Maintenance of genome stability by Fanconi anemia proteins

Mechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3

(2016) A. F. Alpi et al.   BIOCHEMICAL JOURNAL

Cellular response to DNA interstrand crosslinks: the Fanconi anemia pathway

(2016) David Lopez-Martinez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Interplay between Fanconi anemia and homologous recombination pathways in genome integrity

(2016) Johanna Michl et al.   EMBO JOURNAL

Noncanonical views of homology-directed DNA repair

(2016) Priyanka Verma et al.   GENES & DEVELOPMENT

Biallelic inactivation of REV7 is associated with Fanconi anemia

(2016) Dominique Bluteau et al.   JOURNAL OF CLINICAL INVESTIGATION

Complementation of hypersensitivity to DNA interstrand crosslinking agents demonstrates thatXRCC2is a Fanconi anaemia gene

(2016) Jung-Young Park et al.   JOURNAL OF MEDICAL GENETICS

FANCD2 Facilitates Replication through Common Fragile Sites

(2016) Advaitha Madireddy et al.   MOLECULAR CELL

Aldehydes with high and low toxicities inactivate cells by damaging distinct cellular targets

(2016) Ming-Zhang Xie et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The Fanconi anaemia pathway: new players and new functions

(2016) Raphael Ceccaldi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA repair targeted therapy: The past or future of cancer treatment?

(2016) Navnath S. Gavande et al.   PHARMACOLOGY & THERAPEUTICS

Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability

(2016) C. Lachaud et al.   SCIENCE

p53 downregulates the Fanconi anaemia DNA repair pathway

(2016) Sara Jaber et al.   Nature Communications

FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair

(2016) Zeina Kais et al.   Cell Reports

Mutations in the Gene Encoding the E2 Conjugating Enzyme UBE2T Cause Fanconi Anemia

(2015) Asuka Hira et al.   AMERICAN JOURNAL OF HUMAN GENETICS

DNA Damage in Cancer Therapeutics: A Boon or a Curse?

(2015) Anchit Khanna   CANCER RESEARCH

What is the DNA repair defect underlying Fanconi anemia?

(2015) Julien P Duxin et al.   CURRENT OPINION IN CELL BIOLOGY

Fanconi anemia: a model disease for studies on human genetics and advanced therapeutics

(2015) Massimo Bogliolo et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Preventing replication fork collapse to maintain genome integrity

(2015) David Cortez   DNA REPAIR

Regulation of the Rev1-pol   complex during bypass of a DNA interstrand cross-link

(2015) M. Budzowska et al.   EMBO JOURNAL

AluY-mediated germline deletion, duplication and somatic stem cell reversion inUBE2Tdefines a new subtype of Fanconi anemia

(2015) Elizabeth L. Virts et al.   HUMAN MOLECULAR GENETICS

The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription

(2015) Rebekka A. Schwab et al.   MOLECULAR CELL

Alternative end-joining repair pathways are the ultimate backup for abrogated classical non-homologous end-joining and homologous recombination repair: Implications for the formation of chromosome translocations

(2015) George Iliakis et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

DNA interstrand cross-link repair requires replication-fork convergence

(2015) Jieqiong Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells

(2015) Emilie Renaud et al.   NUCLEIC ACIDS RESEARCH

Fanconi anemia (FA) and crosslinker sensitivity: Re-appraising the origins of FA definition

(2015) Giovanni Pagano et al.   PEDIATRIC BLOOD & CANCER

DNA interstrand cross-link repair requires replication-fork convergence

(2015) Jieqiong Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia

(2015) Kimberly A. Rickman et al.   Cell Reports

The Fanconi Anemia Pathway Protects Genome Integrity from R-loops

(2015) María L. García-Rubio et al.   PLoS Genetics

DNA Damage Response Factors from Diverse Pathways, Including DNA Crosslink Repair, Mediate Alternative End Joining

(2015) Sean M. Howard et al.   PLoS Genetics

The Fanconi anemia ID2 complex: Dueling saxes at the crossroads

(2014) Rebecca A Boisvert et al.   CELL CYCLE

Mechanism and regulation of incisions during DNA interstrand cross-link repair

(2014) Jieqiong Zhang et al.   DNA REPAIR

A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression

(2014) K. Skourti-Stathaki et al.   GENES & DEVELOPMENT

Proteomic analysis reveals a FANCA-modulated neddylation pathway involved in CXCR5 membrane targeting and cell mobility

(2014) X. Renaudin et al.   JOURNAL OF CELL SCIENCE

Fanca deficiency reduces A/T transitions in somatic hypermutation and alters class switch recombination junctions in mouse B cells

(2014) Thuy Vy Nguyen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Therapeutic Melting Pot of Never in Mitosis Gene A Related Kinase 2 (Nek2): A Perspective on Nek2 as an Oncology Target and Recent Advancements in Nek2 Small Molecule Inhibition

(2014) Brendan Frett et al.   JOURNAL OF MEDICINAL CHEMISTRY

BRCA1 Promotes Unloading of the CMG Helicase from a Stalled DNA Replication Fork

(2014) David T. Long et al.   MOLECULAR CELL

Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink Repair

(2014) Michael R.G. Hodskinson et al.   MOLECULAR CELL

R-loops induce repressive chromatin marks over mammalian gene terminators

(2014) Konstantina Skourti-Stathaki et al.   NATURE

Fanconi anemia signaling and Mus81 cooperate to safeguard development and crosslink repair

(2014) Meghan Larin et al.   NUCLEIC ACIDS RESEARCH

Biallelic Mutations in BRCA1 Cause a New Fanconi Anemia Subtype

(2014) Sarah L. Sawyer et al.   Cancer Discovery

FANCD2 and CtIP Cooperate to Repair DNA Interstrand Crosslinks

(2014) Olga Murina et al.   Cell Reports

Modularized Functions of the Fanconi Anemia Core Complex

(2014) Yaling Huang et al.   Cell Reports

Coregulation of FANCA and BRCA1 in human cells

(2014) Anneke Haitjema et al.   SpringerPlus

Mutations in ERCC4, Encoding the DNA-Repair Endonuclease XPF, Cause Fanconi Anemia

(2013) Massimo Bogliolo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

TNF-α signaling in Fanconi anemia

(2013) Wei Du et al.   BLOOD CELLS MOLECULES AND DISEASES

The detection and implication of genome instability in cancer

(2013) Larissa Pikor et al.   CANCER AND METASTASIS REVIEWS

PARP and CHK inhibitors interact to cause DNA damage and cell death in mammary carcinoma cells

(2013) Laurence Booth et al.   CANCER BIOLOGY & THERAPY

Fanconi anemia complementation group A (FANCA) localizes to centrosomes and functions in the maintenance of centrosome integrity

(2013) Sunshin Kim et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Fanconi anemia signaling network regulates the spindle assembly checkpoint

(2013) Grzegorz Nalepa et al.   JOURNAL OF CLINICAL INVESTIGATION

Fanconi anaemia and the repair of Watson and Crick DNA crosslinks

(2013) Molly C. Kottemann et al.   NATURE

Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips

(2013) Nikita Gudimchuk et al.   NATURE CELL BIOLOGY

MUS81 promotes common fragile site expression

(2013) Songmin Ying et al.   NATURE CELL BIOLOGY

Damage-dependent regulation of MUS81-EME1 by Fanconi anemia complementation group A protein

(2013) Anaid Benitez et al.   NUCLEIC ACIDS RESEARCH

Evidence of mitochondrial dysfunction and impaired ROS detoxifying machinery in Fanconi Anemia cells

(2013) U Kumari et al.   ONCOGENE

Human Fanconi Anemia Complementation Group A Protein Stimulates the 5’ Flap Endonuclease Activity of FEN1

(2013) Liangyue Qian et al.   PLoS One

Biosensing Approaches for Rapid Genotoxicity and Cytotoxicity Assays upon Nanomaterial Exposure

(2013) Xuena Zhu et al.   Small

Advances in Understanding the Complex Mechanisms of DNA Interstrand Cross-Link Repair

(2013) C. Clauson et al.   Cold Spring Harbor Perspectives in Biology

The FA pathway counteracts oxidative stress through selective protection of antioxidant defense gene promoters

(2012) W. Du et al.   BLOOD

Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4

(2012) Y. Kim et al.   BLOOD

FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway

(2012) A. M. Ali et al.   BLOOD

Human MUS81 complexes stimulate flap endonuclease 1

(2012) Yong-Keol Shin et al.   FEBS Journal

Multiple DNA Binding Domains Mediate the Function of the ERCC1-XPF Protein in Nucleotide Excision Repair

(2012) Yan Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

R Loops: From Transcription Byproducts to Threats to Genome Stability

(2012) Andrés Aguilera et al.   MOLECULAR CELL

FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair

(2012) Weibin Zhou et al.   NATURE GENETICS

Defining the molecular interface that connects the Fanconi anemia protein FANCM to the Bloom syndrome dissolvasome

(2012) K. A. Hoadley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The complex basis underlying common fragile site instability in cancer

(2012) Efrat Ozeri-Galai et al.   TRENDS IN GENETICS

Oxidative stress in Fanconi anaemia: from cells and molecules towards prospects in clinical management

(2011) Giovanni Pagano et al.   BIOLOGICAL CHEMISTRY

Myelodysplasia and leukemia of Fanconi anemia are associated with a specific pattern of genomic abnormalities that includes cryptic RUNX1/AML1 lesions

(2011) S. Quentin et al.   BLOOD

Orchestrating the nucleases involved in DNA interstrand cross-link (ICL) repair

(2011) Blanka Sengerová et al.   CELL CYCLE

Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair

(2011) A. T. Wang et al.   GENES & DEVELOPMENT

Fanconi Anemia Complementation Group A (FANCA) Protein Has Intrinsic Affinity for Nucleic Acids with Preference for Single-stranded Forms

(2011) Fenghua Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA damage induced by endogenous aldehydes: Current state of knowledge

(2011) Georgia-Persephoni Voulgaridou et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice

(2011) Frédéric Langevin et al.   NATURE

Direct Inhibition of TNF-α Promoter Activity by Fanconi Anemia Protein FANCD2

(2011) Nobuko Matsushita et al.   PLoS One

PARP inhibitors: its role in treatment of cancer

(2011) Alice Chen   Chinese Journal of Cancer

Knockdown of μ-Calpain in Fanconi Anemia, FA-A, Cells by siRNA Restores αII Spectrin Levels and Corrects Chromosomal Instability and Defective DNA Interstrand Cross-Link Repair

(2010) Pan Zhang et al.   BIOCHEMISTRY

Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2

(2010) Craig MacKay et al.   CELL

Deficiency of FANCD2-Associated Nuclease KIAA1018/FAN1 Sensitizes Cells to Interstrand Crosslinking Agents

(2010) Katja Kratz et al.   CELL

Human KIAA1018/FAN1 localizes to stalled replication forks via its ubiquitin-binding domain

(2010) Robert D. Shereda et al.   CELL CYCLE

The role of FAN1 nuclease in the Fanconi anemia pathway

(2010) Maria Castella et al.   CELL CYCLE

Mechanisms of Chromosomal Instability

(2010) Sarah L. Thompson et al.   CURRENT BIOLOGY

A Genetic Screen Identifies FAN1, a Fanconi Anemia-Associated Nuclease Necessary for DNA Interstrand Crosslink Repair

(2010) Agata Smogorzewska et al.   MOLECULAR CELL

Preventing Nonhomologous End Joining Suppresses DNA Repair Defects of Fanconi Anemia

(2010) Adele Adamo et al.   MOLECULAR CELL

Mutation of the RAD51C gene in a Fanconi anemia–like disorder

(2010) Fiona Vaz et al.   NATURE GENETICS

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Functional regulation of FEN1 nuclease and its link to cancer

(2010) L. Zheng et al.   NUCLEIC ACIDS RESEARCH

KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents

(2010) K. Yoshikiyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FAN1 Acts with FANCI-FANCD2 to Promote DNA Interstrand Cross-Link Repair

(2010) T. Liu et al.   SCIENCE

Identification of FANCA as a protein interacting with centromere-associated protein E

(2009) J. Du et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

How the Fanconi Anemia Pathway Guards the Genome

(2009) George-Lucian Moldovan et al.   Annual Review of Genetics

Knockdown of αII spectrin in normal human cells by siRNA leads to chromosomal instability and decreased DNA interstrand cross-link repair

(2009) Laura W. McMahon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Fanconi Anemia Core Complex Acts as a Transcriptional Co-regulator in Hairy Enhancer of Split 1 Signaling

(2009) Cédric S. Tremblay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

XPF-ERCC1 Participates in the Fanconi Anemia Pathway of Cross-Link Repair

(2009) N. Bhagwat et al.   MOLECULAR AND CELLULAR BIOLOGY

FANCM Connects the Genome Instability Disorders Bloom's Syndrome and Fanconi Anemia

(2009) Andrew J. Deans et al.   MOLECULAR CELL

Fanconi anemia and its diagnosis

(2009) Arleen D. Auerbach   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Chromosome congression: on the bi-orient express

(2009) Emily A. Foley et al.   NATURE CELL BIOLOGY

The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities

(2009) Valeria Naim et al.   NATURE CELL BIOLOGY

The SH3 Domain of αII Spectrin Is a Target for the Fanconi Anemia Protein, FANCG†

(2008) Joel A. Lefferts et al.   BIOCHEMISTRY

ATR-dependent phosphorylation of FANCA on serine 1449 after DNA damage is important for FA pathway function

(2008) N. B. Collins et al.   BLOOD

Mechanism of Replication-Coupled DNA Interstrand Crosslink Repair

(2008) Markus Räschle et al.   CELL

Fanconi anemia proteins stabilize replication forks

(2008) Lily Chien Wang et al.   DNA REPAIR

Self-Promoted DNA Interstrand Cross-Link Formation by an Abasic Site

(2008) Jonathan T. Sczepanski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics