Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model
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Title
Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model
Authors
Keywords
Parkinson’s disease, α<em class=EmphasisTypeItalic >-</em>synuclein, Telomeres, Microglia
Journal
Acta Neuropathologica Communications
Volume 4, Issue 1, Pages -
Publisher
Springer Nature
Online
2016-08-22
DOI
10.1186/s40478-016-0364-x
References
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Related references
Note: Only part of the references are listed.- Glia and alpha-synuclein in neurodegeneration: A complex interaction
- (2016) Dominik Brück et al. NEUROBIOLOGY OF DISEASE
- Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening
- (2015) Divya D. A. Raj et al. AGING CELL
- Nuclear Receptors License Phagocytosis by Trem2+ Myeloid Cells in Mouse Models of Alzheimer's Disease
- (2015) J. C. Savage et al. JOURNAL OF NEUROSCIENCE
- Neuroinflammation in Alzheimer's disease
- (2015) Michael T Heneka et al. LANCET NEUROLOGY
- Central nervous system myeloid cells as drug targets: current status and translational challenges
- (2015) Knut Biber et al. NATURE REVIEWS DRUG DISCOVERY
- The link between the SNCA gene and parkinsonism
- (2015) Wei Xu et al. NEUROBIOLOGY OF AGING
- Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders
- (2015) Stefano G. Daniele et al. Science Signaling
- Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders
- (2015) Stefano G. Daniele et al. Science Signaling
- Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice
- (2014) Oleg Butovsky et al. ANNALS OF NEUROLOGY
- HTSeq--a Python framework to work with high-throughput sequencing data
- (2014) S. Anders et al. BIOINFORMATICS
- In acute experimental autoimmune encephalomyelitis, infiltrating macrophages are immune activated, whereas microglia remain immune suppressed
- (2014) I. D. Vainchtein et al. GLIA
- What is microglia neurotoxicity (Not)?
- (2014) Knut Biber et al. GLIA
- Presynaptic Alpha-Synuclein Aggregation in a Mouse Model of Parkinson's Disease
- (2014) K. J. Spinelli et al. JOURNAL OF NEUROSCIENCE
- Microglial priming in neurodegenerative disease
- (2014) V. Hugh Perry et al. Nature Reviews Neurology
- Nuclear receptors in neurodegenerative diseases
- (2014) Rebecca Skerrett et al. NEUROBIOLOGY OF DISEASE
- Expression of Inducible Nitric Oxide Synthase (iNOS) in Microglia of the Developing Quail Retina
- (2014) Ana Sierra et al. PLoS One
- Microglial Senescence
- (2013) Wolfgang Streit et al. CNS & Neurological Disorders-Drug Targets
- Telomere length and Parkinson's disease in men: a nested case−control study
- (2013) M. Schürks et al. EUROPEAN JOURNAL OF NEUROLOGY
- Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
- (2013) Katrin Kierdorf et al. NATURE NEUROSCIENCE
- Microglia: New Roles for the Synaptic Stripper
- (2013) Helmut Kettenmann et al. NEURON
- Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies
- (2013) Gaia Codolo et al. PLoS One
- The role of Ser129 phosphorylation of α-synuclein in neurodegeneration of Parkinson’s disease: a review of in vivo models
- (2013) Hiroyasu Sato et al. REVIEWS IN THE NEUROSCIENCES
- Functional diversity of microglia – how heterogeneous are they to begin with?
- (2013) Uwe-Karsten Hanisch Frontiers in Cellular Neuroscience
- The brain’s best friend: microglial neurotoxicity revisited
- (2013) Sabine Hellwig et al. Frontiers in Cellular Neuroscience
- Microglia and monocyte-derived macrophages: functionally distinct populations that act in concert in CNS plasticity and repair
- (2013) Anat London et al. Frontiers in Cellular Neuroscience
- Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease
- (2013) Sheila M. Fleming et al. Jove-Journal of Visualized Experiments
- A System-Level Transcriptomic Analysis of Schizophrenia Using Postmortem Brain Tissue Samples
- (2012) Panos Roussos et al. ARCHIVES OF GENERAL PSYCHIATRY
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- Telomere length shortening in patients with dementia with Lewy bodies
- (2012) K. Kume et al. EUROPEAN JOURNAL OF NEUROLOGY
- Aging-Associated Alteration of Telomere Length and Subtelomeric Status in Female Patients With Parkinson's Disease
- (2012) Toyoki Maeda et al. JOURNAL OF NEUROGENETICS
- Neuroprotective function for ramified microglia in hippocampal excitotoxicity
- (2012) Jonathan Vinet et al. Journal of Neuroinflammation
- Review: Microglia of the aged brain: primed to be activated and resistant to regulation
- (2012) D. M. Norden et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Nuclear Hormone Receptors Enable Macrophages and Dendritic Cells to Sense Their Lipid Environment and Shape Their Immune Response
- (2012) Laszlo Nagy et al. PHYSIOLOGICAL REVIEWS
- A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
- (2012) C. Schulz et al. SCIENCE
- Toll-Like Receptor 4 Promotes α-Synuclein Clearance and Survival of Nigral Dopaminergic Neurons
- (2011) Nadia Stefanova et al. AMERICAN JOURNAL OF PATHOLOGY
- A Percentage Analysis of the Telomere Length in Parkinson's Disease Patients
- (2011) J. Z. Guan et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- In vivo demonstration that -synuclein oligomers are toxic
- (2011) B. Winner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Study of telomere length and different markers of oxidative stress in patients with Parkinson’s disease
- (2010) G. Watfa et al. Journal of Nutrition Health & Aging
- No Evidence for Shorter Leukocyte Telomere Length in Parkinson's Disease Patients
- (2010) J. Eerola et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Morphological impairments in microglia precede age-related neuronal degeneration in senescence-accelerated mice
- (2010) Sanae Hasegawa-Ishii et al. NEUROPATHOLOGY
- Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
- (2010) F. Ginhoux et al. SCIENCE
- Microglial Interactions with Synapses Are Modulated by Visual Experience
- (2010) Marie-Ève Tremblay et al. PLOS BIOLOGY
- edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
- (2009) M. D. Robinson et al. BIOINFORMATICS
- Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
- (2009) Da Wei Huang et al. Nature Protocols
- Cellular glutathione peroxidase in human brain: cellular distribution, and its potential role in the degradation of Lewy bodies in Parkinson’s disease and dementia with Lewy bodies
- (2008) John H. T. Power et al. ACTA NEUROPATHOLOGICA
- Microglial phagocytosis is enhanced by monomeric α-synuclein, not aggregated α-synuclein: Implications for Parkinson's disease
- (2008) Ji-Young Park et al. GLIA
- Assembly-dependent endocytosis and clearance of extracellular a-synuclein
- (2008) He-Jin Lee et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
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