Endocytosis of indium-tin-oxide nanoparticles by macrophages provokes pyroptosis requiring NLRP3-ASC-Caspase1 axis that can be prevented by mesenchymal stem cells

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Pyroptosis of resident macrophages differentially orchestrates inflammatory responses toStaphylococcus aureusin resistant and susceptible mice

(2015) Solène Accarias et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5

(2015) Paul J. Baker et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Alternative activation of macrophages and pulmonary fibrosis are modulated by scavenger receptor, macrophage receptor with collagenous structure

(2015) Shubha Murthy et al.   FASEB JOURNAL

The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein

(2015) Alessia Franceschini et al.   FASEB JOURNAL

K+Efflux Agonists Induce NLRP3 Inflammasome Activation Independently of Ca2+Signaling

(2015) Michael A. Katsnelson et al.   JOURNAL OF IMMUNOLOGY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Sintered Indium-Tin Oxide Particles Induce Pro-Inflammatory Responses In Vitro, in Part through Inflammasome Activation

(2015) Melissa A. Badding et al.   PLoS One

RIPK1 and RIPK3: critical regulators of inflammation and cell death

(2015) Kim Newton   TRENDS IN CELL BIOLOGY

The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine

(2015) L Baron et al.   Cell Death & Disease

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Scavenger Receptor-A (CD204): A Two-Edged Sword in Health and Disease

(2014) Jim L. Kelley et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Cytotoxicity and Characterization of Particles Collected From an Indium–Tin Oxide Production Facility

(2014) Melissa A. Badding et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Inefficient star formation in extremely metal poor galaxies

(2014) Yong Shi et al.   NATURE

The alarmin IL-1α is a master cytokine in acute lung inflammation induced by silica micro- and nanoparticles

(2014) Virginie Rabolli et al.   Particle and Fibre Toxicology

New Insights into Mechanisms Controlling the NLRP3 Inflammasome and Its Role in Lung Disease

(2013) Dominic De Nardo et al.   AMERICAN JOURNAL OF PATHOLOGY

Silica: A lung carcinogen

(2013) Kyle Steenland et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection

(2013) Youssef Aachoui et al.   CURRENT OPINION IN MICROBIOLOGY

Endogenous IL-1α is a chromatin-associated protein in mouse macrophages

(2013) Céline Lamacchia et al.   CYTOKINE

P2X7 receptor is required for neutrophil accumulation in a mouse model of irritant contact dermatitis

(2013) Gabriela L. da Silva et al.   EXPERIMENTAL DERMATOLOGY

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

(2013) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Concise review: Combining human leukocyte antigen G and mesenchymal stem cells for immunosuppressant biotherapy

(2013) Abderrahim Naji et al.   STEM CELLS

Concise Review: Current Status of Stem Cells and Regenerative Medicine in Lung Biology and Diseases

(2013) Daniel J. Weiss   STEM CELLS

Inhaled corticosteroids in severe COPD

(2013) Jean Bousquet   Lancet Respiratory Medicine

Microglial activation of the NLRP3 inflammasome by the priming signals derived from macrophages infected with mycobacteria

(2012) Hye-Mi Lee et al.   GLIA

IL-10 Triggers Changes in Macrophage Phenotype That Promote Muscle Growth and Regeneration

(2012) B. Deng et al.   JOURNAL OF IMMUNOLOGY

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

The antiapoptotic effect of mesenchymal stem cell transplantation on ischemic myocardium is enhanced by anoxic preconditioning

(2011) Aina He et al.   CANADIAN JOURNAL OF CARDIOLOGY

Indium Lung Disease

(2011) Kristin J. Cummings et al.   CHEST

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

Glucocorticoids Sensitize the Innate Immune System through Regulation of the NLRP3 Inflammasome

(2011) John M. Busillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-1  and IL-1  Recruit Different Myeloid Cells and Promote Different Stages of Sterile Inflammation

(2011) P. Rider et al.   JOURNAL OF IMMUNOLOGY

Extracellular ATP Is a Danger Signal Activating P2X7Receptor in Lung Inflammation and Fibrosis

(2010) Nicolas Riteau et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

SR-A/MARCO-mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens

(2010) S. Mukhopadhyay et al.   BLOOD

The Inflammasomes

(2010) Kate Schroder et al.   CELL

The inflammasomes: mechanisms of activation and function

(2010) Eicke Latz   CURRENT OPINION IN IMMUNOLOGY

Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1  and IL-1 

(2010) A. S. Yazdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

(2009) Mohamed Lamkanfi et al.   JOURNAL OF CELL BIOLOGY

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

IL-10 Overexpression Decreases Inflammatory Mediators and Promotes Regenerative Healing in an Adult Model of Scar Formation

(2008) William H. Peranteau et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The scavenger receptor SR-A I/II (CD204) signals via the receptor tyrosine kinase Mertk during apoptotic cell uptake by murine macrophages

(2008) Jill C. Todt et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

Human Leukocyte Antigen-G5 Secretion by Human Mesenchymal Stem Cells Is Required to Suppress T Lymphocyte and Natural Killer Function and to Induce CD4+CD25highFOXP3+Regulatory T Cells

(2007) Zohair Selmani et al.   STEM CELLS

Human Mesenchymal Stem Cells Inhibit Neutrophil Apoptosis: A Model for Neutrophil Preservation in the Bone Marrow Niche

(2007) Lizzia Raffaghello et al.   STEM CELLS