Factors affecting the physical stability (aggregation) of peptide therapeutics

Role of Buffers in Protein Formulations

(2017) Teddy J. Zbacnik et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Citrullination and deamidation affect aggregation properties of amyloid β-proteins

(2016) Dai Osaki et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Deamidation of N76 in human γS-crystallin promotes dimer formation

(2016) Nicholas J. Ray et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Methionine oxidation reduces lag-times for amyloid-β(1–40) fiber formation but generates highly fragmented fibers

(2016) Miao Gu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Phosphorylation Interferes with Maturation of Amyloid-β Fibrillar Structure in the N Terminus

(2016) Nasrollah Rezaei-Ghaleh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Impact of N-terminal Acetylation of α-Synuclein on Phospholipid Membrane Binding and Fibril Structure

(2016) Aditya Iyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Controlled release of biologics for the treatment of type 2 diabetes

(2016) Caslin A. Gilroy et al.   JOURNAL OF CONTROLLED RELEASE

Amyloid-β Peptide Nitrotyrosination Stabilizes Oligomers and Enhances NMDAR-Mediated Toxicity

(2016) Biuse Guivernau et al.   JOURNAL OF NEUROSCIENCE

Peptide backbone modification in the bend region of amyloid-βinhibits fibrillogenesis but not oligomer formation

(2016) Erik C. B. Johnson et al.   JOURNAL OF PEPTIDE SCIENCE

Characterization of Novel Insulin Fibrils That Show Strong Cytotoxicity Under Physiological pH

(2016) Hiromu Yoshihara et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Both Reversible Self-Association and Structural Changes Underpin Molecular Viscoelasticity of mAb Solutions

(2016) Prasad S. Sarangapani et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Immunogenicity of Therapeutic Protein Aggregates

(2016) Ehab M. Moussa et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A pH-Induced Switch in Human Glucagon-like Peptide-1 Aggregation Kinetics

(2016) Karolina L. Zapadka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ionic Strength Modulation of the Free Energy Landscape of Aβ40 Peptide Fibril Formation

(2016) Axel Abelein et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mitigation of reversible self-association and viscosity in a human IgG1 monoclonal antibody by rational, structure-guided Fv engineering

(2016) James C. Geoghegan et al.   mAbs

The activities of amyloids from a structural perspective

(2016) Roland Riek et al.   NATURE

Molecular mechanisms of protein aggregation from global fitting of kinetic models

(2016) Georg Meisl et al.   Nature Protocols

Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading

(2016) Marija Iljina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling and simulation of protein–surface interactions: achievements and challenges

(2016) Musa Ozboyaci et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Phosphorylation modifies the molecular stability of β-amyloid deposits

(2016) Nasrollah Rezaei-Ghaleh et al.   Nature Communications

Structural Characterization of Fibrils from Recombinant Human Islet Amyloid Polypeptide by Solid-State NMR: The Central FGAILS Segment Is Part of the β-Sheet Core

(2016) Franziska Weirich et al.   PLoS One

Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide

(2016) Georg Meisl et al.   Scientific Reports

Stabilization of proteins in solid form

(2015) Marcus T. Cicerone et al.   ADVANCED DRUG DELIVERY REVIEWS

Structural characterization of amyloid fibrils from the human parathyroid hormone

(2015) Mohanraj Gopalswamy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Key interactions of surfactants in therapeutic protein formulations: A review

(2015) Tarik A. Khan et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A multi-pathway perspective on protein aggregation: Implications for control of the rate and extent of amyloid formation

(2015) Damien Hall et al.   FEBS LETTERS

The road to the first, fully active and more stable human insulin variant with an additional disulfide bond

(2015) Tine N. Vinther et al.   JOURNAL OF PEPTIDE SCIENCE

Formulation and Stability of Cytokine Therapeutics

(2015) Tiina Lipiäinen et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Stabilization of Insulin by Adsorption on a Hydrophobic Silane Self-Assembled Monolayer

(2015) Sergio Mauri et al.   LANGMUIR

Agitation of amyloid proteins to speed aggregation measured by ThT fluorescence: A call for standardization

(2015) Kiersten M. Batzli et al.   Materials Science & Engineering C-Materials for Biological Applications

Polysorbate 20 Degradation in Biopharmaceutical Formulations: Quantification of Free Fatty Acids, Characterization of Particulates, and Insights into the Degradation Mechanism

(2015) Anthony Tomlinson et al.   MOLECULAR PHARMACEUTICS

Transformation of Oligomers of Lipidated Peptide Induced by Change in pH

(2015) Ying Wang et al.   MOLECULAR PHARMACEUTICS

Isotope-edited FTIR reveals distinct aggregation and structural behaviors of unmodified and pyroglutamylated amyloid β peptides

(2015) Greg Goldblatt et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

On the lag phase in amyloid fibril formation

(2015) Paolo Arosio et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Advanced protein formulations

(2015) Wei Wang   PROTEIN SCIENCE

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers

(2015) Sarah L. Shammas et al.   Nature Communications

Variant fatty acid-like molecules Conjugation, novel approaches for extending the stability of therapeutic peptides

(2015) Ying Li et al.   Scientific Reports

Early Engineering Approaches to Improve Peptide Developability and Manufacturability

(2014) Jennifer L. Furman et al.   AAPS Journal

Neuropathology and biochemistry of Aβ and its aggregates in Alzheimer’s disease

(2014) Dietmar Rudolf Thal et al.   ACTA NEUROPATHOLOGICA

UV-induced selective oxidation of Met5 to Met-sulfoxide leads to the formation of neurotoxic fibril-incompetent α-synuclein oligomers

(2014) Phelippe Carmo-Gonçalves et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Protein Interactions with Polymer Coatings and Biomaterials

(2014) Qiang Wei et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Native metastable prefibrillar oligomers are the most neurotoxic species among amyloid aggregates

(2014) Marco Diociaiuti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Engineering disulfide bonds within an antibody

(2014) Yoshihisa Hagihara et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Application of Isothermal Titration Calorimetry for Characterizing Thermodynamic Parameters of Biomolecular Interactions: Peptide Self-Assembly and Protein Adsorption Case Studies

(2014) Maryam Kabiri et al.   BIOMACROMOLECULES

Biopharmaceutical liquid formulation: a review of the science of protein stability and solubility in aqueous environments

(2014) Jordan W. Bye et al.   BIOTECHNOLOGY LETTERS

Comparison of the anti-amyloidogenic effect of O-mannosylation, O-galactosylation, and O-GalNAc glycosylation

(2014) Chen Lin et al.   CARBOHYDRATE RESEARCH

Biochemical Stabilization of Glucagon at Alkaline pH

(2014) Nicholas Caputo et al.   Diabetes Technology & Therapeutics

Predicting aggregation-prone sequences in proteins

(2014) Greet De Baets et al.   Essays in Biochemistry

The physical chemistry of the amyloid phenomenon: thermodynamics and kinetics of filamentous protein aggregation

(2014) Alexander K. Buell et al.   Essays in Biochemistry

Forces stabilizing proteins

(2014) C. Nick Pace et al.   FEBS LETTERS

Relationship between the initial rate of protein aggregation and the lag period for amorphous aggregation

(2014) Vera A. Borzova et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

A Genome-Wide Sequence–Structure Analysis Suggests Aggregation Gatekeepers Constitute an Evolutionary Constrained Functional Class

(2014) Greet De Baets et al.   JOURNAL OF MOLECULAR BIOLOGY

Effects of Phenol and meta-Cresol Depletion on Insulin Analog Stability at Physiological Temperature

(2014) Brandon M. Teska et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PASTA 2.0: an improved server for protein aggregation prediction

(2014) Ian Walsh et al.   NUCLEIC ACIDS RESEARCH

The structure of insulin at the air/water interface: monomers or dimers?

