Anti-fibrotic actions of relaxin

Relaxin suppresses atrial fibrillation in aged rats by reversing fibrosis and upregulating Na+ channels

(2016) Brian L. Henry et al.   HEART RHYTHM

H2 and H3 relaxin inhibit high glucose-induced apoptosis in neonatal rat ventricular myocytes

(2015) Xiaohui Zhang et al.   BIOCHIMIE

Pulmonary monoclonal antibody delivery via a portable microfluidic nebulization platform

(2015) Christina Cortez-Jugo et al.   Biomicrofluidics

The Concise Guide to PHARMACOLOGY 2015/16: Nuclear hormone receptors

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Overview

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Enzymes

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Immune Cell and Other Noncardiomyocyte Regulation of Cardiac Hypertrophy and Remodeling

(2015) R. A. Frieler et al.   CIRCULATION

Inhibitory effects of relaxin on cardiac fibroblast-to-myofibroblast transition: an electrophysiological study

(2015) Roberta Squecco et al.   EXPERIMENTAL PHYSIOLOGY

Combination therapy of mesenchymal stem cells and serelaxin effectively attenuates renal fibrosis in obstructive nephropathy

(2015) Brooke M. Huuskes et al.   FASEB JOURNAL

Hepatic fibrosis: Concept to treatment

(2015) Christian Trautwein et al.   JOURNAL OF HEPATOLOGY

Relaxin-2 Does Not Ameliorate Nephropathy in an Experimental Model of Type-1 Diabetes

(2015) Thomas Bernd Dschietzig et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Pretreatment with Relaxin Does Not Restore NO-Mediated Modulation of Calcium Signal in Coronary Endothelial Cells Isolated from Spontaneously Hypertensive Rats

(2015) Silvia Nistri et al.   MOLECULES

Comorbidity of atrial fibrillation and heart failure

(2015) Liang-Han Ling et al.   Nature Reviews Cardiology

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

(2015) Christopher Southan et al.   NUCLEIC ACIDS RESEARCH

Bleomycin in the setting of lung fibrosis induction: From biological mechanisms to counteractions

(2015) Veronica Della Latta et al.   PHARMACOLOGICAL RESEARCH

Mesenchymal stem cells and serelaxin synergistically abrogate established airway fibrosis in an experimental model of chronic allergic airways disease

(2015) Simon G. Royce et al.   Stem Cell Research

Synthetic Covalently Linked Dimeric Form of H2 Relaxin Retains Native RXFP1 Activity and Has ImprovedIn VitroSerum Stability

(2015) Vinojini B. Nair et al.   Biomed Research International

Animal Models to Study Links between Cardiovascular Disease and Renal Failure and Their Relevance to Human Pathology

(2015) Tim D. Hewitson et al.   Frontiers in Immunology

Targeting matrix metalloproteinases in heart disease: Lessons from endogenous inhibitors

(2014) Francis G. Spinale et al.   BIOCHEMICAL PHARMACOLOGY

Serelaxin-mediated signal transduction in human vascular cells: bell-shaped concentration-response curves reflect differential coupling to G proteins

(2014) M Sarwar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Intranasally administered serelaxin abrogates airway remodelling and attenuates airway hyperresponsiveness in allergic airways disease

(2014) S. G. Royce et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Serelaxin Is a More Efficacious Antifibrotic Than Enalapril in an Experimental Model of Heart Disease

(2014) Chrishan S. Samuel et al.   HYPERTENSION

Suppressive effect of compact bone-derived mesenchymal stem cells on chronic airway remodeling in murine model of asthma

(2014) Ismail Ogulur et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Relaxin Activates Peroxisome Proliferator-activated Receptor γ (PPARγ) through a Pathway Involving PPARγ Coactivator 1α (PGC1α)

(2014) Sudhir Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CXCR4 Receptor Overexpression in Mesenchymal Stem Cells Facilitates Treatment of Acute Lung Injury in Rats

(2014) Jing-Xian Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of recombinant human relaxin upon proliferation of cardiac fibroblast and synthesis of collagen under high glucose condition

(2014) P. Wang et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis

(2014) Bryna S. Man Chow et al.   KIDNEY INTERNATIONAL

Protective Effects of Relaxin against Cisplatin-Induced Nephrotoxicity in Rats

(2014) Takuya Yoshida et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Maladaptive Remodeling Is Associated With Impaired Survival in Women But Not in Men After Aortic Valve Replacement

(2014) George Petrov et al.   JACC-Cardiovascular Imaging

Pressor responsiveness to angiotensin II in female mice is enhanced with age: role of the angiotensin type 2 receptor

(2014) Katrina M Mirabito et al.   Biology of Sex Differences

Role of protein kinase C β2 in relaxin-mediated inhibition of cardiac fibrosis

(2014) W. Su et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Gender differences and disparities in all-cause and coronary heart disease mortality: Epidemiological aspects

(2013) Elizabeth Barrett-Connor   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Relaxin Suppresses Atrial Fibrillation by Reversing Fibrosis and Myocyte Hypertrophy and Increasing Conduction Velocity and Sodium Current in Spontaneously Hypertensive Rat Hearts

(2013) Ashish Parikh et al.   CIRCULATION RESEARCH

Relaxin improves multiple markers of wound healing and ameliorates the disturbed healing pattern of genetically diabetic mice

(2013) Alessandra Bitto et al.   CLINICAL SCIENCE

Relaxin Treatment Reverses Insulin Resistance in Mice Fed a High-Fat Diet

(2013) Jeffrey S. Bonner et al.   DIABETES

Insulin-like Factor 3 Promotes Wound Healing at the Ocular Surface

(2013) Ulrike Hampel et al.   ENDOCRINOLOGY

Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertensionin vivo

(2013) Jonathan A. Fallowfield et al.   HEPATOLOGY

Effect of mesenchymal stem cells on inhibiting airway remodeling and airway inflammation in chronic asthma

(2013) Xiahui Ge et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Relaxin decreases the severity of established hepatic fibrosis in mice

(2013) Robert G. Bennett et al.   LIVER INTERNATIONAL

Serum Relaxin Levels in Young Athletic Men Are Comparable With Those in Women

(2013) Jennifer Moriatis Wolf et al.   ORTHOPEDICS

Novel therapeutic strategies for lung disorders associated with airway remodelling and fibrosis

(2013) Simon G. Royce et al.   PHARMACOLOGY & THERAPEUTICS

Relaxin Prevents Cardiac Fibroblast-Myofibroblast Transition via Notch-1-Mediated Inhibition of TGF-β/Smad3 Signaling

(2013) Chiara Sassoli et al.   PLoS One

The Anti-fibrotic Hormone Relaxin is not Reno-protective, Despite Being Active, in an Experimental Model of Type 1 Diabetes

(2013) Su Wong et al.   PROTEIN AND PEPTIDE LETTERS

Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1

(2013) Jingbo Xiao et al.   Nature Communications

A randomized, placebo-controlled clinical trial on the effects of recombinant human relaxin on tooth movement and short-term stability

(2012) Susan P. McGorray et al.   AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS

Combination therapy with relaxin and methylprednisolone augments the effects of either treatment alone in inhibiting subepithelial fibrosis in an experimental model of allergic airways disease

(2012) Simon G. Royce et al.   CLINICAL SCIENCE

The “His and Hers” of the Renin-Angiotensin System

(2012) Lucinda M. Hilliard et al.   CURRENT HYPERTENSION REPORTS

Up-Regulating Relaxin Expression by G-Quadruplex Interactive Ligand to Achieve Antifibrotic Action

(2012) Hui-Ping Gu et al.   ENDOCRINOLOGY

Identification of Key Residues Essential for the Structural Fold and Receptor Selectivity within the A-chain of Human Gene-2 (H2) Relaxin

(2012) Linda J. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of Serelaxin on Cardiac, Renal, and Hepatic Biomarkers in the Relaxin in Acute Heart Failure (RELAX-AHF) Development Program

(2012) Marco Metra et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Molecular and metabolic mechanisms of cardiac dysfunction in diabetes

(2012) Chirag H. Mandavia et al.   LIFE SCIENCES

Relaxin Signals through a RXFP1-pERK-nNOS-NO-cGMP-Dependent Pathway to Up-Regulate Matrix Metalloproteinases: The Additional Involvement of iNOS

(2012) Bryna Suet Man Chow et al.   PLoS One

Expression of RXFP1 in skin of scleroderma patients and control subjects

(2012) N Giordano et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Sugar, Sex, and TGF-β in Diabetic Nephropathy

(2012) Maggie K. Diamond-Stanic et al.   SEMINARS IN NEPHROLOGY

Relaxin Regulates Myofibroblast Contractility and Protects against Lung Fibrosis

(2011) Xiangwei Huang et al.   AMERICAN JOURNAL OF PATHOLOGY

H3 Relaxin Demonstrates Antifibrotic Properties via the RXFP1 Receptor

(2011) Mohammed Akhter Hossain et al.   BIOCHEMISTRY

Relaxin increases human endothelial progenitor cell NO and migration and vasculogenesis in mice

(2011) M. S. Segal et al.   BLOOD

Effects of Relaxin on Arterial Dilation, Remodeling, and Mechanical Properties

(2011) Kirk P. Conrad et al.   CURRENT HYPERTENSION REPORTS

Relaxin Induces Rapid Dilation of Rodent Small Renal and Human Subcutaneous Arteries via PI3 Kinase and Nitric Oxide

(2011) Jonathan T. McGuane et al.   ENDOCRINOLOGY

Relaxin and Castration in Male Mice Protect from, but Testosterone Exacerbates, Age-Related Cardiac and Renal Fibrosis, Whereas Estrogens Are an Independent Determinant of Organ Size

(2011) Tim D. Hewitson et al.   ENDOCRINOLOGY

Serum relaxin levels affect the in vivo properties of some but not all tendons in normally menstruating young women

(2011) S. J. Pearson et al.   EXPERIMENTAL PHYSIOLOGY

Angiogenic Growth Factors Are New and Essential Players in the Sustained Relaxin Vasodilatory Pathway in Rodents and Humans

(2011) Jonathan T. McGuane et al.   HYPERTENSION

Relaxin Ameliorates Hypertension and Increases Nitric Oxide Metabolite Excretion in Angiotensin II But Not N ω -Nitro- l -Arginine Methyl Ester Hypertensive Rats

(2011) Jennifer M. Sasser et al.   HYPERTENSION

Sex Differences in the Pressor and Tubuloglomerular Feedback Response to Angiotensin II

(2011) Russell D. Brown et al.   HYPERTENSION

The Minimal Active Structure of Human Relaxin-2

(2011) Mohammed Akhter Hossain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Relaxin remodels fibrotic healing following myocardial infarction

(2011) Chrishan S Samuel et al.   LABORATORY INVESTIGATION

Relaxin Regulates MMP Expression and Promotes Satellite Cell Mobilization During Muscle Healing in Both Young and Aged Mice

(2010) Xiaodong Mu et al.   AMERICAN JOURNAL OF PATHOLOGY

Regression of Myocardial Hypertrophy After Aortic Valve Replacement: Faster in Women?

