A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1
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Title
A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1
Authors
Keywords
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Journal
Chemical Science
Volume 7, Issue 6, Pages 3805-3819
Publisher
Royal Society of Chemistry (RSC)
Online
2016-02-26
DOI
10.1039/c5sc04754d
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Note: Only part of the references are listed.- Solution Structure, Aggregation Behavior, and Flexibility of Human Relaxin-2
- (2015) Linda M. Haugaard-Kedström et al. ACS Chemical Biology
- Signalling profiles of H3 relaxin, H2 relaxin and R3(BΔ23-27)R/I5 acting at the relaxin family peptide receptor 3 (RXFP3)
- (2014) M Kocan et al. BRITISH JOURNAL OF PHARMACOLOGY
- Serelaxin-mediated signal transduction in human vascular cells: bell-shaped concentration-response curves reflect differential coupling to G proteins
- (2014) M Sarwar et al. BRITISH JOURNAL OF PHARMACOLOGY
- Intranasally administered serelaxin abrogates airway remodelling and attenuates airway hyperresponsiveness in allergic airways disease
- (2014) S. G. Royce et al. CLINICAL AND EXPERIMENTAL ALLERGY
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- (2014) Mohammed Akhter Hossain et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Serelaxin Is a More Efficacious Antifibrotic Than Enalapril in an Experimental Model of Heart Disease
- (2014) Chrishan S. Samuel et al. HYPERTENSION
- Investigation of Interactions at the Extracellular Loops of the Relaxin Family Peptide Receptor 1 (RXFP1)
- (2014) Natalie A. Diepenhorst et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis
- (2014) Bryna S. Man Chow et al. KIDNEY INTERNATIONAL
- The cardiovascular actions of fractalkine/CX3CL1 in the hypothalamic paraventricular nucleus are attenuated in rats with heart failure
- (2013) P. J. Ruchaya et al. EXPERIMENTAL PHYSIOLOGY
- The Relaxin Receptor (RXFP1) Utilizes Hydrophobic Moieties on a Signaling Surface of Its N-terminal Low Density Lipoprotein Class A Module to Mediate Receptor Activation
- (2013) Roy C. K. Kong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Relaxin Family Peptides and Their Receptors
- (2013) R. A. D. Bathgate et al. PHYSIOLOGICAL REVIEWS
- Human relaxin-2: historical perspectives and role in cancer biology
- (2012) Vinojini B. Nair et al. AMINO ACIDS
- Site-specific conjugation of a lanthanide chelator and its effects on the chemical synthesis and receptor binding affinity of human relaxin-2 hormone
- (2012) Fazel Shabanpoor et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Identification of Key Residues Essential for the Structural Fold and Receptor Selectivity within the A-chain of Human Gene-2 (H2) Relaxin
- (2012) Linda J. Chan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial
- (2012) John R Teerlink et al. LANCET
- Mechanisms of fibrosis: therapeutic translation for fibrotic disease
- (2012) Thomas A Wynn et al. NATURE MEDICINE
- Chimeric relaxin peptides highlight the role of the A-chain in the function of H2 relaxin
- (2012) Mohammed Akhter Hossain et al. PEPTIDES
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- (2012) Bryna Suet Man Chow et al. PLoS One
- The Minimal Active Structure of Human Relaxin-2
- (2011) Mohammed Akhter Hossain et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Design, Synthesis, and Characterization of a Single-Chain Peptide Antagonist for the Relaxin-3 Receptor RXFP3
- (2011) Linda M. Haugaard-Kedström et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Relaxin remodels fibrotic healing following myocardial infarction
- (2011) Chrishan S Samuel et al. LABORATORY INVESTIGATION
- Relaxin ameliorates salt-sensitive hypertension and renal fibrosis
- (2011) T. Yoshida et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- The Positive Inotropic Effect of Relaxin-2 in Human Atrial Myocardium is Preserved in End-Stage Heart Failure: Role of Gi-Phosphoinositide-3 Kinase Signaling
- (2010) Thomas Dschietzig et al. JOURNAL OF CARDIAC FAILURE
- The chemically synthesized human relaxin-2 analog, B-R13/17K H2, is an RXFP1 antagonist
- (2009) Mohammed Akhter Hossain et al. AMINO ACIDS
- Modeling the Primary Hormone-Binding Site of RXFP1 and RXFP2
- (2009) Daniel J. Scott et al. Annals of the New York Academy of Sciences
- Scientific Rationale and Design of a Phase I Safety Study of Relaxin in Women with Severe Preeclampsia
- (2009) Elaine Unemori et al. Annals of the New York Academy of Sciences
- Relaxin/RXFP1 Signaling in Prostate Cancer Progression
- (2009) Shu Feng et al. Annals of the New York Academy of Sciences
- Relaxin Reverses Airway Remodeling and Airway Dysfunction in Allergic Airways Disease
- (2009) Simon G. Royce et al. ENDOCRINOLOGY
- A novel approach to improve cardiac performance: cardiac myosin activators
- (2009) John R. Teerlink HEART FAILURE REVIEWS
- Relaxin family peptide receptors – from orphans to therapeutic targets
- (2008) Emma T. van der Westhuizen et al. DRUG DISCOVERY TODAY
- Relaxin Ameliorates Fibrosis in Experimental Diabetic Cardiomyopathy
- (2008) Chrishan S. Samuel et al. ENDOCRINOLOGY
- Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2
- (2008) Ishanee Mookerjee et al. FASEB JOURNAL
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- (2008) Mohammed Akhter Hossain et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Negative cooperativity in H2 relaxin binding to a dimeric relaxin family peptide receptor 1
- (2008) Angela Manegold Svendsen et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
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