirsty L. Spalding et al.   CELL

Acid sphingomyelinase–ceramide system mediates effects of antidepressant drugs

(2013) Erich Gulbins et al.   NATURE MEDICINE

Review: Adult neurogenesis and its role in neuropsychiatric disease, brain repair and normal brain function

(2013) S. M. G. Braun et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Neuroscience of Exercise: From Neurobiology Mechanisms to Mental Health

(2013) Eduardo Matta Mello Portugal et al.   NEUROPSYCHOBIOLOGY

Why Adults Need New Brain Cells

(2013) O. Bergmann et al.   SCIENCE

Young Dentate Granule Cells Mediate Pattern Separation, whereas Old Granule Cells Facilitate Pattern Completion

(2012) Toshiaki Nakashiba et al.   CELL

Fluoxetine Upregulates Phosphorylated-AKT and Phosphorylated-ERK1/2 Proteins in Neural Stem Cells: Evidence for a Crosstalk between AKT and ERK1/2 Pathways

(2012) Wen Huang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Acid Ceramidase (ASAH1) Is a Global Regulator of Steroidogenic Capacity and Adrenocortical Gene Expression

(2012) Natasha C. Lucki et al.   MOLECULAR ENDOCRINOLOGY

Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders

(2012) Mazen A Kheirbek et al.   NATURE NEUROSCIENCE

It’s a Lipid’s World: Bioactive Lipid Metabolism and Signaling in Neural Stem Cell Differentiation

(2012) Erhard Bieberich   NEUROCHEMICAL RESEARCH

The Age of Olfactory Bulb Neurons in Humans

(2012) Olaf Bergmann et al.   NEURON

Proliferative Neural Stem Cells Have High Endogenous ROS Levels that Regulate Self-Renewal and Neurogenesis in a PI3K/Akt-Dependant Manner

(2011) Janel E. Le Belle et al.   Cell Stem Cell

Comparing adult hippocampal neurogenesis in mammalian species and orders: influence of chronological age and life history stage

(2011) Irmgard Amrein et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Brain pathology in Niemann Pick disease type A: insights from the acid sphingomyelinase knockout mice

(2011) Maria Dolores Ledesma et al.   JOURNAL OF NEUROCHEMISTRY

Antidepressants recruit new neurons to improve stress response regulation

(2011) A Surget et al.   MOLECULAR PSYCHIATRY

Adult hippocampal neurogenesis buffers stress responses and depressive behaviour

(2011) Jason S. Snyder et al.   NATURE

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

(2011) Amar Sahay et al.   NATURE

Corridors of migrating neurons in the human brain and their decline during infancy

(2011) Nader Sanai et al.   NATURE

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions

(2011) Guo-li Ming et al.   NEURON

Identification of Novel Functional Inhibitors of Acid Sphingomyelinase

(2011) Johannes Kornhuber et al.   PLoS One

Wnt3a Promotes Hippocampal Neurogenesis by Shortening Cell Cycle Duration of Neural Progenitor Cells

(2010) Yutaka Yoshinaga et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): A Novel Pharmacological Group of Drugs with Broad Clinical Applications

(2010) Johannes Kornhuber et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Syntaxin 4 Is Required for Acid Sphingomyelinase Activity and Apoptotic Function

(2010) Cristiana Perrotta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Mechanism of Lysosomal Acid Sphingomyelinase Maturation

(2010) Russell W. Jenkins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial Membrane Remodeling Is Obligate for Anti-Angiogenic Radiosensitization during Tumor Radiosurgery

(2010) Jean-Philip Truman et al.   PLoS One

The glucocorticoid receptor: Pivot of depression and of antidepressant treatment?

(2010) Christoph Anacker et al.   PSYCHONEUROENDOCRINOLOGY

Neurogenesis-Dependent and -Independent Effects of Fluoxetine in an Animal Model of Anxiety/Depression

(2009) Denis J. David et al.   NEURON

DISC1 Regulates New Neuron Development in the Adult Brain via Modulation of AKT-mTOR Signaling through KIAA1212

(2009) Ju Young Kim et al.   NEURON

Inhibition of PI3K-Akt Signaling Blocks Exercise-Mediated Enhancement of Adult Neurogenesis and Synaptic Plasticity in the Dentate Gyrus

(2009) Elodie Bruel-Jungerman et al.   PLoS One

Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis

(2009) M Bryant Howren et al.   PSYCHOSOMATIC MEDICINE

A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation

(2009) C. D. Clelland et al.   SCIENCE

Mechanisms and Functional Implications of Adult Neurogenesis

(2008) Chunmei Zhao et al.   CELL

The sphingolipid salvage pathway in ceramide metabolism and signaling

(2008) Kazuyuki Kitatani et al.   CELLULAR SIGNALLING

Regulation of neural progenitor cell motility by ceramide and potential implications for mouse brain development

(2008) Guanghu Wang et al.   JOURNAL OF NEUROCHEMISTRY

Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis

(2008) Volker Teichgräber et al.   NATURE MEDICINE

Environmental enrichment, exercise and corticosterone affect endothelial cell proliferation in adult rat hippocampus and prefrontal cortex

(2008) Joakim Ekstrand et al.   NEUROSCIENCE LETTERS

Major Depressive Disorder

(2008) R.H. Belmaker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of New Functional Inhibitors of Acid Sphingomyelinase Using a Structure−Property−Activity Relation Model

(2007) Johannes Kornhuber et al.   JOURNAL OF MEDICINAL CHEMISTRY