LGR5 is required for the maintenance of spheroid-derived colon cancer stem cells

ROS Production and NF-κB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer Initiation

(2013) Kevin B. Myant et al.   Cell Stem Cell

Lgr5 expression as stem cell marker in human gastric gland and its relatedness with other putative cancer stem cell markers

(2013) Chen Wu et al.   GENE

Overexpression of Lgr5 correlates with resistance to 5-FU-based chemotherapy in colorectal cancer

(2013) Hung-Chih Hsu et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Leucine-rich repeat-containing G-protein coupled receptor 5/GPR49 activates G12/13-Rho GTPase pathway

(2013) Mi So Kwon et al.   MOLECULES AND CELLS

LGR5 is a Marker of Poor Prognosis in Glioblastoma and is Required for Survival of Brain Cancer Stem-Like Cells

(2012) Susumu Nakata et al.   BRAIN PATHOLOGY

EphB2 receptor controls proliferation/migration dichotomy of glioblastoma by interacting with focal adhesion kinase

(2012) S D Wang et al.   ONCOGENE

Coaction of Spheroid-Derived Stem-Like Cells and Endothelial Progenitor Cells Promotes Development of Colon Cancer

(2012) Bo Wei et al.   PLoS One

LGR5-Positive Colon Cancer Stem Cells Interconvert with Drug-Resistant LGR5-Negative cells and are Capable of Tumor Reconstitution

(2012) Shinta Kobayashi et al.   STEM CELLS

The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse

(2011) Anna Merlos-Suárez et al.   Cell Stem Cell

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

Significance of Lgr5+ve Cancer Stem Cells in the Colon and Rectum

(2010) Hidekazu Takahashi et al.   ANNALS OF SURGICAL ONCOLOGY

Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in colorectal cancer

(2010) Hiroshi Uchida et al.   CANCER SCIENCE

Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

(2010) Hugo J. Snippert et al.   CELL

CD133+CD44+ subgroups may be human small intestinal stem cells

(2010) Neng-Yi Hou et al.   MOLECULAR BIOLOGY REPORTS

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

Aldehyde Dehydrogenase 1 Is a Marker for Normal and Malignant Human Colonic Stem Cells (SC) and Tracks SC Overpopulation during Colon Tumorigenesis

(2009) E. H. Huang et al.   CANCER RESEARCH

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

CD44 is of Functional Importance for Colorectal Cancer Stem Cells

(2008) L. Du et al.   CLINICAL CANCER RESEARCH

Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation

(2008) Liqin Zhu et al.   NATURE

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

Bmi1 is expressed in vivo in intestinal stem cells

(2008) Eugenio Sangiorgi et al.   NATURE GENETICS