Exploring the immunomodulatory and anticancer properties of zerumbone

An overview of structure–activity relationship studies of curcumin analogs as antioxidant and anti-inflammatory agents

(2017) Laiba Arshad et al.   Future Medicinal Chemistry

Tinospora species: An overview of their modulating effects on the immune system

(2017) Md. Areeful Haque et al.   JOURNAL OF ETHNOPHARMACOLOGY

Immunosuppressive Effects of Natural α,β-Unsaturated Carbonyl-Based Compounds, and Their Analogs and Derivatives, on Immune Cells: A Review

(2017) Laiba Arshad et al.   Frontiers in Pharmacology

Zerumbone induces gastric cancer cells apoptosis: Involving cyclophilin A

(2016) Dong Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Elevated IL-1β expression induces invasiveness of triple negative breast cancer cells and is suppressed by zerumbone

(2016) Myeongjin Jeon et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Zerumbone, a Bioactive Sesquiterpene, Ameliorates Diabetes-Induced Retinal Microvascular Damage through Inhibition of Phospho-p38 Mitogen-Activated Protein Kinase and Nuclear Factor-κB Pathways

(2016) Wayne Liu et al.   MOLECULES

Zerumbone, a Sesquiterpene, Controls Proliferation and Induces Cell Cycle Arrest in Human Laryngeal Carcinoma Cell Line Hep-2

(2016) Srimathi Devi Jegannathan et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Possible Contribution of Zerumbone-Induced Proteo-Stress to Its Anti-Inflammatory Functions via the Activation of Heat Shock Factor 1

(2016) Yoko Igarashi et al.   PLoS One

Bioactive natural products in cancer prevention and therapy: Progress and promise

(2016) Anupam Bishayee et al.   SEMINARS IN CANCER BIOLOGY

Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds

(2016) Muthu K Shanmugam et al.   SEMINARS IN CANCER BIOLOGY

Zerumbone, a Phytochemical of Subtropical Ginger, Protects against Hyperglycemia-Induced Retinal Damage in Experimental Diabetic Rats

(2016) Thing-Fong Tzeng et al.   Nutrients

Zerumbone inhibits growth of hormone refractory prostate cancer cells by inhibiting JAK2/STAT3 pathway and increases paclitaxel sensitivity

(2015) Jessica E. Jorvig et al.   ANTI-CANCER DRUGS

Zerumbone protects INS-1 rat pancreatic beta cells from high glucose-induced apoptosis through generation of reactive oxygen species

(2015) Changyin Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Zerumbone enhances the Th1 response and ameliorates ovalbumin-induced Th2 responses and airway inflammation in mice

(2015) Ying-Hua Shieh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Binding Mode Analysis of Zerumbone to Key Signal Proteins in the Tumor Necrosis Factor Pathway

(2015) Ayesha Fatima et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Zerumbone Suppresses Osteopontin-Induced Cell Invasion Through Inhibiting the FAK/AKT/ROCK Pathway in Human Non-Small Cell Lung Cancer A549 Cells

(2015) Chi Gu Kang et al.   JOURNAL OF NATURAL PRODUCTS

Zerumbone, a ginger sesquiterpene, induces apoptosis and autophagy in human hormone-refractory prostate cancers through tubulin binding and crosstalk between endoplasmic reticulum stress and mitochondrial insult

(2015) Mei-Ling Chan et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Zerumbone attenuates TGF-β1-mediated epithelial–mesenchymal transition via upregulated E-cadherin expression and downregulated Smad2 signalling pathways in non-small cell lung cancer (A549) cells

(2015) You-Cheng Hseu et al.   Journal of Functional Foods

Zerumbone suppresses the motility and tumorigenecity of triple negative breast cancer cells via the inhibition of TGF-β1 signaling pathway

(2015) Sangmin Kim et al.   Oncotarget

Nanostructured lipid carrier improved in vivo anti-tumor and immunomodulatory effect of Zerumbone in 4T1 challenged mice

(2015) Nurul Elyani Mohamad et al.   RSC Advances

Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials

(2015) Ibrahim Jantan et al.   Frontiers in Plant Science

Antisecretory, Gastroprotective, Antioxidant and Anti-Helicobcter Pylori Activity of Zerumbone from Zingiber Zerumbet (L.) Smith

(2015) Heyam Mohamed Ali Sidahmed et al.   PLoS One

Notch2 activation is protective against anticancer effects of zerumbone in human breast cancer cells

(2014) Anuradha Sehrawat et al.   BREAST CANCER RESEARCH AND TREATMENT

Lipid-lowering effects of zerumbone, a natural cyclic sesquiterpene of Zingiber zerumbet Smith, in high-fat diet-induced hyperlipidemic hamsters

(2014) Thing-Fong Tzeng et al.   FOOD AND CHEMICAL TOXICOLOGY

Abrogation of STAT3 signaling cascade by zerumbone inhibits proliferation and induces apoptosis in renal cell carcinoma xenograft mouse model

(2014) Muthu K. Shanmugam et al.   MOLECULAR CARCINOGENESIS

Zerumbone Inhibits Angiogenesis by Blocking NF-κB Activity in Pancreatic Cancer

(2014) Tomoya Shamoto et al.   PANCREAS

Zerumbone Suppresses IL-1β-induced Cell Migration and Invasion by Inhibiting IL-8 and MMP-3 Expression in Human Triple-negative Breast Cancer Cells

(2014) Jeonghun Han et al.   PHYTOTHERAPY RESEARCH

Phytochemical importance of medicinal plants as potential sources of anticancer agents

(2014) Himani RAINA et al.   TURKISH JOURNAL OF BOTANY

Zerumbone, a tropical ginger sesquiterpene, ameliorates streptozotocin-induced diabetic nephropathy in rats by reducing the hyperglycemia-induced inflammatory response

(2013) Thing-Fong Tzeng et al.   Nutrition & Metabolism

Zerumbone inhibits tumor angiogenesis via NF-κB in gastric cancer

(2013) KEN TSUBOI et al.   ONCOLOGY REPORTS

Calpain and Reactive Oxygen Species Targets Bax for Mitochondrial Permeabilisation and Caspase Activation in Zerumbone Induced Apoptosis

(2013) Praveen K. Sobhan et al.   PLoS One

Antimalarial activity and cytotoxicity of zerumbone derivatives

(2013) Uraiwan Sriphana et al.   SCIENCEASIA

Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer

(2012) Remya Prasannan et al.   BIOCHEMICAL PHARMACOLOGY

Zerumbone causes Bax- and Bak-mediated apoptosis in human breast cancer cells and inhibits orthotopic xenograft growth in vivo

(2012) Anuradha Sehrawat et al.   BREAST CANCER RESEARCH AND TREATMENT

The Immunomodulatory and Anticancer Properties of Propolis

(2012) Godfrey Chi-Fung Chan et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Zerumbone isolated from Zingiber zerumbet inhibits inflammation and pain in rats

(2012) M. N. Somchit   Journal of Medicinal Plants Research

Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats

(2012) Zariyantey Abdul Hamid et al.   Journal of Zhejiang University-SCIENCE B

Attractive Reactivity of a Natural Product, Zerumbone

(2011) Takashi KITAYAMA   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Zerumbone Induces Heme Oxygenase-1 Expression in Mouse Skin and Cultured Murine Epidermal Cells through Activation of Nrf2

(2011) J.-W. Shin et al.   Cancer Prevention Research

Chemotypical variations in Withania somnifera lead to differentially modulated immune response in BALB/c mice

(2011) Susheela Kushwaha et al.   VACCINE

Effects of selected food phytochemicals in reducing the toxic actions of TCDD and p,p′-DDT in U937 macrophages

(2010) Eric M. Sciullo et al.   ARCHIVES OF TOXICOLOGY

Characterization of the inclusion complex of zerumbone with hydroxypropyl-β-cyclodextrin

(2010) Eltayeb E.M. Eid et al.   CARBOHYDRATE POLYMERS

Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet)

(2010) Manal Mohamed Elhassan Taha et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Cytotoxicity against cholangiocarcinoma cell lines of zerumbone derivatives

(2010) Uraiwan Songsiang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice

(2010) M.R. Sulaiman et al.   FITOTERAPIA

Combination of Zerumbone and Cisplatin to Treat Cervical Intraepithelial Neoplasia in Female BALB/c Mice

(2010) Ahmad Bustamam Abdul et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Zerumbone induces apoptosis in T-acute lymphoblastic leukemia cells

(2010) Siddig Ibrahim Abdelwahab et al.   LEUKEMIA RESEARCH

Bioactive sesquiterpenes fromCurcuma ochrorhizaandCurcuma heyneana

(2010) Mohd. Aspollah Sukari et al.   NATURAL PRODUCT RESEARCH

In VitroCovalent Binding Proteins of Zerumbone, a Chemopreventive Food Factor

(2009) Kohta OHNISHI et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Zerumbone Abolishes RANKL-Induced NF-κB Activation, Inhibits Osteoclastogenesis, and Suppresses Human Breast Cancer–Induced Bone Loss in Athymic Nude Mice

(2009) Bokyung Sung et al.   CANCER RESEARCH

Zerumbone Enhances TRAIL-Induced Apoptosis through the Induction of Death Receptors in Human Colon Cancer Cells: Evidence for an Essential Role of Reactive Oxygen Species

(2009) S. Yodkeeree et al.   CANCER RESEARCH

Regression of cervical intraepithelial neoplasia by zerumbone in female Balb/c mice prenatally exposed to diethylstilboestrol: Involvement of mitochondria-regulated apoptosis

(2009) Siddig Ibrahim Abdelwahab et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Preliminary analysis of the antinociceptive activity of zerumbone

(2009) M.R. Sulaiman et al.   FITOTERAPIA

Suppression of lipopolysaccharide-stimulated inducible nitric oxide synthase (iNOS) expression by a novel humulene derivative in macrophage cells

(2009) Hye-Young Min et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Anticancer and Antimicrobial Activities of Zerumbone from the Rhizomes of Zingiber zerumbut

(2009) Ahmad B. Abdul et al.   International Journal of Pharmacology

Zerumbone Down-regulates Chemokine Receptor CXCR4 Expression Leading to Inhibition of CXCL12-Induced Invasion of Breast and Pancreatic Tumor Cells

(2008) Bokyung Sung et al.   CANCER RESEARCH

Anti-inflammatory constituents of Zingiber zerumbet

(2008) T.Y. Chien et al.   FOOD CHEMISTRY

Zerumbone, a tropical ginger sesquiterpene, inhibits colon and lung carcinogenesis in mice

(2008) Mihye Kim et al.   INTERNATIONAL JOURNAL OF CANCER