(2014) S. Mauri et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

N-Alpha-Acetylation of α-Synuclein Increases Its Helical Folding Propensity, GM1 Binding Specificity and Resistance to Aggregation

(2014) Tim Bartels et al.   PLoS One

Acylation of Glucagon-Like Peptide-2: Interaction with Lipid Membranes and In Vitro Intestinal Permeability

(2014) Sofie Trier et al.   PLoS One

Non-Arrhenius Protein Aggregation

(2013) Wei Wang et al.   AAPS Journal

pH Dependence of Amylin Fibrillization

(2013) Suman Jha et al.   BIOCHEMISTRY

Off-pathway aggregation can inhibit fibrillation at high protein concentrations

(2013) Taru Deva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Pressure–temperature folding landscape in proteins involved in neurodegenerative diseases and cancer

(2013) Yraima Cordeiro et al.   BIOPHYSICAL CHEMISTRY

Peptides that form β-sheets on hydrophobic surfaces accelerate surface-induced insulin amyloidal aggregation

(2013) Laurent Nault et al.   FEBS LETTERS

Effect of surface chemistry of porous silicon microparticles on glucagon-like peptide-1 (GLP-1) loading, release and biological activity

(2013) Anne Huotari et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Covalently attached fatty acyl chains alter the aggregation behavior of an amyloidogenic peptide derived from humanβ2-microglobulin

(2013) Anoop Rawat et al.   JOURNAL OF PEPTIDE SCIENCE

Modelling amyloid fibril formation kinetics: mechanisms of nucleation and growth

(2013) J E Gillam et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

A Mechanistic Model for Amorphous Protein Aggregation of Immunoglobulin-like Domains

(2013) Madeleine B. Borgia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oxidative stress-induced posttranslational modifications of alpha-synuclein: Specific modification of alpha-synuclein by 4-hydroxy-2-nonenal increases dopaminergic toxicity

(2013) Wei Xiang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Extolling the benefits of molecular therapeutic lipidation

(2013) Miriam Avadisian et al.   Molecular BioSystems

Identification of Oxidation Sites and Covalent Cross-Links in Metal Catalyzed Oxidized Interferon Beta-1a: Potential Implications for Protein Aggregation and Immunogenicity

(2013) Riccardo Torosantucci et al.   MOLECULAR PHARMACEUTICS

Mechanisms of glucagon degradation at alkaline pH

(2013) Nicholas Caputo et al.   PEPTIDES

Oxidation of Therapeutic Proteins and Peptides: Structural and Biological Consequences

(2013) Riccardo Torosantucci et al.   PHARMACEUTICAL RESEARCH

Peptide lipidation stabilizes structure to enhance biological function

(2013) Brian P. Ward et al.   Molecular Metabolism

On-Surface Aggregation of α-Synuclein at Nanomolar Concentrations Results in Two Distinct Growth Mechanisms

(2012) Michael Rabe et al.   ACS Chemical Neuroscience

Human insulin adsorption kinetics, conformational changes and amyloidal aggregate formation on hydrophobic surfaces

(2012) Laurent Nault et al.   Acta Biomaterialia

Lipid Peroxidation Product 4-Hydroxy-2-Nonenal Promotes Seeding-Capable Oligomer Formation and Cell-to-Cell Transfer of α-Synuclein

(2012) Eun-Jin Bae et al.   ANTIOXIDANTS & REDOX SIGNALING

Identification of distinct physiochemical properties of toxic prefibrillar species formed by Aβ peptide variants

(2012) Anna-Lena Göransson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ionic Strength Effects on Amyloid Formation by Amylin Are a Complicated Interplay among Debye Screening, Ion Selectivity, and Hofmeister Effects

(2012) Peter J. Marek et al.   BIOCHEMISTRY

Normal and Reversed Supramolecular Chirality of Insulin Fibrils Probed by Vibrational Circular Dichroism at the Protofilament Level of Fibril Structure

