Article
Biochemistry & Molecular Biology
Katarzyna Bednarska, Izabela Fecka
Summary: Reactive carbonyl species such as MGO and GO are precursors to AGE formation, a major factor in diabetes complications. Vasoprotectives exhibit cardiovascular health benefits. The study showed hesperetin as the most effective RCS scavenger, with rutin, diosmetin, hesperidin, and hesperetin trapping both MGO and GO effectively.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Yue Luo, Jianan Zhang, Chi-Tang Ho, Shiming Li
Summary: This review examines the antiglycation effect and mechanism of tea and tea polyphenols. The findings suggest that tea polyphenols, particularly catechins, have a significant antiglycation effect by trapping alpha-dicarbonyl compounds and impeding the formation of advanced glycation end products (AGEs). Additionally, tea polyphenols alleviate aging, diabetes, and collagen-related diseases or complications through the regulation of receptor for advanced glycation end products (RAGE) expression and subsequent MAPK and TGF-beta pathways.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Chemistry, Applied
Yen-Tung Chen, You-Yu Lin, Min-Hsiung Pan, Chi-Tang Ho, Wei-Lun Hung
Summary: In thermally processed foods, heat-induced toxicants such as alpha-dicarbonyls and advanced glycation end products (AGEs) can be formed. The methylglyoxal (MGO)-trapping and antiglycative activities of herbal tea samples are strongly correlated with their phenolic and flavonoid contents. Rooibos tea exhibits the strongest MGO-trapping and antiglycative activities, reducing the levels of dicarbonyls and AGEs in cookies.
Article
Agriculture, Multidisciplinary
Most. Sharmin Sultana, Shun-ichi Yamamoto, Md. Sanaullah Biswas, Chisato Sakurai, Hayato Isoai, Jun'ichi Mano
Summary: This study reveals that reactive carbonyl species, generated downstream of reactive oxygen species, are the primary cause of plant growth retardation under salt stress.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Laila Anwar, Syed Abid Ali, Sana Khan, Mir Muhammad Uzairullah, Nazish Mustafa, Urooj Anwer Ali, Faheema Siddiqui, Huma Aslam Bhatti, Syed Jawad Rehmani, Ghulam Abbas
Summary: This study investigates the anti-aging ability of Fenugreek seeds and finds that its extract can inhibit the formation of AGEs and improve glycation-induced memory decline. The results suggest that Fenugreek seeds could be a promising functional food in slowing down the harmful process of glycation and aging.
Article
Chemistry, Applied
Hao Zhang, Antonio Dario Troise, Yajing Qi, Gangcheng Wu, Hui Zhang, Vincenzo Fogliano
Summary: This study demonstrated that polyphenols bound to insoluble dietary fiber can scavenge reactive carbonyl species, highlighting the physiological relevance of BP-IDF in limiting carbonyl stress along the gastrointestinal tract.
Article
Cardiac & Cardiovascular Systems
Julio A. Lamprea-Montealegre, Alice M. Arnold, Robyn L. McCLelland, Kenneth J. Mukamal, Luc Djousse, Mary L. Biggs, David S. Siscovick, Russell P. Tracy, Paul J. Beisswenger, Bruce M. Psaty, Joachim H. Ix, Jorge R. Kizer
Summary: This study found that alpha-dicarbonyl-derived AGEs are associated with CVD in an older cohort, but not in a healthier middle-aged/older cohort. The results suggest that AGEs may exert detrimental cardiovascular effects only under conditions of marked dicarbonyl and oxidative stress. Further investigation of alpha-dicarbonyl derivatives could lead to potential new strategies for CVD prevention in high-risk older populations.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Physiology
Xiaoxia Huang, Bingyu Li, Jiaqing Hu, Zhuanhua Liu, Dongping Li, Zhenfeng Chen, Hang Huang, Yanjia Chen, Xiaohua Guo, Yun Cui, Qiaobing Huang
Summary: This study reveals that AGEs mediate kidney injury with characteristic patterns by binding with RAGE and inducing moesin phosphorylation. AGE-BSA stimulation in mice resulted in distinct abnormal angiogenesis, glomerular hypertrophy, mesangial expansion, glomerular atrophy, and fibrosis at different time points. Moesin phosphorylation was accompanied by these AGE-induced alterations, and moesin deficiency attenuated AGE-BSA-induced fibrosis. The phosphorylation of moesin T558 was critical in AGE-induced tube formation.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Plant Sciences
Stefaniya Velichkova, Kenn Foubert, Luc Pieters
Summary: Protein glycation, a post-translational modification, is linked to glucose metabolism defects and the progression of various diseases. Research on antiglycation agents is lacking sufficient clinical data and approved drugs. Scientists are increasingly exploring natural compounds as potential inhibitors of advanced glycation endproduct formation.
Article
Chemistry, Physical
Vaishali Rana, Ahana Mukherjee, Yogita Basnal, Deepak Kushwaha, Jaydeep Bhattacharya, Ranjita Ghosh Moulick
Summary: The elevated blood sugar in Type II diabetes leads to the formation of Advanced Glycation Endproducts (AGEs), which cause severe pathogenic complications. Previous research has shown that AGEs generated from Hemoglobin A0 (HbA0) can synthesize gold nanoparticles (AuNPs). In this study, it was found that these AGEs can also reduce silver ions and synthesize silver nanoparticles (AgNPs) with a different plasmonic response. The research demonstrates that AGEs can be detected by deploying metal salts in solution.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Agronomy
Ajeet Singh Dhaka, Harsh Kumar Dikshit, Gyan P. Mishra, Mechiya Tomuilim Tontang, Nand Lal Meena, Ranjeet Ranjan Kumar, S. V. Ramesh, Sneh Narwal, Muraleedhar Aski, Vinutha Thimmegowda, Sanjeev Gupta, Ramakrishnan M. Nair, Shelly Praveen
Summary: This study investigated the growth conditions and nutritional profiles of six crops as microgreens. The findings showed that microgreens have valuable nutritional elements and diverse health benefits. Red cabbage and pearl-millet microgreens contained higher phenolics, while red radish and pearl-millet microgreens had higher anthocyanin content. Pearl-millet microgreens had the highest dietary fiber content.
Article
Engineering, Biomedical
Julia Kamml, Claire Acevedo, David S. Kammer
Summary: Advanced-Glycation-Endproducts (AGEs) are a major cause of impaired tissue material properties, particularly in collagen fibrils. The mechanical properties of collagen fibrils are altered when AGEs accumulate, which is commonly caused by diabetes and aging. However, the relationship between nano-scale cross-link properties, AGEs density in collagen fibrils, and the mechanical properties at larger scales is not well understood. This study uses molecular dynamics simulations and destructive tensile tests to evaluate the effect of different cross-link densities and mechanical properties on collagen fibril deformation and fracture behavior. It is found that increasing the AGEs density or loading energy capacity leads to stiffening of the collagen fibril. The absorbed energy is stored rather than dissipated through friction, resulting in brittle fracture upon fibrillar failure. The study emphasizes the importance of understanding AGEs properties for a better understanding of impaired tissue behavior and suggests further investigation into the loading energy capacity of AGEs.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Food Science & Technology
Qian Wu, Yingna Feng, Yu Ouyang, Yinggang Liang, Kuoquan Zhao, Ying Wang, Qing Luo, Juan Xiao, Nianjie Feng, Mengzhou Zhou
Summary: The study demonstrated that LSOPC inhibited AGEs formation, alleviated AGEs-induced liver injury by suppressing NF-kappa B nuclear translocation and MAPK signaling pathway activation. Additionally, LSOPC also inhibited the expression of TNF-alpha and IL-6. In conclusion, LSOPC treatment potentially modulated liver injury caused by long-term dietary AGEs by suppressing the RAGE-MAPK-NF-kappa B pathways.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Oncology
Ana-Lucia Mayen, Elom K. Aglago, Viktoria Knaze, Reynalda Cordova, Casper G. Schalkwijk, Karl-Heinz Wagner, Krasimira Aleksandrova, Veronika Fedirko, Pekka Keski-Rahkonen, Michael F. Leitzmann, Verena Katzke, Bernard Srour, Matthias B. Schulze, Giovanna Masala, Vittorio Krogh, Salvatore Panico, Rosario Tumino, Bas Bueno-de-Mesquita, Magritt Brustad, Antonio Agudo, Maria Dolores Chirlaque Lopez, Pilar Amiano, Bodil Ohlsson, Stina Ramne, Dagfinn Aune, Elisabete Weiderpass, Mazda Jenab, Heinz Freisling
Summary: The study found that higher dietary intake of AGEs was inversely associated with the risk of hepatocellular carcinoma and positively associated with the risk of gallbladder cancer. No associations were observed for cancers of the intra and extrahepatic bile ducts.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Orthopedics
Zachary S. Gallate, Danielle N. D'Erminio, Philip Nasser, Damien M. Laudier, James C. Iatridis
Summary: Back and neck pain are major causes of disability, with intervertebral disc degeneration being a contributing factor. Accumulation of advanced glycation endproducts (AGEs) is associated with oxidative stress and collagen damage in the intervertebral disc. The receptors for AGEs (RAGE) and Galectin 3 (Gal3) play important roles in the response to AGEs in the intervertebral disc.
Article
Entomology
Jamie L. Rafter, Justin F. Vendettuoli, Liahna Gonda-King, Daniel Niesen, Navindra P. Seeram, Chad M. Rigsby, Evan L. Preisser
ENVIRONMENTAL ENTOMOLOGY
(2017)
Article
Nutrition & Dietetics
Bohkyung Kim, Minkyung Bae, Young-Ki Park, Hang Ma, Tao Yuan, Navindra P. Seeram, Ji-Young Lee
EUROPEAN JOURNAL OF NUTRITION
(2018)
Article
Plant Sciences
Feifei Liu, Tao Yuan, Wei Liu, Hang Ma, Navindra P. Seeram, Yuanyuan Li, Li Xu, Yu Mu, Xueshi Huang, Liya Li
JOURNAL OF NATURAL PRODUCTS
(2017)
Article
Neurosciences
Nicholas A. DaSilva, Pragati P. Nahar, Hang Ma, Aseel Eid, Zhengxi Wei, Susan Meschwitz, Nasser H. Zawia, Angela L. Slitt, Navindra P. Seeram
NUTRITIONAL NEUROSCIENCE
(2019)
Article
Food Science & Technology
Yuanyuan Li, Jialin Xu, Chunhui Yuan, Hang Ma, Tingting Liu, Feifei Liu, Navindra P. Seeram, Yu Mu, Xueshi Huang, Liya Li
JOURNAL OF FUNCTIONAL FOODS
(2017)
Article
Biochemistry & Molecular Biology
Weixi Liu, Zhengxi Wei, Hang Ma, Ang Cai, Yongqiang Liu, Jiadong Sun, Nicholas A. DaSilva, Shelby L. Johnson, Louis J. Kirschenbaum, Bongsup P. Cho, Joel A. Dain, David C. Rowley, Zahir A. Shaikh, Navindra P. Seeram
Article
Entomology
Jamie L. Rafter, Liahna Gonda-King, Daniel Niesen, Navindra P. Seeram, Chad M. Rigsby, Evan L. Preisser
Article
Biochemistry & Molecular Biology
Shelby L. Johnson, Riley D. Kirk, Nicholas A. DaSilva, Hang Ma, Navindra P. Seeram, Matthew J. Bertin
Article
Biochemistry & Molecular Biology
Chang Liu, Tess Puopolo, Huifang Li, Ang Cai, Navindra P. Seeram, Hang Ma
Summary: This study confirms the inhibitory activity of a library of minor cannabinoids on SARS-CoV-2 M-Pro through biochemical analysis and molecular docking techniques. It also reveals that the anti-M-Pro effects of cannabinoids are influenced by decarboxylation and the length of the alkyl side chain.
Article
Food Science & Technology
Kara J. Torrey, Yongqiang Liu, Huifang Li, Hang Ma, Christopher W. Via, Matthew J. Bertin, Navindra P. Seeram
Summary: Maple water products, tapped directly from maple trees, lack industry consensus on their authenticity, hindering their promotion in the functional beverage market. This study aims to establish standards of identity for maple water and analyze its chemical composition. The research shows that pasteurized maple water has a stable chemical composition over a 12-month period and exhibits similar phytochemical profiles and chemical characteristics to phenolic-enriched maple syrup extract. Additionally, both maple water and maple syrup extract show moderate antioxidant and anti-inflammatory effects. This critical information will help define and distinguish maple water from other beverages, promoting growth in the maple industry.
Meeting Abstract
Biochemistry & Molecular Biology
Hang Ma, Weixi Liu, Joel A. Dain, Navindra P. Seeram
Meeting Abstract
Biochemistry & Molecular Biology
Hang Ma, Shelby L. Johnson, Nicholas A. DaSilva, Yongqiang Liu, Tao Yuan, Navindra P. Seeram
Meeting Abstract
Zoology
M. Skrip, N. Seeram, T. Yuan, H. Ma, S. Mcwilliams
INTEGRATIVE AND COMPARATIVE BIOLOGY
(2017)
Article
Dermatology
Hang Ma, Jialin Xu, Nicholas A. DaSilva, Ling Wang, Zhengxi Wei, Liangran Guo, Shelby L. Johnson, Wei Lu, Jun Xu, Qiong Gu, Navindra P. Seeram
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2017)
Article
Chemistry, Medicinal
Abdullatif Bin Muhsinah, Hang Ma, Nicholas A. DaSilva, Tao Yuan, Navindra P. Seeram
NATURAL PRODUCT COMMUNICATIONS
(2017)
Article
Biochemistry & Molecular Biology
Davide Risso, Gillian Dunngalvin, Sameer Saxena, Andrea Doolan, Lisa Spence, Kavita Karnik
Summary: This study investigated the gastrointestinal tolerance of low-calorie sugar D-allulose in young children and found that it was well tolerated. It can be considered as a candidate for replacing added sugars with lower caloric content in commercially produced goods.
Article
Biochemistry & Molecular Biology
Xinying Suo, Anna Baggio, Nicoletta Pellegrini, Silvia Vincenzetti, Elena Vittadini
Summary: This study investigated the effects of shape, gluten, and structural breakdown on the starch digestibility and glycemic index of gluten-containing and gluten-free pasta. The results showed that mastication effort, shape, and gluten content had significant impacts on starch digestion and glycemic index, with gluten being the major factor affecting the amount of digested starch.
Article
Biochemistry & Molecular Biology
Xinnuo Hu, Yanjun Yang, Cuihua Chang, Junhua Li, Yujie Su, Luping Gu
Summary: Fish collagen was enzymatically hydrolyzed using alkaline, papain, and ginger protease. The addition of ginger protease increased the degree of hydrolysis and resulted in changes in the amino acid composition and molecular weight distribution of the peptides. Combined hydrolysis with ginger protease improved the ACE inhibitory activity of the sample but affected fibroblast proliferation activity.
Article
Biochemistry & Molecular Biology
Tong Nie, Xin Wang, Aqun Li, Anshan Shan, Jun Ma
Summary: This study investigated the mechanism by which hesperidin prevents nonalcoholic fatty liver disease (NAFLD) by modulating fatty acid beta oxidation. The results suggest that hesperidin promotes fatty acid beta oxidation by activating SIRT1/PGC1 alpha, thus improving NAFLD.
Article
Biochemistry & Molecular Biology
Li Li, Jing Zhao, Jinxue Wang, Qianqian Xiong, Xuechun Lin, Xiaolei Guo, Fan Peng, Wangqun Liang, Xuezhi Zuo, Chenjiang Ying
Summary: The daily administration of 10 g d-1 inulin-type fructans significantly reduced the circulating arsenic retention in end-stage renal disease by increasing the arsenic clearance rate through urine and dialysis. However, it was found to be ineffective for other trace elements.
Article
Biochemistry & Molecular Biology
Chuanchuan Wang, Weixuan Chen, Yishan Jiang, Xiao Xiao, Qianhui Zou, Jiarui Liang, Yu Zhao, Qianxu Wang, Tian Yuan, Rui Guo, Xuebo Liu, Zhigang Liu
Summary: Autism Spectrum Disorder (ASD) symptoms may be improved through modulation of gut microbiota. This study investigated the effects of a synbiotic treatment on an ASD-like mouse model, and found that it rectified social impairments, attenuated inflammatory cytokine expressions, protected gut barrier integrity, and altered gut microbiota composition. The synbiotic treatment elevated beneficial metabolites and upregulated genes associated with their synthesis. Overall, the synbiotic combination mitigated ASD-related social impairments through regulation of the gut-brain axis.
Review
Biochemistry & Molecular Biology
Chunli Kong, Caiping Duan, Yixuan Zhang, Yiying Wang, Zheng Yan, Sumei Zhou
Summary: This review critically discusses the physicochemical properties of bioactive molecules in kidney beans and focuses on the current knowledge of non-starch polysaccharide (NSP) structure and function on intestinal health and metabolism. It also provides suggestions for further investigation and development of NSPs as novel plant carbohydrate resources.
Article
Biochemistry & Molecular Biology
Fei Shen, Qianqian Wang, Sami Ullah, Ya Pan, Minjie Zhao, Jing Wang, Ming Chen, Fengqin Feng, Hao Zhong
Summary: This study investigated the peristalsis-promoting potential of Ligilactobacillus acidipiscis YJ5 and its underlying molecular mechanism in relieving constipation. The results showed that L. acidipiscis YJ5 intervention increased intestinal peristalsis in zebrafish and mouse models, reduced colonic aquaporin expression, repaired intestinal morphological damage, enhanced the colonic mucosal barrier, and reversed the gut microbiota structure. The positive effects of L. acidipiscis YJ5 were attributed to its metabolites such as malic acid and heliangin.
Article
Biochemistry & Molecular Biology
Zhuo Qu, Jiahui Tian, Jiachen Sun, Ying Shi, Jianqiang Yu, Wannian Zhang, Chunlin Zhuang
Summary: Smoking is the main risk factor for lung cancer, but garlic oil compound DATS shows potential as a chemopreventive agent. DATS can inhibit the carcinogenic effects of tobacco and regulate gut microbiota, as well as activate the PPAR-gamma pathway to suppress tumor growth.
Article
Biochemistry & Molecular Biology
Yanli Zhang, Jielun Hu, Yadong Zhong, Shuai Liu, Liandi Liu, Xinyi Mu, Chunhua Chen, Shenji Yang, Guohao Li, Duoduo Zhang, Xinru Huang, Jinrui Yang, Xiaojun Huang, Shuigen Bian, Shaoping Nie
Summary: The study found that different ratios of insoluble and soluble dietary fiber have distinct effects on gut microbiota and serum metabolites. Increasing the ratio of insoluble dietary fiber increases the relative abundance and acid production of specific bacterial genera, while increasing the ratio of soluble dietary fiber increases the diversity and relative abundance of other bacterial genera and regulates metabolic pathways.
Article
Biochemistry & Molecular Biology
Enhui Tang, Tong Hu, Zhaokang Jiang, Xiaojun Shen, Huan Lin, Haiyan Xian, Xinlan Wu
Summary: Isoquercitrin alleviates lipopolysaccharide-induced intestinal mucosal barrier damage in mice by inhibiting the TLR4/MyD88/NF-kappa B signaling pathway and modulating the intestinal flora.
Article
Biochemistry & Molecular Biology
Nesma A. Abd Elrazik, Sahar A. Helmy
Summary: This study found that betanin, the major pigment in red beetroot, has a protective effect against bleomycin-induced pulmonary fibrosis in rats. The protective effect may be attributed to the attenuation of the NLRP3/IL-1 beta/TGF-beta 1 signaling pathway and the suppression of the EMT process.
Article
Biochemistry & Molecular Biology
Sha Li, Longchen Shang, Yuanyuan Chen, Rong Song, Jing Li, Bin Li
Summary: A new form of konjac fiber was prepared that could instantly expand in contact with digestive fluid, inhibiting the digestion of food. The digestion regulation ability of the fiber was influenced by the freezing temperature used during preparation, with the fiber prepared at -20 degrees C showing the best performance in delaying gastric emptying and preventing intestinal starch hydrolysis.
Article
Biochemistry & Molecular Biology
Xian Xia, Jiangdong Li, Rui Liang, Yi Li, Xiaojuan Ma, Ying Yang, Daniel Lozano-Ojalvo
Summary: This study aimed to reduce the allergenicity of ovomucoid through unfolding-assisted glycation. The results showed that maltose glycation effectively reduced the IgG-binding capacity of the allergen. Unfolded and glycated ovomucoid exhibited enhanced antioxidant activity and metal ion chelating ability.