Immunosenescence and hurdles in the clinical management of older HIV-patients

CD4+/CD8+ ratio, age, and risk of serious noncommunicable diseases in HIV-infected adults on antiretroviral therapy

(2016) Jessica L. Castilho et al.   AIDS

Treatment intensification followed by interleukin-7 reactivates HIV without reducing total HIV DNA

(2016) Christine Katlama et al.   AIDS

The Impact of Non-Antiretroviral Polypharmacy on the Continuity of Antiretroviral Therapy (ART) Among HIV Patients

(2016) Hartmut B. Krentz et al.   AIDS PATIENT CARE AND STDS

The Effect of Chloroquine on Immune Activation and Interferon Signatures Associated with HIV-1

(2016) Jeffrey M. Jacobson et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

To clear, or not to clear (senescent cells)? That is the question

(2016) Amaia Lujambio   BIOESSAYS

Repeated Cycles of Recombinant Human Interleukin 7 in HIV-Infected Patients With Low CD4 T-Cell Reconstitution on Antiretroviral Therapy: Results of 2 Phase II Multicenter Studies

(2016) Rodolphe Thiébaut et al.   CLINICAL INFECTIOUS DISEASES

Host Resistance and Immune Aging

(2016) Thilinie Bandaranayake et al.   CLINICS IN GERIATRIC MEDICINE

Infection-related and -unrelated malignancies, HIV and the aging population

(2016) L Shepherd et al.   HIV MEDICINE

The role of tenofovir alafenamide in future HIV management

(2016) A Antela et al.   HIV MEDICINE

Chronic HIV-1 Infection Induces B-Cell Dysfunction That Is Incompletely Resolved by Long-Term Antiretroviral Therapy

(2016) Laila N. Abudulai et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Long-Term Mortality in HIV-Infected Individuals 50 Years or Older

(2016) Rebecca A. Legarth et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Narrowing the Gap in Life Expectancy Between HIV-Infected and HIV-Uninfected Individuals With Access to Care

(2016) Julia L. Marcus et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Population-Based Estimates of Life Expectancy After HIV Diagnosis

(2016) Azfar-e-Alam Siddiqi et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Soluble endothelial protein C receptor (sEPCR) as an inflammatory biomarker in naive HIV-infected patients during ART

(2016) S. Chiappetta et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The Latent Reservoir for HIV-1: How Immunologic Memory and Clonal Expansion Contribute to HIV-1 Persistence

(2016) Alexandra J. Murray et al.   JOURNAL OF IMMUNOLOGY

Cytomegalovirus driven immunosenescence—An immune phenotype with or without clinical impact?

(2016) Cecilia Söderberg-Nauclér et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Characteristics and Outcome of Patients Diagnosed With HIV at Older Age

(2016) Ilan Asher et al.   MEDICINE

Risk factors for mortality during antiretroviral therapy in older populations in resource-limited settings

(2016) Daniel O'Brien et al.   Journal of the International AIDS Society

Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection

(2016) Matthias Hoffmann et al.   PLoS Pathogens

NK Cells in HIV Disease

(2016) Eileen Scully et al.   Current HIV/AIDS Reports

Relevance of Interleukin-6 and D-Dimer for Serious Non-AIDS Morbidity and Death among HIV-Positive Adults on Suppressive Antiretroviral Therapy

(2016) Birgit Grund et al.   PLoS One

Smoking and life expectancy among HIV-infected individuals on antiretroviral therapy in Europe and North America

(2015) Marie Helleberg et al.   AIDS

Life expectancy of HIV-positive individuals on combination antiretroviral therapy in Canada

(2015) Sophie Patterson et al.   BMC INFECTIOUS DISEASES

A Paradoxical Treatment for a Paradoxical Condition: Infliximab Use in Three Cases of Mycobacterial IRIS

(2015) Denise C. Hsu et al.   CLINICAL INFECTIOUS DISEASES

Age at Entry Into Care, Timing of Antiretroviral Therapy Initiation, and 10-Year Mortality Among HIV-Seropositive Adults in the United States

(2015) Jessie K. Edwards et al.   CLINICAL INFECTIOUS DISEASES

Prevalence of concomitant medications in older HIV+ patients and comparison with general population

(2015) Mercedes Gimeno-Gracia et al.   HIV CLINICAL TRIALS

Poor functional immune recovery in aged HIV-1-infected patients following successfully treatment with antiretroviral therapy

(2015) Taissa M. Kasahara et al.   HUMAN IMMUNOLOGY

Thymic Function Is Most Severely Impaired in Chronic HIV-1 Infection, but Individuals With Faster Disease Progression During Early HIV-1 Infection Expressed Lower Levels of RTEs

(2015) Sijia He et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques

(2015) Luca Micci et al.   JOURNAL OF CLINICAL INVESTIGATION

Future challenges for clinical care of an ageing population infected with HIV: a modelling study

(2015) Mikaela Smit et al.   LANCET INFECTIOUS DISEASES

Cabotegravir plus rilpivirine, once a day, after induction with cabotegravir plus nucleoside reverse transcriptase inhibitors in antiretroviral-naive adults with HIV-1 infection (LATTE): a randomised, phase 2b, dose-ranging trial

(2015) David A Margolis et al.   LANCET INFECTIOUS DISEASES

Immunosenescence: Implications for response to infection and vaccination in older people

(2015) Alejandra Pera et al.   MATURITAS

Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection

(2015)   NEW ENGLAND JOURNAL OF MEDICINE

Risk of Severe Non AIDS Events Is Increased among Patients Unable to Increase their CD4+ T-Cell Counts >200+/μl Despite Effective HAART

(2015) Giuseppe Lapadula et al.   PLoS One

Beneficial Effects of cART Initiated during Primary and Chronic HIV-1 Infection on Immunoglobulin-Expression of Memory B-Cell Subsets

(2015) Manuela Pogliaghi et al.   PLoS One

Intracellular expression of Tat alters mitochondrial functions in T cells: a potential mechanism to understand mitochondrial damage during HIV-1 replication

(2015) Sara Rodríguez-Mora et al.   Retrovirology

Role of PD-1 co-inhibitory pathway in HIV infection and potential therapeutic options

(2015) Vijayakumar Velu et al.   Retrovirology

HIV-associated memory B cell perturbations

(2015) Zhiliang Hu et al.   VACCINE

An assessment of adverse drug reactions among HIV positive patients receiving antiretroviral treatment in South Africa

(2015) Lieketseng J Masenyetse et al.   AIDS Research and Therapy

Life expectancy among HIV-positive patients in Rwanda: a retrospective observational cohort study

(2015) Sabin Nsanzimana et al.   Lancet Global Health

Aging with HIV vs. HIV Seroconversion at Older Age: A Diverse Population with Distinct Comorbidity Profiles

(2015) Giovanni Guaraldi et al.   PLoS One

Impact on life expectancy of HIV-1 positive individuals of CD4+ cell count and viral load response to antiretroviral therapy

(2014) Margaret T. May et al.   AIDS

Long-term Mortality in HIV-Positive Individuals Virally Suppressed for >3 Years With Incomplete CD4 Recovery

(2014) Frederik N. Engsig et al.   CLINICAL INFECTIOUS DISEASES

Cellular senescence and the senescent secretory phenotype in age-related chronic diseases

(2014) Yi Zhu et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Cellular signaling in the aging immune system

(2014) Tamas Fulop et al.   CURRENT OPINION IN IMMUNOLOGY

Aging of the human innate immune system in HIV infection

(2014) Heidi J Zapata et al.   CURRENT OPINION IN IMMUNOLOGY

Assessment of chloroquine as a modulator of immune activation to improve CD4 recovery in immune nonresponding HIV-infected patients receiving antiretroviral therapy

(2014) J-P Routy et al.   HIV MEDICINE

Age-Related Decrease in TCR Repertoire Diversity Measured with Deep and Normalized Sequence Profiling

(2014) O. V. Britanova et al.   JOURNAL OF IMMUNOLOGY

Soluble Markers of Inflammation and Coagulation but Not T-Cell Activation Predict Non–AIDS-Defining Morbid Events During Suppressive Antiretroviral Treatment

(2014) Allan R. Tenorio et al.   JOURNAL OF INFECTIOUS DISEASES

Immuno-Virological Discordance and the Risk of Non-AIDS and AIDS Events in a Large Observational Cohort of HIV-Patients in Europe

(2014) Alexander Zoufaly et al.   PLoS One

Older HIV-infected patients on antiretroviral therapy have B-cell expansion and attenuated CD4 cell increases with immune activation reduction

(2013) Robert C. Kalayjian et al.   AIDS

The CD4/CD8 ratio as a marker T-cell activation, senescence and activation/exhaustion in treated HIV-infected children and young adults

(2013) Talía Sainz et al.   AIDS

Maraviroc reduces cytokine expression and secretion in human adipose cells without altering adipogenic differentiation

(2013) Julieta Díaz-Delfín et al.   CYTOKINE

Aging, Antiretrovirals, and Adherence: A Meta Analysis of Adherence among Older HIV-Infected Individuals

(2013) Luwam Ghidei et al.   DRUGS & AGING

Clinical pharmacokinetics of antiretroviral drugs in older persons

(2013) John C Schoen et al.   Expert Opinion on Drug Metabolism & Toxicology

Effect of Age on the CD4+ T-Cell Impairment in HIV-Infected Persons Without and With cART

(2013) Kristina Allers et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Is HIV a Model of Accelerated or Accentuated Aging?

(2013) S. Pathai et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

HIV Protease Inhibitors Disrupt Lipid Metabolism by Activating Endoplasmic Reticulum Stress and Inhibiting Autophagy Activity in Adipocytes

(2013) Beth S. Zha et al.   PLoS One

Can early therapy reduce inflammation?

(2013) Netanya G. Sandler et al.   Current Opinion in HIV and AIDS

Differences in Human Immunodeficiency Virus Care and Treatment Among Subpopulations in the United States

(2013) H. Irene Hall et al.   JAMA Internal Medicine

Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function

(2012) Anna C. Hearps et al.   AGING CELL

HIV infection induces age-related changes to monocytes and innate immune activation in young men that persist despite combination antiretroviral therapy

(2012) Anna C. Hearps et al.   AIDS

Paucity of IL-21-producing CD4+ T cells is associated with Th17 cell depletion in SIV infection of rhesus macaques

(2012) L. Micci et al.   BLOOD

Predictors of first-line antiretroviral therapy discontinuation due to drug-related adverse events in HIV-infected patients: a retrospective cohort study

(2012) Mattia CF Prosperi et al.   BMC INFECTIOUS DISEASES

Effects of Recombinant Human Interleukin 7 on T-Cell Recovery and Thymic Output in HIV-Infected Patients Receiving Antiretroviral Therapy: Results of a Phase I/IIa Randomized, Placebo-Controlled, Multicenter Study

(2012) Y. Lévy et al.   CLINICAL INFECTIOUS DISEASES

Maintenance of Peripheral Naive T Cells Is Sustained by Thymus Output in Mice but Not Humans

(2012) Ineke den Braber et al.   IMMUNITY

HIV and Aging

(2012) Kevin P. High et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Effects of Hydroxychloroquine on Immune Activation and Disease Progression Among HIV-Infected Patients Not Receiving Antiretroviral Therapy

(2012) Nicholas I. Paton et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Reduced Inflammation and Lymphoid Tissue Immunopathology in Rhesus Macaques Receiving Anti–Tumor Necrosis Factor Treatment During Primary Simian Immunodeficiency Virus Infection

(2012) Brian Tabb et al.   JOURNAL OF INFECTIOUS DISEASES

CD4 Cell Count and the Risk of AIDS or Death in HIV-Infected Adults on Combination Antiretroviral Therapy with a Suppressed Viral Load: A Longitudinal Cohort Study from COHERE

(2012)   PLOS MEDICINE

Differential regulation of toll-like receptor pathways in acute and chronic HIV-1 infection

(2011) J. Judy Chang et al.   AIDS

Hydroxychloroquine drastically reduces immune activation in HIV-infected, antiretroviral therapy-treated immunologic nonresponders

(2011) S. Piconi et al.   BLOOD

CD4+ T-Cell Counts and Plasma HIV-1 RNA Levels Beyond 5 Years of Highly Active Antiretroviral Therapy

(2011) Xiuhong Li et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Ageing with HIV: medication use and risk for potential drug-drug interactions

(2011) C. Marzolini et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Dendritic Cell Dysfunction During Primary HIV-1 Infection

(2011) Jinghe Huang et al.   JOURNAL OF INFECTIOUS DISEASES

The Dual Impact of HIV-1 Infection and Aging on Naïve CD4+ T-Cells: Additive and Distinct Patterns of Impairment

(2011) Tammy M. Rickabaugh et al.   PLoS One

Oncogene- and tumor suppressor gene-mediated suppression of cellular senescence

(2011) Lars-Gunnar Larsson   SEMINARS IN CANCER BIOLOGY

Interleukin-21 administration to rhesus macaques chronically infected with simian immunodeficiency virus increases cytotoxic effector molecules in T cells and NK cells and enhances B cell function without increasing immune activation or viral replication

(2011) Suresh Pallikkuth et al.   VACCINE

Virologic and immunologic response to HAART, by age and regimen class

(2010) Keri N Althoff et al.   AIDS

HIV Infection, Inflammation, Immunosenescence, and Aging

(2010) Steven G. Deeks   Annual Review of Medicine

Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults

(2010) Sebastian Seidler et al.   BMC IMMUNOLOGY

Low CD4+T Cell Count Is a Risk Factor for Cardiovascular Disease Events in the HIV Outpatient Study

(2010) Kenneth A. Lichtenstein et al.   CLINICAL INFECTIOUS DISEASES

Differential Effects of Efavirenz and Lopinavir/Ritonavir on Human Adipocyte Differentiation, Gene Expression and Release of Adipokines and Pro-Inflammatory Cytokines.

(2010) Jose M. Gallego-Escuredo et al.   CURRENT HIV RESEARCH

Telomere/telomerase dynamics within the human immune system: Effect of chronic infection and stress

(2010) Rita B. Effros   EXPERIMENTAL GERONTOLOGY

A challenge for the future: aging and HIV infection

(2010) Tammy M. Rickabaugh et al.   IMMUNOLOGIC RESEARCH

Association of Immunologic and Virologic Factors With Myocardial Infarction Rates in a US Healthcare System

(2010) Virginia A Triant et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

cART Durability and Causes for Treatment Switching or Discontinuation in HIV-Positive Patients Older Than 50 Years of Age

(2010) Giovanna Orlando et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Impaired Functions of Peripheral Blood Monocyte Subpopulations in Aged Humans

(2010) Joseph Nyugen et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The Virologic and Immunologic Effects of Cyclosporine as an Adjunct to Antiretroviral Therapy in Patients Treated during Acute and Early HIV‐1 Infection

(2010) Martin Markowitz et al.   JOURNAL OF INFECTIOUS DISEASES

Reduction of Immune Activation with Chloroquine Therapy during Chronic HIV Infection

(2010) S. M. Murray et al.   JOURNAL OF VIROLOGY

Death rates in HIV-positive antiretroviral-naive patients with CD4 count greater than 350 cells per μL in Europe and North America: a pooled cohort observational study

(2010)   LANCET

In vivo expansion of naive and activated CD4+CD25+FOXP3+ regulatory T cell populations in interleukin-2-treated HIV patients

(2010) L. Weiss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

First Report on a Series of HIV Patients Undergoing Rapamycin Monotherapy After Liver Transplantation

(2010) Fabrizio Di Benedetto et al.   TRANSPLANTATION

Early Immune Senescence in HIV Disease

(2010) Seema Desai et al.   Current HIV/AIDS Reports

Survival following HIV infection of a cohort followed up from seroconversion in the UK

(2009) Fiona M Ewings et al.   AIDS

Response to combination antiretroviral therapy: variation by age

(2009)   AIDS

Changes in Outcome of Persons Initiating Highly Active Antiretroviral Therapy at a CD4 Count Less Than 50 Cells/mm3

(2009) Kholoud Porter et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Poor Initial CD4+ Recovery With Antiretroviral Therapy Prolongs Immune Depletion and Increases Risk for AIDS and Non-AIDS Diseases

(2009) Jason V Baker et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Premature Aging of T cells Is Associated With Faster HIV-1 Disease Progression

(2009) Weiwei Cao et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Evidence of premature immune aging in patients thymectomized during early childhood

(2009) Delphine Sauce et al.   JOURNAL OF CLINICAL INVESTIGATION

Interleukin-2 Therapy in Patients with HIV Infection

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

Coimmunization with an optimized IL15 plasmid adjuvant enhances humoral immunity via stimulating B cells induced by genetically engineered DNA vaccines expressing consensus JEV and WNV E DIII

(2009) Mathura P. Ramanathan et al.   VACCINE

Stability of antiretroviral regimens in patients with viral suppression

(2008) Rebecca K Lodwick et al.   AIDS

Patients presenting with AIDS in the HAART era: a collaborative cohort analysis

(2008) Cristina Mussini et al.   AIDS

Effect of age and HAART regimen on clinical response in an urban cohort of HIV-infected individuals

(2008) Adena H Greenbaum et al.   AIDS

HIV-induced immunodeficiency and mortality from AIDS-defining and non-AIDS-defining malignancies

(2008)   AIDS

The role of HIV in serious diseases other than AIDS

(2008) Andrew N Phillips et al.   AIDS

Life after the thymus: CD31+ and CD31- human naive CD4+ T-cell subsets

(2008) S. Kohler et al.   BLOOD

Adverse drug reactions in adult medical inpatients in a South African hospital serving a community with a high HIV/AIDS prevalence: prospective observational study

(2008) Ushma Mehta et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Aging and Infectious Diseases: Workshop on HIV Infection and Aging: What Is Known and Future Research Directions

(2008) Rita B. Effros et al.   CLINICAL INFECTIOUS DISEASES

The associations between age and the development of laboratory abnormalities and treatment discontinuation for reasons other than virological failure in the first year of highly active antiretroviral therapy

(2008) CA Sabin et al.   HIV MEDICINE