(2010) G. Petrov et al.   CIRCULATION

Antifibrotic Properties of Relaxin:In VivoMechanism of Action in Experimental Renal Tubulointerstitial Fibrosis

(2010) Tim D. Hewitson et al.   ENDOCRINOLOGY

Gender Differences in Pressure-Natriuresis and Renal Autoregulation

(2010) Lucinda M. Hilliard et al.   HYPERTENSION

Prevention of Bleomycin-Induced Pulmonary Fibrosis by a Novel Antifibrotic Peptide with Relaxin-Like Activity

(2010) A. Pini et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Human Umbilical Cord Mesenchymal Stem Cells Reduce Fibrosis of Bleomycin-Induced Lung Injury

(2009) Yuben Moodley et al.   AMERICAN JOURNAL OF PATHOLOGY

Scar Prevention and Cosmetically Enhanced Wound Healing Using Relaxin

(2009) Dennis R. Stewart   Annals of the New York Academy of Sciences

Relaxin Reduces Fibrosis in Models of Progressive and Established Hepatic Fibrosis

(2009) Robert G. Bennett et al.   Annals of the New York Academy of Sciences

A Randomized, Double-Blind, Placebo-Controlled Trial of Relaxin for Cervical Ripening in Post-Delivery Date Pregnancies

(2009) Gerson Weiss et al.   Annals of the New York Academy of Sciences

Recombinant human relaxin in the treatment of systemic sclerosis with diffuse cutaneous involvement: A randomized, double-blind, placebo-controlled trial

(2009) Dinesh Khanna et al.   ARTHRITIS AND RHEUMATISM

Relaxin Reverses Airway Remodeling and Airway Dysfunction in Allergic Airways Disease

(2009) Simon G. Royce et al.   ENDOCRINOLOGY

Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study

(2009) John R Teerlink et al.   LANCET

The potential roles of cell migration and extra-cellular matrix interactions in Dupuytren’s disease progression and recurrence

(2009) Linda Vi et al.   MEDICAL HYPOTHESES

Relaxin signaling activates peroxisome proliferator-activated receptor gamma

(2009) Sudhir Singh et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Cardiovascular effects of relaxin: from basic science to clinical therapy

(2009) Xiao-Jun Du et al.   Nature Reviews Cardiology

Detection of RXFP1 receptors in skin biopsies from children with congenital adrenal hyperplasia: A preliminary report

(2009) Timothy E. Cooney et al.   Journal of Pediatric Urology

Relaxin Ameliorates Fibrosis in Experimental Diabetic Cardiomyopathy

(2008) Chrishan S. Samuel et al.   ENDOCRINOLOGY

Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2

(2008) Ishanee Mookerjee et al.   FASEB JOURNAL

Gender and human chronic renal disease

(2008) Sharon Silbiger et al.   Gender Medicine

Relaxin, a pleiotropic vasodilator for the treatment of heart failure

(2008) Sam L. Teichman et al.   HEART FAILURE REVIEWS

Enhanced Angiotensin II Type 2 Receptor Mechanisms Mediate Decreases in Arterial Pressure Attributable to Chronic Low-Dose Angiotensin II in Female Rats

(2008) Amanda K. Sampson et al.   HYPERTENSION

Mast cell inhibition and reduced ventricular arrhythmias in a swine model of acute myocardial infarction upon therapeutic administration of relaxin

(2008) S. Nistri et al.   INFLAMMATION RESEARCH

Functional and histopathological improvement of the post-infarcted rat heart upon myoblast cell grafting and relaxin therapy

(2008) Massimo Bonacchi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS

Effect of Relaxin on TGF-β1 Expression in Cultured Vaginal Fibroblasts From Women With Stress Urinary Incontinence

(2008) Yan Wen et al.   Reproductive Sciences

Relaxin as a Protective Substance in Preservation Solutions for Organ Transplantation, as Shown in an Isolated Perfused Rat Liver Model

(2008) M.U. Boehnert et al.   TRANSPLANTATION PROCEEDINGS

Endogenous Relaxin Does Not Affect Chronic Pressure Overload-Induced Cardiac Hypertrophy and Fibrosis

(2007) Qi Xu et al.   ENDOCRINOLOGY

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY

Adenovirus-mediated delivery of relaxin reverses cardiac fibrosis

(2007) R.A.D. Bathgate et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY