The Paravascular Pathway for Brain Waste Clearance: Current Understanding, Significance and Controversy

Omega-3 polyunsaturated fatty acids promote amyloid-β clearance from the brain through mediating the function of the glymphatic system

(2017) Huixia Ren et al.   FASEB JOURNAL

Potential Modes of Intercellular α-Synuclein Transmission

(2017) Dario Valdinocci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases

(2017) Toshiaki Taoka et al.   JAPANESE JOURNAL OF RADIOLOGY

Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts

(2017) Minghuan Wang et al.   JOURNAL OF NEUROSCIENCE

Cortical Spreading Depression Closes Paravascular Space and Impairs Glymphatic Flow: Implications for Migraine Headache

(2017) Aaron J. Schain et al.   JOURNAL OF NEUROSCIENCE

White matter damage and glymphatic dysfunction in a model of vascular dementia in rats with no prior vascular pathologies

(2017) Poornima Venkat et al.   NEUROBIOLOGY OF AGING

Continuous theta burst stimulation facilitates the clearance efficiency of the glymphatic pathway in a mouse model of sleep deprivation

(2017) Dong-xu Liu et al.   NEUROSCIENCE LETTERS

Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases

(2017) Toshiaki Taoka et al.   Japanese Journal of Radiology

Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice

(2017) Xiao-fei He et al.   Frontiers in Molecular Neuroscience

Vascular basement membranes as pathways for the passage of fluid into and out of the brain

(2016) Alan W. J. Morris et al.   ACTA NEUROPATHOLOGICA

Obstructive sleep apnea decreases central nervous system-derived proteins in the cerebrospinal fluid

(2016) Yo-El S. Ju et al.   ANNALS OF NEUROLOGY

Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease

(2016) Matthew J. Simon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Blood–brain barrier and blood–cerebrospinal fluid barrier in normal and pathological conditions

(2016) Masaki Ueno et al.   Brain Tumor Pathology

Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases

(2016) Erik N. T. P. Bakker et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Imaging the Perivascular Space as a Potential Biomarker of Neurovascular and Neurodegenerative Diseases

(2016) Joel Ramirez et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

4D flow MRI for intracranial hemodynamics assessment in Alzheimer’s disease

(2016) Leonardo A Rivera-Rivera et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Impairment of the glymphatic system after diabetes

(2016) Quan Jiang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Glymphatic clearance controls state-dependent changes in brain lactate concentration

(2016) Iben Lundgaard et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Paravascular channels, cisterns, and the subarachnoid space in the rat brain: A single compartment with preferential pathways

(2016) Beatrice Bedussi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation

(2016) Thiyagaragan M. Achariyar et al.   Molecular Neurodegeneration

Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease

(2016) Weiguo Peng et al.   NEUROBIOLOGY OF DISEASE

Lymphatics in Neurological Disorders: A Neuro-Lympho-Vascular Component of Multiple Sclerosis and Alzheimer’s Disease?

(2016) Antoine Louveau et al.   NEURON

Mechanism of depression as a risk factor in the development of Alzheimer’s disease: the function of AQP4 and the glymphatic system

(2016) Maosheng Xia et al.   PSYCHOPHARMACOLOGY

Glymphatic solute transport does not require bulk flow

(2016) Mahdi Asgari et al.   Scientific Reports

Expression of the Astrocyte Water Channel Aquaporin-4 in the Mouse Brain

(2015) Jacqueline A. Hubbard et al.   ASN Neuro

Ultra-fast magnetic resonance encephalography of physiological brain activity – Glymphatic pulsation mechanisms?

(2015) Vesa Kiviniemi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Effect of Body Posture on Brain Glymphatic Transport

(2015) H. Lee et al.   JOURNAL OF NEUROSCIENCE

Biomarkers of Traumatic Injury Are Transported from Brain to Blood via the Glymphatic System

(2015) B. A. Plog et al.   JOURNAL OF NEUROSCIENCE

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

The Glymphatic System: A Beginner’s Guide

(2015) Nadia Aalling Jessen et al.   NEUROCHEMICAL RESEARCH

Impairment of paravascular clearance pathways in the aging brain

(2014) Benjamin T. Kress et al.   ANNALS OF NEUROLOGY

Failure of Perivascular Drainage of β-amyloid in Cerebral Amyloid Angiopathy

(2014) Cheryl A. Hawkes et al.   BRAIN PATHOLOGY

Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury

(2014) Jeffrey J. Iliff et al.   JOURNAL OF NEUROSCIENCE

Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer’s disease mouse models

(2013) Michal Arbel-Ornath et al.   ACTA NEUROPATHOLOGICA

Brain-wide pathway for waste clearance captured by contrast-enhanced MRI

(2013) Jeffrey J. Iliff et al.   JOURNAL OF CLINICAL INVESTIGATION

Blood–brain barrier structure and function and the challenges for CNS drug delivery

(2013) N. Joan Abbott   JOURNAL OF INHERITED METABOLIC DISEASE

Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer

(2013) Lijun Yang et al.   Journal of Translational Medicine

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain

(2013) Vinita Rangroo Thrane et al.   Scientific Reports

Basic Vascular Neuroanatomy of the Brain and Spine: What the General Interventional Radiologist Needs to Know

(2013) Sun Ahn et al.   SEMINARS IN INTERVENTIONAL RADIOLOGY

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy

(2011) Cheryl A. Hawkes et al.   ACTA NEUROPATHOLOGICA

Trafficking of Glucose, Lactate, and Amyloid-β from the Inferior Colliculus through Perivascular Routes

(2009) Kelly K Ball et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Lymphatic drainage of the brain and the pathophysiology of neurological disease

(2008) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

(2008) R. O. Carare et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Diffusion in Brain Extracellular Space

(2008) Eva Syková et al.   PHYSIOLOGICAL REVIEWS