Vesicular uptake blockade generates the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde in PC12 cells: relevance to the pathogenesis of Parkinson's disease

Neurodegeneration and Motor Dysfunction in Mice Lacking Cytosolic and Mitochondrial Aldehyde Dehydrogenases: Implications for Parkinson's Disease

(2012) Margaret Chia-Ying Wey et al.   PLoS One

Mitochondrial dysfunction mediated by quinone oxidation products of dopamine: Implications in dopamine cytotoxicity and pathogenesis of Parkinson's disease

(2011) Sirsendu Jana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Oxidation of 3,4-Dihydroxyphenylacetaldehyde, a Toxic Dopaminergic Metabolite, to a Semiquinone Radical and anortho-Quinone

(2011) David G. Anderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Association Study Confirms SNPs inSNCAand theMAPTRegion as Common Risk Factors for Parkinson Disease

(2010) Todd L. Edwards et al.   ANNALS OF HUMAN GENETICS

Catechols in post-mortem brain of patients with Parkinson disease

(2010) D. S. Goldstein et al.   EUROPEAN JOURNAL OF NEUROLOGY

The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties

(2010) Thomas Näsström et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Neurotoxicity of DOPAL: Behavioral and Stereological Evidence for Its Role in Parkinson Disease Pathogenesis

(2010) W. Michael Panneton et al.   PLoS One

Products of Oxidative Stress Inhibit Aldehyde Oxidation and Reduction Pathways in Dopamine Catabolism Yielding Elevated Levels of a Reactive Intermediate

(2009) Yunden Jinsmaa et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Protein Reactivity of 3,4-Dihydroxyphenylacetaldehyde, a Toxic Dopamine Metabolite, Is Dependent on Both the Aldehyde and the Catechol

(2009) Jennifer N. Rees et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

(2009) Wataru Satake et al.   NATURE GENETICS

Interplay between Cytosolic Dopamine, Calcium, and α-Synuclein Causes Selective Death of Substantia Nigra Neurons

(2009) Eugene V. Mosharov et al.   NEURON

Endogenous catecholamine enhances the dysfunction of unfolded protein response and α-synuclein oligomerization in PC12 cells overexpressing human α-synuclein

(2009) Satoru Ito et al.   NEUROSCIENCE RESEARCH

Central Role of α-Synuclein Oligomers in Neurodegeneration in Parkinson Disease

(2008) Aleksey G. Kazantsev et al.   ARCHIVES OF NEUROLOGY

Meeting Report: Consensus Statement—Parkinson’s Disease and the Environment: Collaborative on Health and the Environment and Parkinson’s Action Network (CHE PAN) Conference 26–28 June 2007

(2008) Jeff Bronstein et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Reduced vesicular storage of dopamine exacerbates methamphetamine-induced neurodegeneration and astrogliosis

(2008) Thomas S. Guillot et al.   JOURNAL OF NEUROCHEMISTRY

Unregulated Cytosolic Dopamine Causes Neurodegeneration Associated with Oxidative Stress in Mice

(2008) L. Chen et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial Complex I Inhibitor Rotenone Inhibits and Redistributes Vesicular Monoamine Transporter 2 via Nitration in Human Dopaminergic SH-SY5Y Cells

(2008) M. Watabe et al.   MOLECULAR PHARMACOLOGY

Rotenone-induced PC12 cell toxicity is caused by oxidative stress resulting from altered dopamine metabolism

(2008) Yan Sai et al.   TOXICOLOGY IN VITRO