Binding Mode Analysis of Zerumbone to Key Signal Proteins in the Tumor Necrosis Factor Pathway

Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer

(2012) Remya Prasannan et al.   BIOCHEMICAL PHARMACOLOGY

Zerumbone inhibits interleukin-6 and induces apoptosis and cell cycle arrest in ovarian and cervical cancer cells

(2012) Siddig Ibrahim Abdelwahab et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Structural Basis of Wnt Recognition by Frizzled

(2012) C. Y. Janda et al.   SCIENCE

Structure-based design and biological profile of (E)-N-(4-Nitrobenzylidene)-2-naphthohydrazide, a novel small molecule inhibitor of IκB kinase-β

(2011) Carolina M. Avila et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure and dynamics of the kinase IKK-β – A key regulator of the NF-kappa B transcription factor

(2011) Munishikha Kalia et al.   JOURNAL OF STRUCTURAL BIOLOGY

Crystal structure of inhibitor of κB kinase β

(2011) Guozhou Xu et al.   NATURE

Identification of Human IKK-2 Inhibitors of Natural Origin (Part I): Modeling of the IKK-2 Kinase Domain, Virtual Screening and Activity Assays

(2011) Esther Sala et al.   PLoS One

Discovery of a novel IKK-β inhibitor by ligand-based virtual screening techniques

(2010) Stefan M. Noha et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Zerumbone induces apoptosis in T-acute lymphoblastic leukemia cells

(2010) Siddig Ibrahim Abdelwahab et al.   LEUKEMIA RESEARCH

Cancer Prevention With Natural Compounds

(2010) Norleena P. Gullett et al.   SEMINARS IN ONCOLOGY

4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors

(2009) John Liddle et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In VitroCovalent Binding Proteins of Zerumbone, a Chemopreventive Food Factor

(2009) Kohta OHNISHI et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Identification of a small molecule inhibitor of serine 276 phosphorylation of the p65 subunit of NF-κB using in silico molecular docking

(2009) Mary Law et al.   CANCER LETTERS

Zerumbone Abolishes RANKL-Induced NF-κB Activation, Inhibits Osteoclastogenesis, and Suppresses Human Breast Cancer–Induced Bone Loss in Athymic Nude Mice

(2009) Bokyung Sung et al.   CANCER RESEARCH

Zerumbone Enhances TRAIL-Induced Apoptosis through the Induction of Death Receptors in Human Colon Cancer Cells: Evidence for an Essential Role of Reactive Oxygen Species

(2009) S. Yodkeeree et al.   CANCER RESEARCH

Cytotoxic Activities ofPhysalis minimaL. Chloroform Extract on Human Lung Adenocarcinoma NCI-H23 Cell Lines by Induction of Apoptosis

(2009) Ooi Kheng Leong et al.   Evidence-based Complementary and Alternative Medicine

Regression of cervical intraepithelial neoplasia by zerumbone in female Balb/c mice prenatally exposed to diethylstilboestrol: Involvement of mitochondria-regulated apoptosis

(2009) Siddig Ibrahim Abdelwahab et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

A Structural Guide to Proteins of the NF- B Signaling Module

(2009) T. Huxford et al.   Cold Spring Harbor Perspectives in Biology

The IKK Complex, a Central Regulator of NF- B Activation

(2009) A. Israel   Cold Spring Harbor Perspectives in Biology

Presenting and exploring biological pathways with PathVisio

(2008) Martijn P van Iersel et al.   BMC BIOINFORMATICS

Zerumbone Down-regulates Chemokine Receptor CXCR4 Expression Leading to Inhibition of CXCL12-Induced Invasion of Breast and Pancreatic Tumor Cells

(2008) Bokyung Sung et al.   CANCER RESEARCH

Advances in Targeting IKK and IKK-Related Kinases for Cancer Therapy

(2008) D.-F. Lee et al.   CLINICAL CANCER RESEARCH

Typhonium flagelliforme inhibits cancer cell growth in vitro and induces apoptosis: An evaluation by the bioactivity guided approach

(2008) Choon-Sheen Lai et al.   JOURNAL OF ETHNOPHARMACOLOGY

Structure of a NEMO/IKK-Associating Domain Reveals Architecture of the Interaction Site

(2008) Mia Rushe et al.   STRUCTURE

Docking of molecules identified in bioactive medicinal plants extracts into the p50 NF-kappaB transcription factor: correlation with inhibition of NF-kappaB/DNA interactions and inhibitory effects on IL-8 gene expression

(2008) Laura Piccagli et al.   BMC STRUCTURAL BIOLOGY

TNFα acting on TNFR1 promotes breast cancer growth via p42/P44 MAPK, JNK, Akt and NF-κB-dependent pathways

(2007) Martín A. Rivas et al.   EXPERIMENTAL CELL RESEARCH