(2012) Dmitry Kurouski et al.   BIOPHYSICAL JOURNAL

Review self-assembly of amphipathic β-sheet peptides: Insights and applications

(2012) Charles J. Bowerman et al.   BIOPOLYMERS

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Cell Interaction Study of Amyloid by Using Luminescent Conjugated Polythiophene: Implication that Amyloid Cytotoxicity Is Correlated with Prolonged Cellular Binding

(2012) Tamotsu Zako et al.   CHEMBIOCHEM

Surface chemistry at the nanometer scale influences insulin aggregation

(2012) Lalit M. Pandey et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Physicochemical Strategies for Inhibition of Amyloid Fibril Formation: An Overview of Recent Advances

(2012) R. Liu et al.   CURRENT MEDICINAL CHEMISTRY

Nanoscopic and Photonic Ultrastructural Characterization of Two Distinct Insulin Amyloid States

(2012) Katarzyna Maria Psonka-Antonczyk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Effect of Osmolytes on Protein Fibrillation

(2012) Francesca Macchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Immunogenicity of protein aggregates—Concerns and realities

(2012) Wei Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Influence of acylation on the adsorption of GLP-2 to hydrophobic surfaces

(2012) Charlotte Pinholt et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Kinetic pathways to peptide aggregation on surfaces: The effects of β-sheet propensity and surface attraction

(2012) Alex Morriss-Andrews et al.   JOURNAL OF CHEMICAL PHYSICS

Turn Nucleation Perturbs Amyloid β Self-Assembly and Cytotoxicity

(2012) Todd M. Doran et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure and Composition of Insulin Fibril Surfaces Probed by TERS

(2012) Dmitry Kurouski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Deamidation Accelerates Amyloid Formation and Alters Amylin Fiber Structure

(2012) Emily B. Dunkelberger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Coassembly of Enantiomeric Amphipathic Peptides into Amyloid-Inspired Rippled β-Sheet Fibrils

(2012) Ria J. Swanekamp et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effects of Ligands on Unfolding of the Amyloid β-Peptide Central Helix: Mechanistic Insights from Molecular Dynamics Simulations

(2012) Mika Ito et al.   PLoS One

Disulfide Bridges Remain Intact while Native Insulin Converts into Amyloid Fibrils

(2012) Dmitry Kurouski et al.   PLoS One

Aggregation gatekeepers modulate protein homeostasis of aggregating sequences and affect bacterial fitness

(2012) J. Beerten et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Interactions of formulation excipients with proteins in solution and in the dried state

(2011) Satoshi Ohtake et al.   ADVANCED DRUG DELIVERY REVIEWS

Molecular origins of surfactant-mediated stabilization of protein drugs

(2011) Hyo Jin Lee et al.   ADVANCED DRUG DELIVERY REVIEWS

Protein–excipient interactions: Mechanisms and biophysical characterization applied to protein formulation development

(2011) Tim J. Kamerzell et al.   ADVANCED DRUG DELIVERY REVIEWS

Understanding protein adsorption phenomena at solid surfaces

(2011) Michael Rabe et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Hydrophobic, Aromatic, and Electrostatic Interactions Play a Central Role in Amyloid Fibril Formation and Stability

(2011) Karen E. Marshall et al.   BIOCHEMISTRY

Protein palmitoylation and subcellular trafficking

(2011) Clara Aicart-Ramos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Protein–surfactant interactions: A tale of many states

(2011) Daniel Otzen   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Spontaneous inter-conversion of insulin fibril chirality

(2011) Dmitry Kurouski et al.   CHEMICAL COMMUNICATIONS

Factors affecting the formation of insulin amyloid spherulites

(2011) Michael I. Smith et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

The Slowly Aggregating Salmon Calcitonin: A Useful Tool for the Study of the Amyloid Oligomers Structure and Activity

(2011) Marco Diociaiuti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural Basis for Increased Toxicity of Pathological Aβ42:Aβ40Ratios in Alzheimer Disease

(2011) Kris Pauwels et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fibril Structure of Human Islet Amyloid Polypeptide

(2011) Sahar Bedrood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of m-cresol-induced Protein Aggregation Studied Using a Model Protein Cytochrome c

(2011) Surinder M. Singh et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Effects of Surfaces and Leachables on the Stability of Biopharmaceuticals

(2011) Jared S. Bee et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Aggregation in Protein-Based Biotherapeutics: Computational Studies and Tools to Identify Aggregation-Prone Regions

(2011) Neeraj J. Agrawal et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Population of Nonnative States of Lysozyme Variants Drives Amyloid Fibril Formation

(2011) Alexander K. Buell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanomechanics of functional and pathological amyloid materials

(2011) Tuomas P. J. Knowles et al.   Nature Nanotechnology

GLP-1 analogs containing disulfide bond exhibited prolonged half-life in vivo than GLP-1

(2011) Ying Li et al.   PEPTIDES

The Degradation of Polysorbates 20 and 80 and its Potential Impact on the Stability of Biotherapeutics

(2011) Ravuri S. K. Kishore et al.   PHARMACEUTICAL RESEARCH

Effect of Surfaces on Amyloid Fibril Formation

(2011) Bradley Moores et al.   PLoS One

Role of amino acid hydrophobicity, aromaticity, and molecular volume on IAPP(20-29) amyloid self-assembly

(2011) Todd M. Doran et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Salt-Induced Modulation of the Pathway of Amyloid Fibril Formation by the Mouse Prion Protein

(2010) Shweta Jain et al.   BIOCHEMISTRY

Amyloid-β Fibrillogenesis Seeded by Interface-Induced Peptide Misfolding and Self-Assembly

(2010) Eva Y. Chi et al.   BIOPHYSICAL JOURNAL

Influence of PEGylation with linear and branched PEG chains on the adsorption of glucagon to hydrophobic surfaces

(2010) Charlotte Pinholt et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Amyloid structure - one but not the same: the many levels of fibrillar polymorphism

(2010) Jesper S. Pedersen et al.   FEBS Journal

Pyroglutamate-Aβ: Role in the natural history of Alzheimer's disease

(2010) Adam P. Gunn et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Protein aggregation—Pathways and influencing factors

(2010) Wei Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Comparative Evaluation of Disodium Edetate and Diethylenetriaminepentaacetic Acid as Iron Chelators to Prevent Metal -Catalyzed Destabilization of a Therapeutic Monoclonal Antibody

(2010) Shuxia Zhou et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Degradation of Polysorbates 20 and 80: Studies on Thermal Autoxidation and Hydrolysis

(2010) Ravuri S.K. Kishore et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: Implications to tetramer stability and ligand-binding

(2010) Daniela B.B. Trivella et al.   JOURNAL OF STRUCTURAL BIOLOGY

Assays for α-synuclein aggregation

(2010) Lise Giehm et al.   METHODS

Exploring the sequence determinants of amyloid structure using position-specific scoring matrices

(2010) Sebastian Maurer-Stroh et al.   NATURE METHODS

Stability of Protein Pharmaceuticals: An Update

(2010) Mark Cornell Manning et al.   PHARMACEUTICAL RESEARCH

Protein aggregation: more than just fibrils

(2009) Mark R.H. Krebs et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Pyroglutamate Formation Influences Solubility and Amyloidogenicity of Amyloid Peptides

(2009) Dagmar Schlenzig et al.   BIOCHEMISTRY

Divorcing folding from function: How acylation affects the membrane-perturbing properties of an antimicrobial peptide

(2009) Brian Vad et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Lipopeptide detergents for membrane protein studies

(2009) Gilbert G Privé   CURRENT OPINION IN STRUCTURAL BIOLOGY

Application of High Hydrostatic Pressure to Dissociate Aggregates and Refold Proteins

(2009) Matthew Seefeldt et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Safety, tolerability, pharmacodynamics and pharmacokinetics of albiglutide, a long-acting glucagon-like peptide-1 mimetic, in healthy subjects

(2009) M. A. Bush et al.   DIABETES OBESITY & METABOLISM

Protein sequences encode safeguards against aggregation

(2009) Joke Reumers et al.   HUMAN MUTATION

Protein Oxidation During Long Storage: Identification of the Oxidation Sites in Dihydrofolate Reductase from Escherichia coli through LC-MS and Fragment Studies

(2009) T. Takenawa et al.   JOURNAL OF BIOCHEMISTRY

The Recombinant Amyloid-β Peptide Aβ1–42 Aggregates Faster and Is More Neurotoxic than Synthetic Aβ1–42

(2009) Verena H. Finder et al.   JOURNAL OF MOLECULAR BIOLOGY

The Common Architecture of Cross-β Amyloid

(2009) Thomas R. Jahn et al.   JOURNAL OF MOLECULAR BIOLOGY

Methionine, tryptophan, and histidine oxidation in a model protein, PTH: Mechanisms and stabilization

(2009) Junyan A. Ji et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Pharmacokinetics and Pharmacodynamics of Liraglutide, a Long-Acting, Potent Glucagon-Like Peptide-1 Analog

(2009) Jerry Meece   PHARMACOTHERAPY

Amyloidogenicity and Aggregate Cytotoxicity of Human Glucagon-Like Peptide-1 (hGLP-1)

(2009) S. Poon et al.   PROTEIN AND PEPTIDE LETTERS

BETASCAN: Probable β-amyloids Identified by Pairwise Probabilistic Analysis

(2009) Allen W. Bryan et al.   PLoS Computational Biology

Dissociation of Amyloid Fibrils of α-Synuclein in Supercooled Water

(2008) Hai-Young Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cold- and Pressure-Induced Dissociation of Protein Aggregates and Amyloid Fibrils

(2008) Rajesh Mishra et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of Aggregation-Prone Elements by Using Interaction-Energy Matrices

(2008) Jennifer M. Bui et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Glutaminyl cyclases from animals and plants: a case of functionally convergent protein evolution

(2008) Stephan Schilling et al.   BIOLOGICAL CHEMISTRY

Pathogenesis of and Therapeutic Strategies to Ameliorate the Transthyretin Amyloidoses

(2008) Yoshiki Sekijima et al.   CURRENT PHARMACEUTICAL DESIGN

Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of Albiglutide, a Long-Acting Glucagon-Like Peptide-1 Mimetic, in Patients with Type 2 Diabetes

(2008) Jessica E. Matthews et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Prediction of Aggregation-Prone Regions in Structured Proteins

(2008) Gian Gaetano Tartaglia et al.   JOURNAL OF MOLECULAR BIOLOGY

Deamidation destabilizes and triggers aggregation of a lens protein, βA3-crystallin

(2008) Takumi Takata et al.   PROTEIN SCIENCE

Isomerization and/or racemization at Asp23 of Aβ42 do not increase its aggregative ability, neurotoxicity, and radical productivity in vitro

(2007) Kazuma Murakami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanisms of Protein Fibril Formation: Nucleated Polymerization with Competing Off-Pathway Aggregation

(2007) Evan T. Powers et al.   BIOPHYSICAL JOURNAL

Dual effects of Tween 80 on protein stability

(2007) Wei Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Polysorbates 20 and 80 Used in the Formulation of Protein Biotherapeutics: Structure and Degradation Pathways

(2007) Bruce A. Kerwin   JOURNAL OF PHARMACEUTICAL SCIENCES

Low levels of asparagine deamidation can have a dramatic effect on aggregation of amyloidogenic peptides: Implications for the study of amyloid formation

(2002) Melanie R. Nilsson et al.   PROTEIN SCIENCE