Overexpression of 4EBP1, p70S6K, Akt1 or Akt2 differentially promotes Coxsackievirus B3-induced apoptosis in HeLa cells

GAPDH binds to active Akt, leading to Bcl-xL increase and escape from caspase-independent cell death

(2013) M A Jacquin et al.   CELL DEATH AND DIFFERENTIATION

Cell survival and metastasis regulation by Akt signaling in colorectal cancer

(2013) Ekta Agarwal et al.   CELLULAR SIGNALLING

Both PI3K- and mTOR-Signaling Pathways Take Part in CVB3-Induced Apoptosis of HeLa Cells

(2013) Xin Li et al.   DNA AND CELL BIOLOGY

Akt1-Mediated Regulation of Macrophage Polarization in a Murine Model of Staphylococcus aureus Pulmonary Infection

(2013) Feng Xu et al.   JOURNAL OF INFECTIOUS DISEASES

Paclitaxel-Induced Apoptosis Is BAK-Dependent, but BAX and BIM-Independent in Breast Tumor

(2013) Anna V. Miller et al.   PLoS One

Diet-Induced Obesity Exacerbates Auditory Degeneration via Hypoxia, Inflammation, and Apoptosis Signaling Pathways in CD/1 Mice

(2013) Juen-Haur Hwang et al.   PLoS One

Inhibition of AKT enhances mitotic cell apoptosis induced by arsenic trioxide

(2013) Ling-Huei Yih et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Streptococcus pneumoniae ClpP protease induces apoptosis via caspase-independent pathway in human neuroblastoma cells: Cytoplasmic relocalization of p53

(2013) Jun-Oh Lee et al.   TOXICON

Apaf-1- and Caspase-8-independent apoptosis

(2012) T Imao et al.   CELL DEATH AND DIFFERENTIATION

Akt3 Deficiency in Macrophages Promotes Foam Cell Formation and Atherosclerosis in Mice

(2012) Liang Ding et al.   Cell Metabolism

Eeyarestatin causes cervical cancer cell sensitization to bortezomib treatment by augmenting ER stress and CHOP expression

(2012) German J. Brem et al.   GYNECOLOGIC ONCOLOGY

Bim, a Proapoptotic Protein, Up-regulated via Transcription Factor E2F1-dependent Mechanism, Functions as a Prosurvival Molecule in Cancer

(2012) Raghu Gogada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PP242 Mammalian Target of Rapamycin (mTOR) Inhibitor Activates Extracellular Signal-regulated Kinase (ERK) in Multiple Myeloma Cells via a Target of Rapamycin Complex 1 (TORC1)/ Eukaryotic Translation Initiation Factor 4E (eIF-4E)/RAF Pathway and Activation Is a Mechanism of Resistance

(2012) Bao Hoang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P2Y12protects platelets from apoptosis via PI3k-dependent Bak/Bax inactivation

(2012) S. ZHANG et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Distinct roles of AKT isoforms in regulating β1-integrin activity, migration, and invasion in prostate cancer

(2012) Reetta Virtakoivu et al.   MOLECULAR BIOLOGY OF THE CELL

ER Stress in Retinal Degeneration in S334ter Rho Rats

(2012) Vishal M. Shinde et al.   PLoS One

CHOP Potentially Co-Operates with FOXO3a in Neuronal Cells to Regulate PUMA and BIM Expression in Response to ER Stress

(2012) Arindam P. Ghosh et al.   PLoS One

A BAX/BAK and Cyclophilin D-Independent Intrinsic Apoptosis Pathway

(2012) Sebastián Zamorano et al.   PLoS One

Bim Links ER Stress and Apoptosis in Cells Expressing Mutant SOD1 Associated with Amyotrophic Lateral Sclerosis

(2012) Kai Y. Soo et al.   PLoS One

Prognostic impact of the expression/phosphorylation of the BH3-only proteins of the BCL-2 family in glioblastoma multiforme

(2012) P F Cartron et al.   Cell Death & Disease

Inhibition of Bax protects neuronal cells from oligomeric Aβ neurotoxicity

(2012) W Kudo et al.   Cell Death & Disease

The immunity-related GTPase Irgm3 relieves endoplasmic reticulum stress response during coxsackievirus B3 infection via a PI3K/Akt dependent pathway

(2011) Zhen Liu et al.   CELLULAR MICROBIOLOGY

In Vivo Activity of Combined PI3K/mTOR and MEK Inhibition in a KrasG12D;Pten Deletion Mouse Model of Ovarian Cancer

(2011) K. M. Kinross et al.   MOLECULAR CANCER THERAPEUTICS

MiR-145 directly targets p70S6K1 in cancer cells to inhibit tumor growth and angiogenesis

(2011) Qing Xu et al.   NUCLEIC ACIDS RESEARCH

S6K1 and 4E-BP1 Are Independent Regulated and Control Cellular Growth in Bladder Cancer

(2011) Roman Nawroth et al.   PLoS One

Akt2 Modulates Glucose Availability and Downstream Apoptotic Pathways during Development

(2010) Penny J. Jensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reovirus Infection or Ectopic Expression of Outer Capsid Protein  1 Induces Apoptosis Independently of the Cellular Proapoptotic Proteins Bax and Bak

(2010) M. L. Wisniewski et al.   JOURNAL OF VIROLOGY

S6K1 deficiency protects against apoptosis in hepatocytes

(2009) Águeda González-Rodriguez et al.   HEPATOLOGY

S6K Directly Phosphorylates IRS-1 on Ser-270 to Promote Insulin Resistance in Response to TNF-α Signaling through IKK2

(2008) Jin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin Resistance in Striated Muscle-specific Integrin Receptor β1-deficient Mice

(2008) Haihong Zong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY