Urolithin C, a gut metabolite of ellagic acid, induces apoptosis in PC12 cells through a mitochondria-mediated pathway

Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways

(2017) Chao Zhang et al.   Redox Biology

Deoxynivalenol induces apoptosis in PC12 cells via the mitochondrial pathway

(2016) Xichun Wang et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Methylated urolithin A, the modified ellagitannin-derived metabolite, suppresses cell viability of DU145 human prostate cancer cells via targeting miR-21

(2016) Benhong Zhou et al.   FOOD AND CHEMICAL TOXICOLOGY

Chromatographic and spectroscopic characterization of urolithins for their determination in biological samples after the intake of foods containing ellagitannins and ellagic acid

(2016) Rocío García-Villalba et al.   JOURNAL OF CHROMATOGRAPHY A

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

Quantitative analysis of the expression of caspase 3 and caspase 9 in different types of atherosclerotic lesions in the human aorta

(2015) Igor A. Sobenin et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Urolithins at physiological concentrations affect the levels of pro-inflammatory cytokines and growth factor in cultured cardiac cells in hyperglucidic conditions

(2015) Roberto Sala et al.   Journal of Functional Foods

Activation of intrinsic apoptotic signaling pathway in cancer cells by Cymbopogon citratus polysaccharide fractions

(2014) Ramar Thangam et al.   CARBOHYDRATE POLYMERS

Metabolic Fate of Ellagitannins: Implications for Health, and Research Perspectives for Innovative Functional Foods

(2014) Cristina Garcia-Muñoz et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

PE-induced apoptosis in SMMC-7721 cells: Involvement of Erk and Stat signalling pathways

(2014) LI XUE et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Pilot Walnut Intervention Study of Urolithin Bioavailability in Human Volunteers

(2014) Beate Pfundstein et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Role of human gut microbiota metabolism in the anti-inflammatory effect of traditionally used ellagitannin-rich plant materials

(2014) Jakub P. Piwowarski et al.   JOURNAL OF ETHNOPHARMACOLOGY

Allethrin induces oxidative stress, apoptosis and calcium release in rat testicular carcinoma cells (LC540)

(2014) Golla Madhubabu et al.   TOXICOLOGY IN VITRO

Pomegranate phenolics inhibit formation of advanced glycation endproducts by scavenging reactive carbonyl species

(2014) Weixi Liu et al.   Food & Function

The role of cell signalling in the crosstalk between autophagy and apoptosis

(2013) Laurence A. Booth et al.   CELLULAR SIGNALLING

Phase-II metabolism limits the antiproliferative activity of urolithins in human colon cancer cells

(2013) Antonio González-Sarrías et al.   EUROPEAN JOURNAL OF NUTRITION

Protective Effect ofPunica granatumL. against Serum/Glucose Deprivation-Induced PC12 Cells Injury

(2013) Fatemeh Forouzanfar et al.   Evidence-based Complementary and Alternative Medicine

Biological Significance of Urolithins, the Gut Microbial Ellagic Acid-Derived Metabolites: The Evidence So Far

(2013) Juan Carlos Espín et al.   Evidence-based Complementary and Alternative Medicine

Pomegranate Juice Metabolites, Ellagic Acid and Urolithin A, Synergistically Inhibit Androgen-Independent Prostate Cancer Cell Growth via Distinct Effects on Cell Cycle Control and Apoptosis

(2013) Roberto Vicinanza et al.   Evidence-based Complementary and Alternative Medicine

In vitro antioxidant and antiproliferative effects of ellagic acid and its colonic metabolite, urolithins, on human bladder cancer T24 cells

(2013) Zhenpeng Qiu et al.   FOOD AND CHEMICAL TOXICOLOGY

Urolithins Display both Antioxidant and Pro-oxidant Activities Depending on Assay System and Conditions

(2013) Tuija Kallio et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Extracts fromEpilobiumsp. Herbs, Their Components and Gut Microbiota Metabolites ofEpilobiumEllagitannins, Urolithins, Inhibit Hormone-Dependent Prostate Cancer Cells-(LNCaP) Proliferation and PSA Secretion

(2013) Magdalena Stolarczyk et al.   PHYTOTHERAPY RESEARCH

Modelling the possible bioactivity of ellagitannin-derived metabolites. In silico tools to evaluate their potential xenoestrogenic behavior

(2013) Luca Dellafiora et al.   Food & Function

Isoalantolactone Induces Reactive Oxygen Species Mediated Apoptosis in Pancreatic Carcinoma PANC-1 Cells

(2012) Muhammad Khan et al.   International Journal of Biological Sciences

Intestinal Ellagitannin Metabolites Ameliorate Cytokine-Induced Inflammation and Associated Molecular Markers in Human Colon Fibroblasts

(2012) Juan A. Giménez-Bastida et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ellagitannin metabolites, urolithin A glucuronide and its aglycone urolithin A, ameliorate TNF-α-induced inflammation and associated molecular markers in human aortic endothelial cells

(2012) Juan A. Giménez-Bastida et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Punica granatum Protects Against Oxidative Stress in PC12 Cells and Oxidative Stress-Induced Alzheimer's Symptoms in Mice

(2011) Soo Jung Choi et al.   JOURNAL OF MEDICINAL FOOD

Antiglycative and neuroprotective activity of colon-derived polyphenol catabolites

(2011) Elena Verzelloni et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Colon Cancer Chemopreventive Activities of Pomegranate Ellagitannins and Urolithins

(2010) Sashi G. Kasimsetty et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inhibition of γ-secretase activity reduces Aβ production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: Implications for the treatment of Alzheimer's disease

(2009) Baiyang Sheng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of Pomegranate Chemical Constituents/Intestinal Microbial Metabolites on CYP1B1 in 22Rv1 Prostate Cancer Cells

(2009) Sashi G. Kasimsetty et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Urolithins, Intestinal Microbial Metabolites of Pomegranate Ellagitannins, Exhibit Potent Antioxidant Activity in a Cell-Based Assay

(2009) Dobroslawa Bialonska et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effects of Fruit Ellagitannin Extracts, Ellagic Acid, and Their Colonic Metabolite, Urolithin A, on Wnt Signaling†

(2009) Meenakshi Sharma et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Gene expression, cell cycle arrest and MAPK signalling regulation in Caco-2 cells exposed to ellagic acid and its metabolites, urolithins

(2009) Antonio González-Sarrías et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice

(2009) Antonio González-Sarrías et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Erlotinib Induces Mitochondrial-Mediated Apoptosis in Human H3255 Non-Small-Cell Lung Cancer Cells with Epidermal Growth Factor ReceptorL858R Mutation through Mitochondrial Oxidative Phosphorylation-Dependent Activation of BAX and BAK

(2008) Y.-H. Ling et al.   MOLECULAR PHARMACOLOGY