In search of a small molecule agonist of the relaxin receptor RXFP1 for the treatment of liver fibrosis

Expression of RXFP1 Is Decreased in Idiopathic Pulmonary Fibrosis. Implications for Relaxin-based Therapies

(2016) Jiangning Tan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Anti-fibrotic actions of relaxin

(2016) C S Samuel et al.   BRITISH JOURNAL OF PHARMACOLOGY

A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1

(2016) Mohammed Akhter Hossain et al.   Chemical Science

The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1

(2016) Ashish Sethi et al.   Nature Communications

Activation of Relaxin Family Receptor 1 from Different Mammalian Species by Relaxin Peptide and Small-Molecule Agonist ML290

(2015) Zaohua Huang et al.   Frontiers in Endocrinology

Relaxin Activates Peroxisome Proliferator-activated Receptor γ (PPARγ) through a Pathway Involving PPARγ Coactivator 1α (PGC1α)

(2014) Sudhir Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Investigation of Interactions at the Extracellular Loops of the Relaxin Family Peptide Receptor 1 (RXFP1)

(2014) Natalie A. Diepenhorst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Addressing liver disease in the UK: a blueprint for attaining excellence in health care and reducing premature mortality from lifestyle issues of excess consumption of alcohol, obesity, and viral hepatitis

(2014) Roger Williams et al.   LANCET

GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis

(2014) Inmaculada Lopez-Sanchez et al.   Nature Communications

Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertensionin vivo

(2013) Jonathan A. Fallowfield et al.   HEPATOLOGY

The Relaxin Receptor (RXFP1) Utilizes Hydrophobic Moieties on a Signaling Surface of Its N-terminal Low Density Lipoprotein Class A Module to Mediate Receptor Activation

(2013) Roy C. K. Kong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Relaxin decreases the severity of established hepatic fibrosis in mice

(2013) Robert G. Bennett et al.   LIVER INTERNATIONAL

Genetic Characteristics of the Human Hepatic Stellate Cell Line LX-2

(2013) Ralf Weiskirchen et al.   PLoS One

Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1

(2013) Jingbo Xiao et al.   Nature Communications

Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial

(2012) John R Teerlink et al.   LANCET

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Relaxin Signals through a RXFP1-pERK-nNOS-NO-cGMP-Dependent Pathway to Up-Regulate Matrix Metalloproteinases: The Additional Involvement of iNOS

(2012) Bryna Suet Man Chow et al.   PLoS One

Expression of RXFP1 in skin of scleroderma patients and control subjects

(2012) N Giordano et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Relaxin Activates Multiple cAMP Signaling Pathway Profiles in Different Target Cells

(2009) Michelle L. Halls et al.   Annals of the New York Academy of Sciences

Reversal of Cardiac Fibrosis and Related Dysfunction by Relaxin

(2009) Xiao-Jun Du et al.   Annals of the New York Academy of Sciences

Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2

(2008) Ishanee Mookerjee et al.   FASEB JOURNAL

Computer-assisted image analysis of liver collagen: Relationship to Ishak scoring and hepatic venous pressure gradient

(2008) Vincenza Calvaruso et al.   HEPATOLOGY

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS