Bile acids at the cross-roads of gut microbiome–host cardiometabolic interactions

Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism

(2017) Preeti Pathak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The FXR agonist PX20606 ameliorates portal hypertension by targeting vascular remodelling and sinusoidal dysfunction

(2017) Philipp Schwabl et al.   JOURNAL OF HEPATOLOGY

Association of oral microbiome with type 2 diabetes risk

(2017) J. Long et al.   JOURNAL OF PERIODONTAL RESEARCH

Bile acid profiles over 5 years after gastric bypass and duodenal switch: results from a randomized clinical trial

(2017) Hilde Risstad et al.   Surgery for Obesity and Related Diseases

Dietary Choline and Betaine and Risk of CVD: A Systematic Review and Meta-Analysis of Prospective Studies

(2017) Katie Meyer et al.   Nutrients

Host Genotype and Gut Microbiome Modulate Insulin Secretion and Diet-Induced Metabolic Phenotypes

(2017) Julia H. Kreznar et al.   Cell Reports

Distinct patterns in the gut microbiota after surgical or medical therapy in obese patients

(2017) Daniel A. Medina et al.   PeerJ

Stable engraftment of human microbiota into mice with a single oral gavage following antibiotic conditioning

(2017) Christopher Staley et al.   Microbiome

Childhood BMI in relation to microbiota in infancy and lifetime antibiotic use

(2017) K. Korpela et al.   Microbiome

Confounding Effects of Metformin on the Human Gut Microbiome in Type 2 Diabetes

(2016) Adil Mardinoglu et al.   Cell Metabolism

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

(2016) Annika Wahlström et al.   Cell Metabolism

Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis

(2016) Filipe De Vadder et al.   Cell Metabolism

The Cardiovascular Biology of Glucagon-like Peptide-1

(2016) Daniel J. Drucker   Cell Metabolism

Gut Microbiome Associates With Lifetime Cardiovascular Disease Risk Profile Among Bogalusa Heart Study ParticipantsNovelty and Significance

(2016) Tanika N. Kelly et al.   CIRCULATION RESEARCH

Effects of obeticholic acid on lipoprotein metabolism in healthy volunteers

(2016) R. Pencek et al.   DIABETES OBESITY & METABOLISM

Microbiota-induced obesity requires farnesoid X receptor

(2016) Ava Parséus et al.   GUT

Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice

(2016) Yang Xu et al.   HEPATOLOGY

Regulation of lipid metabolism by obeticholic acid in hyperlipidemic hamsters

(2016) Bin Dong et al.   JOURNAL OF LIPID RESEARCH

Interaction between dietary lipids and gut microbiota regulates hepatic cholesterol metabolism

(2016) Robert Caesar et al.   JOURNAL OF LIPID RESEARCH

Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans

(2016) Shogo Takahashi et al.   JOURNAL OF LIPID RESEARCH

Beneficial effect of farnesoid X receptor activation on metabolism in a diabetic rat model

(2016) HONG-MEI ZHANG et al.   Molecular Medicine Reports

Human gut microbes impact host serum metabolome and insulin sensitivity

(2016) Helle Krogh Pedersen et al.   NATURE

Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health

(2016) Susan A. Joyce et al.   Annual Review of Food Science and Technology

FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis

(2016) Len Verbeke et al.   Scientific Reports

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism

(2016) Limin Zhang et al.   mSystems

Linkages between oral commensal bacteria and atherosclerotic plaques in coronary artery disease patients

(2016) Jyoti Chhibber-Goel et al.   npj Biofilms and Microbiomes

Intestinal Microbial Metabolites Are Linked to Severity of Myocardial Infarction in Rats

(2016) Vy Lam et al.   PLoS One

Bacterial Communities Associated with Atherosclerotic Plaques from Russian Individuals with Atherosclerosis

(2016) Elvira E. Ziganshina et al.   PLoS One

Unconjugated Bile Acids Influence Expression of Circadian Genes: A Potential Mechanism for Microbe-Host Crosstalk

(2016) Kalaimathi Govindarajan et al.   PLoS One

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

(2015) Zeneng Wang et al.   CELL

MAFG Is a Transcriptional Repressor of Bile Acid Synthesis and Metabolism

(2015) Thomas Q. de Aguiar Vallim et al.   Cell Metabolism

The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity

(2015) Evie P.M. Broeders et al.   Cell Metabolism

Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella

(2015) Petia Kovatcheva-Datchary et al.   Cell Metabolism

The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood LipidsNovelty and Significance

(2015) Jingyuan Fu et al.   CIRCULATION RESEARCH

How informative is the mouse for human gut microbiota research?

(2015) T. L. A. Nguyen et al.   Disease Models & Mechanisms

Efficacy of Obeticholic Acid in Patients With Primary Biliary Cirrhosis and Inadequate Response to Ursodeoxycholic Acid

(2015) Gideon M. Hirschfield et al.   GASTROENTEROLOGY

TGR5 contributes to glucoregulatory improvements after vertical sleeve gastrectomy in mice

(2015) Anne K McGavigan et al.   GUT

Akkermansia muciniphilaand improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology

(2015) Maria Carlota Dao et al.   GUT

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

(2015) Sungsoon Fang et al.   NATURE MEDICINE

The gut microbiome, diet and links to cardiometabolic and chronic disorders

(2015) Judith Aron-Wisnewsky et al.   Nature Reviews Nephrology

Efficacy and Safety of Evolocumab in Reducing Lipids and Cardiovascular Events

(2015) Marc S. Sabatine et al.   NEW ENGLAND JOURNAL OF MEDICINE

Changes in Bile Acid Profile After Laparoscopic Sleeve Gastrectomy are Associated with Improvements in Metabolic Profile and Fatty Liver Disease

(2015) Ajay P. Belgaumkar et al.   OBESITY SURGERY

Fate, activity, and impact of ingested bacteria within the human gut microbiota

(2015) Muriel Derrien et al.   TRENDS IN MICROBIOLOGY

FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic–pituitary–adrenal axis

(2015) Rachel J. Perry et al.   Nature Communications

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

(2015) Mohamed-Sami Trabelsi et al.   Nature Communications

The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance

(2015) Manya Warrier et al.   Cell Reports

In silico analyses of metagenomes from human atherosclerotic plaque samples

(2015) Suparna Mitra et al.   Microbiome

Randomised clinical trial: the beneficial effects of VSL#3 in obese children with non-alcoholic steatohepatitis

(2014) A. Alisi et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis

(2014) J. S. Bajaj et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Establishment of Intestinal Microbiota during Early Life: a Longitudinal, Explorative Study of a Large Cohort of Danish Infants

(2014) A. Bergstrom et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

New and emerging regulators of intestinal lipoprotein secretion

(2014) Changting Xiao et al.   ATHEROSCLEROSIS

Activation of farnesoid X receptor (FXR) protects against fructose-induced liver steatosis via inflammatory inhibition and ADRP reduction

(2014) Xijun Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dietary effects on human gut microbiome diversity

(2014) Zhenjiang Xu et al.   BRITISH JOURNAL OF NUTRITION

Altering the Intestinal Microbiota during a Critical Developmental Window Has Lasting Metabolic Consequences

(2014) Laura M. Cox et al.   CELL

Sitagliptin, a DPP-4 Inhibitor, Acutely Inhibits Intestinal Lipoprotein Particle Secretion in Healthy Humans

(2014) C. Xiao et al.   DIABETES

Exercise and associated dietary extremes impact on gut microbial diversity

(2014) Siobhan F Clarke et al.   GUT

Infant antibiotic exposure and the development of childhood overweight and central adiposity

(2014) M B Azad et al.   INTERNATIONAL JOURNAL OF OBESITY

Antidyslipidemic effects of a farnesoid X receptor antagonist in primates

(2014) Yuichiro Amano et al.   LIFE SCIENCES

Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal

(2014) Johannes Schmitt et al.   LIVER INTERNATIONAL

Effect of Probiotic (VSL#3) and Omega-3 on Lipid Profile, Insulin Sensitivity, Inflammatory Markers, and Gut Colonization in Overweight Adults: A Randomized, Controlled Trial

(2014) Hemalatha Rajkumar et al.   MEDIATORS OF INFLAMMATION

FXR is a molecular target for the effects of vertical sleeve gastrectomy

(2014) Karen K. Ryan et al.   NATURE

Rapid changes in the gut microbiome during human evolution

(2014) Andrew H. Moeller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut

(2014) S. A. Joyce et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbiota Modification with Probiotics Induces Hepatic Bile Acid Synthesis via Downregulation of the Fxr-Fgf15 Axis in Mice

(2014) Chiara Degirolamo et al.   Cell Reports

Association of Antibiotics in Infancy With Early Childhood Obesity

(2014) L. Charles Bailey et al.   JAMA Pediatrics

Inactivation of the cardiomyocyte glucagon-like peptide-1 receptor (GLP-1R) unmasks cardiomyocyte-independent GLP-1R-mediated cardioprotection

(2014) John R. Ussher et al.   Molecular Metabolism

Bile Acid Receptor TGR5 Agonism Induces NO Production and Reduces Monocyte Adhesion in Vascular Endothelial Cells

(2013) Taiki Kida et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation

(2013) Brian J. Bennett et al.   Cell Metabolism

MicroRNA-144 Regulates Hepatic ATP Binding Cassette Transporter A1 and Plasma High-Density Lipoprotein After Activation of the Nuclear Receptor Farnesoid X Receptor

(2013) Thomas Q. de Aguiar Vallim et al.   CIRCULATION RESEARCH

The gut microbiome as novel cardio-metabolic target: the time has come!

(2013) S. Vinje et al.   EUROPEAN HEART JOURNAL

Bile acids induce arrhythmias in human atrial myocardium—implications for altered serum bile acid composition in patients with atrial fibrillation

(2013) Peter P Rainer et al.   HEART

Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats

(2013) Len Verbeke et al.   HEPATOLOGY

Contribution of the 7β-hydroxysteroid dehydrogenase fromRuminococcus gnavusN53 to ursodeoxycholic acid formation in the human colon

(2013) Ja-Young Lee et al.   JOURNAL OF LIPID RESEARCH

Differential regulation of bile acid and cholesterol metabolism by the farnesoid X receptor inLdlr−/−mice versus hamsters

(2013) Christophe Gardès et al.   JOURNAL OF LIPID RESEARCH

Richness of human gut microbiome correlates with metabolic markers

(2013) Emmanuelle Le Chatelier et al.   NATURE

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Gut metagenome in European women with normal, impaired and diabetic glucose control

(2013) Fredrik H. Karlsson et al.   NATURE

GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure

(2013) Minsuk Kim et al.   NATURE MEDICINE

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human Gut Microbiota Changes Reveal the Progression of Glucose Intolerance

(2013) Xiuying Zhang et al.   PLoS One

Predicting and Manipulating Cardiac Drug Inactivation by the Human Gut Bacterium Eggerthella lenta

(2013) H. J. Haiser et al.   SCIENCE

Pitfalls and limitations in translation from biomarker discovery to clinical utility in predictive and personalised medicine

(2013) Elisabeth Drucker et al.   EPMA Journal

Data mining the human gut microbiota for therapeutic targets

(2012) M. Collison et al.   BRIEFINGS IN BIOINFORMATICS

Branched-Chain and Aromatic Amino Acids Are Predictors of Insulin Resistance in Young Adults

(2012) P. Wurtz et al.   DIABETES CARE

Fibroblast Growth Factor-19 Action in the Brain Reduces Food Intake and Body Weight and Improves Glucose Tolerance in Male Rats

(2012) Karen K. Ryan et al.   ENDOCRINOLOGY

Cholesterol lowering and inhibition of sterol absorption by Lactobacillus reuteri NCIMB 30242: a randomized controlled trial

(2012) M L Jones et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Intestinal microbiota determine severity of myocardial infarction in rats

(2012) Vy Lam et al.   FASEB JOURNAL

Arm reactions evoked by the initial exposure to a small balance perturbation: A pilot study

(2012) Philippe Corbeil et al.   GAIT & POSTURE

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

(2012) Kristin I. Stanford et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method

(2012) Juan C. García-Cañaveras et al.   JOURNAL OF LIPID RESEARCH

Gut microbiota composition correlates with diet and health in the elderly

(2012) Marcus J. Claesson et al.   NATURE

Antibiotics in early life alter the murine colonic microbiome and adiposity

(2012) Ilseung Cho et al.   NATURE

The Microbiota of the Gut in Preschool Children With Normal and Excessive Body Weight

(2012) Caroline L.J. Karlsson et al.   Obesity

Cholesterol-lowering efficacy of a microencapsulated bile salt hydrolase-active Lactobacillus reuteri NCIMB 30242 yoghurt formulation in hypercholesterolaemic adults

(2011) Mitchell L. Jones et al.   BRITISH JOURNAL OF NUTRITION

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

(2011) Thijs W.H. Pols et al.   Cell Metabolism

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Enteric Microbiome Metabolites Correlate with Response to Simvastatin Treatment

(2011) Rima Kaddurah-Daouk et al.   PLoS One

Swine as Models in Biomedical Research and Toxicology Testing

(2011) M. M. Swindle et al.   VETERINARY PATHOLOGY

Inhibition of Monocyte Adhesion to Endothelial Cells and Attenuation of Atherosclerotic Lesion by a Glucagon-like Peptide-1 Receptor Agonist, Exendin-4

(2010) M. Arakawa et al.   DIABETES

Differential Adaptation of Human Gut Microbiota to Bariatric Surgery-Induced Weight Loss: Links With Metabolic and Low-Grade Inflammation Markers

(2010) J.-P. Furet et al.   DIABETES

Human oral, gut, and plaque microbiota in patients with atherosclerosis

(2010) O. Koren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic gut microbial modulation of bile acid metabolism in host tissue compartments

(2010) J. R. Swann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A synthetic farnesoid X receptor (FXR) agonist promotes cholesterol lowering in models of dyslipidemia

(2009) Mark J. Evans et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Isolation and characterization of a bile acid inducible 7α-dehydroxylating operon in Clostridium hylemonae TN271

(2009) Jason M. Ridlon et al.   ANAEROBE

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Identification of Novel Pathways That Control Farnesoid X Receptor-mediated Hypocholesterolemia

(2009) Yanqiao Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR−/−and apoE−/−mice

(2009) Helen B. Hartman et al.   JOURNAL OF LIPID RESEARCH

Discovery of XL335 (WAY-362450), a Highly Potent, Selective, and Orally Active Agonist of the Farnesoid X Receptor (FXR)

(2009) Brenton Flatt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antiatherosclerotic effect of farnesoid X receptor

(2008) Andrea Mencarelli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

FXR nuclear receptor down-regulation in left ventricle of aging SHR: A possible end-stage heart failure bioenergetics adjustment

(2008) V. Salpeas et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Targeting bile-acid signalling for metabolic diseases

(2008) Charles Thomas et al.   NATURE REVIEWS DRUG DISCOVERY

Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome

(2008) B. V. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA